1. Yanling Ouyang

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    1. Mentioned In 22 Articles

    2. An easy method to differentiate retinal arteries from veins by spectral domain optical coherence tomography: retrospective, observational case series

      An easy method to differentiate retinal arteries from veins by spectral domain optical coherence tomography: retrospective, observational case series

      Background Recently it was shown that retinal vessel diameters could be measured using spectral domain optical coherence tomography (OCT). It has also been suggested that retinal vessels manifest different features on spectral domain OCT (SD-OCT) depending on whether they are arteries or veins. Our study was aimed to present a reliable SD-OCT assisted method of differentiating retinal arteries from veins. Methods Patients who underwent circular OCT scans centred at the optic disc using a Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany) were retrospectively reviewed. Individual retinal vessels were identified on infrared reflectance (IR) images and given unique labels for subsequent grading ...

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    3. The Retinal Disease Screening Study: Retrospective Comparison of Nonmydriatic Fundus Photography and Three-Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities

      The Retinal Disease Screening Study: Retrospective Comparison of Nonmydriatic Fundus Photography and Three-Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities
      ...s Photography and Three-Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities 1. Yanling Ouyang^1,^2, 2. Florian M. Heussen^1,^2, 3. Pearse A. Keane^3, 4. Srinivas R. Sadda^1 and 5. Alexander...
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    4. Comparison of Non-Mydriatic Fundus Photography and Three Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities

      Comparison of Non-Mydriatic Fundus Photography and Three Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities

      Purpose:To determine the sensitivity of detection for retinal abnormalities using 3D-OCT versus single field fundus imaging. Methods:Images from consecutive patients in a retina clinic undergoing simultaneous 3D-OCT (512x128) and single, foveal non-mydriatic 45 degree color fundus imaging with 3D-OCT-1000 (Topcon Corp, Tokyo, Japan) in a 4 months period were retrospectively collected. Findings for each modality were graded independently by two graders as present, questionable or absent. Findings were separated into 3 categories for intermodality comparisons: epiretinal, retinal/subretinal, and RPE/choroidal. The approximate location of findings in relation to the 3D-OCT field was noted as infield and out ...

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    5. Optical Coherence Tomography–Based Observation of the Natural History of Drusenoid Lesion in Eyes with Dry Age-Related Macular Degeneration

      Optical Coherence Tomography–Based Observation of the Natural History of Drusenoid Lesion in Eyes with Dry Age-Related Macular Degeneration
      ...ed Observation of the Natural History of Drusenoid Lesion in Eyes with Dry Age-Related Macular Degeneration * Yanling Ouyang, MD Affiliations + Doheny Eye Institute, Keck School of Medicine, University of Southern Califo...
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    6. Different phenotypes of the appearance of the outer plexiform layer on optical coherence tomography

      Different phenotypes of the appearance of the outer plexiform layer on optical coherence tomography

      Purpose To present a selected case series of different phenotypes of the normal outer plexiform layer (OPL) visualized by optical coherence tomography (OCT). Methods Five cases were selected to represent the spectrum of appearances of the OPL in this case series. Categorical descriptions of each manifestation were then developed. Additional SD-OCT scans were obtained from a normal volunteer to further support the hypothesis. Results The inner one-third of the OPL typically appears hyperreflective on OCT, while the outer two-thirds (Henle fiber layer) may have a more varied appearance. Six different phenotypes of Henle fiber layer reflectivity were noted in this ...

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    7. Evaluation of the Axial Location of Cystoid Spaces in Retinal Vein Occlusion Using Optical Coherence Tomography

      Evaluation of the Axial Location of Cystoid Spaces in Retinal Vein Occlusion Using Optical Coherence Tomography

      Purpose: To analyze the axial distribution of intraretinal cystoid changes in patients with retinal vein occlusion (RVO), incorporating a new hypothesis about the optical coherence tomographic boundary between the outer nuclear layer and the outer plexiform layer. Methods: Data were collected from patients with RVO who underwent spectral domain coherence tomography imaging. For each image set, certified graders evaluated each retinal layer for cystoid macular edema, defined as hyporeflective intraretinal cystoid spaces. Subretinal fluid, if present, was also noted. Results: Forty-eight eyes were evaluated (24 branch RVO, 18 central RVO, 6 hemiretinal vein occlusion). Cystoid macular edema was present in ...

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    8. The Retinal Disease Screening Study: Prospective Comparison of Nonmydriatic Fundus Photography and Optical Coherence Tomography for Detection of Retinal Irregularities

      The Retinal Disease Screening Study: Prospective Comparison of Nonmydriatic Fundus Photography and Optical Coherence Tomography for Detection of Retinal Irregularities
      ...f Nonmydriatic Fundus Photography and Optical Coherence Tomography for Detection of Retinal Irregularities 1. Yanling Ouyang^1,^2,^4, 2. Florian M. Heussen^1,^2,^4, 3. Pearse A. Keane^3, 4. SriniVas R. Sadda^1 and 5. Ale...
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    9. Semiautomated Segmentation of the Choroid in Spectral-domain Optical Coherence Tomography Volume Scans

      Semiautomated Segmentation of the Choroid in Spectral-domain Optical Coherence Tomography Volume Scans

      Purpose: Changes in the choroid, in particular its thickness, are believed to be of importance in the pathophysiology of a number of retinal diseases. The purpose of this study is to adapt the graph search algorithm to semi-automatically identify the choroidal layer in spectral-domain optical coherence tomography (SD-OCT) volume scans and compare its performance to manual delineation. Methods: A graph-based multi-stage segmentation approach was used to identify the choroid, defined as the layer between the outer border of the retinal pigment epithelium (RPE) band and the choroid-sclera junction. Thirty randomly chosen macular SD-OCT (Heidelberg Spectralis) volumes were obtained from 20 ...

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    10. The Retinal Disease Screening Study: Prospective Comparison of Non-Mydriatic FP and Optical Coherence Tomography for Detection of Retinal Irregularities

      The Retinal Disease Screening Study: Prospective Comparison of Non-Mydriatic FP and Optical Coherence Tomography for Detection of Retinal Irregularities

      Purpose:To compare the sensitivity of volume scanning with optical coherence tomography (OCT), to non-mydriatic fundus photography, for the detection of retinal abnormalities in asymptomatic populations. Methods:Asymptomatic subjects without known ocular disease recruited over a six-month period .For each eye, two undilated 45º fundus images, and four undilated volume OCT image sets covering the macula and optic nerve, were obtained. Fundus photographs were evaluated for abnormalities both inside and outside the fundal area covered by OCT. OCT image sets were evaluated for internal limiting membrane irregularities, abnormal retinal thickness, hyper/hyporeflective foci, and photoreceptor/retinal pigment epithelium irregularities. Detection ...

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    11. Juxtapapillary Pigment Epithelium Detachment Observed in Asymptomatic Participants using Optical Coherence Tomograph

      Juxtapapillary Pigment Epithelium Detachment Observed in Asymptomatic Participants using Optical Coherence Tomograph

      Purpose. To use three-dimensional optical coherence tomography (3D-OCT) to assess the prevalence of juxtapapillary retinal pigment epithelial detachments (jPED) in an asymptomatic population. Methods. Asymptomatic participants (i.e. family members of patients) were prospectively recruited over a six-month period. Each subject completed a questionnaire prior to the acquisition of two undilated 45º fundus images and two undilated raster 3D-OCT scans (512x128) covering the macula and optic nerve from each eye using 3D-OCT-1000 (Topcon Co, Tokyo). Fundus images were graded for the presence of peripapillary atrophy (PPA), peripapillary pigment (PPP), drusen in the macula and drusen elsewhere; while 3D-OCT scans were ...

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    12. Diurnal Variation of Choroidal Thickness in Normal, Healthy Subjects Measured by Spectral Domain Optical Coherence Tomography

      Diurnal Variation of Choroidal Thickness in Normal, Healthy Subjects Measured by Spectral Domain Optical Coherence Tomography
      Purpose. To describe the pattern and magnitude of diurnal variation of choroidal thickness (CT), its relation to systemic and ocular factors, and to determine the intervisit reproducibility of diurnal patterns. Methods. A prospective study was conducted on 12 healthy volunteers who each underwent sequential ocular imaging on two separate days at five fixed, 2-hour time intervals. Spectral domain optical coherence tomography (OCT) with enhanced depth imaging and image tracking was performed using a standardized protocol. Choroidal and retinal thicknesses were independently assessed by two masked graders. CT diurnal variation was assessed using repeated-measures ANOVA. Results. A significant diurnal variation in ...
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    13. Assessment of Differential Pharmacodynamic Effects using Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration

      Assessment of Differential Pharmacodynamic Effects using Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration

      Purpose: To assess the differential pharmacodynamic effects of bevacizumab (Avastin), pegaptanib (Macugen), and verteporfin photodynamic therapy (PDT), using novel OCT parameters, in a recently completed phase III/IV clinical trial. Methods: Data from 122 patients participating in the Avastin (Bevacizumab) for Choroidal neovascularization (ABC) trial, were evaluated. Stratus OCT images were analyzed using custom software - changes in volume of the neurosensory retina, subretinal fluid (SRF), pigment epithelium detachment (PED), and subretinal tissue, were calculated over the 54-week trial period. Results: Reductions in retinal oedema were more than twice as great from bevacizumab than pegaptanib (-0.82 mm3 versus -0.31 ...

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  2. About Yanling Ouyang

    Yanling Ouyang is with the Doheny Eye Institute and the Department of Ophthalmology at the Keck School of Medicine of the University of Southern California.