1. Yoshihisa Kinoshita

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    1. Mentioned In 14 Articles

    2. Impact on Optical Coherence Tomographic Coronary Findings of Fluvastatin Alone versus Fluvastatin+ Ezetimibe

      Impact on Optical Coherence Tomographic Coronary Findings of Fluvastatin Alone versus Fluvastatin+ Ezetimibe

      Although lipid lowering therapy by statin and ezetimibe has been reported to provide greater reduction in low-density lipoprotein cholesterol (LDL-C) levels than statin monotherapy, the effect of supplemental therapy on plaque stabilization is yet to be fully elucidated. Cap thickness of fibroatheroma evaluated by Optical coherence tomography (OCT) is a major determinant of vulnerable plaque. The primary objective of this study is to evaluate the effect of ezetimibe in addition to fluvastatin on progression of coronary atherosclerotic plaque evaluated by OCT. Sixty-three angina pectoris patients with intermediate, non-culprit, lipid-rich plaque lesions evaluated by OCT were enrolled. The patients were divided ...

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    3. Impact of Cholesterol Metabolism on Coronary Plaque Vulnerability of Target Vessels : A Combined Analysis of Virtual Histology Intravascular Ultrasound and Optical Coherence Tomography

      Impact of Cholesterol Metabolism on Coronary Plaque Vulnerability of Target Vessels : A Combined Analysis of Virtual Histology Intravascular Ultrasound and Optical Coherence Tomography
      ...* Tsuyoshi Ito, MD, * Daisuke Yokota, MD, * Shuichi Ishizuka, MD, * Tairo Kurita, MD, * Masashi Kimura, MD, * Yoshihisa Kinoshita, MD, * Yasushi Asakura, MD, * Etsuo Tsuchikane, MD, PhD, * Osamu Katoh, MD, * Takahiko Suz...
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    4. Morphological differences of tissue characteristics between early, late, and very late restenosis lesions after first generation drug-eluting stent implantation: an optical coherence tomography study

      Morphological differences of tissue characteristics between early, late, and very late restenosis lesions after first generation drug-eluting stent implantation: an optical coherence tomography study

      Aims Restenosis of drug-eluting stents (DESs) might be different from that of bare metal stent restenosis in diverse ways including mechanisms and time course; however, these have not been fully examined. To gain insight into the mechanisms and time course of DES restenosis, we evaluated the characteristics of restenotic lesions of first generation DES using optical coherence tomography (OCT). Methods and results We compared the morphological characteristics of early in-stent restenosis (<1 year: E-ISR, n = 43), late ISR (1–3 years: L-ISR, n = 22), and very late ISR (>3 years: VL-ISR, n = 21). OCT qualitative restenotic tissue analysis included the ...

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    5. Response to Letter Regarding Article, "Impact of Frequency-Domain Optical Coherence Tomography Guidance for Optimal Coronary Stent Implantation in Comparison With Intravascular Ultrasound Guidance"

      Response to Letter Regarding Article, "Impact of Frequency-Domain Optical Coherence Tomography Guidance for Optimal Coronary Stent Implantation in Comparison With Intravascular Ultrasound Guidance"
      ...Tsuyoshi Ito, MD, 4. Tairo Kurita, MD, 5. Nobuyoshi Tanaka, MD, 6. Masashi Kimura, MD, 7. Tatsuya Ito, MD, 8. Yoshihisa Kinoshita, MD, 9. Etsuo Tsuchikane, MD, 10. Keiko Asakura, MD, 11. Yasushi Asakura, MD, 12....
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    6. Association of coronary plaque composition and arterial remodelling: A optical coherence tomography study - Corrected Proof

      Association of coronary plaque composition and arterial remodelling: A optical coherence tomography study - Corrected Proof

      Background Conflicting data have been reported about the association between plaque composition and remodelling index (RI). The aim of this study is to evaluate the relationship between plaque morphology obtained by optical coherence tomography (OCT) and arterial remodelling. Methods and results OCT and intravascular ultrasound imaging pull back was performed at corresponding sites on 94 lesions in 47 patients. OCT plaque characteristics for lipid content, fibrous cap thickness, thin-cap fibroatheroma (TCFA), plaque rupture, thrombus, calcification and erosion were derived using validated criteria. Compared with intermediate/negative remodelling (RI<1.0), positive remodelling (RI>1.0) was associated with presence of higher lipid pool (2.86 ...

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    7. The impact of epicardial fat volume on coronary plaque vulnerability: insight from optical coherence tomography analysis

      The impact of epicardial fat volume on coronary plaque vulnerability: insight from optical coherence tomography analysis

      Aims Epicardial fat volume (EFV) has been implicated in coronary artery disease. Relationship between EFV and coronary plaque vulnerability has not been elucidated. The aim of this study was to investigate the association of EFV with coronary plaque vulnerability by using optical coherence tomography (OCT). Methods and results We enrolled 117 patients who underwent multislice computed tomography (MSCT) and OCT. EFV was quantified on MSCT. Patients were categorized according to tertiles of EFV: low tertile, EFV 3 ; mid-tertile, 104.1 cm 3 ≤ EFV ≤ 130.7 cm 3 ; high tertile, EFV > 130.7 cm 3 . A total of 180 vessels and ...

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    8. Feature Of The Week 6/5/11: Researchers from Toyohashi Heart Center Compare Multislice Computed Tomography and Optical Coherence Tomography for In-Vivo Assessment of Vulnerable Plaque

      Feature Of The Week 6/5/11: Researchers from Toyohashi Heart Center Compare Multislice Computed Tomography and Optical Coherence Tomography for In-Vivo Assessment of Vulnerable Plaque
      Cardiovascular disease is one of the major causes of death in the world. One component of this deadly disease is the rupture or thin walled unstable plaques. Increased detection of rupture-prone vulnerable plaque could be promising for better risk stratification of patients. Intravascular OCT has emerged as one of the most promising techniques for non-ionizing, high-resolution, in-vivo plaque characterization and assessment. However OCT is still an (minimally) invasive procedure. Multislice computed tomography (MSCT) has been proposed as a noninvasive imaging technique that can evaluate not only coronary artery stenosis but also detect and classify coronary plaque in vivo. However, the ...
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    9. Difference of Tissue Characteristics Between Early and Very Late Restenosis Lesions After Bare-Metal Stent Implantation: An Optical Coherence Tomography Study

      Difference of Tissue Characteristics Between Early and Very Late Restenosis Lesions After Bare-Metal Stent Implantation: An Optical Coherence Tomography Study
      Background—Although in-stent restenosis (ISR) after bare-metal stent (BMS) implantation peaks in the early phase, very late (VL) ISR occasionally is observed beyond a few years after BMS implantation. To date, this mechanism has not been fully clarified. Methods and Results—We compared the morphological characteristics of VL-ISR (>5 years, without restenosis within the first year) (n=43) to those of early (E) ISR (within the first year) (n=39) using optical coherence tomography (OCT). Qualitative restenotic tissue analysis included assessment of tissue structure (homogeneous or heterogeneous), presence of microvessels, disrupted intima with cavity, and intraluminal material and was performed ...
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    10. Comparison of In Vivo Assessment of Vulnerable Plaque by 64-Slice Multislice Computed Tomography Versus Optical Coherence Tomography

      Comparison of In Vivo Assessment of Vulnerable Plaque by 64-Slice Multislice Computed Tomography Versus Optical Coherence Tomography
      The aim of this study was to investigate the possibility of 64-slice multislice computed tomography (MSCT) to detect vulnerable plaque derived by optical coherence tomography. From September 2007 through December 2009, 122 lesions in 81 patients were evaluated by 64-slice MSCT and optical coherence tomography. Based on optical coherence tomographic findings, lesions were classified as thin-capped fibroatheroma (TCFA; n = 37) and non-TCFA (n = 85). Mean computed tomographic density value of the lesion was lower and remodeling index was larger in the TCFA group (44.9 ± 19.2 vs 78.7 ± 25.0 HU, p
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    11. In-vivo detection of the frequency and distribution of thin-cap fibroatheroma and ruptured plaques in patients with coronary artery disease: an optical coherence tomographic study

      In-vivo detection of the frequency and distribution of thin-cap fibroatheroma and ruptured plaques in patients with coronary artery disease: an optical coherence tomographic study
      Objectives: The purpose of this study was to assess the prevalence and to quantify the thin-cap fibroatheroma (TCFA) and ruptured plaques in patients with coronary artery disease using optical coherence tomography (OCT). Background: TCFA lesions are the most prevalent precursors of plaque rupture, and are responsible for acute coronary syndromes (ACS). There are limited data regarding the frequency and distribution of TCFA in diseased coronary arteries. Methods: Coronary artery OCT was performed in 78 vessels in 47 patients, with stable angina (SA) or ACS. OCT plaque characteristics were derived using criteria that had been validated earlier. TCFA was defined as ...
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    12. Different Patterns of Vascular Response Between Patients With or Without Diabetes Mellitus After Drug-Eluting Stent Implantation: Optical Coherence Tomographic Analysis

      Different Patterns of Vascular Response Between Patients With or Without Diabetes Mellitus After Drug-Eluting Stent Implantation: Optical Coherence Tomographic Analysis
      ...udhir Rathore, MD, Tsuyoshi Itoh, MD, Maoto Habara, MD, Kenya Nasu, MD, Masashi Kimura, MD, Tatsuya Itoh, MD, Yoshihisa Kinoshita, MD, Mariko Ehara, MD, Etsuo Tsuchikane, MD, Keiko Asakura, MD, Yasushi Asakura, MD, Osamu...
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    13. Comparative Analysis of Vascular Responses Following Stent Implantation in the Lesion Wth Acute Coronary Syndrome Between Paclitaxel-Eluting and Bare-Metal Stent Using Optical Coherence Tomography

      ...; Mitsuyasu Terashima; Tsuyoshi Ito; Nobuyoshi Tanaka; Kenya Nasu; Tatsuya Ito; Masashi Kimura; Mariko Ehara; Yoshihisa Kinoshita; Etsuo Tsuchikane; Yasushi Asakura; Osamu Katoh; Takahiko Suzuki Toyohashi Heart Cntr, Toy...
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    14. Difference in Neointimal Growth on the Stent Struts Crossing a Side Branch Between Sirolimus-Eluting Stent and Bare-Metal Stent: An Optical Coherence Tomography Analysis

      Difference in Neointimal Growth on the Stent Struts Crossing a Side Branch Between Sirolimus-Eluting Stent and Bare-Metal Stent: An Optical Coherence Tomography Analysis
      ...^; Yasushi Asakura^; Tetsuo Matsubara^; Hitoshi Matsuo^; Keiko Asakura^; Etsuo Tsuchikane^; Mariko Ehara^; Yoshihisa Kinoshita^; Masashi Kimura^; Kenya Nasu^; Osamu Katoh^; Takahiko Suzuki^ Toyohashi Heart Cntr, Toyoh...
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  2. About Yoshihisa Kinoshita

    Yoshihisa Kinoshita

    Yoshihisa Kinoshita is at co-director of the Toyohashi Heart Center in Toyohashi Japan.