1. Yu Chen

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    1. Mentioned In 81 Articles

    2. Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease

      Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease
      Chronic kidney disease (CKD) is characterized by a progressive loss of renal function over time. Histopathological analysis of the condition of glomeruli and the proximal convolutional tubules over time can provide valuable insights into the progression of CKD. Optical coherence tomography (OCT) is a technology that can analyze the microscopic structures of a kidney in a nondestructive manner. Recently, we have shown that OCT can provide real-time imaging of kidney ...
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    3. Monitoring Kidney Microanatomy Changes During Ischemia-Reperfusion Process Using Texture Analysis of OCT Images

      Monitoring Kidney Microanatomy Changes During Ischemia-Reperfusion Process Using Texture Analysis of OCT Images
      Impact Statement: Tubular diameter has been developed previously as a potential biomarker for the transplant kidney. However, the tubular lumens were segmented out based on an empirically-determined threshold. In our study, a fully automatic texture analysis algorithm has been developed for OCT image analysis of kidney microanatomy during ischemia-reperfusion process. Our method can potentially be applicable in evaluating the status of donor kidneys prior to and after their transplantation. Abstract ...
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    4. Apparatus and methods for non-invasive assessment of transplant kidney viability

      Apparatus and methods for non-invasive assessment of transplant kidney viability
      A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their post-transplant outcomes. KVAS includes an optical device augmented by an intelligent algorithm that can evaluate the viability or quality of the donor kidney in a real-time, non-invasive way. In particular, it includes a handheld optical coherence tomography (OCT) imaging device and at ...
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    5. Optical coherence microscopy with extended focus for in vivo embryonic imaging

      Optical coherence microscopy with extended focus for in vivo embryonic imaging
      Optical coherence microscopy (OCM) has unique advantages of high-resolution volumetric imaging without relying on exogenous labels or dyes. It combines the coherence-gated depth discrimination of optical coherence tomography (OCT) with the high lateral resolution of confocal microscopy, offering an excellent balance between the resolutions and imaging depth. However, as the lateral resolution becomes higher, the imaging depth of OCM decreases and its three-dimensional imaging capability is greatly degraded. To overcome ...
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    6. Coherence gated doppler motion sensor and medical applications

      Coherence gated doppler motion sensor and medical applications
      A motion sensor applicable to medical procedures includes a source of light with a wavelength bandwidth and an optical detector. A first optical coupler terminates in a first probe tip and couples the light into the first probe tip. A second optical coupler terminates in a second probe tip and directs onto the detector scattered light returning through the second probe tip. A presentation device outputs a signal that indicates ...
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    7. Imaging Spinal Structures With Polarization-Sensitive Optical Coherence Tomography

      Imaging Spinal Structures With Polarization-Sensitive Optical Coherence Tomography
      Impact Statement: We investigate polarization-sensitive optical coherence tomography (PS-OCT) to obtain both intensity and polarization contrast images of in vivo and ex vivo spinal structures like subcutaneous fat, supraspinous ligament, interspinous ligament, ligamentum flavum, dura, and spinal cord in a piglet model. The PS-OCT can provide enhanced contrast characteristic structures compared to the intensity OCT; therefore it has the potential for guidance in spine interventional procedures. Abstract: We investigate polarization-sensitive ...
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    8. Multi-modality Optical Imaging of Rat Kidney Dysfunction: In Vivo Response to Various Ischemia Times

      Multi-modality Optical Imaging of Rat Kidney Dysfunction: In Vivo Response to Various Ischemia Times
      We observed in vivo kidney dysfunction with various ischemia times at 30, 75, 90, and 120 min using multi-modality optical imaging: optical coherence tomography (OCT), Doppler OCT (DOCT), and two-photon microscopy (TPM). We imaged the renal tubule lumens and glomerulus at several areas of each kidney before, during, and after ischemia of 5-month-old female Munich-Wistar rats. For animals with 30 and 75 min ischemia times, we observed that all areas ...
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    9. Research Associate Position in OCT at the University of Maryland

      Research Associate Position in OCT at the University of Maryland
      Position description: A Postdoctoral Research Associate position is available at the University of Maryland, College Park. Research projects include intraoperative imaging of transplant kidney viability using OCT in collaboration with Georgetown University Medical Center, and development of automatic image processing algorithm to predict organ viability. Required expertise: Ph.D. in physics, electrical engineering, optical engineering, or biomedical/bioengineering. Hand-on experience on optical and electronic instrumentation and strong programming skills (Matlab ...
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    10. Optical Coherence Tomography of the Aging Kidney

      Optical Coherence Tomography of the Aging Kidney
      Objectives: The aging kidney exhibits a progressive decline in renal function with characteristic histopathologic changes and is a risk factor for renal transplant. However, the degree to which the kidney exhibits this decline depends on several factors that vary from one individual to the next. Optical coherence tomography is an evolving noninvasive imaging technology that has recently been used to evaluate acute tubular necrosis of living-human donor kidneys before their ...
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    11. OCT imaging of myocardium extending to pulmonary vein

      OCT imaging of myocardium extending to pulmonary vein
      In this study, we propose to use optical coherence tomography to enable a direct visualization of myocardium extending into the pulmonary vein (PV). The results showed that there are obvious differences in the morphology of myocardium and fibrous tissue in the transition region of myocardial sleeve, which is in agreement with the histological analysis. In addition, the myocardial area in transition point has three layers in the depth of 1 ...
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    12. Label-free imaging of developing vasculature in zebrafish with phase variance optical coherence microscopy

      Label-free imaging of developing vasculature in zebrafish with phase variance optical coherence microscopy
      A phase variance optical coherence microscope (pvOCM) has been created to visualize blood flow in the vasculature of zebrafish embryos, without using exogenous labels. The pvOCM imaging system has axial and lateral resolutions of 2 m in tissue, and imaging depth of more than 100 m. Imaging of 25 days post-fertilization zebrafish embryos identified the detailed structures of somites, spinal cord, gut and notochord based on intensity contrast. Visualization of ...
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    13. Optical Coherence Tomographic Elastography Reveals Mesoscale Shear Strain Inhomogeneities in the Annulus Fibrosus

      Optical Coherence Tomographic Elastography Reveals Mesoscale Shear Strain Inhomogeneities in the Annulus Fibrosus
      Study Design. Basic science study using in vitro tissue testing and imaging to characterize local strains in annulus fibrosus (AF) tissue. Objective. To characterize mesoscale strain inhomogeneities between lamellar and inter-/translamellar (ITL) matrix compartments during tissue shear loading. Summary of Background Data. The intervertebral disc (IVD) is characterized by significant heterogeneities in tissue structure and plays a critical role in load distribution and force transmission in the spine. In ...
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    14. Validation of human small-airway measurements using endobronchial optical coherence tomography: an observational study

      Validation of human small-airway measurements using endobronchial optical coherence tomography: an observational study
      Background Small-airway remodelling is the cardinal pathological feature underlying chronic obstructive pulmonary disease (COPD). Identification of early-stage pathological changes is crucial for the diagnosis, treatment, and prognosis of respiratory diseases. Our study aimed to investigate the usefulness of endobronchial optical coherence tomography (EB-OCT) in assessment of small-airways morphology in patients with pulmonary nodules who were scheduled for lung resection surgery (four had COPD, four were smokers with normal lung function ...
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      Mentions: Yu Chen Wei Wang
    15. Validation of human small airway measurements using endobronchial optical coherence tomography

      Validation of human small airway measurements using endobronchial optical coherence tomography
      Background Small airway remodeling is the cardinal feature underlying chronic airway diseases. There is no modality which identifies small airway pathological changes, which is crucial for early diagnosis, efficacy and prognostic assessment. Objective To evaluate the usefulness of endobronchial optical coherence tomography (EB-OCT) in assessing small airways morphology in vivo . Methods Twelve patients with pulmonary nodules scheduled for lung resection underwent spirometry, multi-detector computed tomography (MDCT) and EB-OCT. We measured ...
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  2. About Yu Chen

    Yu Chen

    Yu Chen received his B.S. degree in Physics from Peking University of China in 1997, and his Ph.D. degree in Bioengineering from University of Pennsylvania in 2003. From 2003-2007, he worked at the Research Laboratory of Electronics at the Massachusetts Institute of Technology (MIT) as the Postdoctoral Research Associate and Research Scientist, focused on the technology development and clinical applications of optical coherence tomography (OCT). He is currently an Assistant Professor of Bioengineering at the University of Maryland, College Park. His research interests include the development of multi-modal optical imaging and spectroscopy technologies as well as the applications in early cancer detection and functional brain imaging.

  3. Quotes

    1. Due to lack of visual feedback, failure rates are often high, leading to multiple needle insertions.
      In Optical Coherence Tomography Used to Image Pain Management in Labor and Diabetic Retinopathy and Glaucoma
    2. Due to lack of visual feedback, failure rates are often high, leading to multiple needle insertions...Side effects of these failures can include trauma to blood vessels and punctures in the dura, the outermost membrane surrounding the brain and spinal cord...An OCT forward-imaging probe can provide anesthesiologists with real-time visualization of the microarchitecture of tissues and important landmarks, and thus could significantly improve the accuracy and the safety of the needle-based procedure.
      In Precision-Guided Epidurals and Better Blood Monitors
    3. An OCT forward-imaging probe can provide anesthesiologists with real-time visualization of the microarchitecture of tissues and important landmarks, and thus could significantly improve the accuracy and the safety of the needle-based procedure.
      In Precision-Guided Epidurals and Better Blood Monitors