1. Zhongping Chen

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    1. Mentioned In 235 Articles

    2. Optical Vaginal Biopsy Using Optical Coherence Tomography

      Optical Vaginal Biopsy Using Optical Coherence Tomography
      Objective Optical coherence tomography is a noninvasive technology that visualizes tissue microstructure with high spatial resolution. We designed a novel vaginal system that demonstrates a clear distinction between vaginal tissues planes. In this study, we sought to compare vaginal tomographic images of premenopausal, perimenopausal, and postmenopausal women, demonstrate feasibility of tracking vaginal tissue changes after treatment with fractional-pixel CO 2 laser therapy, and obtain a histologic correlation of these findings ...
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    3. Extended imaging depth of en-face optical coherence tomography based on fast measurement of a reflection matrix by wide-field heterodyne detection

      Extended imaging depth of en-face optical coherence tomography based on fast measurement of a reflection matrix by wide-field heterodyne detection
      Multiple light scattering in biomedical tissue limits the penetration depth of optical imaging systems such as optical coherence tomography. To increase the imaging depth in scattering media, a computational method based on coherent reflection matrix measurement has been developed using low coherence interferometry. The complex reflection matrix is obtained via point-by-point scanning followed by a phase-shifting method; then singular value decomposition is used to retrieve the singly back-scattered light. However ...
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    4. Optical coherence elastography (OCE) method under acoustic radiation force excitation using OCT doppler variance methods and OCT correlation-based methods

      Optical coherence elastography (OCE) method under acoustic radiation force excitation using OCT doppler variance methods and OCT correlation-based methods
      A system for imaging and quantifying shear wave and shear modulus under orthogonal acoustic radiation force (ARF) excitation using the OCT Doppler variance apparatus. The ARF perpendicular or with at least a perpendicular component to the OCT beam is produced by a remote ultrasonic transducer. The OCT Doppler variance apparatus, which is sensitive to the transverse vibration, is used to measure the ARF induced vibration. For analysis of the shear ...
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    5. In vivo evaluation of posterior eye elasticity using shaker-based optical coherence elastography

      In vivo evaluation of posterior eye elasticity using shaker-based optical coherence elastography
      Age-related macular degeneration (AMD) is a progressive retinal disease and becomes the leading cause of blindness. It is well established that early detection is the key to preservation of functional vision. However, it is very difficult to diagnose AMD in very early stages, before structural changes are evident. Consequently, investigating the biomechanical properties of the retina maybe essential for understanding its physiological function. In this study, we present a shear ...
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    6. Spatiotemporal dynamics of pial collateral blood flow following permanent middle cerebral artery occlusion in a rat model of sensory-based protection: a Doppler optical coherence tomography study

      Spatiotemporal dynamics of pial collateral blood flow following permanent middle cerebral artery occlusion in a rat model of sensory-based protection: a Doppler optical coherence tomography study
      There is a growing recognition regarding the importance of pial collateral flow in the protection from impending ischemic stroke both in preclinical and clinical studies. Collateral flow is also a major player in sensory stimulation-based protection from impending ischemic stroke. Doppler optical coherence tomography has been employed to image spatiotemporal patterns of collateral flow within the dorsal branches of the middle cerebral artery (MCA) as it provides a powerful tool ...
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    7. The Use of Optical Coherence Tomography and Convolutional Neural Networks to Distinguish Normal and Abnormal Oral Mucosa

      The Use of Optical Coherence Tomography and Convolutional Neural Networks to Distinguish Normal and Abnormal Oral Mucosa
      Incomplete surgical resection of head and neck squamous cell carcinoma (HNSCC) is the most common cause of local HNSCC recurrence. Currently, surgeons rely on pre‐operative imaging, direct visualization, palpation, and frozen section to determine the extent of tissue resection. It has been demonstrated that optical coherence tomography (OCT), a minimally invasive, non‐ionizing near infrared mesoscopic imaging modality can resolve subsurface differences between normal and abnormal head and neck ...
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    8. Automatic three-dimensional segmentation method for OCT and doppler OCT angiography

      Automatic three-dimensional segmentation method for OCT and doppler OCT angiography
      A three-dimensional (three dimensional) segmentation method with intensity-based Doppler variance (IBDV) based on swept-source OCT. The automatic three dimensional segmentation method is used to obtain seven surfaces of intra-retinal layers. The microvascular network of the retina, which is acquired by the IBDV method, can be divided into six layers. The microvascular network of the six individual layers are visualized, and the morphology and contrast images can be improved by using ...
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    9. Method to characterize cut gemstones using optical coherence tomography

      Method to characterize cut gemstones using optical coherence tomography
      The invention includes an improvement in a method of assessing a gemstone having at least one planar face with an internally reflecting surface including the steps of optically modifying the at least one planar face of the gemstone to return a sample beam from an internally reflecting plane corresponding to the at least one planar face to an optical coherence tomography (OCT) system; selectively directing the sample beam from an ...
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    10. Acoustic Radiation Force Optical Coherence Elastography

      Acoustic Radiation Force Optical Coherence Elastography
      Mechanical properties, such as the elasticity and viscosity, are often major indicators of diseases. Over the years, tissue mechanical properties have been demonstrated to be an early indicator for cardiovascular disease. Mechanical imaging technologies have been quickly evolving with a goal to effectively diagnose coronary artery disease and atherosclerosis in their early stages. By combining the advantages of acoustic and optical properties, acoustic radiation force optical coherence elastography (ARF-OCE) has ...
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    11. Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review

      Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review
      Diagnosis of inhalation injury has been clinically challenging. Currently, assessment of inhalation injury relies on subjective clinical exams and bronchoscopy, which provides little understanding of tissue conditions and results in limited prognostics. Endoscopic Optical coherence tomography (OCT) technology has been recently utilized in the airway for direct assessment of respiratory tract disorders and injuries. Endoscopic OCT is capable of capturing highresolution images of tissue morphology 1-3 mm beneath the surface ...
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    12. Dynamic programming and automated segmentation of optical coherence tomography images of the neonatal subglottis: enabling efficient diagnostics to manage subglottic stenosis

      Dynamic programming and automated segmentation of optical coherence tomography images of the neonatal subglottis: enabling efficient diagnostics to manage subglottic stenosis
      Subglottic stenosis (SGS) is a challenging disease to diagnose in neonates. Long-range optical coherence tomography (OCT) is an optical imaging modality that has been described to image the subglottis in intubated neonates. A major challenge associated with OCT imaging is the lack of an automated method for image analysis and micrometry of large volumes of data that are acquired with each airway scan (1 to 2 Gb). We developed a ...
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    13. Assessment of blood coagulation using an acoustic radiation force based optical coherence elastography (ARF-OCE)

      Assessment of blood coagulation using an acoustic radiation force based optical coherence elastography (ARF-OCE)
      An apparatus and method of using an optical coherence elastography (OCE) under acoustic radiation force (ARF) excitation includes the steps of inducing an excitation wave in a blood sample by use of an ultrasound beam from an ultrasonic transducer; measuring an elastic property of the blood sample by use of an optical coherence tomography (OCT) beam transverse to the ultrasound beam to dynamically measure the elastic property of the blood ...
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    14. Fiber-based polarization-sensitive optical coherence tomography of a minimalistic system configuration

      Fiber-based polarization-sensitive optical coherence tomography of a minimalistic system configuration
      We present a very simple method of constructing a polarization-sensitive optical coherence tomography (PS-OCT) system. An ordinary fiber-based swept-source OCT system was reconfigured for PS-OCT by adding a long section of polarization-maintaining fiber in the sample arm. Two polarization modes of a large group-delay difference formed spatially distinguished polarization channels. The depth-encoded information on the polarization states was retrieved by an amplitude-based analysis. We found that our method provides an ...
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    15. Multimodal endoscopy for colorectal cancer detection by optical coherence tomography and near-infrared fluorescence imaging

      Multimodal endoscopy for colorectal cancer detection by optical coherence tomography and near-infrared fluorescence imaging
      While colonoscopy is the gold standard for diagnosis and classification of colorectal cancer (CRC), its sensitivity and specificity are operator-dependent and are especially poor for small and flat lesions. Contemporary imaging modalities, such as optical coherence tomography (OCT) and near-infrared (NIR) fluorescence, have been investigated to visualize microvasculature and morphological changes for detecting early stage CRC in the gastrointestinal (GI) tract. In our study, we developed a multimodal endoscopic system ...
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    16. Automatic Proximal Airway Volume Segmentation Using Optical Coherence Tomography for Assessment of Inhalation Injury

      Automatic Proximal Airway Volume Segmentation Using Optical Coherence Tomography for Assessment of Inhalation Injury
      Background Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury with a mortality rate of up to 40%. Early management of ARDS has been difficult due to the lack of sensitive imaging tools and robust analysis software. We previously designed an optical coherence tomography (OCT) system to evaluate mucosa thickness (MT) post smoke inhalation, but the analysis relied on manual segmentation. The aim of this study ...
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    17. 1-15 of 235 1 2 3 4 ... 14 15 16 »
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  2. About Zhongping Chen

    Zhongping Chen

    Zhongping Chen is a Professor of Biomedical Engineering and Director of the F-OCT Laboratory at the University of California, Irvine. He is a Co-founder and Chairman of OCT Medical Imaging Inc. Dr. Chen received his B.S. degree in Applied Physics from Shanghai Jiao Tong University in 1982, his M.S. degree in Electrical Engineering in 1987, and his Ph.D. degree in Applied Physics from Cornell University in 1993. Dr. Chen’s research interests encompass the areas of biomedical photonics, microfabrication, biomaterials and biosensors. His research group has pioneered the development of functional optical coherence tomography, which simultaneously provides high resolution 3-D images of tissue structure, blood flow, and birefringence. These functional extensions of OCT offer contrast enhancements and provide mapping of many clinically important parameters. In addition, his group has developed a number of endoscopic and intravascular rotational and linear 2-D probes for OCT and MPM imaging and translated these technologies to clinical applications through collaboration with clinicians. He has led numerous major research projects funded by NIH, NSF, DOD, and DARPA, including several interdisciplinary research projects such as the NIH Biomedical Research Partnership (BRP) grant and NSF Biophotonics Partnership Initiative grant. Dr. Chen has published more than 200 peer-reviewed papers and review articles and holds a number of patents in the fields of biomaterials, biosensors, and biomedical imaging. Dr. Chen is a Fellow of the American Institute of Medical and Biological Engineering (AIMBE), a Fellow of SPIE, and a Fellow of the Optical Society of America.