Vibrational Optical Coherence Tomography Detects Unique Skin Fibrotic States: Preliminary Results of Animal and Human Studies
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Yale University
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Yale University
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Mentioned In 65 Articles
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The long-term effects of anti-vascular endothelial growth factor therapy on the optical coherence tomography angiographic appearance of neovascularization in age-related macular degeneration
Background The short-term effects of anti-vascular endothelial growth factor (anti-VEGF) treatment on macular neovascularization (MNV) morphology is well described, but long-term studies on morphologic changes and correlation of such changes to the type of MNV have not been conducted. This study aims to determine if different types of MNVs in neovascular AMD (nAMD) behave differently with anti-VEGF treatment as visualized on optical coherence tomography angiography (OCTA). Methods Treatment-nave nAMD patients ...Read Full Article -
Management of Stromal Herpes Simplex Virus Keratitis With Epithelial Ulceration Using Optical Coherence Tomography–Generated Corneal Thickness Maps
Purpose: To report 2 cases of herpes simplex virus (HSV) stromal keratitis with epithelial ulceration that were managed using optical coherence tomographygenerated pachymetric and corneal epithelial thickness maps. Methods: Two patients with a history of HSV keratitis with nonhealing epithelial defects were referred to the Athens Vision Eye Institute. Anterior segment optical coherence tomographygenerated pachymetric and corneal epithelial thickness maps showed subclinical stromal edema and irregular epithelium, thus indicating diagnoses ...Read Full ArticleMentions: Yale University -
Multimodality Imaging-Based Characterization of Regional Material Properties in a Murine Model of Aortic Dissection
hronic infusion of angiotensin-II in atheroprone ( ApoE / ) mice provides a reproducible model of dissection in the suprarenal abdominal aorta, often with a false lumen and intramural thrombus that thickens the wall. Such lesions exhibit complex morphologies, with different regions characterized by localized changes in wall composition, microstructure, and properties. We sought to quantify the multiaxial mechanical properties of murine dissecting aneurysm samples by combining in vitro extension-distension data with full-field ...Read Full Article -
Morphological changes in intraretinal microvascular abnormalities after anti-VEGF therapy visualized on optical coherence tomography angiography
Background To examine the baseline morphological characteristics and alterations in intraretinal microvascular abnormalities (IRMAs) in response to anti-vascular endothelial growth factor (anti-VEGF) treatment, documented by optical coherence tomography angiography (OCTA) in diabetic eyes. Methods In this retrospective study, IRMAs were evaluated with multimodal imaging (fundus photography, fluorescein angiography, OCTA) in treatment-nave diabetic eyes before and after anti-VEGF treatment for diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR) and ...Read Full Article -
Overhead Mounted Optical Coherence Tomography in Childhood Glaucoma Evaluation
Prcis: Overhead mounted spectral-domain optical coherence tomography enables high quality imaging of the optic nerve and macula in childhood glaucoma and is particularly useful when standard tabletop optical coherence tomography has failed or is not possible. Purpose: Tabletop optical coherence tomography, integral to adult glaucoma management, can be limited in childhood glaucoma patients due to young age, poor cooperation, and/or technical challenges. To address these imaging difficulties, we determined ...Read Full Article -
Intravascular Imaging for Venous Interventions
Purpose of Review This review surveys the clinical landscape of intravascular imaging for endovenous interventions. Recent Findings Endovascular imaging has become increasingly important for diagnosing venous pathology and guiding venous interventions. In particular, intravascular ultrasound (IVUS) provides 3D high-resolution cross-sectional imaging of vessel and surrounding tissues, often in anatomic locations inaccessible to surface ultrasound, namely the superior vena cava, inferior vena cava, and caval-iliac veins. Summary Current well-established indications for ...Read Full Article -
Yale University Receives a NIH Grant for Xenopus As A Model System for Hydrocephaly and Ependymal Ciliogenesis
...genitor cell fate, which can have important implications for treatment.Read Full ArticleYale University Receives a 2020 NIH Grant for $236,175 for Xenopus As A Model System for Hydrocephaly and Epen...
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Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography
Background The purpose of this study was to investigate the association between diabetic retinopathy (DR) severity and macular choriocapillaris (CC) flow deficit percentage (FD %) in different macular regions using swept-source optical coherence tomography angiography (SS-OCTA). Methods Diabetic patients with SS-OCTA images were graded by severity and retrospectively assessed. CC FD % was calculated in four different regions of the OCTA image: inner, middle, outer, and full-field region. The generalized estimating equations ...Read Full Article -
Visualizing flow in an intact CSF network using optical coherence tomography: implications for human congenital hydrocephalus
Cerebrospinal fluid (CSF) flow in the brain ventricles is critical for brain development. Altered CSF flow dynamics have been implicated in congenital hydrocephalus (CH) characterized by the potentially lethal expansion of cerebral ventricles if not treated. CH is the most common neurosurgical indication in children effecting 1 per 1000 infants. Current treatment modalities are limited to antiquated brain surgery techniques, mostly because of our poor understanding of the CH pathophysiology ...Read Full ArticleMentions: Yale University -
Hemoglobin level and macular thinning in sickle cell disease
...icine and Yale School of Public Health, New Haven, CT, USA; 7Department of Pediatric Hematology and Oncology, Yale University School of Medicine, New Haven, CT, USA Purpose: To study the relationship between complete blo...Read Full ArticleMentions: Yale University -
Redox imaging and optical coherence tomography of the respiratory ciliated epithelium
Optical coherence tomography (OCT) is an emerging technology for in vivo airway and lung imaging. However, OCT lacks sensitivity to the metabolic changes caused by inflammation, which drives chronic respiratory diseases such as asthma and chronic obstructive pulmonary disorder. Redox imaging (RI) is a label-free technique that uses the autofluorescence of the metabolic coenzymes NAD(P)H and flavin adenine dinucleotide (FAD) to probe cellular metabolism and could provide complimentary ...Read Full Article -
Gray Optic Disc Crescent: Evaluation of Anatomical Correlate by Spectral Domain Optical Coherence Tomography
Purpose To test the hypothesis that the anatomical correlate of the gray optic disc crescent is pigmentation of externally oblique border tissue of Elschnig. Design Observational cross-sectional study. Participants African American adult males with or without clinically apparent gray optic disc crescents. Methods McNemars test for paired data and kappa statistic with 95% confidence intervals were used to examine the relationships between eyes with or without gray optic disc crescents ...Read Full Article -
Optical coherence tomography substudy of a prospective multicentre randomised post-market trial to assess the safety and effectiveness of the Firehawk cobalt-chromium coronary stent (rapamycin target-eluting) system for the treatment of atherosclerotic le
Aims: Durable polymer drug-eluting stents (DP-DES) may contribute to persistent inflammation, delayed endothelial healing and subsequent late DES thrombosis. The aim of this optical coherence tomography (OCT) substudy was to compare healing and neointimal coverage of a novel bioabsorbable polymer sirolimus-eluting stent (Firehawk ) (BP-DES) versus the DP-DES (XIENCE) at 90 days in an all-comers patient population. Methods and results: The TARGET All Comers study is a prospective multicentre randomised post-market ...Read Full Article -
Perimeter Medical Imaging Inc Appoints Charles S. Carignan, MD as New CEO
...eveloper of the Aegea Vapor System for endometrial ablation.Dr. Carignan earned his undergraduate degree from Yale University, received his M.D. degree from the College of Physicians and Surgeons of Columbia University a...Read Full Article
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About Yale University
Yale University comprises three major academic components: Yale College (the undergraduate program), the Graduate School of Arts and Sciences, and the professional schools. In addition, Yale encompasses a wide array of centers and programs, libraries, museums, and administrative support offices. Approximately 11,250 students attend Yale. Also see Yale School of Medicine.