1. Zhejiang University

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    1. Mentioned In 93 Articles

    2. High performance OCTA enabled by combining features of shape, intensity, and complex decorrelation

      High performance OCTA enabled by combining features of shape, intensity, and complex decorrelation
      Motion contrast optical coherence tomography angiography (OCTA) entails a precise identification of dynamic flow signals from the static background, but an intermediate region with voxels exhibiting a mixed distribution of dynamic and static scatterers is almost inevitable in practice, which degrades the vascular contrast and connectivity. In this work, the static-dynamic intermediate region was pre-defined according to the asymptotic relation between inverse signal-to-noise ratio (iSNR) and decorrelation, which was theoretically ...
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    3. Fast simulation and design of the fiber probe with a fiber-based pupil filter for optical coherence tomography using the eigenmode expansion approach

      Fast simulation and design of the fiber probe with a fiber-based pupil filter for optical coherence tomography using the eigenmode expansion approach
      Fiber probes for optical coherence tomography (OCT) recently employ a short section of step-index multimode fiber (SIMMF) to generate output beams with extended depth of focus (DOF). As the focusing region of the output beam is generally close to the probe end, it is not feasible to adopt the methods for bulk-optics with spatial pupil filters to the fiber probes with fiber-based filters. On the other hand, the applicable method ...
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    4. Novel endoscopic optical diagnostic technologies in medical trial research: recent advancements and future prospects

      Novel endoscopic optical diagnostic technologies in medical trial research: recent advancements and future prospects
      Novel endoscopic biophotonic diagnostic technologies have the potential to non-invasively detect the interior of a hollow organ or cavity of the human body with subcellular resolution or to obtain biochemical information about tissue in real time. With the capability to visualize or analyze the diagnostic target in vivo, these techniques gradually developed as potential candidates to challenge histopathology which remains the gold standard for diagnosis. Consequently, many innovative endoscopic diagnostic ...
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    5. Comparison of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol for the prediction of thin-cap fibroatheroma determined by intravascular optical coherence tomography

      Comparison of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol for the prediction of thin-cap fibroatheroma determined by intravascular optical coherence tomography
      Background The correlation among the ratios of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/ HDL-C), total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) and thin-cap fibroatheroma has not yet been established. Methods It was a single center, retrospective observational study. In total, we recruited 421 patients (82.4% men; mean age 65.73 10.44 years) with one culprit vessel which determined by intravascular optical coherence tomography (OCT). The thinnest-capped fibroatheroma ...
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    6. Characterisation of macular superficial vessel density alteration in preclinical ethambutol-induced optic neuropathy using optical coherence tomography angiography

      Characterisation of macular superficial vessel density alteration in preclinical ethambutol-induced optic neuropathy using optical coherence tomography angiography
      Aim To investigate the changes in macular vessel density (mVD) and its relationship to macular ganglion cellinner plexiform layer (mGCIPL) thickness in patients receiving ethambutol (EMB) therapy for tuberculosis without recognisable clinical symptoms or signs of EMB-induced optic neuropathy (EON). Methods A total of 23 eyes of 13 patients using EMB therapy for 6 months without EON (preclinical EON) as the EMB group, 40 eyes of 23 healthy individuals as ...
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    7. Spectral-domain optical coherence tomography finding in cytomegalovirus retinitis in AIDS patients

      Spectral-domain optical coherence tomography finding in cytomegalovirus retinitis in AIDS patients
      AIM To observe the findings of spectral domain optical coherence tomography (SD-OCT) scan in cytomegalovirus retinitis (CMVR). METHODS Forty-six eyes of 33 patients with acquired immunodeficiency syndrome and CMVR were enrolled in the study. Complete ophthalmologic examinations, color fundus photography, SD-OCT and fundus autofluorescence (FAF) were performed for all patients at the first visit and each follow-up visit. Retinal necrosis in CMVR was analyzed on SD-OCT and classified into two ...
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    8. Biomimetic remineralization of artificial caries dentin lesion using Ca/P-PILP

      Biomimetic remineralization of artificial caries dentin lesion using Ca/P-PILP
      Objective To assess the ultrastructural change of demineralized dentin collagen during calcium phosphate polymer-induced liquid precursor (Ca/P-PILP) mediated remineralization process and to evaluate the biomimetic remineralization potential of high concentration Ca/P-PILP at demineralized artificial caries dentin lesion, additionally to investigate the bond interfacial integrity as well as the bonding strength of the biomimetic remineralized artificial caries dentin lesion. Methods Demineralized dentin collagen of 5 m thick was biomimetically ...
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    9. Machine learning helps improve diagnostic ability of subclinical keratoconus using Scheimpflug and OCT imaging modalities

      Machine learning helps improve diagnostic ability of subclinical keratoconus using Scheimpflug and OCT imaging modalities
      Purpose To develop an automated classification system using a machine learning classifier to distinguish clinically unaffected eyes in patients with keratoconus from a normal control population based on a combination of Scheimpflug camera images and ultra-high-resolution optical coherence tomography (UHR-OCT) imaging data. Methods A total of 121 eyes from 121 participants were classified by 2 cornea experts into 3 groups: normal (50 eyes), with keratoconus (38 eyes) or with subclinical ...
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    10. Association of Optical Coherence Tomography Angiography Metrics With Detection of Impaired Macular Microvasculature and Decreased Vision in Amblyopic Eyes

      Association of Optical Coherence Tomography Angiography Metrics With Detection of Impaired Macular Microvasculature and Decreased Vision in Amblyopic Eyes
      Importance Microvascular abnormalities in amblyopia are becoming evident with high-resolution imaging, such as optical coherence tomography angiography (OCT-A); however, to our knowledge, the clinical significance and use of these findings are unknown. Objective To assess changes in quantitative OCT-A metrics in amblyopic eyes and explore their association with visual acuity in children. Design, Setting, and Participants This population-based nested case-control study included children aged 6 to 8 years who were ...
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    11. Prediction of response to anti‐vascular endothelial growth factor treatment in diabetic macular oedema using an optical coherence tomography‐based machine learning method

      Prediction of response to anti‐vascular endothelial growth factor treatment in diabetic macular oedema using an optical coherence tomography‐based machine learning method
      Purpose To predict the anti‐vascular endothelial growth factor (VEGF) therapeutic response of diabetic macular oedema (DME) patients from optical coherence tomography (OCT) at the initiation stage of treatment using a machine learning‐based self‐explainable system. Methods A total of 712 DME patients were included and classified into poor and good responder groups according to central macular thickness decrease after three consecutive injections. Machine learning models were constructed to ...
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    12. Microangiography method and system based on full-space modulation spectrum splitting and angle compounding

      Microangiography method and system based on full-space modulation spectrum splitting and angle compounding
      A microangiography method and system based on full-space modulation spectrum splitting and angle compounding is disclosed. Label-free three-dimensional optical coherence tomography angiography is realized by combining the three-dimensional space resolution capability of an optical coherence tomography and the motion recognition capability of a dynamic scattering technology. Probe light of different incident angles is encoded with a transverse scanning modulation spectrum in a spatial frequency domain, incident angle-resolved sub-angiograms which are ...
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    13. Synchronous fingerprint acquisition system based on total internal reflection and optical coherence tomography

      Synchronous fingerprint acquisition system based on total internal reflection and optical coherence tomography
      he research of external fingerprint collected by total internal reflection (TIR) has been carried out for decades and research of internal fingerprint of optical coherence tomography (OCT) has just begun. The internal fingerprint can be hardly affected by the finger surface status, due to its strong anti-interference and anti-spoofing ability, which can serve as a powerful supplement to external fingerprint. However, matching fingerprints acquired by different ways can lead to ...
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    14. Ticagrelor versus clopidogrel for prevention of subclinical stent thrombosis detected by optical coherence tomography in patients with drug-eluting stent implantation—a multicenter and randomized study

      Ticagrelor versus clopidogrel for prevention of subclinical stent thrombosis detected by optical coherence tomography in patients with drug-eluting stent implantation—a multicenter and randomized study
      Introduction : This prospective, multicenter, randomized study was designed to analyze the benefits of ticagrelor over clopidogrel in reducing subclinical stent thrombosis (ST) in patients with coronary artery disease who underwent implantation of a second-generation drug-eluting stent (DES). Methods : About 352 patients with single de novo coronary stenosis were randomly assigne`d to either clopidogrel group (aspirin plus clopidogrel) or ticagrelor group (aspirin plus ticagrelor) after DES implantation for 1 year ...
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    15. INS-fOCT: a label-free, all-optical method for simultaneously manipulating and mapping brain function

      INS-fOCT: a label-free, all-optical method for simultaneously manipulating and mapping brain function
      Significance: Current approaches to stimulating and recording from the brain have combined electrical or optogenetic stimulation with recording approaches, such as two-photon, electrophysiology (EP), and optical intrinsic signal imaging (OISI). However, we lack a label-free, all-optical approach with high spatial and temporal resolution. Aim: To develop a label-free, all-optical method that simultaneously manipulates and images brain function using pulsed near-infrared light (INS) and functional optical coherence tomography (fOCT), respectively. Approach ...
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    16. Uniform focusing with an extended depth range and increased working distance for optical coherence tomography by an ultrathin monolith fiber probe

      Uniform focusing with an extended depth range and increased working distance for optical coherence tomography by an ultrathin monolith fiber probe
      It is difficult to maintain high transverse resolution over an increased depth range using miniature probes for optical coherence tomography (OCT) due to the rapid divergence of light and the space limitation. To solve this problem, we introduce a fiber-based filter in the proposed probe to manipulate its output beam. Significant mode interference (MI) is exploited to enhance the depth of focus (DOF), and the mode phase difference is tuned ...
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  2. About Zhejiang University

    Zhejiang University

    Zhejiang University, sometimes referred to as Zheda, is a national university in China. Founded in 1897, Zhejiang University is one of China's oldest and most prestigious institutions of higher education. Zhejiang University is located approximately 112 miles (180 km) southwest of Shanghai in the city of Hangzhou, Zhejiang Province. Zhejiang University Library collection contains about 6.9 million volumes, making it one of the largest academic libraries in the country. The university focuses on both undergraduate and graduate education.