1. Yifan Jian

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    1. Mentioned In 30 Articles

    2. Real-time retinal layer segmentation of OCT volumes with GPU accelerated inferencing using a compressed, low-latency neural network

      Real-time retinal layer segmentation of OCT volumes with GPU accelerated inferencing using a compressed, low-latency neural network
      Segmentation of retinal layers in optical coherence tomography (OCT) is an essential step in OCT image analysis for screening, diagnosis, and assessment of retinal disease progression. Real-time segmentation together with high-speed OCT volume acquisition allows rendering of en face OCT of arbitrary retinal layers, which can be used to increase the yield rate of high-quality scans, provide real-time feedback during image-guided surgeries, and compensate aberrations in adaptive optics (AO) OCT ...
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    3. Real-time retinal layer segmentation of OCT Volumes with GPU and Deep learning

      Real-time retinal layer segmentation of OCT Volumes with GPU and Deep learning
      Segmentation of retinal layers in optical coherence tomography (OCT) is an essential step in OCT image analysis for screening, diagnosis, and assessment of retinal disease progression. Real-time segmentation together with high-speed OCT volume acquisition allows rendering of en face OCT of arbitrary retinal layers, which can be used to increase the yield rate of high-quality scans, provide real-time feedback during image-guided surgeries, and compensate aberrations in adaptive optics (AO) OCT ...
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    4. Oregon Health and Sciences University Receives a 2020 NIH Grant for Artificial Intelligence Assisted Panoramic Optical Coherence Tomography for Retinopathy of Prematurity

      Oregon Health and Sciences University Receives a 2020 NIH Grant  for Artificial Intelligence Assisted Panoramic Optical Coherence Tomography for Retinopathy of Prematurity
      ...Assisted Panoramic Optical Coherence Tomography for Retinopathy of Prematurity. The principal investigator is Yifan Jian.

      Below is a summary of the proposed work. The long-term goal of...

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    5. Sensorless adaptive-optics optical coherence tomographic angiography

      Sensorless adaptive-optics optical coherence tomographic angiography
      Optical coherence tomographic angiography (OCTA) can image the retinal blood flow but visualization of the capillary caliber is limited by the low lateral resolution. Adaptive optics (AO) can be used to compensate ocular aberrations when using high numerical aperture (NA), and thus improve image resolution. However, previously reported AO-OCTA instruments were large and complex, and have a small sub-millimeter field of view (FOV) that hinders the extraction of biomarkers with ...
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    6. Depth-resolved optimization of a real-time sensorless adaptive optics optical coherence tomography

      Depth-resolved optimization of a real-time sensorless adaptive optics optical coherence tomography
      Sensorless adaptive optics optical coherence tomography (AO-OCT) is a technology to image retinal tissue with high resolution by compensating ocular aberrations without wavefront sensors. In this Letter, a fast and robust hill-climbing algorithm is developed to optimize five Zernike modes in AO-OCT with a numerical aperture between that of conventional AO and commercial OCT systems. The merit function is generated in real time using graphics processing unit while axially tracking ...
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    7. Pseudo-real-time retinal layer segmentation for high-resolution adaptive optics optical coherence tomography

      Pseudo-real-time retinal layer segmentation for high-resolution adaptive optics optical coherence tomography
      We present a pseudo-real-time retinal layer segmentation for high-resolution Sensorless Adaptive Optics-Optical Coherence Tomography (SAO-OCT). Our pseudo-real-time segmentation method is based on Dijkstras algorithm that uses the intensity of pixels and the vertical gradient of the image to find the minimum cost in a geometric graph formulation within a limited search region. It segments six retinal layer boundaries in an iterative process according to their order of prominence. The segmentation ...
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    8. Directional optical coherence tomography reveals melanin concentration-dependent scattering properties of retinal pigment epithelium

      Directional optical coherence tomography reveals melanin concentration-dependent scattering properties of retinal pigment epithelium
      Optical coherence tomography (OCT) is a powerful tool in ophthalmology that provides in vivo morphology of the retinal layers and their light scattering properties. The directional (angular) reflectivity of the retinal layers was investigated with focus on the scattering from retinal pigment epithelium (RPE). The directional scattering of the RPE was studied in three mice strains with three distinct melanin concentrations: albino (BALB/c), agouti (129S1/SvlmJ), and strongly pigmented ...
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    9. Multi-scale and -contrast sensorless adaptive optics optical coherence tomography

      Multi-scale and -contrast sensorless adaptive optics optical coherence tomography
      Background: The roles of the retinal microvasculature and the retinal pigment epithelium (RPE) in maintaining the health and metabolic activity of the retina lend great clinical value to their high-resolution visualization. Methods: By integrating polarization diversity detection (PDD) into multi-scale and -contrast sensorless adaptive optics optical coherence tomography (MSC-SAO-OCT), we have developed a novel multi-contrast SAO OCT system for imaging pigment in the RPE as well as flow in the ...
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    10. Aperture phase modulation with adaptive optics

      Aperture phase modulation with adaptive optics
      Speckle is an inevitable consequence of the use of coherent light in imaging and acts as noise that corrupts image formation in most applications. Optical coherence tomographic imaging, as a technique employing coherence time gating, suffers from speckle. We present here a novel method of suppressing speckle noise intrinsically compatible with adaptive optics (AO) for confocal coherent imaging: modulation of the phase in the system pupil aperture with a segmented ...
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    11. Visible light sensorless adaptive optics for retinal structure and fluorescence imaging

      Visible light sensorless adaptive optics for retinal structure and fluorescence imaging
      Optical coherence tomography (OCT) has emerged as a powerful imaging instrument and technology in biomedicine. OCT imaging is predominantly performed using wavelengths in the near infrared; however, visible light (VIS) has been recently employed in OCT systems with encouraging results for high-resolution retinal imaging. Using a broadband supercontinuum VIS source, we present a sensorless adaptive optics (SAO) multimodal imaging system driven by VIS-OCT for volumetric retinal structural imaging, followed by ...
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    12. Aperture Phase Modulation with Adaptive Optics: A Novel Approach for Speckle Reduction and Structure Extraction in Optical Coherence Tomography

      Aperture Phase Modulation with Adaptive Optics: A Novel Approach for Speckle Reduction and Structure Extraction in Optical Coherence Tomography
      Speckle is an inevitable consequence of the use of coherent light in optical coherence tomography (OCT), and often acts as noise that obscures micro-structures of biological tissue. We here present a novel method of suppressing speckle noise intrinsically compatible with adaptive optics (AO) in OCT system: by modulating the phase inside the imaging system pupil aperture with a segmented deformable mirror, thus producing minor perturbations in the point spread function ...
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    13. Postdoctoral Fellowship/Research Associate Position at the Casey Eye Institute, Oregon Health & Science University

      Postdoctoral Fellowship/Research Associate Position at the Casey Eye Institute, Oregon Health & Science University
      ...g. Broad experience in optics, signal processing, and image processing are also desirable. Please Contact Dr. Yifan Jian at jian@ohsu.edu or Dr. David Huang at huangd@ohsu.edu or details. Applications, including a statem...
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    14. Effective bidirectional scanning pattern for optical coherence tomography angiography

      Effective bidirectional scanning pattern for optical coherence tomography angiography
      We demonstrate the utility of a novel scanning method for optical coherence tomography angiography (OCTA). Although raster scanning is commonly used for OCTA imaging, a bidirectional approach would lessen the distortion caused by galvanometer-based scanners as sources continue to increase sweep rates. As shown, a unidirectional raster scan approach has a lower effective scanning time than bidirectional approaches; however, a strictly bidirectional approach causes contrast variation along the B-scan direction ...
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    15. Multiscale sensorless adaptive optics OCT angiography system for in vivo human retinal imaging

      Multiscale sensorless adaptive optics OCT angiography system for in vivo human retinal imaging
      We present a multiscale sensorless adaptive optics (SAO) OCT system capable of imaging retinal structure and vasculature with various fields-of-view (FOV) and resolutions. Using a single deformable mirror and exploiting the polarization properties of light, the SAO-OCT-A was implemented in a compact and easy to operate system. With the ability to adjust the beam diameter at the pupil, retinal imaging was demonstrated at two different numerical apertures with the same ...
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    16. Strip-based registration of serially acquired optical coherence tomography angiography

      Strip-based registration of serially acquired optical coherence tomography angiography
      The visibility of retinal microvasculature in optical coherence tomography angiography (OCT-A) images is negatively affected by the small dimension of the capillaries, pulsatile blood flow, and motion artifacts. Serial acquisition and time-averaging of multiple OCT-A images can enhance the definition of the capillaries and result in repeatable and consistent visualization. We demonstrate an automated method for registration and averaging of serially acquired OCT-A images. Ten OCT-A volumes from six normal ...
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  2. About Yifan Jian

    Yifan Jian

    Yifan Jian is currently pursuing the PhD degree in Biomedical Research Optics Group, Simon Fraser University under Dr. Marinko V. Sarunic's supervision. He worked on developing the AO-OCT for small animal retinal imaging and GPU accelerated real time OCT data processing and volumetric rendering. His main research focus is novel biophotonics applications such as optical coherence tomography. He is also interested in medical image processing such as compressive sampling (CS) OCT and volumetric registration.