1. Zhao Wang

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    1. Mentioned In 43 Articles

    2. Application and Evaluation of Highly Automated Software for Comprehensive Stent Analysis in Intravascular Optical Coherence Tomography

      Application and Evaluation of Highly Automated Software for Comprehensive Stent Analysis in Intravascular Optical Coherence Tomography
      Intravascular optical coherence tomography (IVOCT) is used to assess stent tissue coverage and malapposition in stent evaluation trials. We developed the OCT Image Visualization and Analysis Toolkit for Stent (OCTivat-Stent), for highly automated analysis of IVOCT pullbacks. Algorithms automatically detected the guidewire, lumen boundary, and stent struts; determined the presence of tissue coverage for each strut; and estimated the stent contour for comparison of stent and lumen area. Strut-level tissue ...
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    3. Analysis of optical tomography (OCT) images

      Analysis of optical tomography (OCT) images
      A method includes storing three-dimensional image data acquired intravascularly via an optical coherence tomography (OCT) apparatus. The image data is analyzed to compute a probability estimate of stent presence at support positions appearing in an A-line. Stent strut locations are located in three-dimensional space based on the computed probability estimate of stent presence.
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    4. Computer-Aided Analysis of Gland-Like Subsurface Hyposcattering Structures in Barrett’s Esophagus Using Optical Coherence Tomography

      Computer-Aided Analysis of Gland-Like Subsurface Hyposcattering Structures in Barrett’s Esophagus Using Optical Coherence Tomography
      (1) Background: Barretts esophagus (BE) is a complication of chronic gastroesophageal reflux disease and is a precursor to esophageal adenocarcinoma. The clinical implication of subsurface glandular structures of Barretts esophagus is not well understood. Optical coherence tomography (OCT), also known as volumetric laser endomicroscopy (VLE), can assess subsurface glandular structures, which appear as subsurface hyposcattering structures (SHSs). The aim of this study is to develop a computer-aided algorithm and apply ...
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    5. Feature Of The Week 10/08/2018: Clinical Utility of Ultrahigh-Speed Endoscopic Optical Coherence Tomography in Gastroenterology

      Feature Of The Week 10/08/2018: Clinical Utility of Ultrahigh-Speed Endoscopic Optical Coherence Tomography in Gastroenterology
      Barretts esophagus (BE) surveillance is limited by biopsy sampling error. Optical coherence tomography (OCT) enables microscopic resolution, high speed, volumetric imaging and is commercially available as volumetric laser endomicroscopy (VLE, NinePoint Medical). Studies investigated cross-sectional OCT dysplasia features, including a diagnostic algorithm (VLE-DA), however, many VLE studies used ex vivo specimens due to challenges in registering biopsy with OCT. We previously demonstrated ultrahigh-speed endoscopic OCT 10x faster than commercial instruments ...
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    6. Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography

      Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography
      Background This study aimed to evaluate the use of ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography (OCT) with micromotor catheters for the in vivo assessment of Barretts esophagus and dysplasia. Methods 74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology (49 nondysplastic Barretts esophagus [NDBE], 25 neoplasia) were obtained from 14 patients with Barretts esophagus and a history of dysplasia and 30 with NDBE. The associations between ...
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    7. Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo

      Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo
      Devices that perform wide field-of-view (FOV) precision optical scanning are important for endoscopic assessment and diagnosis of luminal organ disease such as in gastroenterology. Optical scanning for in vivo endoscopic imaging has traditionally relied on one or more proximal mechanical actuators, limiting scan accuracy and imaging speed. There is a need for rapid and precise two-dimensional (2D) microscanning technologies to enable the translation of benchtop scanning microscopies to in vivo ...
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    8. Ultrahigh-speed endoscopic optical coherence tomography and angiography enables delineation of lateral margins of endoscopic mucosal resection: a case report

      Ultrahigh-speed endoscopic optical coherence tomography and angiography enables delineation of lateral margins of endoscopic mucosal resection: a case report
      Endoscopic mucosal resection (EMR) is a common technique for resecting dysplastic lesions in Barretts esophagus (BE), stomach, and colon, 1 but precise delineation of dysplastic margins before resection and verification of complete removal after resection remain challenging. 2 , 3 Endoscopic optical coherence tomography (OCT) enables three-dimensional visualization of tissue microstructure and is commercially available as Volumetric Laser Endomicroscopy (NinePoint Medical, Bedford, MA, USA). 4 , 5 We recently developed an ultrahigh-speed ...
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    9. Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study

      Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study
      Background Previous studies have demonstrated that statin therapy improves cardiac outcomes, probably by stabilizing thin‐cap fibroatheroma in patients with coronary artery disease. However, major adverse cardiac events still occur in some patients, despite statin therapy. The aim of this study is to identify clinical predictors for the lack of a favorable vascular response to statin therapy in patients with coronary artery disease. Methods and Results A total of 140 ...
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    10. Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source

      Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source
      Endoscopic optical coherence tomography (OCT) instruments are mostly side viewing and rely on at least one proximal scan, thus limiting accuracy of volumetric imaging and en face visualization. Previous forward-viewing OCT devices had limited axial scan speeds. We report a forward-viewing fiber scanning 3D-OCT probe with 900 m field of view and 5 m transverse resolution, imaging at 1 MHz axial scan rate in the human gastrointestinal tract. The probe ...
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    11. Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography

      Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography
      Objectives: Certain neointimal patterns including neoatherosclerosis (NA) are known to be associated with poor clinical outcome. The prevalence and time course of different neointimal patterns have not been studied systematically. The aim of this study was to investigate the serial changes in neointimal pattern after drug-eluting stent implantation. Patients and methods: A total of 132 patients with 207 drug-eluting stents, who underwent two follow-up optical coherence tomography studies at 6 ...
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    12. Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study

      Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study
      Background Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. Objectives This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). Methods The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence ...
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    13. Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study

      Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study
      Background Plaque rupture and erosion are the 2 most common mechanisms for acute coronary syndromes. However, the outcome of these 2 distinct pathologies in patients with acute coronary syndromes has never been studied. Methods and Results We retrospectively studied 141 patients with acute coronary syndromes who underwent optical coherence tomography ( OCT ) imaging of the culprit lesion prior to stenting from the Massachusetts General Hospital OCT Registry. Management (stent versus no ...
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    14. Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus: a pilot study (with video)

      Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus: a pilot study (with video)
      Background and Aims Angiogenesis is associated with neoplastic progression of Barretts esophagus (BE). Volumetric optical coherence tomography angiography (OCTA) visualizes subsurface microvasculature without exogenous contrast agents. We investigated the association of OCTA microvascular features with low-grade dysplasia (LGD) and high-grade dysplasia (HGD). Methods Fifty-two patients undergoing BE surveillance or endoscopic eradication therapies for dysplasia were imaged using volumetric OCTA and corresponding histological diagnoses obtained, to yield 97 data sets (non-dysplastic ...
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    15. Cubic meter volume optical coherence tomography

      Cubic meter volume optical coherence tomography
      Optical coherence tomography (OCT) is a powerful three-dimensional (3D) imaging modality with micrometer-scale axial resolution and up to multi-GigaVoxel/s imaging speed. However, the imaging range of high-speed OCT has been limited. Here, we report 3D OCT over cubic meter volumes using a long coherence length, 1310 nm vertical-cavity surface-emitting laser and silicon photonic integrated circuit dual-quadrature receiver technology combined with enhanced signal processing. We achieved 15 m depth resolution ...
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    16. Volumetric Mapping of Barrett’s Esophagus and Dysplasia With en face Optical Coherence Tomography Tethered Capsule

      Volumetric Mapping of Barrett’s Esophagus and Dysplasia With en face Optical Coherence Tomography Tethered Capsule
      To the Editor: Dysplasia in Barretts Esophagus (BE) is patchy ( 1 ) and sometimes missed by random biopsies. Optical coherence tomography (OCT) can image large areas of the esophagus; however, slow imaging speeds in earlier studies limited visualization to cross-sections. Cross-sectional OCT detected high-grade dysplasia with sensitivity / specificity of ~80 % ( 2 , 3 ). Tethered OCT capsules were demonstrated for cross-sectional imaging in unsedated screening to detect BE ( 4 , 5 ). Our group recently ...
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  2. About Zhao Wang

    Zhao Wang

    Zhao Wang is a PhD candidate with Dr. Andrew Rollins in the department of biomedical engineering at Case Western Reserve University. His research interests include intravascular OCT, image analysis and computer vision.