1. Yuichi Ozaki

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    1. Mentioned In 27 Articles

    2. First Report of Edge Vascular Response at 12 Months of Magmaris, A Second-Generation Drug-Eluting Resorbable Magnesium Scaffold, Assessed by Grayscale Intravascular Ultrasound, Virtual Histology, and Optical Coherence Tomography. A Biosolve-II Trial Sub-S

      First Report of Edge Vascular Response at 12 Months of Magmaris, A Second-Generation Drug-Eluting Resorbable Magnesium Scaffold, Assessed by Grayscale Intravascular Ultrasound, Virtual Histology, and Optical Coherence Tomography. A Biosolve-II Trial Sub-S
      Introduction and objective The edge vascular response (EVR) remains unknown in second generation drug-eluting Resorbable Magnesium Scaffold (RMS), such as Magmaris. The aim of the study was to evaluate tissue modifications in the RMS edges over time, assessed by different invasive imaging modalities. Methods The patients treated with the device were assessed by optical coherence tomography (OCT), grayscale intravascular ultrasound (IVUS), and virtual histology IVUS at baseline and 12 months ...
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    3. Exploring the use of intracoronary imaging devices such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS), as a means of focusing on the prediction and prevention of coronary artery disease

      Exploring the use of intracoronary imaging devices such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS), as a means of focusing on the prediction and prevention of coronary artery disease
      Following on from a previous finding that there was a significant association between the increase in inflammatory monocytes after AMI and microcirculation impairment, and another that direct rennin inhibitors mediate the suppression of inflammatory monocytes after AMI to improve myocardial relief rate, the researchers are setting out to: discover the significance of peripheral blood monocytes in microcirculation impairment; clarify the influence of renin/aldosterone (the renin-angiotensin-aldosterone system is the most ...
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      Mentions: Yuichi Ozaki
    4. Serial 3-Dimensional Optical Coherence Tomography Assessment of Jailed Side-Branch by Second-Generation Drug-Eluting Absorbable Metal Scaffold (From the BIOSOLVE-II Trial)

      Serial 3-Dimensional Optical Coherence Tomography Assessment of Jailed Side-Branch by Second-Generation Drug-Eluting Absorbable Metal Scaffold (From the BIOSOLVE-II Trial)
      Second-generation drug-eluting absorbable metal scaffold (DREAMS 2G) is used for treating coronary lesions. However, the natural history of the jailed side-branch (SB) after DREAMS 2G implantation remains to be elucidated. The aim of this study is to investigate the effect of scaffold struts on jailed SBs as assessed by 3-dimensional (3D) optical coherence tomography (OCT) after implantation of DREAMS 2G. We enrolled the patients who received a DREAMS 2G implantation ...
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    5. Impact of procedural characteristics on coronary vessel wall healing following implantation of second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary artery lesions: an optical coherence tomography analysis

      Impact of procedural characteristics on coronary vessel wall healing following implantation of second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary artery lesions: an optical coherence tomography analysis
      Aims Second-generation drug-eluting absorbable metal scaffold (DREAMS 2G) is an alternative novel device for treating coronary lesions. However, the relationship between in-scaffold dimensions after implantation of DREAMS 2G and vessel healing and luminal results at follow-up is unknown. The aim of this study is, therefore, to investigate whether the expansion index after implantation of DREAMS 2G as assessed by optical coherence tomography (OCT) impacts late luminal status and healing of ...
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    6. Effect of Early Pitavastatin Therapy on Coronary Fibrous-Cap Thickness Assessed by Optical Coherence Tomography in Patients With Acute Coronary Syndrome : The ESCORT Study

      Effect of Early Pitavastatin Therapy on Coronary Fibrous-Cap Thickness Assessed by Optical Coherence Tomography in Patients With Acute Coronary Syndrome : The ESCORT Study
      Objectives The aim of the present study was to assess the effect of early statin therapy on fibrous-cap thickness in coronary plaques of patients with acute coronary syndrome (ACS) by using optical coherence tomography. Background Statins can contribute to the stabilization of coronary plaques. Methods This is a prospective, randomized, active-controlled, single-center study. Patients with ACS and untreated dyslipidemia were enrolled and randomly allocated (ratio 1:1) to either the ...
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    7. Prognosis of spontaneous coronary artery dissection treated by percutaneous coronary intervention with optical coherence tomography

      Prognosis of spontaneous coronary artery dissection treated by percutaneous coronary intervention with optical coherence tomography
      Background Although about half of patients with spontaneous coronary artery dissection (SCAD) face ongoing necrosis, conservative therapy is recommended due to a high complication rate in angiography-guided percutaneous coronary intervention (PCI). The aim of this study was to investigate clinical outcomes of SCAD treated by optical coherence tomography (OCT)-guided PCI. Methods This study consisted of consecutive 306 patients with acute coronary syndrome (ACS) who underwent OCT-guided PCI. Based on ...
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    8. Vasa Vasorum Restructuring in Human Atherosclerotic Plaque Vulnerability

      Vasa Vasorum Restructuring in Human Atherosclerotic Plaque Vulnerability
      Background Previous studies have suggested that vasa vasorum (VV) is associated with plaque progression and vulnerability. Objectives The aim of this study was to investigate the relationship between coronary neovascularization structures and plaque characteristics. Methods We included 53 patients who underwent optical coherence tomography to observe the proximal left anterior descending coronary artery. Patients were classified into 5 groups according to lesion characteristics: normal; fibrous plaque (FP); fibroatheroma (FA); plaque ...
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    9. Effect of Atorvastatin Therapy on Fibrous Cap Thickness in Coronary Atherosclerotic Plaque as Assessed by Optical Coherence Tomography The EASY-FIT Study

      Effect of Atorvastatin Therapy on Fibrous Cap Thickness in Coronary Atherosclerotic Plaque as Assessed by Optical Coherence Tomography The EASY-FIT Study
      ...dy Kenichi Komukai, MD^∗; Takashi Kubo, MD, PhD^∗; Hironori Kitabata, MD, PhD^∗; Yoshiki Matsuo, MD, PhD^∗; Yuichi Ozaki, MD^∗; Shigeho Takarada, MD, PhD^∗; Yasushi Okumoto, MD^†; Yasutsugu Shiono, MD^∗; Makoto Orii, M...
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    10. Difference of Ruptured Plaque Morphology between Asymptomatic Coronary Artery Disease and Non-ST Elevation Acute Coronary Syndrome Patients: an Optical Coherence Tomography Study

      Difference of Ruptured Plaque Morphology between Asymptomatic Coronary Artery Disease and Non-ST Elevation Acute Coronary Syndrome Patients: an Optical Coherence Tomography Study
      Background Autopsy studies have reported that rupture of a thin-cap fibroatheroma and subsequent thrombus formation is the major mechanism leading to acute coronary syndrome (ACS). However, it is not clear why only some plaque ruptures lead to ACS. Optical coherence tomography (OCT) is a high-resolution imaging modality which is capable of investigating detailed coronary plaque morphology in vivo. The objective of this study was to determine whether ruptured plaque morphology ...
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    11. Association between P-selectin Glycoprotein Ligand-1 and Pathogenesis in Acute Coronary Syndrome Assessed by Optical Coherence Tomography

      Association between P-selectin Glycoprotein Ligand-1 and Pathogenesis in Acute Coronary Syndrome Assessed by Optical Coherence Tomography
      Objective Although monocytes appear to be actively involved in the onset of acute coronary syndrome (ACS), they are heterogenous in human peripheral blood. How up-regulation of monocyte subsets leads to coronary plaque rupture followed by thrombus formation remains unclear. Recent studies have shown that P-selectin glycoprotein ligand-1 (PSGL-1) is involved in monocyte activation in patients with thrombus formation. We therefore investigated the relationship between the expression of PSGL-1 on monocyte ...
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    12. Comparison of diagnostic accuracy between multidetector computed tomography and virtual histology intravascular ultrasound for detecting optical coherence tomography-derived fibroatheroma

      Comparison of diagnostic accuracy between multidetector computed tomography and virtual histology intravascular ultrasound for detecting optical coherence tomography-derived fibroatheroma
      Histopathological studies have reported that optical coherence tomography (OCT) can accurately detect fibroatheroma that is involved in not only culprit lesion of acute coronary syndrome but also no-reflow phenomenon after percutaneous coronary intervention. Studies have demonstrated superiority of OCT in plaque characterization and interruption of arterial wall component. At current, multidetector computed tomography (MDCT) and virtual histology intravascular ultrasound (VH-IVUS) are considered as alternative imaging devices for coronary plaque characterization ...
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    13. Prevalence of spontaneous coronary artery dissection in patients with acute coronary syndrome

      Prevalence of spontaneous coronary artery dissection in patients with acute coronary syndrome
      Aims: Spontaneous coronary artery dissection (SCAD) found typically in young females without classical coronary risk factors is thought to be a very rare cause of acute coronary syndrome (ACS). The prevalence of SCAD in ACS subjects has been unclear, probably due to the nature of coronary angiography. The aim of this study was to use optical coherence tomography (OCT) to investigate the prevalence of SCAD in ACS. Methods and results ...
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    14. Inter-Scan Reproducibility of Geometric Coronary Artery Measurements Using Frequency-Domain Optical Coherence Tomography

      Inter-Scan Reproducibility of Geometric Coronary Artery Measurements Using Frequency-Domain Optical Coherence Tomography
      Frequency-domain optical coherence tomography (FD-OCT) is a novel technology which provides high-resolution cross-sectional images of coronary arteries. The aim of this study was to evaluate the inter-scan reproducibility of geometric FD-OCT measurements in the clinical setting. We examined 20 coronary lesions using FD-OCT. Following the FD-OCT image acquisition (1 st pullback), and after the disengagement and re-engagement of the guiding catheter, an additional acquisition (2 nd pullback) was performed using ...
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    15. Fatty streak assessed by optical coherence tomography: early atherosclerosis detection

      Fatty streak assessed by optical coherence tomography: early atherosclerosis detection
      Macrophage plays a crucial role for atherosclerotic plaque and its measurement is important. Fatty streak consists of macrophage foam cells, but its assessment by optical coherence tomography (OCT) has not been established in vivo. These images were derived from an aorta of Watanabe heritable hyperlipidaemia rabbit ex vivo. OCT...
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  2. About Yuichi Ozaki

    Yuichi Ozaki is in the Department of Cardiovascular Medicine at Wakayama Medical University in Japan.