1. Zhongping Chen

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    1. Mentioned In 240 Articles

    2. Laryngeal epithelial thickness: a comparison between optical coherence tomography and histology

      Objectives: Optical coherence tomography, an imaging modality using near-infrared light, produces cross-sectional tissue images with a lateral pixel resolution of 10 μm. However, normative data is first needed on epithelial thickness for lesion characterisation, and, to date, little exists. The purpose of our study is to measure normal laryngeal epithelial thickness by in vivo optical coherence tomography, and compare these values to those obtained from fixed ex-vivo laryngectomy specimens. Design ...
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    3. Detection and monitoring of early airway injury effects of half-mustard (2-chloroethylethylsulfide) exposure using high-resolution optical coherence tomography

      Optical coherence tomography (OCT) is a noninvasive, high-resolution imaging technology capable of delivering real-time, near-histologic images of tissues. Mustard gas is a vesicant-blistering agent that can cause severe and lethal damage to airway and lungs. The ability to detect and assess airway injury in the clinical setting of mustard exposure is currently limited. The purpose of this study is to assess the ability to detect and monitor progression of half-mustard ...
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    4. Optical coherent tomographic (OCT) imaging apparatus and method using a fiber bundle

      Comment "Since 2004, Moptim imaging technical Ltd has cooperated with Graduate school at shenzhen Tsinghua University of China in OCT (optical ..." - John Sibney
      A fiber-optic bundle based optical coherence tomography (OCT) probe method is demonstrated in a multimode optical fiber bundle based OCT system. The system can achieve a lateral resolution of 12 .mu.m and an axial resolution of 10 .mu.m using a super-luminescent diode source. This imaging approach eliminates any moving parts in the probe and has a primary advantage for use in extremely compact and safe OCT endoscopes to ...
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    5. Endovascular Optical Coherence Tomography Device (Wo 2009/094341)

      Endovascular Optical Coherence Tomography Device (Wo 2009/094341)
      An endovascular OCT probe is included in an endovasculiar access device for intravascular imaging. The probe includes a hollow coil wire defining an axial lumen of the endovascular access device. A single mode optical fiber for transmitting light is disposed in the axial lumen of the hollow coil wire so that translation and rotation of the hollow coil wire carrying the optical fiber within the endovascular access device is stabilized ...
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    6. In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients

      In vivo, non-invasive optical coherence tomography (OCT) permits high-resolution imaging of tissue surfaces and subsurfaces, with the potential capability for detection and mapping of epithelial pathologies.To evaluate the clinical capability of non-invasive in vivo OCT for diagnosing oral dysplasia and malignancy.In 50 patients with oral lesions, conventional clinical examination was followed by OCT imaging, then standard biopsy and histopathology. Two blinded, pre-standardized investigators separately diagnosed each lesion based ...
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    7. Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles

      ... and Lih-Huei L. Liaw University of California, Irvine, Beckman Laser Institute, Irvine, California 92612 Zhongping Chen University of California, Irvine, Department of Biomedical Engineering, Department of Chemical ...
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    8. Gastrointestinal Optical Coherence Tomography: Clinical Applications, Limitations, and Research Priorities

      Optical coherence tomography provides the highest resolution available of any of the technologies currently used in endoscopic imaging. There are several potential clinical applications for optical coherence tomography, particularly with precancerous conditions of the gastrointestinal tract. The future of optical coherence tomography is discussed.
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    9. Axial resolution and depth range of high-resolution spectral domain optical coherence tomography at 1.3 um

      We built a high-speed, real-time spectral domain optical coherence tomography (SD-OCT) system at the 1.3 µm region using an InGaAs line-scan camera with 1024 pixels and 46.99 klines/s. In SD-OCT, the actual spatial resolution can be different from the theoretical one due to the large bandwidth of the light source and the finite number of detector pixels, especially for a long center wavelength. We calculated and compared ...
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    10. In-vivo office-based dynamic imaging of vocal cords in awake patients with swept-source optical coherence tomography

      Optical coherence tomography (OCT) is an evolving noninvasive imaging modality and has been used to image the human larynx during surgical endoscopy. The design of a long GRIN lens based probe capable of capturing images of the human larynx by use of swept-source OCT during a typical office-based laryngoscopy examination is presented. In vivo OCT imaging of the human larynx is demonstrated with 40 fame/second. Dynamic vibration of the ...
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    11. 181-195 of 240 « 1 2 ... 10 11 12 13 14 15 16 »
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  2. About Zhongping Chen

    Zhongping Chen

    Zhongping Chen is a Professor of Biomedical Engineering and Director of the F-OCT Laboratory at the University of California, Irvine. He is a Co-founder and Chairman of OCT Medical Imaging Inc. Dr. Chen received his B.S. degree in Applied Physics from Shanghai Jiao Tong University in 1982, his M.S. degree in Electrical Engineering in 1987, and his Ph.D. degree in Applied Physics from Cornell University in 1993. Dr. Chen’s research interests encompass the areas of biomedical photonics, microfabrication, biomaterials and biosensors. His research group has pioneered the development of functional optical coherence tomography, which simultaneously provides high resolution 3-D images of tissue structure, blood flow, and birefringence. These functional extensions of OCT offer contrast enhancements and provide mapping of many clinically important parameters. In addition, his group has developed a number of endoscopic and intravascular rotational and linear 2-D probes for OCT and MPM imaging and translated these technologies to clinical applications through collaboration with clinicians. He has led numerous major research projects funded by NIH, NSF, DOD, and DARPA, including several interdisciplinary research projects such as the NIH Biomedical Research Partnership (BRP) grant and NSF Biophotonics Partnership Initiative grant. Dr. Chen has published more than 200 peer-reviewed papers and review articles and holds a number of patents in the fields of biomaterials, biosensors, and biomedical imaging. Dr. Chen is a Fellow of the American Institute of Medical and Biological Engineering (AIMBE), a Fellow of SPIE, and a Fellow of the Optical Society of America.