1. Xincheng Yao

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    1. Mentioned In 26 Articles

    2. OCT feature analysis guided artery-vein differentiation in OCTA

      OCT feature analysis guided artery-vein differentiation in OCTA
      Differential artery-vein analysis promises better sensitivity for retinal disease detection and classification. However, clinical optical coherence tomography angiography (OCTA) instruments lack the function of artery-vein differentiation. This study aims to verify the feasibility of using OCT intensity feature analysis to guide artery-vein differentiation in OCTA. Four OCT intensity profile features, including i) ratio of vessel width to central reflex, ii) average of maximum profile brightness, iii) average of median profile ...
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      Mentions: Xincheng Yao
    3. Comparative Optical Coherence Tomography Angiography of Wild-Type and rd10 Mouse Retinas

      Comparative Optical Coherence Tomography Angiography of Wild-Type and rd10 Mouse Retinas
      Purpose : To conduct longitudinal optical coherence tomography angiography (OCTA) to characterize dynamic changes of trilaminar vascular plexuses in wild-type (WT) and retinal degeneration 10 (rd10) mouse retinas. Methods : Longitudinal in vivo OCT/OCTA measurements of WT and rd10 mouse retinas were conducted at postnatal day 14 (P14), P17, P21, P24, and P28. OCT images were used to quantify retinal thickness changes, while OCTA images were used to investigate vascular dynamics ...
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      Mentions: Xincheng Yao
    4. Functional optical coherence tomography of retinal photoreceptors

      Functional optical coherence tomography of retinal photoreceptors
      Age-related macular degeneration (AMD) is the leading cause of severe vision loss and legal blindness. It is known that retinal photoreceptors are the primary target of AMD. Therefore, a reliable method for objective assessment of photoreceptor function is needed for early detection and reliable treatment evaluation of AMD and other eye diseases such as retinitis pigmentosa that are known to cause photoreceptor dysfunctions. Stimulus-evoked intrinsic optical signal (IOS) changes promise ...
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      Mentions: Xincheng Yao
    5. QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES FOR OBJECTIVE CLASSIFICATION AND STAGING OF DIABETIC RETINOPATHY

      QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES FOR OBJECTIVE CLASSIFICATION AND STAGING OF DIABETIC RETINOPATHY
      Purpose: This study aims to characterize quantitative optical coherence tomography angiography (OCTA) features of nonproliferative diabetic retinopathy (NPDR) and to validate them for computer-aided NPDR staging. Methods: One hundred and twenty OCTA images from 60 NPDR (mild, moderate, and severe stages) patients and 40 images from 20 control subjects were used for this study conducted in a tertiary, subspecialty, academic practice. Both eyes were photographed and all the OCTAs were ...
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      Mentions: Xincheng Yao
    6. Color Fundus Image Guided Artery-Vein Differentiation in Optical Coherence Tomography Angiography

      Color Fundus Image Guided Artery-Vein Differentiation in Optical Coherence Tomography Angiography
      Purpose : This study aimed to develop a method for automated artery-vein classification in optical coherence tomography angiography (OCTA), and to verify that differential artery-vein analysis can improve the sensitivity of OCTA detection and staging of diabetic retinopathy (DR). Methods : For each patient, the color fundus image was used to guide the artery-vein differentiation in the OCTA image. Traditional mean blood vessel caliber (m-BVC) and mean blood vessel tortuosity (m-BVT) in ...
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      Mentions: Xincheng Yao
    7. Functional optical coherence tomography of neurovascular coupling interactions in the retina

      Functional optical coherence tomography of neurovascular coupling interactions in the retina
      Quantitative evaluation of retinal neurovascular coupling is essential for a better understanding of visual function and early detection of eye diseases. However, there is no established method to monitor coherent interactions between stimulus‐evoked neural activity and hemodynamic responses at high resolution. Here we report a multi‐modal functional optical coherence tomography (OCT) imaging methodology to enable concurrent intrinsic optical signal (IOS) imaging of stimulus‐evoked neural activity and hemodynamic ...
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      Mentions: Xincheng Yao
    8. Computer-aided classification of sickle cell retinopathy using quantitative features in optical coherence tomography angiography

      Computer-aided classification of sickle cell retinopathy using quantitative features in optical coherence tomography angiography
      As a new optical coherence tomography (OCT) imaging modality, there is no standardized quantitative interpretation of OCT angiography (OCTA) characteristics of sickle cell retinopathy (SCR). This study is to demonstrate computer-aided SCR classification using quantitative OCTA features, i.e., blood vessel tortuosity (BVT), blood vessel diameter (BVD), vessel perimeter index (VPI), foveal avascular zone (FAZ) area, FAZ contour irregularity, parafoveal avascular density (PAD). It was observed that combined features show ...
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    9. University of Illinois at Chicago Receives NIH Grant for Functional Imaging of Retinal Photoreceptors

      University of Illinois at Chicago Receives NIH Grant  for Functional Imaging of Retinal Photoreceptors
      The University of Illinois at Chicago Received at 2017 NIH Grant for $299,044 for Functional Imaging of Retinal Photoreceptoers. The principal investigator is Zincheng Yao. The program began in 2014 and ends in 2019. Below is a summary of the proposed work. Many eye diseases, such as age-related macular degeneration (AMD), diabetic retinopathy (DR) and glaucoma, involve pathological changes in retinal photoreceptors and/or inner retinal neurons. It is ...
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    10. Quantitative characteristics of sickle cell retinopathy in optical coherence tomography angiography

      Quantitative characteristics of sickle cell retinopathy in optical coherence tomography angiography
      Early detection is an essential step for effective intervention of sickle cell retinopathy (SCR). Emerging optical coherence tomography angiography (OCTA) provides excellent three-dimensional (3D) resolution to enable label-free, noninvasive visualization of retinal vascular structures, promising improved sensitivity in detecting SCR. However, quantitative analysis of SCR characteristics in OCTA images is yet to be established. In this study, we conducted comprehensive analysis of six OCTA parameters, including blood vessel tortuosity, vessel ...
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      Mentions: Xincheng Yao
    11. In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

      In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas
      Intrinsic optical signal (IOS) imaging promises a noninvasive method for advanced study and diagnosis of eye diseases. Before pursuing clinical applications, it is essential to understand anatomic and physiological sources of retinal IOSs and to establish the relationship between IOS distortions and eye diseases. The purpose of this study was designed to demonstrate the feasibility of in vivo IOS imaging of mouse models. A high spatiotemporal resolution spectral domain optical ...
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      Mentions: Xincheng Yao
    12. Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers

      Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers
      Blood flow changes are highly related to neural activities in the retina. It has been reported that neural activity increases when flickering light stimulation of the retina is used. It is known that blood flow changes with flickering light stimulation can be altered in patients with vascular disease and that measurement of flicker-induced vasodilatation is an easily applied tool for monitoring functional microvascular alterations. However, details of distortions in retinal ...
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      Mentions: Xincheng Yao
    13. In vivo intrinsic optical signal imaging of mouse retinas

      In vivo intrinsic optical signal imaging of mouse retinas
      Intrinsic optical signal (IOS) imaging is a promising noninvasive method for advanced study and diagnosis of eye diseases. Before pursuing clinical applications, more IOS studies employing animal models are necessary to establish the relationship between IOS distortions and eye diseases. Ample mouse models are available for investigating the relationship between IOS distortions and eye diseases. However, in vivo IOS imaging of mouse retinas is challenging due to the small ocular ...
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      Mentions: Xincheng Yao
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  2. About Xincheng Yao

    Xincheng Yao

    Xincheng Yao is an Assistant Professor in the Department of Biomedical Engineering at the University of Alabama.

  3. Quotes

    1. We can’t use functional OCT/OCTA in the brain to look at neurovascular coupling at the cellular level because the brain is surrounded by the skull, and fine resolution isn’t possible...But we can use functional OCT/OCTA to examine the interactions between individual photoreceptors and their blood vessels in the retina, which is much more accessible in the eye.
      In Detecting eye and brain disease earlier