1. Yingtian Pan

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    1. Mentioned In 25 Articles

    2. Cerebral capillary flow imaging by wavelength‐division‐multiplexing swept‐source optical Doppler tomography

      Cerebral capillary flow imaging by wavelength‐division‐multiplexing swept‐source optical Doppler tomography
      Swept‐source optical coherence tomography has demonstrated the unique advantages for fast imaging rate and long imaging distance, however, limited axial resolution and complex phase noises restrict swept‐source optical coherence Doppler tomography (SS‐ODT) for quantitative capillary blood flow imaging in the deep cortices. Here, the wavelength‐division‐multiplexing optical Doppler tomography (WDM‐ODT) method, which divides a single interferogram into multiple phase‐correlated interferograms, is proposed to effectively ...
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    3. Volumetric Doppler angle correction for ultrahigh-resolution optical coherence Doppler tomography

      Volumetric Doppler angle correction for ultrahigh-resolution optical coherence Doppler tomography
      Ultrahigh-resolution optical coherence Doppler tomography (ODT) demonstrates great potential for quantitative blood flow imaging owing to its large field of view and capillary resolution. However, ODT only detects the axial flow velocity and requires Doppler angle correction to retrieve the absolute velocity. Although methods for Doppler angle tracking of single or few large vessels have been reported, a method that enables angle correction of the entire 3D microvascular networks remains ...
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    4. High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging

      High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging
      Noninvasive microvascular imaging using optical coherence Doppler tomography (ODT) has shown great promise in brain studies; however, high-speed microcirculatory imaging in deep brain remains an open quest. A high-speed 1.3m swept-source ODT (SS-ODT) system is reported which was based on a 200kHz vertical-cavity-surface-emitting laser. Phase errors induced by sweep-trigger desynchronization were effectively reduced by spectral phase encoding and instantaneous correlation among the A-scans. Phantom studies have revealed a significant ...
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    5. Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo

      Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo
      Despite widespread applications of multiphoton microscopy in microcirculation, its small field of view and inability to instantaneously quantify cerebral blood flow velocity (CBFv) in vascular networks limit its utility in investigating the heterogeneous responses to brain stimulations. Optical Doppler tomography (ODT) provides 3D images of CBFv networks, but it suffers poor sensitivity for measuring capillary flows. Here we report on a new method, contrast-enhanced ODT with Intralipid that significantly improves ...
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    6. Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

      Optical coherence Doppler tomography for quantitative cerebral blood flow imaging
      Optical coherence Doppler tomography (ODT) is a promising neurotechnique that permits 3D imaging of the cerebral blood flow (CBF) network; however, quantitative CBF velocity (CBFv) imaging remains challenging. Here we present a simple phase summation method to enhance slow capillary flow detection sensitivity without sacrificing dynamic range for fast flow and vessel tracking to improve angle correction for absolute CBFv quantification. Flow phantom validation indicated that the CBFv quantification accuracy ...
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    7. Optical detection of brain function: simultaneous imaging of cerebral vascular response, tissue metabolism, and cellular activity in vivo

      Optical detection of brain function: simultaneous imaging of cerebral vascular response, tissue metabolism, and cellular activity in vivo
      ...ltaneous imaging of cerebral vascular response, tissue metabolism, and cellular activity in vivo Congwu Du^1, Yingtian Pan^2, ^1Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA ^2Department o...
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    8. Enhancing Detection of Bladder Carcinoma In Situ by 3-Dimensional Optical Coherence Tomography

      Enhancing Detection of Bladder Carcinoma In Situ by 3-Dimensional Optical Coherence Tomography
      Purpose: We examined the usefulness of 3-dimensional optical coherence tomography to enhance the diagnosis of urothelial carcinoma in situ.Materials and Methods: By expressing SV40T antigen with uroplakin II promoter, carcinoma in situ readily develops in SV40T transgenic mice at about ages 8 to 20 weeks and then frank high grade papillary carcinoma develops in bladder epithelium. We examined 10 control and 40 SV40T mice during weeks 8 to 20 ...
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    9. Diagnosis of Bladder Cancer With Microelectromechanical Systems-based Cystoscopic Optical Coherence Tomography

      Objectives To examine the utility and potential limitations of microelectromechanical systems-based spectral-domain cystoscopic optical coherence tomography (COCT) so as to improve the diagnosis of early bladder cancer. Methods An optical coherence tomography catheter was integrated into the single instrument channel of a 22F cystoscope to permit white-light-guided COCT over a large field of view (4.6 mm wide and 2.1 mm deep per scan at 8 frames/s) and ...
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  2. About Yingtian Pan

    Yingtian Pan

    Yingtian Pan is an Associate Professor, Department of Biomedical Engineering, State University of New York at Stony Brook.  Research Focus: 2D and 3D cross-sectional optical imaging of biological tissue at close to cellular resolution (e.g., 2-10µm) and at depths of 1-3mm can have significant impacts on noninvasive or minimally invasive clinical diagnosis of tissue abnormalities, e.g., tumorigenesis, as well as engineering tissue growth and repair. Laser scanning endoscopes, based on optical coherence tomography (OCT), have been developed and tested on a wide variety of tissues both ex vivo and in vivo.

  3. Quotes

    1. We show that quantitative flow imaging can provide a lot of useful physiological and functional information that we haven’t had access to before.
      In This is Your Brain's Blood Vessels on Cocaine