1. Yuhua Zhang

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    1. Mentioned In 15 Articles

    2. An imaging system integrating optical coherence tomography and interferometry for in vivo measurement of the thickness and dynamics of the tear film

      An imaging system integrating optical coherence tomography and interferometry for in vivo measurement of the thickness and dynamics of the tear film
      Background The outermost layer of the tear film consists of a thin lipid layer (LL). The lipid layer serves as a barrier against evaporation of the aqueous component of the tear film. The ability to simultaneously image both the lipid layer thickness and overall tear film thickness is novel, and will help further understandings of mechanisms of how the lipid layer assembles and interacts with the full tear film thickness ...
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    3. OPTICAL COHERENCE TOMOGRAPHY AND HISTOLOGY OF AGE-RELATED MACULAR DEGENERATION SUPPORT MITOCHONDRIA AS REFLECTIVITY SOURCES

      OPTICAL COHERENCE TOMOGRAPHY AND HISTOLOGY OF AGE-RELATED MACULAR DEGENERATION SUPPORT MITOCHONDRIA AS REFLECTIVITY SOURCES
      Purpose: Widespread adoption of optical coherence tomography has revolutionized the diagnosis and management of retinal disease. If the cellular and subcellular sources of reflectivity in optical coherence tomography can be identified, the value of this technology will be advanced even further toward precision medicine, mechanistic thinking, and molecular discovery. Four hyperreflective outer retinal bands are created by the exquisite arrangement of photoreceptors, Mller cells, retinal pigment epithelium, and Bruch membrane ...
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    4. Exploring Photoreceptor Reflectivity Through Multimodal Imaging Of Outer Retinal Tubulation In Advanced AGE-RELATED Macular Degeneration

      Exploring Photoreceptor Reflectivity Through Multimodal Imaging Of Outer Retinal Tubulation In Advanced AGE-RELATED Macular Degeneration
      Purpose: To investigate the microscopic structure of outer retinal tubulation (ORT) and optical properties of cone photoreceptors in vivo, we studied ORT appearance by multimodal imaging, including spectral domain optical coherence tomography (SD-OCT) and adaptive optics scanning laser ophthalmoscopy. Methods: Four eyes of four subjects with advanced age-related macular degeneration underwent color fundus photography, infrared reflectance imaging, SD-OCT, and adaptive optics scanning laser ophthalmoscopy with a high-resolution research instrument. Outer ...
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    5. Quantitative Analysis of Outer Retinal Tubulation in Age-Related Macular Degeneration From Spectral-Domain Optical Coherence Tomography and Histology

      Quantitative Analysis of Outer Retinal Tubulation in Age-Related Macular Degeneration From Spectral-Domain Optical Coherence Tomography and Histology
      Purpose : To assess outer retinal tubulation (ORT) morphology from spectral-domain optical coherence tomography (SD-OCT) volumes and donor eye histology, analyze ORT reflectivity, and estimate the number of cones surviving in ORT. Methods : In SD-OCT volumes from nine patients with advanced AMD, ORT was analyzed en face and in B-scans. The hyperreflective ORT border in cross-section was delineated and surface area calculated. Reflectivity was compared between ORT types (Closed, Open, Forming ...
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    6. Optical Coherence Tomographic Findings Correspond to Histology

      Optical Coherence Tomographic Findings Correspond to Histology
      Purpose: To compare optical coherence tomography (OCT) and histology of outer retinal tubulation (ORT) secondary to advanced age-related macular degeneration in patients and in postmortem specimens, with particular attention to the basis of the hyperreflective border of ORT. Method: A private referral practice (imaging) and an academic research laboratory (histology) collaborated on two retrospective case series. High-resolution OCT raster scans of 43 eyes (34 patients) manifesting ORT secondary to advanced ...
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    7. OUTER RETINAL TUBULATION IN ADVANCED AGE-RELATED MACULAR DEGENERATION: Optical Coherence Tomographic Findings Correspond to Histology.

      OUTER RETINAL TUBULATION IN ADVANCED AGE-RELATED MACULAR DEGENERATION: Optical Coherence Tomographic Findings Correspond to Histology.
      Purpose: To compare optical coherence tomography (OCT) and histology of outer retinal tubulation (ORT) secondary to advanced age-related macular degeneration in patients and in postmortem specimens, with particular attention to the basis of the hyperreflective border of ORT. Method: A private referral practice (imaging) and an academic research laboratory (histology) collaborated on two retrospective case series. High-resolution OCT raster scans of 43 eyes (34 patients) manifesting ORT secondary to advanced ...
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    8. University of Alabama Receives NIH Grant for Studying In Vivo Ultrastructure of Chorioretinal Disease.

      University of Alabama Receives NIH Grant for Studying In Vivo Ultrastructure of Chorioretinal Disease.
      ...rant for $367,500 for Studying In Vivo Ultrastructure of Chorioretinal Disease. The principal investigator is Yuhua Zhang. The program begain in 2015 and ends in 2019. Below is a summary of the proposed work. Age-relate...
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    9. Adaptive Optics Scanning Laser Ophthalmoscopy Images Demonstrate Abnormal Cone Structure in a Family with the Mitochondrial DNA T8993C Mutation

      ...l Cone Structure in a Family with the Mitochondrial DNA T8993C Mutation Michael K. Yoon ^1, Austin Roorda ^2, Yuhua Zhang ^2, Chiaki Nakanishi ^1, Lee-Jun C. Wong ^3, Qing Zhang ^3, Leslie Gillum ^4, Ari Green ^4, and Ja...
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    10. 1-15 of 15
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  2. About Yuhua Zhang

    Yuhua Zhang

    Yuhua Zhang is at the Department of Biomedical Engineering, University of Alabama at Birmingham.