1. Zhejiang University

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    1. Mentioned In 76 Articles

    2. Correlation of optical attenuation coefficient estimated using optical coherence tomography with changes in astrocytes and neurons in a chronic photothrombosis stroke model

      Correlation of optical attenuation coefficient estimated using optical coherence tomography with changes in astrocytes and neurons in a chronic photothrombosis stroke model
      The optical attenuation coefficient (OAC) estimated using optical coherence tomography (OAC-OCT) offers a label-free 3D mapping of tissue infarction, but the physiological origin of the OAC contrast remains unclear. For effectively suppressing OAC fluctuations, we propose a hybrid (wavelength/angle) division multiplexing (HDM) method, which improved the OAC contrast by 70.7% in tissue phantoms. To test the feasibility of OAC-based infarction detection, triphenyltetrazolium chloride (TTC) staining was performed on ...
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    3. COMPARISON OF PROJECTION-RESOLVED OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY-BASED METRICS FOR THE EARLY DETECTION OF RETINAL MICROVASCULAR IMPAIRMENTS IN DIABETES MELLITUS

      COMPARISON OF PROJECTION-RESOLVED OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY-BASED METRICS FOR THE EARLY DETECTION OF RETINAL MICROVASCULAR IMPAIRMENTS IN DIABETES MELLITUS
      Purpose: To determine the ability of nonperfusion, vessel density , and morphologic measurements using projection-resolved optical coherence tomography angiography to detect early retinal microvasculature impairments in diabetes mellitus. Methods: A retrospective review was performed on Type 2 diabetes mellitus patients with no diabetic retinopathy (DR) or mild nonproliferative DR and age-matched controls imaged with optical coherence tomography angiography . Foveal avascular zone-related metrics and extrafoveal avascular area were measured in optical coherence ...
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    4. Optical Coherence Tomography Angiography in Pinguecula and Pterygium

      Optical Coherence Tomography Angiography in Pinguecula and Pterygium
      Purpose: To investigate the density of conjunctival blood vessels in normal eyes and in eyes with pinguecula or pterygium . Methods: In this cross-sectional study, the conjunctival blood vessel density of 15 normal eyes, 15 pinguecula eyes, and 15 pterygium eyes of 43 healthy adults was assessed using optical coherence tomography angiography with an anterior segment lens adapter. The nasal surface of each eye (3 3 mm) was scanned 3 times ...
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    5. Velocity range estimation for liquid flow based on optical micro-angiography

      Velocity range estimation for liquid flow based on optical micro-angiography
      Optical micro-angiography (OMAG) is widely used in vivo imaging due to its non-invasive and highly sensitive measurements. It can effectively distinguish flowing and stationary particles for applications such as micro-size blood vessel. However, the detectable flow velocity of OMAG is restricted by the system parameters. Their relationship is usually unknown and thus increase the difficulty of OMAG application on liquid flow measurements. This study for the first time proposes a ...
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    6. Improve depth of field of optical coherence tomography using finite energy Airy beam

      Improve depth of field of optical coherence tomography using finite energy Airy beam
      We report a technique to break the depth of field (DOF) limit in optical coherence tomography (OCT) using a finite energy Airy beam. The Airy beam is generated using a phase mask in a Fourier transform schematic and provides the DOF improvement due to its low diffraction. We compare Airy beam OCT with conventional Gaussian beam OCT using lateral resolution and sensitivity. Experimental data from the polystyrene beads in water ...
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    7. Anterior Segment Biometry with Phenylephrine and Tropicamide during Accommodation Imaged with Ultralong Scan Depth Optical Coherence Tomography

      Anterior Segment Biometry with Phenylephrine and Tropicamide during Accommodation Imaged with Ultralong Scan Depth Optical Coherence Tomography
      Purpose . To investigate the influence of phenylephrine and tropicamide on anterior segment biometry with ultralong scan depth optical coherence tomography (UL-OCT) during accommodation. Methods . In this study, 20 left eyes of healthy volunteers with a meanstandard deviation age of 31.055.84years and a mean refraction of 1.161.11 diopters (range 03.0D) were imaged using UL-OCT after instillation of artificial tears, phenylephrine, and tropicamide in three follow-up trials ...
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    8. The relation between optical coherence tomography-detected layered pattern and acute side branch occlusion after provisional stenting of coronary bifurcation lesions

      The relation between optical coherence tomography-detected layered pattern and acute side branch occlusion after provisional stenting of coronary bifurcation lesions
      Background/Purpose. Layered pattern (presumed to be healed plaque after a thrombotic event) can be observed by optical coherence tomography (OCT). We sought to assess the ability of OCT-detected plaque composition to predict acute side branch (SB) occlusion after provisional bifurcation stenting. Methods This is a retrospective observational study using pre-intervention OCT in the main vessel to predict Thrombolysis in Myocardial Infarction (TIMI) flow grade 1 in a SB (diameter ...
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    9. Viscosity monitoring during hemodiluted blood coagulation using optical coherence elastography

      Viscosity monitoring during hemodiluted blood coagulation using optical coherence elastography
      Rapid and accurate clot diagnostic systems are needed for the assessment of hemodiluted blood coagulation. We develop a real-time optical coherence elastography (OCE) system, which measures the attenuation coefficient of a compressional wave induced by a piezoelectric transducer (PZT) in a drop of blood using optical coherence tomography (OCT), for the determination of viscous properties during the dynamic whole blood coagulation process. Changes in the viscous properties increase the attenuation ...
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    10. Loquat Bruise Detection Using Optical Coherence Tomography Based on Microstructural Parameters

      Loquat Bruise Detection Using Optical Coherence Tomography Based on Microstructural Parameters
      Slight postharvest bruises of loquats remarkably affect the quality and shelf life of the fruits, but they are difficult to identify using visual inspection. Sub-surface structural changes in cells caused by mechanical injury or impact can be detected using spectroscopy-based methods from different angles. Optical coherence tomography (OCT), a non-destructive technology, can acquire cross-sectional images to analyze sub-surface structures of loquats, thus offering the potential to identify fruit bruises. This ...
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    11. All-fiber probe for optical coherence tomography with an extended depth of focus by a high-efficient fiber-based filter

      All-fiber probe for optical coherence tomography with an extended depth of focus by a high-efficient fiber-based filter
      Although methods have been proposed to maintain high transverse resolution over an increased depth range, it is not straightforward to scale down the bulk-optic solutions to minimized probes of optical coherence tomography (OCT). In this paper, we propose a high-efficient fiber-based filter in an all-fiber OCT probe to realize an extended depth of focus (DOF) while maintaining a high transverse resolution. Mode interference in the probe is exploited to modulate ...
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    12. Adaptive classifier allows enhanced flow contrast in OCT angiography using a histogram-based motion threshold and 3D Hessian analysis-based shape filtering

      Adaptive classifier allows enhanced flow contrast in OCT angiography using a histogram-based motion threshold and 3D Hessian analysis-based shape filtering
      In this Letter, we propose an adaptive digital classifier for flow contrast enhancement in optical coherence tomography angiography (OCTA). To solve the depth dependence in the initial motion-based classification, a depth-adaptive motion threshold was determined by performing a histogram analysis of an en-face image at each depth and identifying the static and dynamic voxel populations through fitting. In the follow-up shape-based classification, to adapt to the deformed vessel shapes in ...
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    13. Noninvasive structural and microvascular anatomy of oral mucosae using handheld optical coherence tomography

      Noninvasive structural and microvascular anatomy of oral mucosae using handheld optical coherence tomography
      In this study, we demonstrated the feasibility of using a handheld optical coherence tomography (OCT) for in vivo visualizations of the microstructural and microvascular features of various oral mucosal types. To scan arbitrary locations of the oral mucosa, a scanning probe was developed, composed of a probe body fabricated by a 3D printer, miniaturized two-axis galvanometer, relay lenses, and reflective prism. With a 3D printing technique, the probe weight and ...
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    14. Phase and amplitude correction in polygon tunable laser-based optical coherence tomography

      Phase and amplitude correction in polygon tunable laser-based optical coherence tomography
      Phase instability is a serious problem in swept-source optical coherence tomography (OCT) with polygon tunable lasers; however, these devices have additional issues. We found that polygon tunable lasers also have fluctuations in output power and sweep range: the former creates artifacts that may impair the recognition of sample information, and the latter reduces the interference signal utilization during phase correction. We demonstrate a method that uses the calibration signal to ...
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    15. Spectral-domain optical coherence tomography dynamic changes and steroid response in multiple evanescent white dot syndrome

      Spectral-domain optical coherence tomography dynamic changes and steroid response in multiple evanescent white dot syndrome
      Dear Editor, Multiple evanescent white dot syndrome (MEWDS) was first described in 1984 as a rare, acute, unilateral, multifocal retinochoroidal disorder, typically affecting young myopic women[1]. Previous studies with fluorescein angiography (FA) and electrophysiology suggested that MEWDS to be a disease in the retinal pigment epithelium (RPE) or outer retina[2], while recent studies with spectraldomain optical coherence tomography (SD-OCT) suggested it may be an outer retinal disease due ...
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    16. In Vivo Calcium Detection by Comparing Optical Coherence Tomography, Intravascular Ultrasound, and Angiography

      In Vivo Calcium Detection by Comparing Optical Coherence Tomography, Intravascular Ultrasound, and Angiography
      Objectives The aim of this study was to evaluate optical coherence tomography (OCT) and intravascular ultrasound (IVUS) versus coronary angiography in the assessment of target lesion calcification and its effect on stent expansion. Background IVUS is more sensitive than angiography in the detection of coronary artery calcium, but the relationship among IVUS, OCT, and angiography has not been studied. Methods Overall, 440 lesions (440 patients with stable angina) underwent OCT- ...
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  2. About Zhejiang University

    Zhejiang University

    Zhejiang University, sometimes referred to as Zheda, is a national university in China. Founded in 1897, Zhejiang University is one of China's oldest and most prestigious institutions of higher education. Zhejiang University is located approximately 112 miles (180 km) southwest of Shanghai in the city of Hangzhou, Zhejiang Province. Zhejiang University Library collection contains about 6.9 million volumes, making it one of the largest academic libraries in the country. The university focuses on both undergraduate and graduate education.