1. Zhongping Chen

    0 Comments Leave a Comment

    1-15 of 229 1 2 3 4 ... 14 15 16 »
    1. Mentioned In 229 Articles

    2. Automatic three-dimensional segmentation method for OCT and doppler OCT angiography

      Automatic three-dimensional segmentation method for OCT and doppler OCT angiography
      A three-dimensional (three dimensional) segmentation method with intensity-based Doppler variance (IBDV) based on swept-source OCT. The automatic three dimensional segmentation method is used to obtain seven surfaces of intra-retinal layers. The microvascular network of the retina, which is acquired by the IBDV method, can be divided into six layers. The microvascular network of the six individual layers are visualized, and the morphology and contrast images can be improved by using ...
      Read Full Article
    3. Method to characterize cut gemstones using optical coherence tomography

      Method to characterize cut gemstones using optical coherence tomography
      The invention includes an improvement in a method of assessing a gemstone having at least one planar face with an internally reflecting surface including the steps of optically modifying the at least one planar face of the gemstone to return a sample beam from an internally reflecting plane corresponding to the at least one planar face to an optical coherence tomography (OCT) system; selectively directing the sample beam from an ...
      Read Full Article
    4. Acoustic Radiation Force Optical Coherence Elastography

      Acoustic Radiation Force Optical Coherence Elastography
      Mechanical properties, such as the elasticity and viscosity, are often major indicators of diseases. Over the years, tissue mechanical properties have been demonstrated to be an early indicator for cardiovascular disease. Mechanical imaging technologies have been quickly evolving with a goal to effectively diagnose coronary artery disease and atherosclerosis in their early stages. By combining the advantages of acoustic and optical properties, acoustic radiation force optical coherence elastography (ARF-OCE) has ...
      Read Full Article
    5. Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review

      Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review
      Diagnosis of inhalation injury has been clinically challenging. Currently, assessment of inhalation injury relies on subjective clinical exams and bronchoscopy, which provides little understanding of tissue conditions and results in limited prognostics. Endoscopic Optical coherence tomography (OCT) technology has been recently utilized in the airway for direct assessment of respiratory tract disorders and injuries. Endoscopic OCT is capable of capturing highresolution images of tissue morphology 1-3 mm beneath the surface ...
      Read Full Article
    6. Dynamic programming and automated segmentation of optical coherence tomography images of the neonatal subglottis: enabling efficient diagnostics to manage subglottic stenosis

      Dynamic programming and automated segmentation of optical coherence tomography images of the neonatal subglottis: enabling efficient diagnostics to manage subglottic stenosis
      Subglottic stenosis (SGS) is a challenging disease to diagnose in neonates. Long-range optical coherence tomography (OCT) is an optical imaging modality that has been described to image the subglottis in intubated neonates. A major challenge associated with OCT imaging is the lack of an automated method for image analysis and micrometry of large volumes of data that are acquired with each airway scan (1 to 2 Gb). We developed a ...
      Read Full Article
    7. Assessment of blood coagulation using an acoustic radiation force based optical coherence elastography (ARF-OCE)

      Assessment of blood coagulation using an acoustic radiation force based optical coherence elastography (ARF-OCE)
      An apparatus and method of using an optical coherence elastography (OCE) under acoustic radiation force (ARF) excitation includes the steps of inducing an excitation wave in a blood sample by use of an ultrasound beam from an ultrasonic transducer; measuring an elastic property of the blood sample by use of an optical coherence tomography (OCT) beam transverse to the ultrasound beam to dynamically measure the elastic property of the blood ...
      Read Full Article
    8. Fiber-based polarization-sensitive optical coherence tomography of a minimalistic system configuration

      Fiber-based polarization-sensitive optical coherence tomography of a minimalistic system configuration
      We present a very simple method of constructing a polarization-sensitive optical coherence tomography (PS-OCT) system. An ordinary fiber-based swept-source OCT system was reconfigured for PS-OCT by adding a long section of polarization-maintaining fiber in the sample arm. Two polarization modes of a large group-delay difference formed spatially distinguished polarization channels. The depth-encoded information on the polarization states was retrieved by an amplitude-based analysis. We found that our method provides an ...
      Read Full Article
    9. Multimodal endoscopy for colorectal cancer detection by optical coherence tomography and near-infrared fluorescence imaging

      Multimodal endoscopy for colorectal cancer detection by optical coherence tomography and near-infrared fluorescence imaging
      While colonoscopy is the gold standard for diagnosis and classification of colorectal cancer (CRC), its sensitivity and specificity are operator-dependent and are especially poor for small and flat lesions. Contemporary imaging modalities, such as optical coherence tomography (OCT) and near-infrared (NIR) fluorescence, have been investigated to visualize microvasculature and morphological changes for detecting early stage CRC in the gastrointestinal (GI) tract. In our study, we developed a multimodal endoscopic system ...
      Read Full Article
    10. Automatic Proximal Airway Volume Segmentation Using Optical Coherence Tomography for Assessment of Inhalation Injury

      Automatic Proximal Airway Volume Segmentation Using Optical Coherence Tomography for Assessment of Inhalation Injury
      Background Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury with a mortality rate of up to 40%. Early management of ARDS has been difficult due to the lack of sensitive imaging tools and robust analysis software. We previously designed an optical coherence tomography (OCT) system to evaluate mucosa thickness (MT) post smoke inhalation, but the analysis relied on manual segmentation. The aim of this study ...
      Read Full Article
    11. The effect of melanin on in vivo optical coherence tomography of the skin in a multiethnic cohort

      The effect of melanin on in vivo optical coherence tomography of the skin in a multiethnic cohort
      Background Noninvasive real‐time assessment of living tissue is quickly becoming invaluable for bolstering histologic and dermatoscopic measures of cutaneous conditions. While many skin researchers have explored the utility of noninvasive imaging in inflammatory and malignant skin conditions, there is yet to be a definitive and direct assessment of the effects of melanin on the quality of optical coherence tomography (OCT) imaging and its accuracy in multiethnic patient populations. We ...
      Read Full Article
    12. Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography

      Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography
      Objectives Surgical margin status is a significant determinant of treatment outcome in oral cancer. Negative surgical margins can decrease the loco-regional recurrence by five-fold. The current standard of care of intraoperative clinical examination supplemented by histological frozen section, can result in a risk of positive margins from 5 to 17 percent. In this study, we attempted to assess the utility of intraoperative optical coherence tomography (OCT) imaging with automated diagnostic ...
      Read Full Article
    13. Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography

      Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography
      An integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE). The steps include performing OCT to generate a returned optical signal, performing US imaging to generate a returned ultrasound signal, performing PRARF-OCE to generate a returned PR-ARF-OCE signal by generating a amplitude modulated ultrasound beam or chirped amplitude modulated ultrasound beam to ...
      Read Full Article
    14. Integrated ultrasound, OCT, PA and/or florescence imaging endoscope for diagnosing cancers in gastrointestinal, respiratory, and urogenital tracts

      Integrated ultrasound, OCT, PA and/or florescence imaging endoscope for diagnosing cancers in gastrointestinal, respiratory, and urogenital tracts
      A multimodality imaging system including ultrasound, optical coherence tomography (OCT), photoacoustic (PA) imaging, florescence imaging and endoscopic catheter for imaging inside the gastrointestinal tract with real-time automatic image co-registration capability, including: an ultrasound subsystem for imaging; an optical coherence tomography (OCT) subsystem for imaging, a PA microscopy or tomography subsystem for imaging and a florescence imaging subsystem for imaging. An invasive interventional imaging device is included with an instrumentality to ...
      Read Full Article
    15. Perspective: Current challenges and solutions of Doppler optical coherence tomography and angiography for neuroimaging

      Perspective: Current challenges and solutions of Doppler optical coherence tomography and angiography for neuroimaging
      The nervous system, based on a complex network of nerves and cells, carries messages by transmitting signals to and from different parts of the body. The supply of blood flow in the nervous system is critical to maintain physiological functions. Optical coherence tomography (OCT) has the ability to noninvasively image the microvascular networks and accurately quantify the blood flow in vivo with high spatial and temporal resolutions in three dimensions ...
      Read Full Article
    16. Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns

      Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns
      Background The prevalence of acute respiratory distress syndrome (ARDS) in mechanically ventilated burn patients is 33%, with mortality varying from 1146% depending on ARDS severity. Despite the new Berlin definition for ARDS, prompt bedside diagnosis is lacking. We developed and tested a bedside technique of fiberoptic-bronchoscopy-based optical coherence tomography (OCT) measurement of airway mucosal thickness (MT) for diagnosis of ARDS following smoke inhalation injury (SII) and burns. Methods 16 female ...
      Read Full Article
    17. 1-15 of 229 1 2 3 4 ... 14 15 16 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. About Zhongping Chen

    Zhongping Chen

    Zhongping Chen is a Professor of Biomedical Engineering and Director of the F-OCT Laboratory at the University of California, Irvine. He is a Co-founder and Chairman of OCT Medical Imaging Inc. Dr. Chen received his B.S. degree in Applied Physics from Shanghai Jiao Tong University in 1982, his M.S. degree in Electrical Engineering in 1987, and his Ph.D. degree in Applied Physics from Cornell University in 1993. Dr. Chen’s research interests encompass the areas of biomedical photonics, microfabrication, biomaterials and biosensors. His research group has pioneered the development of functional optical coherence tomography, which simultaneously provides high resolution 3-D images of tissue structure, blood flow, and birefringence. These functional extensions of OCT offer contrast enhancements and provide mapping of many clinically important parameters. In addition, his group has developed a number of endoscopic and intravascular rotational and linear 2-D probes for OCT and MPM imaging and translated these technologies to clinical applications through collaboration with clinicians. He has led numerous major research projects funded by NIH, NSF, DOD, and DARPA, including several interdisciplinary research projects such as the NIH Biomedical Research Partnership (BRP) grant and NSF Biophotonics Partnership Initiative grant. Dr. Chen has published more than 200 peer-reviewed papers and review articles and holds a number of patents in the fields of biomaterials, biosensors, and biomedical imaging. Dr. Chen is a Fellow of the American Institute of Medical and Biological Engineering (AIMBE), a Fellow of SPIE, and a Fellow of the Optical Society of America.