1. Yale University

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    1. Mentioned In 54 Articles

    2. Redox imaging and optical coherence tomography of the respiratory ciliated epithelium

      Explore SPIE Digital Library Pulmonology
      Redox imaging and optical coherence tomography of the respiratory ciliated epithelium
      Optical coherence tomography (OCT) is an emerging technology for in vivo airway and lung imaging. However, OCT lacks sensitivity to the metabolic changes caused by inflammation, which drives chronic respiratory diseases such as asthma and chronic obstructive pulmonary disorder. Redox imaging (RI) is a label-free technique that uses the autofluorescence of the metabolic coenzymes NAD(P)H and flavin adenine dinucleotide (FAD) to probe cellular metabolism and could provide complimentary ...
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      Mentions: University of Wisconsin Thorlabs Yale University

    3. Gray Optic Disc Crescent: Evaluation of Anatomical Correlate by Spectral Domain Optical Coherence Tomography

      Explore ophthalmologyglaucoma.org Ophthalmology
      Gray Optic Disc Crescent: Evaluation of Anatomical Correlate by Spectral Domain Optical Coherence Tomography
      Purpose To test the hypothesis that the anatomical correlate of the gray optic disc crescent is pigmentation of externally oblique border tissue of Elschnig. Design Observational cross-sectional study. Participants African American adult males with or without clinically apparent gray optic disc crescents. Methods McNemars test for paired data and kappa statistic with 95% confidence intervals were used to examine the relationships between eyes with or without gray optic disc crescents ...
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      Mentions: Duke University Yale University

    4. Optical coherence tomography substudy of a prospective multicentre randomised post-market trial to assess the safety and effectiveness of the Firehawk cobalt-chromium coronary stent (rapamycin target-eluting) system for the treatment of atherosclerotic le

      Explore eurointervention.org Cardiology
      Optical coherence tomography substudy of a prospective multicentre randomised post-market trial to assess the safety and effectiveness of the Firehawk cobalt-chromium coronary stent (rapamycin target-eluting) system for the treatment of atherosclerotic le
      Aims: Durable polymer drug-eluting stents (DP-DES) may contribute to persistent inflammation, delayed endothelial healing and subsequent late DES thrombosis. The aim of this optical coherence tomography (OCT) substudy was to compare healing and neointimal coverage of a novel bioabsorbable polymer sirolimus-eluting stent (Firehawk ) (BP-DES) versus the DP-DES (XIENCE) at 90 days in an all-comers patient population. Methods and results: The TARGET All Comers study is a prospective multicentre randomised post-market ...
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      Mentions: Yale University University College London Patrick W. Serruys

    6. Optical coherence tomography and autofluorescence microscopy of respiratory ciliated epithelia

      Explore SPIE Digital Library Pulmonology
      Optical coherence tomography and autofluorescence microscopy of respiratory ciliated epithelia
      Efficient mucociliary clearance is necessary to protect the respiratory tract from infection. Mucociliary dysfunction is common in respiratory diseases including asthma, chronic obstructive pulmonary disease, and cystic fibrosis. Rescuing mucociliary clearance by stimulating the metabolism of respiratory ciliated epithelia could offer new treatments for respiratory diseases. However, the coupling between cellular metabolism and mechanical output in respiratory ciliated epithelia is poorly understood. We propose to study this coupling with autofluorescence ...
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      Mentions: Yale University Vanderbilt University Michael A. Choma

    7. Visualization and quantification of injury to the ciliated epithelium using quantitative flow imaging and speckle variance optical coherence tomography

      Explore Nature Publishing Group
      Visualization and quantification of injury to the ciliated epithelium using quantitative flow imaging and speckle variance optical coherence tomography
      Mucociliary flow is an important defense mechanism in the lung to remove inhaled pathogens and pollutants. Disruption of ciliary flow can lead to respiratory infections. Multiple factors, from drugs to disease can cause an alteration in ciliary flow. However, less attention has been given to injury of the ciliated epithelium. In this study, we show how optical coherence tomography (OCT) can be used to investigate injury to the ciliated epithelium ...
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      Mentions: Yale University Michael A. Choma

    10. Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography

      Explore Wiley Online Library
      Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography
      Background and Objective Cilia-driven mucociliary clearance is an important self-defense mechanism of great clinical importance in pulmonary research. Conventional light microscopy possesses the capability to visualize individual cilia and its beating pattern but lacks the throughput to assess the global ciliary activities and flow dynamics. Optical coherence tomography (OCT), which provides depth-resolved cross-sectional images, was recently introduced to this area. Materials and Methods Fourteen de-identified human tracheobronchial tissues are directly ...
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      Mentions: Columbia University Yale University Michael A. Choma

    11. Analysis of Craniocardiac Malformations in Xenopus using Optical Coherence Tomography : Scientific Reports

      Explore Nature Publishing Group Cardiology , Developmental Biology
      Analysis of Craniocardiac Malformations in Xenopus using Optical Coherence Tomography : Scientific Reports
      Birth defects affect 3% of children in the United States. Among the birth defects, congenital heart disease and craniofacial malformations are major causes of mortality and morbidity. Unfortunately, the genetic mechanisms underlying craniocardiac malformations remain largely uncharacterized. To address this, human genomic studies are identifying sequence variations in patients, resulting in numerous candidate genes. However, the molecular mechanisms of pathogenesis for most candidate genes are unknown. Therefore, there is a ...
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      Mentions: Yale University Michael A. Choma

    15. Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows

      Explore OSA | OSA Publishing Developmental Biology
      Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows
      We present a new OCT method for flow speed quantification and directional velocimetry: particle streak velocimetry-OCT (PSV-OCT). PSV-OCT generates two-dimensional, 2.5-vector component ( v x ,| v y |, v z ) maps of microscale flow velocity fields. Knowledge of 2.5-vector components also enables the estimation of total flow speed. The enabling insight behind PSV-OCT is that tracer particles in sparsely-seeded fluid flow trace out streaks in ( x,z,t )-space. The ...
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      Mentions: Yale University Michael A. Choma

    16. Micell Technologies Completes Enrollment in OCT Study Designed to Evaluate Superior Performance of MiStent SES Compared to Xience

      Explore Yahoo! Finance Cardiology , Clinical Trials
      Micell Technologies Completes Enrollment in OCT Study Designed to Evaluate Superior Performance of MiStent SES Compared to Xience
      ...apeutics (TCT) Conference by Alexandra Lansky, M.D., Director, Yale Cardiovascular Clinical Research Program, Yale School of Medicine, New Haven, Conn. Highlights of the data include no target lesion events in the DESSOL...
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      Mentions: Yale University Patrick W. Serruys Erasmus University
    17. 1-15 of 54 1 2 3 4 »
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  4. About Yale University

    Yale University

    Yale University comprises three major academic components: Yale College (the undergraduate program), the Graduate School of Arts and Sciences, and the professional schools. In addition, Yale encompasses a wide array of centers and programs, libraries, museums, and administrative support offices. Approximately 11,250 students attend Yale.  Also see Yale School of Medicine.

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