1. Yoshiaki Yasuno

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    1. Mentioned In 142 Articles

    2. Pixel-wise segmentation of severely pathologic retinal pigment epithelium and choroidal stroma using multi-contrast Jones matrix optical coherence tomography

      Pixel-wise segmentation of severely pathologic retinal pigment epithelium and choroidal stroma using multi-contrast Jones matrix optical coherence tomography
      Tissue segmentation of retinal optical coherence tomography (OCT) is widely used in ophthalmic diagnosis. However, its performance in severe pathologic cases is still insufficient. We propose a pixel-wise segmentation method that uses the multi-contrast measurement capability of Jones matrix OCT (JM-OCT). This method is applicable to both normal and pathologic retinal pigment epithelium (RPE) and choroidal stroma. In this method, features, which are sensitive to specific tissues of interest, are ...
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    3. Comparison of intensity, phase retardation, and local birefringence images for filtering blebs using polarization-sensitive optical coherence tomography

      Comparison of intensity, phase retardation, and local birefringence images for filtering blebs using polarization-sensitive optical coherence tomography
      Polarization-sensitive optical coherence tomography (PS-OCT) allows the recording of depth-resolved polarimetric measurements. It has been reported that phase retardation and local birefringence images can noninvasively detect fibrotic area in blebs after glaucoma surgery. Evaluation of scar fibrosis in blebs is important not only for predicting bleb function, but also for planning revision trabeculectomy. Herein, we characterize the intensity, phase retardation, and local birefringence images of blebs using PS-OCT. A total ...
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    4. Simultaneous tissue birefringence and deformation measurement by polarization sensitive optical coherence elastography with active compression

      Simultaneous tissue birefringence and deformation measurement by polarization sensitive optical coherence elastography with active compression
      Polarization sensitive optical coherence tomography (PS-OCT) measures tissue birefringence, while optical coherence elastography (OCE) reveals the mechanical property of the tissue. Since both birefringence and mechanical properties are associated with tissue microstructures such as collagen, simultaneous PS-OCT and OCE measurement will provide useful insight for the tissue microstructures. In this paper, we present a combined PS-OCT and OCE technique. The PS-OCT is based on Jones matrix OCT theory. It measures ...
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    5. Objective evaluation of choroidal melanin contents with polarization-sensitive optical coherence tomography

      Objective evaluation of choroidal melanin contents with polarization-sensitive optical coherence tomography
      We non-invasively evaluated choroidal melanin contents in human eyes with PS-OCT. We calculated the percentage area of low DOPU in the choroidal interstitial stroma for Vogt-Koyanagi- Harada disease with sunset glow fundus, without sunset glow fundus, control group and tessellated fundus with high myopia. The mean percentage area of low DOPU in the sunset group was significantly lower than the other groups. PS-OCT provides an in vivo objective evaluation of ...
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    6. Eye-motion-corrected optical coherence tomography angiography using Lissajous scanning

      Eye-motion-corrected optical coherence tomography angiography using Lissajous scanning
      To correct eye motion artifacts in en face optical coherence tomography angiography (OCT-A) images, a Lissajous scanning method with subsequent software-based motion correction is proposed. The standard Lissajous scanning pattern is modified to be compatible with OCT-A and a corresponding motion correction algorithm is designed. The effectiveness of our method was demonstrated by comparing en face OCT-A images with and without motion correction. The method was further validated by comparing ...
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    7. Generation and optimization of superpixels as image processing kernels for Jones matrix optical coherence tomography

      Generation and optimization of superpixels as image processing kernels for Jones matrix optical coherence tomography
      Jones matrix-based polarization sensitive optical coherence tomography (JM-OCT) simultaneously measures optical intensity, birefringence, degree of polarization uniformity, and OCT angiography. The statistics of the optical features in a local region, such as the local mean of the OCT intensity, are frequently used for image processing and the quantitative analysis of JM-OCT. Conventionally, local statistics have been computed with fixed-size rectangular kernels. However, this results in a trade-off between image sharpness ...
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    8. Introduction to the feature issue on the 25 year anniversary of optical coherence tomography

      Introduction to the feature issue on the 25 year anniversary of optical coherence tomography
      This feature issue commemorates the approximately 25 year history of Optical Coherence Tomography (OCT), one of the most successful biophotonic technologies. While OCT has technological origins traceable to ultrafast laser development and fiber optic system test instrumentation of the 1980s, innovations in low coherence interferometry for optical ranging and imaging for biomedical applications in the U.S., Europe and Japan by the early 1990s led to coinage of the now ...
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    9. Multi-contrast imaging of human posterior eye by Jones matrix optical coherence tomography

      Multi-contrast imaging of human posterior eye by Jones matrix optical coherence tomography
      A multi-contrast imaging of pathologic posterior eyes is demonstrated by Jones matrix optical coherence tomography (Jones matrix OCT). The Jones matrix OCT provides five tomographies, which includes scattering, local attenuation, birefringence, polarization uniformity, and optical coherence angiography, by a single scan. The hardware configuration, algorithms of the Jones matrix OCT as well as its application to ophthalmology is discussed.
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    10. Noise-bias and polarization-artifact corrected optical coherence tomography by maximum a-posteriori intensity estimation

      Noise-bias and polarization-artifact corrected optical coherence tomography by maximum a-posteriori intensity estimation
      We propose using maximum a-posteriori (MAP) estimation to improve the image signal-to-noise ratio (SNR) in polarization diversity (PD) optical coherence tomography. PD-detection removes polarization artifacts, which are common when imaging highly birefringent tissue or when using a flexible fiber catheter. However, dividing the probe power to two polarization detection channels inevitably reduces the SNR. Applying MAP estimation to PD-OCT allows for the removal of polarization artifacts while maintaining and improving ...
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    11. Three-dimensional eye motion correction by Lissajous scan optical coherence tomography

      Three-dimensional eye motion correction by Lissajous scan optical coherence tomography
      A three-dimensional optical coherence tomography imaging method based on Lissajous scanning is presented. This method was designed to correct eye motion in OCT images. A Lissajous scanning pattern, which has a trajectory that frequently overlaps with itself, is adopted as the OCT scanning protocol to obtain measurement data. Eye motion artifacts are then corrected automatically by software. By comparing the images without and with motion correction, we show the effectiveness ...
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    12. Polarization sensitive optical coherence tomography – a review [Invited]

      Polarization sensitive optical coherence tomography – a review [Invited]
      Optical coherence tomography (OCT) is now a well-established modality for high-resolution cross-sectional and three-dimensional imaging of transparent and translucent samples and tissues. Conventional, intensity based OCT, however, does not provide a tissue-specific contrast, causing an ambiguity with image interpretation in several cases. Polarization sensitive (PS) OCT draws advantage from the fact that several materials and tissues can change the lights polarization state, adding an additional contrast channel and providing quantitative ...
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    13. High contrast and polarization-artifact-free optical coherence tomography by maximum a-posteriori estimation

      High contrast and polarization-artifact-free optical coherence tomography by maximum a-posteriori estimation
      We propose a maximum a-posteriori (MAP) intensity estimator to improve the image contrast of polarization diversity (PD)-OCT imaging to achieve high contrast polarization-artifact-free images. The MAP estimator compensates for the inevitable reduction of signal-to-noise ratio (SNR) in PD-OCT caused by the splitting of power into two polarization detection channels. It also has low noise-offset in low intensity regions such as the vitreous. This method is applied to posterior eye ...
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    14. Birefringence and vascular imaging of in vivo human skin by Jones-matrix optical coherence tomography

      Birefringence and vascular imaging of in vivo human skin by Jones-matrix optical coherence tomography
      A customized 1310-nm Jones-matrix optical coherence tomography (JM-OCT) for dermatological investigation was constructed and used for in vivo normal human skin tissue imaging. This system can simultaneously measure the threedimensional depth-resolved local birefringence, complex-correlation based OCT angiography (OCT-A), degree-ofpolarization- uniformity (DOPU) and scattering OCT intensity. By obtaining these optical properties of tissue, the morphology, vasculature, and collagen content of skin can be deduced and visualized. Structures in the deep layers ...
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    15. Motion-corrected en face optical coherence tomography angiography imaging based on the modified Lissajous scanning pattern

      Motion-corrected en face optical coherence tomography angiography imaging based on the modified Lissajous scanning pattern
      A motion - corrected en face optical coherence tomography angiography (OCT - A) imaging method is presented in this paper. This method was designed to correct eye motion artifacts in en face OCT - A images automatically using a software. A modified Lissajous scanning pattern, which is compatible with OCT - A, was adopted as the scanning protocol for the optical coherence tomography (OCT) machine to obtain the OCT - A data. The OCT - A ...
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    16. Evaluation of intraretinal migration of retinal pigment epithelial cells with Jones matrix optical coherence tomography

      Evaluation of intraretinal migration of retinal pigment epithelial cells with Jones matrix optical coherence tomography
      We evaluated intraretinal RPE migration in AMD using multimodal imaging including polarimetric images. Depolarized light images were computed using a PS-SLO. M-DOPU was calculated using multifunctional Jones-matrix OCT. RPE migration was detected in 59 of 155 eyes. Focal similarities could be confirmed among en-face projection images of minimum M-DOPU, depolarized light images, and NIR-AF images.
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  2. About Yoshiaki Yasuno

    Yoshiaki Yasuno

    Yoshiaki Yasuno is a Researcher in the Computational Optics Group in the Institute of Applied Physics, University of Tsukuba in Japan.