1. Zhongping Chen

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    1. Mentioned In 236 Articles

    2. In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients

      In vivo, non-invasive optical coherence tomography (OCT) permits high-resolution imaging of tissue surfaces and subsurfaces, with the potential capability for detection and mapping of epithelial pathologies.To evaluate the clinical capability of non-invasive in vivo OCT for diagnosing oral dysplasia and malignancy.In 50 patients with oral lesions, conventional clinical examination was followed by OCT imaging, then standard biopsy and histopathology. Two blinded, pre-standardized investigators separately diagnosed each lesion based ...
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    3. Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles

      ... and Lih-Huei L. Liaw University of California, Irvine, Beckman Laser Institute, Irvine, California 92612 Zhongping Chen University of California, Irvine, Department of Biomedical Engineering, Department of Chemical ...
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    4. Gastrointestinal Optical Coherence Tomography: Clinical Applications, Limitations, and Research Priorities

      Optical coherence tomography provides the highest resolution available of any of the technologies currently used in endoscopic imaging. There are several potential clinical applications for optical coherence tomography, particularly with precancerous conditions of the gastrointestinal tract. The future of optical coherence tomography is discussed.
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    5. Axial resolution and depth range of high-resolution spectral domain optical coherence tomography at 1.3 um

      We built a high-speed, real-time spectral domain optical coherence tomography (SD-OCT) system at the 1.3 µm region using an InGaAs line-scan camera with 1024 pixels and 46.99 klines/s. In SD-OCT, the actual spatial resolution can be different from the theoretical one due to the large bandwidth of the light source and the finite number of detector pixels, especially for a long center wavelength. We calculated and compared ...
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    6. In-vivo office-based dynamic imaging of vocal cords in awake patients with swept-source optical coherence tomography

      Optical coherence tomography (OCT) is an evolving noninvasive imaging modality and has been used to image the human larynx during surgical endoscopy. The design of a long GRIN lens based probe capable of capturing images of the human larynx by use of swept-source OCT during a typical office-based laryngoscopy examination is presented. In vivo OCT imaging of the human larynx is demonstrated with 40 fame/second. Dynamic vibration of the ...
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    7. Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynx

      Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that has been used to image the human larynx during surgical endoscopy. The design of a long gradient-index lens-based probe capable of capturing images of the human larynx by use of spectral domain OCT during a typical o ... [J. Biomed. Opt. 14, 014017 (2009)] published Wed Feb 11, 2009.
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    8. Effect of Erythrocyte Aggregation on Hematocrit Measurement Using Spectral-Domain Optical Coherence Tomography

      Optical coherence tomography (OCT) has the potential to be a noninvasive method for hematocrit (HCT) measurement. This study shows the effect of erythrocyte aggregation at the level seen in healthy humans and pathological states on HCT measurement based on monitoring the slope changes in OCT depth reflectivity profile using spectral-domain optical coherence tomography (SDOCT). Our measurement indicates that the HCT estimated by SDOCT depends on the erythrocyte aggregation state and ...
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    9. Imaging the Human Tympanic Membrane Using Optical Coherence Tomography In Vivo.

      Objective: Optical coherence tomography (OCT) is a diagnostic imaging modality that combines low coherence light with interferometry to produce high-resolution cross-sectional images of living tissues. Using this technology, we have imaged in vivo the human tympanic membrane (TM) in the office clinic setting and characterized TM microstructure in normal and pathologic conditions. Study Design: Prospective clinical trial. Materials and Methods: The normal and diseased TMs in 10 adult subjects were ...
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    10. 181-195 of 236 « 1 2 ... 10 11 12 13 14 15 16 »
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  2. About Zhongping Chen

    Zhongping Chen

    Zhongping Chen is a Professor of Biomedical Engineering and Director of the F-OCT Laboratory at the University of California, Irvine. He is a Co-founder and Chairman of OCT Medical Imaging Inc. Dr. Chen received his B.S. degree in Applied Physics from Shanghai Jiao Tong University in 1982, his M.S. degree in Electrical Engineering in 1987, and his Ph.D. degree in Applied Physics from Cornell University in 1993. Dr. Chen’s research interests encompass the areas of biomedical photonics, microfabrication, biomaterials and biosensors. His research group has pioneered the development of functional optical coherence tomography, which simultaneously provides high resolution 3-D images of tissue structure, blood flow, and birefringence. These functional extensions of OCT offer contrast enhancements and provide mapping of many clinically important parameters. In addition, his group has developed a number of endoscopic and intravascular rotational and linear 2-D probes for OCT and MPM imaging and translated these technologies to clinical applications through collaboration with clinicians. He has led numerous major research projects funded by NIH, NSF, DOD, and DARPA, including several interdisciplinary research projects such as the NIH Biomedical Research Partnership (BRP) grant and NSF Biophotonics Partnership Initiative grant. Dr. Chen has published more than 200 peer-reviewed papers and review articles and holds a number of patents in the fields of biomaterials, biosensors, and biomedical imaging. Dr. Chen is a Fellow of the American Institute of Medical and Biological Engineering (AIMBE), a Fellow of SPIE, and a Fellow of the Optical Society of America.