1. Yuankai K. Tao

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    1. Mentioned In 50 Articles

    2. Spectrally Encoded Coherence Tomography and Reflectometry (SECTR): simultaneous en face and cross-sectional imaging at 2 gigapixels-per-second

      Spectrally Encoded Coherence Tomography and Reflectometry (SECTR): simultaneous en face and cross-sectional imaging at 2 gigapixels-per-second
      Non-invasive biological imaging is crucial for understanding in vivo structure and function. Optical coherence tomography (OCT) and reflectance confocal microscopy are two of the most widely used optical modalities for exogenous contrast-free high-resolution three-dimensional imaging in non-fluorescent scattering tissues. However, sample motion remains a critical barrier to raster-scanned acquisition and reconstruction of wide-field anatomically accurate volumetric datasets. We introduce spectrally encoded coherence tomography and reflectometry (SECTR), a high-speed multimodality system ...
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    3. Advances in intraoperative optical coherence tomography for surgical guidance

      Advances in intraoperative optical coherence tomography for surgical guidance
      Translation of optical coherence tomography (OCT) technologies for intraoperative visualization enables in vivo micron-resolution imaging of subsurface tissue structures and image-guided clinical decision-making. Over the last decade, intraoperative OCT has evolved from two-dimensional imaging using handheld probes to include biopsy-needles for minimally invasive deep-tissue imaging, surgical instrumentation using optical feedback for tremor dampening and stabilization, and stereomicroscope integrated systems that provide real-time three- and four-dimensional visualization of surgical maneuvers. In ...
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    4. Multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography at 400 kHz

      Multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography at 400 kHz
      Multimodal imaging systems that combine scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) have demonstrated the utility of concurrent en face and volumetric imaging for aiming, eye tracking, bulk motion compensation, mosaicking, and contrast enhancement. However, this additional functionality trades off with increased system complexity and cost because both SLO and OCT generally require dedicated light sources, galvanometer scanners, relay and imaging optics, detectors, and control and digitization electronics ...
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    5. Multi-volumetric registration and mosaicking using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Multi-volumetric registration and mosaicking using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
      Ophthalmic diagnostic imaging using optical coherence tomography (OCT) is limited by bulk eye motions and a fundamental trade-off between field-of-view (FOV) and sampling density. Here, we introduced a novel multi-volumetric registration and mosaicking method using our previously described multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and OCT (SS-SESLO-OCT) system. Our SS-SESLO-OCT acquires an entire en face fundus SESLO image simultaneously with every OCT cross-section at 200 frames-per-second. In vivo human ...
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    6. Image-guided feedback for ophthalmic microsurgery using multimodal intraoperative swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Image-guided feedback for ophthalmic microsurgery using multimodal intraoperative swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
      Surgical interventions for ocular diseases involve manipulations of semi-transparent structures in the eye, but limited visualization of these tissue layers remains a critical barrier to developing novel surgical techniques and improving clinical outcomes. We addressed limitations in image-guided ophthalmic microsurgery by using microscope-integrated multimodal intraoperative swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography (iSS-SESLO-OCT). We previously demonstrated in vivo human ophthalmic imaging using SS-SESLO-OCT, which enabled simultaneous acquisition ...
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    7. Automated feature extraction for retinal vascular biometry in zebrafish using OCT angiography

      Automated feature extraction for retinal vascular biometry in zebrafish using OCT angiography
      Zebrafish have been identified as an ideal model for angiogenesis because of anatomical and functional similarities with other vertebrates. The scale and complexity of zebrafish assays are limited by the need to manually treat and serially screen animals, and recent technological advances have focused on automation and improving throughput. Here, we use optical coherence tomography (OCT) and OCT angiography (OCT-A) to perform noninvasive, in vivo imaging of retinal vasculature in ...
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    8. Modular multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography scan-head for surgical microscope-integrated and slit-lamp imaging

      Modular multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography scan-head for surgical microscope-integrated and slit-lamp imaging
      anning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) enable noninvasive in vivo diagnostic imaging and provide complementary en face and depth-resolved visualization of ophthalmic structures, respectively. We previously demonstrated concurrent multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and OCT (SS-SESLO-OCT) at 1060 nm using a swept-source and double clad fiber coupler. Here, we present system enhancements and novel designs for a modular SS-SESLO-OCT scan-head that can be coupled to ...
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    9. Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
      Scanning laser ophthalmoscopy (SLO) benefits diagnostic imaging and therapeutic guidance by allowing for high-speeden faceimaging of retinal structures. When combined with optical coherence tomography (OCT), SLO enables real-time aiming and retinal tracking and provides complementary information for post-acquisition volumetric co-registration, bulk motion compensation, and averaging. However, multimodality SLO-OCT systems generally require dedicated light sources, scanners, relay optics, detectors, and additional digitization and synchronization electronics, which increase system complexity. Here, we ...
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    10. New faculty at Vanderbilt University: Kenny Tao uses optical coherence tomography to improve delicate eye surgeries |

      New faculty at Vanderbilt University: Kenny Tao uses optical coherence tomography to improve delicate eye surgeries |
      Kenny Tao was incredibly close to becoming a surgeon instead of a biomedical engineer. The only thing standing in the way of medical school: a renowned adviser who convinced him to take a different path. Fortunately for Vanderbilt, the new assistant professor of biomedical engineering did change his mind and now brings both his improvements to optical coherence tomography and his wry sense of humor to the universitys laboratories and ...
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    11. The Feasibility of Spectral-Domain Optical Coherence Tomography Grading of Anterior Chamber Inflammation in a Rabbit Model of Anterior Uveitis

      The Feasibility of Spectral-Domain Optical Coherence Tomography Grading of Anterior Chamber Inflammation in a Rabbit Model of Anterior Uveitis
      Purpose : To determine the feasibility and accuracy of spectral-domain optical coherence tomography (SD-OCT) based grading of anterior chamber cell, using aqueous sampling as a standard, in a rabbit model of anterior uveitis. Methods : Adult Dutch-belted rabbits were preimmunized with M. tuberculosis (Tb) H37RA antigen, 1 week prior to induction of anterior uveitis with an intracameral injection of Tb antigen. The anterior chamber was imaged with SD-OCT, followed by a slit ...
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    12. Multimodal ophthalmic imaging using swept source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Multimodal ophthalmic imaging using swept source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
      Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) benefit clinical diagnostic imaging in ophthalmology by enabling in vivo noninvasive en face and volumetric visualization of retinal structures, respectively. Spectrally encoding methods enable confocal imaging through fiber optics and reduces system complexity. Previous applications in ophthalmic imaging include spectrally encoded confocal scanning laser ophthalmoscopy (SECSLO) and a combined SECSLO-OCT system for image guidance, tracking, and registration. However, spectrally encoded imaging ...
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    13. Image-guided modified deep anterior lamellar keratoplasty (DALK) corneal transplant using intraoperative optical coherence tomography

      Image-guided modified deep anterior lamellar keratoplasty (DALK) corneal transplant using intraoperative optical coherence tomography
      ...p anterior lamellar keratoplasty (DALK) corneal transplant using intraoperative optical coherence tomography Yuankai K. Tao ; Michael LaBarbera ; Justis P. Ehlers ; Sunil K. Srivastava ; William J. Dupps; Image-guided m...
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    14. Intraoperative optical coherence tomography using an optimized reflective optical relay, real-time heads-up display, and semitransparent surgical instrumentation

      Intraoperative optical coherence tomography using an optimized reflective optical relay, real-time heads-up display, and semitransparent surgical instrumentation
      ...optimized reflective optical relay, real-time heads-up display, and semitransparent surgical instrumentation Yuankai K. Tao ; Mohamed T. El-Haddad ; Sunil K. Srivastava ; Daniel Feiler ; Amanda I. Noonan ; Andrew M. Rol...
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    15. Feature Of The Week 03/08/2015: Endoscopic Optical Coherence Angiography Enables Three Dimensional Visualization of Subsurface Microvasculature

      Feature Of The Week 03/08/2015: Endoscopic Optical Coherence Angiography Enables Three Dimensional Visualization of Subsurface Microvasculature
      Endoscopic imaging technologies such as confocal laser endomicroscopy (CLE) and narrowband imaging (NBI) have been used to investigate vascular changes as hallmarks of early cancer in the GI tract. However, the limited frame rate and field of view make CLE imaging sensitive to motion artifacts, whereas NBI has limited resolution and visualizes only the surface vascular pattern. Endoscopic optical coherence tomography (OCT) enables high speed volumetric imaging of subsurface features ...
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  2. About Yuankai K. Tao

    Yuankai K. Tao

    Yuankai Kenny Tao is a postdoc in the Laser Medicine and Medical Imaging Group at MIT and was foremerly a graduate student working with Professor Izatt in the Department of Biomedical Engineering at Duke University.  Kenny's thesis work investigated the development of coherence-gated and resolution-multiplexed optical imaging systems with applications in ophthalmic imaging.