1. Zhihua Ding

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    1. Mentioned In 44 Articles

    2. Microangiography method and system based on full-space modulation spectrum splitting and angle compounding

      Microangiography method and system based on full-space modulation spectrum splitting and angle compounding
      A microangiography method and system based on full-space modulation spectrum splitting and angle compounding is disclosed. Label-free three-dimensional optical coherence tomography angiography is realized by combining the three-dimensional space resolution capability of an optical coherence tomography and the motion recognition capability of a dynamic scattering technology. Probe light of different incident angles is encoded with a transverse scanning modulation spectrum in a spatial frequency domain, incident angle-resolved sub-angiograms which are ...
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    3. Uniform focusing with an extended depth range and increased working distance for optical coherence tomography by an ultrathin monolith fiber probe

      Uniform focusing with an extended depth range and increased working distance for optical coherence tomography by an ultrathin monolith fiber probe
      It is difficult to maintain high transverse resolution over an increased depth range using miniature probes for optical coherence tomography (OCT) due to the rapid divergence of light and the space limitation. To solve this problem, we introduce a fiber-based filter in the proposed probe to manipulate its output beam. Significant mode interference (MI) is exploited to enhance the depth of focus (DOF), and the mode phase difference is tuned ...
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    4. All-fiber probe for optical coherence tomography with an extended depth of focus by a high-efficient fiber-based filter

      All-fiber probe for optical coherence tomography with an extended depth of focus by a high-efficient fiber-based filter
      Although methods have been proposed to maintain high transverse resolution over an increased depth range, it is not straightforward to scale down the bulk-optic solutions to minimized probes of optical coherence tomography (OCT). In this paper, we propose a high-efficient fiber-based filter in an all-fiber OCT probe to realize an extended depth of focus (DOF) while maintaining a high transverse resolution. Mode interference in the probe is exploited to modulate ...
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    5. Lens-free all-fiber probe with an optimized output beam for optical coherence tomography

      Lens-free all-fiber probe with an optimized output beam for optical coherence tomography
      A high-efficiency lensless all-fiber probe for optical coherence tomography (OCT) is presented. The probe is composed of a segment of large-core multimode fiber (MMF), a segment of tapered MMF, and a length of single-mode fiber (SMF). A controllable output beam can be designed by a simple adjustment of its probe structure parameters (PSPs), instead of the selection of fibers with different optical parameters. A side-view probe with a diameter of ...
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    6. Quasi-needle-like focus synthesized by optical coherence tomography

      Quasi-needle-like focus synthesized by optical coherence tomography
      It is known that lateral resolution and depth of focus (DOF) in an optical imaging system are coupled, and a compromise between them has to be made. In this Letter, we propose to resolve the trade-off between lateral resolution and the DOF by a synthetic effective point spread function in optical path length (OPL) domain. A quasi-needle-like focus is synthesized by optical coherence tomography. We demonstrate that the synthesized quasi-needle-like ...
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    7. Motion correction using overlapped data correlation based on a spatial-spectral encoded parallel optical coherence tomography

      Motion correction using overlapped data correlation based on a spatial-spectral encoded parallel optical coherence tomography
      This paper presents an approach to remove motion artifacts based on a spatial-spectral encoded parallel OCT (SSE-POCT) system, where encoded rectangular illumination is employed. Motion artifacts within a B-scan are avoided due to parallel detection intrinsic to parallel OCT, while those between successive B-scans are estimated and corrected by a proposed overlapped data correlation (ODC) algorithm. To preserve axial resolution, decoded B-scan corresponding to complete spectrum is stitched from successive ...
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    8. A useful way to develop effective in vivo skin optical clearing agents

      A useful way to develop effective in vivo skin optical clearing agents
      Skin optical clearing has shown tremendous potential in improving various optical imaging performances, but there is some certain blindness in screening out high-efficiency in vivo optical clearing methods. In this work, three optical clearing agents: sucrose (Suc), fructose (Fruc) and PEG-400 (PEG), and two chemical penetration enhancers: propylene glycol (PG) and thiazone (Thiaz) were used. PEG was firstly mixed with the two penetration enhancers, respectively, and then mixed with Fruc ...
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    9. Angular compounding by full-channel B-scan modulation encoding for optical coherence tomography speckle reduction

      Angular compounding by full-channel B-scan modulation encoding for optical coherence tomography speckle reduction
      We describe an angular compounding method by full-channel B-scan modulation encoding for speckle reduction in optical coherence tomography. The complex-valued spectral interferogram (SI) is reconstructed by removing one of the conjugate terms in the depth space. Fourier transform of the complex SI along the lateral direction enables a full-channel (with both negative and positive Fourier space) for B-scan modulation in the spatial frequency ( ) domain. A full-size probe beam, determined by ...
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    10. Hybrid averaging offers high-flow contrast by cost apportionment among imaging time, axial, and lateral resolution in optical coherence tomography angiography

      Hybrid averaging offers high-flow contrast by cost apportionment among imaging time, axial, and lateral resolution in optical coherence tomography angiography
      The current temporal, wavelength, angular, and spatial averaging approaches trade imaging time and resolution for multiple independent measurements that improve the flow contrast in optical coherence tomography angiography (OCTA). We find that these averaging approaches are equivalent in principle, offering almost the same flow contrast enhancement as the number of averages increases. Based on this finding, we propose a hybrid averaging strategy for contrast enhancement by cost apportionment. We demonstrate ...
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    11. Optical coherence tomography angiography offers comprehensive evaluation of skin optical clearing in vivo by quantifying optical properties and blood flow imaging simultaneously

      Optical coherence tomography angiography offers comprehensive evaluation of skin optical clearing in vivo by quantifying optical properties and blood flow imaging simultaneously
      Tissue optical clearing (TOC) is helpful for reducing scattering and enhancing the penetration depth of light, and shows promising potential in optimizing optical imaging performances. A mixture of fructose with PEG-400 and thiazone (FPT) is used as an optical clearing agent in mouse dorsal skin and evaluated with OCT angiography (Angio-OCT) by quantifying optical properties and blood flow imaging simultaneously. It is observed that FPT leads to an improved imaging ...
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    12. Single-shot angular compounded optical coherence tomography angiography by splitting full-space B-scan modulation spectrum for flow contrast enhancement

      Single-shot angular compounded optical coherence tomography angiography by splitting full-space B-scan modulation spectrum for flow contrast enhancement
      We proposed a single-shot spatial angular compounded optical coherence tomography angiography (AC-Angio-OCT) for blood flow contrast enhancement. By encoding incident angles in B-scan modulation frequencies and splitting the modulation spectrum in the spatial frequency domain, angle-resolved independent subangiograms were obtained and compounded to improve the flow contrast. A full space of the spatial frequency domain allows a wide modulation spectrum. To get access to the full space of the spatial ...
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    13. Improved motion contrast and processing efficiency in OCT angiography using complex-correlation algorithm

      Improved motion contrast and processing efficiency in OCT angiography using complex-correlation algorithm
      The complex-based OCT angiography (Angio-OCT) offers high motion contrast by combining both the intensity and phase information. However, due to involuntary bulk tissue motions, complex-valued OCT raw data are processed sequentially with different algorithms for correcting bulk image shifts (BISs), compensating global phase fluctuations (GPFs) and extracting flow signals. Such a complicated procedure results in massive computational load. To mitigate such a problem, in this work, we present an inter-frame ...
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    14. Statistical analysis of motion contrast in optical coherence tomography angiography

      Statistical analysis of motion contrast in optical coherence tomography angiography
      Optical coherence tomography angiography (Angio-OCT), mainly based on the temporal dynamics of OCT scattering signals, has found a range of potential applications in clinical and scientific research. Based on the model of random phasor sums, temporal statistics of the complex-valued OCT signals are mathematically described. Statistical distributions of the amplitude differential and complex differential Angio-OCT signals are derived. The theories are validated through the flow phantom and live animal experiments ...
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    15. Assessment of Full-Eye Response to Osmotic Stress in Mouse Model In Vivo Using Optical Coherence Tomography

      Assessment of Full-Eye Response to Osmotic Stress in Mouse Model In Vivo Using Optical Coherence Tomography
      NaCl based solutions were applied as osmotic stress agents to alter the hydration state of the mouse eye. Full-eye responses to these osmotic challenges were monitored in vivo using a custom-built optical coherence tomography (OCT) with an extended imaging range of 12.38mm. Dynamic changes in the mouse eye were quantified based on the OCT images using several parameters, including the central corneal thickness (CCT), the anterior chamber depth (ACD ...
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    16. Statistical analysis of motion contrast in optical coherence tomography angiography

      Statistical analysis of motion contrast in optical coherence tomography angiography
      Optical coherence tomography angiography (Angio-OCT), mainly based on the temporal dynamics of OCT scattering signals, has found a range of potential applications in clinical and scientific researches. In this work, based on the model of random phasor sums, temporal statistics of the complex-valued OCT signals are mathematically described. Statistical distributions of the amplitude differential (AD) and complex differential (CD) Angio-OCT signals are derived. The theories are validated through the flow ...
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    17. 1-15 of 44 1 2 3 »
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  2. About Zhihua Ding

    Zhihua Ding

    Zhihua Ding is from State Key Laboratory of Modern Optical Instrumentation Department at Zhejiang University in China.