1. Yali Jia

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    1. Mentioned In 99 Articles

    2. Systems and methods for retinal layer segmentation in OCT imaging and OCT angiography

      Systems and methods for retinal layer segmentation in OCT imaging and OCT angiography
      Disclosed herein are methods and systems for segmenting, visualizing, and quantifying the layered structure of retina in optical coherence tomography datasets. The disclosed methods have particular application to OCT angiography data, where specific retina layers have distinct vascular structures and characteristics that can be altered in various pathological conditions of the eye.
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    3. Rodent retinal circulation organization and oxygen metabolism revealed by visible-light optical coherence tomography

      Rodent retinal circulation organization and oxygen metabolism revealed by visible-light optical coherence tomography
      Visible light optical coherence tomography (vis-OCT) is an emerging label-free and high-resolution 3-dimensional imaging technique that can provide retinal oximetry, angiography, and flowmetry in one modality. In this paper, we studied the organization of the arterial and venous retinal circulation in rats using vis-OCT. Arterioles were found predominantly in the superficial vascular plexus whereas veins tended to drain capillaries from the deep capillary plexus. After that, we determined the oxygen ...
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    4. Quantitative evaluation of retinal artery occlusion using optical coherence tomography angiography: A case report

      Quantitative evaluation of retinal artery occlusion using optical coherence tomography angiography: A case report
      Rationale: Retinal artery occlusion (RAO) results in painless, catastrophic vision loss in a period of seconds. Optical coherence tomography angiography (OCTA) can image retinal microcirculation, which is helpful to evaluate treatment response during the follow-up period. Using a single case with central RAO, we report its retinal perfusion changes before and after treatment using OCTA. Patient concerns: A 36-year-old Chinese man came to our clinic with a sudden, painless loss ...
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    5. Automated segmentation of retinal layer boundaries and capillary plexuses in wide-field optical coherence tomographic angiography

      Automated segmentation of retinal layer boundaries and capillary plexuses in wide-field optical coherence tomographic angiography
      Advances in the retinal layer segmentation of structural optical coherence tomography (OCT) images have allowed the separation of capillary plexuses in OCT angiography (OCTA). With the increased scanning speeds of OCT devices and wider field images (10 mm on fast-axis), greater retinal curvature and anatomic variations have introduced new challenges. In this study, we developed a novel automated method to segment seven retinal layer boundaries and two retinal plexuses in ...
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    6. Classification of Choroidal Neovascularization Using Projection-Resolved Optical Coherence Tomographic Angiography

      Classification of Choroidal Neovascularization Using Projection-Resolved Optical Coherence Tomographic Angiography
      Purpose : To evaluate if projection-resolved optical coherence tomographic angiography (PR-OCTA) reduces projection artifact with less attenuation of choroidal neovascularization (CNV) flow signal compared to conventional OCTA with slab subtraction. Methods : In this retrospective cross-sectional study, participants with subfoveal treatment-nave CNV secondary to age-related macular degeneration underwent OCTA. Scans were exported for custom processing including manual segmentation as necessary, application of slab subtraction and PR-OCTA algorithm, and calculation of CNV vascular ...
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    7. Systems And Methods For REFLECTANCE-BASED PROJECTION-RESOLVED Optical Coherence Tomography Angiography

      Systems And Methods For REFLECTANCE-BASED PROJECTION-RESOLVED Optical Coherence Tomography Angiography
      Embodiments provide systems and methods associated with a reflectance-based projection-resolved (rbPR) optical coherence tomography angiography (OCTA) algorithm which uses optical coherence tomography (OCT) reflectance to enhance the flow signal and suppress the projection artifacts in 3-dimensional OCTA. rbPR improves the vascular connectivity and improved the discrimination of the deeper plexus angiograms in healthy eyes, compared to prior PR-OCTA method. Additionally, rbPR removes flow projection artifacts more completely from the outer ...
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    8. Deep learning for the segmentation of preserved photoreceptors on en face optical coherence tomography in two inherited retinal diseases

      Deep learning for the segmentation of preserved photoreceptors on en face optical coherence tomography in two inherited retinal diseases
      The objective quantification of photoreceptor loss in inherited retinal degenerations (IRD) is essential for measuring disease progression, and is now especially important with the growing number of clinical trials. Optical coherence tomography (OCT) is a non-invasive imaging technology widely used to recognize and quantify such anomalies. Here, we implement a versatile method based on a convolutional neural network to segment the regions of preserved photoreceptors in two different IRDs (choroideremia ...
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    9. Automated Quantification of Nonperfusion Areas in 3 Vascular Plexuses With Optical Coherence Tomography Angiography in Eyes of Patients With Diabetes

      Automated Quantification of Nonperfusion Areas in 3 Vascular Plexuses With Optical Coherence Tomography Angiography in Eyes of Patients With Diabetes
      Importance Diabetic retinopathy (DR) is a leading cause of vision loss that is managed primarily through qualitative clinical examination of the retina. Optical coherence tomography angiography (OCTA) may offer an objective and quantitative method of evaluating DR. Objective To quantify capillary nonperfusion in 3 vascular plexuses in the macula of eyes patients with diabetes of various retinopathy severity using projection-resolved OCTA (PR-OCTA). Design, Setting, and Participants Cross-sectional study at a ...
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    10. Systems and methods of choroidal neovascularization detection using optical coherence tomography angiography

      Systems and methods of choroidal neovascularization detection using optical coherence tomography angiography
      Disclosed are systems and methods to automatically detect choroidal neovascularization (CNV) in the outer retina using OCT angiography. Further disclosed are methods of removing projection artifacts from the outer retina and for combining brightness, orientation, and position information in a context-aware saliency model to quantify CNV area in OCT angiograms.
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    11. Evaluation of Automatically Quantified Foveal Avascular Zone Metrics for Diagnosis of Diabetic Retinopathy Using Optical Coherence Tomography Angiography

      Evaluation of Automatically Quantified Foveal Avascular Zone Metrics for Diagnosis of Diabetic Retinopathy Using Optical Coherence Tomography Angiography
      Purpose : To describe an automated algorithm to quantify the foveal avascular zone (FAZ), using optical coherence tomography angiography (OCTA), and to compare its performance for diagnosis of diabetic retinopathy (DR) and association with best-corrected visual acuity (BCVA) to that of extrafoveal avascular area (EAA). Methods : We obtained 3 3-mm macular OCTA scans in diabetic patients with various levels of DR and healthy controls. An algorithm based on a generalized gradient ...
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    12. Fast and robust standard-deviation-based method for bulk motion compensation in phase-based functional OCT

      Fast and robust standard-deviation-based method for bulk motion compensation in phase-based functional OCT
      Phase-based optical coherence tomography (OCT), such as OCT angiography (OCTA) and Doppler OCT, is sensitive to the confounding phase shift introduced by subject bulk motion. Traditional bulk motion compensation methods are limited by their accuracy and computing cost-effectiveness. In this Letter, to the best of our knowledge, we present a novel bulk motion compensation method for phase-based functional OCT. Bulk motion associated phase shift can be directly derived by solving ...
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    13. Automated spectroscopic retinal oximetry with visible-light optical coherence tomography

      Automated spectroscopic retinal oximetry with visible-light optical coherence tomography
      Accurate, quantitative assessment of retinal blood oxygen saturation ( sO 2 ) may provide a useful early indicator of pathophysiology in several ocular diseases. Here, with visible-light optical coherence tomography (OCT), we demonstrate an automated spectroscopic retinal oximetry algorithm to measure the sO 2 within the retinal arteries (A- sO 2 ) and veins (V- sO 2 ) in rats by automatically detecting the vascular posterior boundary on cross-sectional structural OCT. The algorithm was ...
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    14. Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence Tomography Angiography

      Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence Tomography Angiography
      Purpose: To investigate the changes in the retinal vasculature in different parts of the fundus in eyes with primary angle closure glaucoma (PACG). Methods: Healthy subjects and those with PACG were enrolled. Optical coherence tomography and a split-spectrum amplitude decorrelation angiography algorithm were used to quantify the retinal vessel densities in the parafoveal and peripapillary areas. Results: Thirty-nine eyes from 24 PACG patients and 39 eyes from 20 age- and ...
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    15. Automated detection of preserved photoreceptor on optical coherence tomography in choroideremia based on machine learning

      Automated detection of preserved photoreceptor on optical coherence tomography in choroideremia based on machine learning
      Optical coherence tomography (OCT) can demonstrate early deterioration of the photoreceptor integrity caused by inherited retinal degeneration diseases (IRD). A machine learning method based on random forests was developed to automatically detect continuous areas of preserved ellipsoid zone structure (an easily recognizable part of the photoreceptors on OCT) in sixteen eyes of patients with choroideremia (a type of IRD). Pseudopodial extensions protruding from the preserved ellipsoid zone areas are detected ...
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