1. Xingde Li

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    1. Mentioned In 46 Articles

    2. Super-achromatic monolithic microprobe for ultrahigh-resolution endoscopic optical coherence tomography at 800 nm

      Super-achromatic monolithic microprobe for ultrahigh-resolution endoscopic optical coherence tomography at 800 nm
      Endoscopic optical coherence tomography (OCT) has emerged as a valuable tool for advancing our understanding of the histomorphology of various internal luminal organs and studying the pathogenesis of relevant diseases. To date, this technology affords limited resolving power for discerning subtle pathological changes associated with early diseases. In addition, it remains challenging to access small luminal organs or pass through narrow luminal sections without potentially causing trauma to tissue with ...
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    3. Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source

      Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source
      Endoscopic optical coherence tomography (OCT) instruments are mostly side viewing and rely on at least one proximal scan, thus limiting accuracy of volumetric imaging and en face visualization. Previous forward-viewing OCT devices had limited axial scan speeds. We report a forward-viewing fiber scanning 3D-OCT probe with 900 m field of view and 5 m transverse resolution, imaging at 1 MHz axial scan rate in the human gastrointestinal tract. The probe ...
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    4. Introduction to the feature issue on the 25 year anniversary of optical coherence tomography

      Introduction to the feature issue on the 25 year anniversary of optical coherence tomography
      This feature issue commemorates the approximately 25 year history of Optical Coherence Tomography (OCT), one of the most successful biophotonic technologies. While OCT has technological origins traceable to ultrafast laser development and fiber optic system test instrumentation of the 1980s, innovations in low coherence interferometry for optical ranging and imaging for biomedical applications in the U.S., Europe and Japan by the early 1990s led to coinage of the now ...
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    5. Robust and fast characterization of OCT-based optical attenuation using a novel frequency-domain algorithm for brain cancer detection

      Robust and fast characterization of OCT-based optical attenuation using a novel frequency-domain algorithm for brain cancer detection
      Cancer is known to alter the local optical properties of tissues. The detection of OCT-based optical attenuation provides a quantitative method to efficiently differentiate cancer from non-cancer tissues. In particular, the intraoperative use of quantitative OCT is able to provide a direct visual guidance in real time for accurate identification of cancer tissues, especially these without any obvious structural layers, such as brain cancer. However, current methods are suboptimal in ...
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    6. Optical clearing for luminal organ imaging with ultrahigh-resolution optical coherence tomography

      Optical clearing for luminal organ imaging with ultrahigh-resolution optical coherence tomography
      The imaging depth of optical coherence tomography (OCT) in highly scattering biological tissues (such as luminal organs) is limited, particularly for OCT operating at shorter wavelength regions (such as around 800nm). For the first time, the optical clearing effect of the mixture of liquid paraffin and glycerol on luminal organs was explored with ultrahigh-resolution spectral domain OCT at 800nm.Ex vivostudies were performed on pig esophagus and bronchus, and guinea ...
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    7. Optimal operational conditions for supercontinuum-based ultrahigh-resolution endoscopic OCT imaging

      Optimal operational conditions for supercontinuum-based ultrahigh-resolution endoscopic OCT imaging
      We investigated the optimal operational conditions for utilizing a broadband supercontinuum (SC) source in a portable 800 nm spectral-domain (SD) endoscopic OCT system to enable high resolution, high-sensitivity, and high-speed imaging in vivo . A SC source with a 3-dB bandwidth of 246 nm was employed to obtain an axial resolution of 2.7 m (in air) and an optimal detection sensitivity of 107 dB with an imaging speed up to ...
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    8. New Imaging Technique Could Make Brain Tumor Removal Safer, More Effective, Study Suggests

      New Imaging Technique Could Make Brain Tumor Removal Safer, More Effective, Study Suggests
      Brain surgery is famously difficult for good reason: When removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible while keeping crucial brain tissue intact and visually distinguishing the two is often impossible. Now Johns Hopkins researchers report they have developed an imaging technology that could provide surgeons with a color-coded map of a patients brain showing which ...
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    9. Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography

      Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography
      More complete brain cancer resection can prolong survival and delay recurrence. However, it is challenging to distinguish cancer from noncancer tissues intraoperatively, especially at the transitional, infiltrative zones. This is especially critical in eloquent regions (for example, speech and motor areas). This study tested the feasibility of label-free, quantitative optical coherence tomography (OCT) for differentiating cancer from noncancer in human brain tissues. Fresh ex vivo human brain tissues were obtained ...
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  2. About Xingde Li

    Xingde Li

    Xingde Li is an Associate Professor in the Department of Biomedical Engineering and the Electrical and Computer Engineering at Johns Hopkins University.

  3. Quotes

    1. This new system represents a significant advance in real-time, 3-D endoscopic OCT imaging in that it offers the highest volumetric imaging speed in an endoscopic setting, while maintaining a small probe size and a low, safe drive voltage.
      In New High-speed 3-D Imaging System Holds Potential for Improved Cancer Screening