1. Yali Jia

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    1. Mentioned In 88 Articles

    2. Automated spectroscopic retinal oximetry with visible-light optical coherence tomography

      Automated spectroscopic retinal oximetry with visible-light optical coherence tomography
      Accurate, quantitative assessment of retinal blood oxygen saturation ( sO 2 ) may provide a useful early indicator of pathophysiology in several ocular diseases. Here, with visible-light optical coherence tomography (OCT), we demonstrate an automated spectroscopic retinal oximetry algorithm to measure the sO 2 within the retinal arteries (A- sO 2 ) and veins (V- sO 2 ) in rats by automatically detecting the vascular posterior boundary on cross-sectional structural OCT. The algorithm was ...
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    3. Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence Tomography Angiography

      Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence Tomography Angiography
      Purpose: To investigate the changes in the retinal vasculature in different parts of the fundus in eyes with primary angle closure glaucoma (PACG). Methods: Healthy subjects and those with PACG were enrolled. Optical coherence tomography and a split-spectrum amplitude decorrelation angiography algorithm were used to quantify the retinal vessel densities in the parafoveal and peripapillary areas. Results: Thirty-nine eyes from 24 PACG patients and 39 eyes from 20 age- and ...
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    4. Automated detection of preserved photoreceptor on optical coherence tomography in choroideremia based on machine learning

      Automated detection of preserved photoreceptor on optical coherence tomography in choroideremia based on machine learning
      Optical coherence tomography (OCT) can demonstrate early deterioration of the photoreceptor integrity caused by inherited retinal degeneration diseases (IRD). A machine learning method based on random forests was developed to automatically detect continuous areas of preserved ellipsoid zone structure (an easily recognizable part of the photoreceptors on OCT) in sixteen eyes of patients with choroideremia (a type of IRD). Pseudopodial extensions protruding from the preserved ellipsoid zone areas are detected ...
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    5. Polarization-multiplexed, dual-beam swept source optical coherence tomography angiography

      Polarization-multiplexed, dual-beam swept source optical coherence tomography angiography
      A polarization-multiplexed, dual-beam setup is proposed to expand the field of view for a swept source optical coherence tomography angiography (OCTA) system. This method used a Wollaston prism to split sample path light into two orthogonal-polarized beams. This allowed two beams to shine on the cornea at an angle separation of ~ 14 degrees, which led to a separation of ~ 4.2 mm on the retina. A 3-mm glass plate was ...
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    6. Automated detection of photoreceptor disruption in mild diabetic retinopathy on volumetric optical coherence tomography

      Automated detection of photoreceptor disruption in mild diabetic retinopathy on volumetric optical coherence tomography
      Diabetic retinopathy is a pathology where microvascular circulation abnormalities ultimately result in photoreceptor disruption and, consequently, permanent loss of vision. Here, we developed a method that automatically detects photoreceptor disruption in mild diabetic retinopathy by mapping ellipsoid zone reflectance abnormalities from en face optical coherence tomography images. The algorithm uses a fuzzy c-means scheme with a redefined membership function to assign a defect severity level on each pixel and generate ...
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    7. OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia

      OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia
      Purpose Use projection-resolved OCT angiography to investigate the autoregulatory response in the 3 parafoveal retinal plexuses under hyperoxia. Design Prospective cohort study. Participants Nine eyes from 9 healthy participants. Methods One eye from each participant was scanned using a commercial spectral-domain OCT system. Two repeated macular scans (3 3 mm 2 ) were acquired at baseline and during oxygen breathing. The split-spectrum amplitude-decorrelation algorithm was used to detect blood flow. The ...
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    8. Automated drusen detection in dry age-related macular degeneration by multiple-depth, en face optical coherence tomography

      Automated drusen detection in dry age-related macular degeneration by multiple-depth, en face optical coherence tomography
      We introduce a method to automatically detect drusen in dry age-related macular degeneration (AMD) from optical coherence tomography with minimum need for layer segmentation. The method is based on the en face detection of drusen areas in C-scans at certain distances above the Bruchs membrane, circumventing the difficult task of pathologic retinal pigment epithelium segmentation. All types of drusen can be detected, including the challenging subretinal drusenoid deposits (pseudodrusen). The ...
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    9. Projection-resolved optical coherence tomography angiography exhibiting early flow prior to clinically observed retinal angiomatous proliferation

      Projection-resolved optical coherence tomography angiography exhibiting early flow prior to clinically observed retinal angiomatous proliferation
      Purpose The purpose of this study is to analyze early retinal angiomatous proliferation (RAP) utilizing a novel imaging modality, Projection-Resolved Optical Coherence Tomography Angiography (PR-OCTA). Observations Five months prior to the diagnosis of a RAP lesion, cross-sectional PR-OCTA demonstrated flow in the outer retina contiguous with the deep retinal capillary plexus (DCP) and adjacent to a small pigment epithelial detachment. After development of a clinically visible RAP lesion, cross-sectional PR-OCTA ...
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    10. Register Now for the International Congress on OCT Angiography, "en face" OCT, and Advances in OCT on December 15th in Rome Italy which Already has over 1,000 Attendees.

      Register Now for the International Congress on OCT Angiography, "en face" OCT, and Advances in OCT  on December 15th in Rome Italy which Already has over 1,000 Attendees.
      ...sweet weather and Rome beauty. The conference organizers include Bruno Lumbroso, David Huang, Gabriel Coscas, Yali Jia, K. Bailey Freund, Richard Rosen, Philip Rosenfeld, David Sarraf, Eric Souied, Richard Spaide, Giovan...
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    11. Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis

      Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis
      Background Quantitative assessment of optic nerve damage is important in the evaluation of optic neuritis (ON) and multiple sclerosis (MS). Objective To detect optic nerve damage using optical coherence tomography (OCT) and OCT angiography in MS. Methods Peripapillary retinal nerve fibre layer (NFL) thickness, macular ganglion cell complex (GCC) thickness and Optic Nerve Head Flow Index (ONH-FI) were measured. The ONH-FI was defined as flow signal averaged over the optic ...
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    12. Optical Coherence Tomography Angiography of the Peripapillary Retina in Primary Angle-Closure Glaucoma

      Optical Coherence Tomography Angiography of the Peripapillary Retina in Primary Angle-Closure Glaucoma
      Purpose To measure the change of peripapillary retinal vessel density (VD) in eyes with a history of acute primary angle closure glaucoma (PACG). Design Case-control study. Methods Twenty-one consecutive Chinese patients with history of unilateral acute PACG were enrolled. Eyes with acute PACG constituted the case group, while the contralateral eyes without attack constituted the control. All patients underwent ophthalmic examinations including best-corrected visual acuity, intraocular pressure, and visual field ...
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    13. Projection-Resolved Optical Coherence Tomography Angiography of Macular Retinal Circulation in Glaucoma

      Projection-Resolved Optical Coherence Tomography Angiography of Macular Retinal Circulation in Glaucoma
      Purpose To detect macular perfusion defects in glaucoma using projection-resolved optical coherence tomography (OCT) angiography. Design Prospective observation study. Participants A total of 30 perimetric glaucoma and 30 age-matched normal participants were included. Methods One eye of each participant was imaged using 6 6mm macular OCT angiography (OCTA) scan pattern by 70-kHz 840-nm spectral-domain OCT. Flow signal was calculated by the split-spectrum amplitude-decorrelation angiography algorithm. A projection-resolved OCTA (PR-OCTA) algorithm ...
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    14. Regression-based algorithm for bulk motion subtraction in optical coherence tomography angiography

      Regression-based algorithm for bulk motion subtraction in optical coherence tomography angiography
      We developed an algorithm to remove decorrelation noise due to bulk motion in optical coherence tomography angiography (OCTA) of the posterior eye. In this algorithm, OCTA B-frames were divided into segments within which the bulk motion velocity could be assumed to be constant. This velocity was recovered using linear regression of decorrelation versus the logarithm of reflectance in axial lines (A-lines) identified as bulk tissue by percentile analysis. The fitting ...
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