1. Yali Jia

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    1. Mentioned In 119 Articles

    2. Longitudinal Detection of Radiation-Induced Peripapillary and Macular Retinal Capillary Ischemia Using Optical Coherence Tomography Angiography

      Longitudinal Detection of Radiation-Induced Peripapillary and Macular Retinal Capillary Ischemia Using Optical Coherence Tomography Angiography
      Purpose To study longitudinal changes in retinal capillary circulation in eyes treated with iodine 125 (I-125) plaque brachytherapy for uveal melanoma using optical coherence tomography angiography (OCTA). Design Longitudinal prospective study of 21 subjects undergoing treatment for uveal melanoma with I-125 plaque brachytherapy. Eyes with melanoma were imaged with OCTA prior to treatment and at 12 month intervals until 2 years post-brachytherapy. Participants After IRB-approval, participants were enrolled prospectively from ...
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    3. Automated quantification of nonperfusion in the retina using optical coherence tomography angiography

      Automated quantification of nonperfusion in the retina using optical coherence tomography angiography
      Disclosed are methods and systems for measuring areas of nonperfusion in the retina using OCT imaging. The disclosed methods and systems allow for the automated segmentation and quantification of avascular areas of the retina utilizing information obtained from both structural OCT and OCT angiography (OCTA) data. The disclosed methods include filtering approaches which enhance vessel structure while suppressing noise, dynamic thresholding approaches to mitigate the detrimental effects of within-scan variability ...
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    4. Detecting and measuring areas of choriocapillaris low perfusion in intermediate, non-neovascular age-related macular degeneration

      Detecting and measuring areas of choriocapillaris low perfusion in intermediate, non-neovascular age-related macular degeneration
      Age-related macular degeneration (AMD) is a vision-threatening disease that affects the outer retina and choroid of elderly adults. Because photoreceptors are found in the outer retina and rely primarily on the trophic support of the underlying choriocapillaris, imaging of flow or lack thereof in choriocapillaris by optical coherence tomography angiography (OCTA) has great clinical potential in AMD assessment. We introduce a metric using OCTA, named focal perfusion loss (FPL) to ...
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    5. Detection of reduced retinal vessel density in eyes with geographic atrophy secondary to age-related macular degeneration using projection-resolved optical coherence tomography angiography

      Detection of reduced retinal vessel density in eyes with geographic atrophy secondary to age-related macular degeneration using projection-resolved optical coherence tomography angiography
      Purpose To compare retinal vessel density in eyes with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) to age-matched healthy eyes using projection-resolved optical coherence tomography angiography (PR-OCTA). Design Prospective cross-sectional study. Methods Study participants underwent macular 33-mm OCTA scans with spectral domain OCTA. Reflectance-compensated retinal vessel densities were calculated on projection-resolved superficial vascular complex (SVC), intermediate capillary plexus (ICP), and deep capillary plexus (DCP). Quantitative analysis using normalized ...
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    6. Automated segmentation of peripapillary retinal boundaries in OCT combining a convolutional neural network and a multi-weights graph search

      Automated segmentation of peripapillary retinal boundaries in OCT combining a convolutional neural network and a multi-weights graph search
      Quantitative analysis of the peripapillary retinal layers and capillary plexuses from optical coherence tomography (OCT) and OCT angiography images depend on two segmentation tasks delineating the boundary of the optic disc and delineating the boundaries between retinal layers. Here, we present a method combining a neural network and graph search to perform these two tasks. A comparison of this novel methods segmentation of the disc boundary showed good agreement with ...
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    7. Monitoring retinal responses to acute intraocular pressure elevation in rats with visible light optical coherence tomography

      Monitoring retinal responses to acute intraocular pressure elevation in rats with visible light optical coherence tomography
      Elevated intraocular pressure (IOP) is an important risk factor for glaucoma. However, the role of IOP in glaucoma progression, as well as retinal physiology in general, remains incompletely understood. We demonstrate the use of visible light optical coherence tomography to measure retinal responses to acute IOP elevation in Brown Norway rats. We monitored retinal responses in reflectivity, angiography, blood flow, oxygen saturation (sO2 ), and oxygen metabolism over a range of ...
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    8. High dynamic range optical coherence tomography angiography (HDR-OCTA)

      High dynamic range optical coherence tomography angiography (HDR-OCTA)
      The dynamic range of current optical coherence tomography (OCT) angiography (OCTA) images is limited by the fixed scanning intervals. High speed OCT devices introduce the possibility of extending the flow signal dynamic range. In this study, we created a novel scanning pattern for achieving high dynamic range (HDR)-OCTA with a superior scanning efficiency. We implemented a bidirectional, interleaved scanning pattern that is sensitive to different flow speeds by adjustable ...
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    9. Systems and methods to compensate for reflectance variation in OCT angiography

      Systems and methods to compensate for reflectance variation in OCT angiography
      Methods and systems for improving quantification of OCT angiography data are disclosed. The disclosure specifically relates to methods for compensating for the effect of tissue reflectance to improve the accuracy and repeatability of OCT angiography measurements. These improvements are effected by deriving and then utilizing a dynamic thresholding approach to process decorrelation data to properly classify flow versus non-flow data in OCT angiograms. The disclosed methods overcome quantification errors associated ...
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    10. Correlation of Outer Retinal Degeneration and Choriocapillaris Loss in Stargardt Disease Using En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography

      Correlation of Outer Retinal Degeneration and Choriocapillaris Loss in Stargardt Disease Using En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography
      Purpose This study measured and correlated degeneration of the junction between the inner and outer segments (IS/OS), the retinal pigment epithelium (RPE), and the choriocapillaris (CC) in Stargardt disease (STGD). Design Prospective cross-sectional study. Methods This study was conducted at the Casey Eye Institute. A total of 23 patients with STGD were enrolled and underwent optical coherence tomography angiography (OCTA). Scans were centered on the fovea. OCT slab projections ...
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    11. Signal strength reduction effects in optical coherence tomographic angiography

      Signal strength reduction effects in optical coherence tomographic angiography
      Objective To elucidate the relationship between vessel density (VD) measurements and signal strength in optical coherence tomography angiography (OCTA). Design Cross-sectional study. Subjects: Healthy volunteers. Methods OCTA images obtained from healthy volunteers were analyzed to demonstrate the relationship between signal strength index (SSI) and VD. Experiments were performed to determine the effects of signal strength reduction on VD measurements on the Optovue/AngioVue and Cirrus/AngioPlex OCTA systems. Signal strength ...
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    12. Maximum value projection produces better en face OCT angiograms than mean value projection

      Maximum value projection produces better en face OCT angiograms than mean value projection
      Optical coherence tomography angiography (OCTA) images rely on en face data projections for both qualitative and quantitative interpretation. Both maximum value and mean value projections are commonly used, and many researchers consider them essentially interchangeable approaches. On the contrary, we find that maximum value projection achieves a consistently higher signal-to-noise ratio and higher image contrast across multiple vascular layers, in both healthy eyes and for each disease examined.
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    13. OHSU Receives NIH Grant for Wide-Field and Projection-Resolved Optical Coherence Angiography in Diabetic Retinopathy

      OHSU Receives NIH Grant for Wide-Field and Projection-Resolved Optical Coherence Angiography in Diabetic Retinopathy
      ... and Projection-Resolved Optical Coherence Angiography in Diabetic Retinopathy. The principal investigator is Yali Jia. The program began in 2019 and ends in 2021. Below is a summary of the proposed work. Our group has ...
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    14. Systems and methods for automated segmentation of retinal fluid in optical coherence tomography

      Systems and methods for automated segmentation of retinal fluid in optical coherence tomography
      Disclosed herein are methods and systems for the identification and characterization of fluid accumulation in the retina using OCT imaging. The disclosed methods and systems are directed to the automated segmentation of retinal fluid using 2D or 3D structural OCT scan images. Approaches for visualization and quantification of both intraretinal and subretinal fluid are presented. Methods are also disclosed for using OCT angiography data to improve the quality of retinal ...
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    15. Detection of Non-exudative Choroidal Neovascularization and Progression to Exudative Choroidal Neovascularization Using Optical Coherence Tomography Angiography

      Detection of Non-exudative Choroidal Neovascularization and Progression to Exudative Choroidal Neovascularization Using Optical Coherence Tomography Angiography
      Objective To detect non-exudative choroidal neovascularization (CNV) in age-related macular degeneration with optical coherence tomography angiography (OCTA) and determine risk of developing exudative CNV compared to eyes without non-exudative CNV. Design Prospective longitudinal observational study Participants Consecutive patients with drusen and pigmentary changes in the study eye and exudative neovascular AMD in the fellow eye. Methods Study participants underwent spectral domain OCTA (AngioVue, Optovue, Inc), clinical exam, and structural OCT ...
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