1. Wolfgang Drexler

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    1. Mentioned In 141 Articles

    2. Method For Image Range Extension In Optical Coherence Tomography (Wo 2010/007025)

      Method For Image Range Extension In Optical Coherence Tomography (Wo 2010/007025)
      A method of generating a tomogram of a sample (18) wherein an analysis beam (Ed) is subject to dispersion distortion, the method comprising: a) detecting the analysis beam (Ed) b) generating a signal (s) representative of the intensity of wavelengths in the analysis beam (Ed); c) generating (46, 48) a first spatial domain signal (S) representative of the signal (s) so generated; d) detecting (50) a desired signal component of ...
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    3. Spectroscopic measurements with dispersion encoded full range frequency domain optical coherence tomography in single- and multilayered weakly scattering phantoms

      Spectroscopic measurements with dispersion encoded full range frequency domain optical coherence tomography in single- and multilayered weakly scattering phantoms
      ...ics : Dispersion ToC Category: Category Pending Citation Boris Hermann, Bernd Hofer, Christoph Meier, and Wolfgang Drexler, "Spectroscopic measurements with dispersion encoded full range frequency domain optical co...
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    4. High-Resolution Ocular Imaging: Combining Advanced Optics and Microtechnology

      Recent developments in imaging technologies offer great potential for the assessment of retinal ganglion cell disorders, with particular relevance to glaucoma. In particular, advances in this field have allowed unprecedented in vivo access to the retinal layers, using many different properties of light to differentiate cellular structures. This article is a summary of currently available and investigational advanced, high-resolution imaging technologies and their potential applications to glaucoma. It represents the ...
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    5. Techniques for extraction of depth-resolved in vivo human retinal intrinsic optical signals with optical coherence tomography

      Purpose To demonstrate acquisition and analysis methods for depth-resolved observation of slow retinal physiology induced changes in infrared backscatter in vivo. Methods A dark-adapted human was briefly subjected to a localized photobleach. For 20 min before and 30 min after the stimulus, volumetric optical coherence tomograms were collected partially overlapping the bleached region. Tomograms were segmented into retinal layers by a newly described algorithm exploiting information in adjacent B-scans. En ...
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    6. Watching Cells Migrate

      Watching Cells Migrate
      Cell motility and chemotaxis play an important role for tissue engineering, repair and replacement of damaged organs. Conventional studies of cell migration have largely relied on the use of 2D monolayer cultures on transparent surfaces; however it is questionable how well these relate to in-vivo processes. Recent developments in the field of tissue engineering have enabled cells to be grown in 3D organotypic cultures, which more closely resemble the complex ...
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    7. Three- and four-dimensional visualization of cell migration using optical coherence tomography

      Conventionally, cell chemotaxis is studied on two-dimensional (2D) transparent surfaces, due to limitations in optical and image data-collection techniques. However, surfaces that more closely mimic the natural environment of cells are often opaque. Optical coherence tomography (OCT) is a noninvasive label-free imaging technique, which offers the potential to visualize moving cells on opaque surfaces and in three dimensions (3D). Here, we demonstrate that OCT is an effective means of time-lapse ...
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    8. Wide field visualization of retinal and choroidal microstructure in vivo using frequency domain OCT at 1060 nm with up to 47000 lines/s

      ...(12) Boris Hermann, M. Esmaeelpour, Boris Povazay, Bernd Hofer, F. Bounaparte, Nick Sheen, Rachel North, and Wolfgang Drexler Cardiff Univ. (United Kingdom) We^ present in vivo frequency domain optical coherence tomogra...
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  2. About Wolfgang Drexler

    Wolfgang Drexler

    Wolfgang Drexler was a Full Professor of Biomedical Imaging at the School of Optometry and Vision Sciences at Cardiff University, Wales, UK from 2006 to 2009. Since October 2009 he is a Full Professor of Medical Physics and the Head of the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna, Austria, Honorary Distinguished Professor at Cardiff University and is also Director of the Christian Doppler Laboratory. He is a member of the Austrian Academy of Science and has published more than 150 publications (including Nature Medicine and PNAS).


    1. State-of-the-art OCT technology has its limitations: it is bulky, the size of a desk top and quite expensive, costing anything in the region of €100, 000 per unit. It can detect abnormalities but at the present moment, compact, cost effective versions that can be used outside of hospitals and in private practice in a hand held mode do not exist...The core component of our OCTChip project targets the size of a 1 cent coin. It will reduce costs and is maintenance free. Hence retinal diseases like Diabetic Retinopathy and Glaucoma as well as other retina diseases that are worldwide leading causes for blindness might be diagnosed via screening with this cost-effective compact point-of-care version of OCT...OCTChip fosters wide spread use to visualise and quantify the retina in more definition, so we can diagnose diseases better, quicker, and cheaper.
      In Coin-Sized Scanner to Target Blindness
    2. Miniaturization of OCT-based imaging technology on integrated photonics enables a novel, unique generation of not only cost-effective, but also compact, robust and nearly maintenance-free handheld OCT systems...The partners of the BiopsyPen Project have exquisite complementary expertise to accomplish a significant step towards this ambitious goal.”
      In MedLumics Announces “BiopsyPen Project” with €3.6M EU in Funding; Initiative Aimed at New Clinical Applications for Optical Coherence Tomography
    3. Swept-source technology from Insight has the potential to revolutionize OCT in the future, especially regarding ease of use, flexibility, and unique OCT performance.
      In Akinetic all-semiconductor swept lasers boost OCT image quality
    4. Lasers and light-­‐based methods have long promised to deliver benefits to clinicians through faster, more accurate, more sensitive, and more cost-­‐effective diagnosis of cancer and other important diseases, but so far most optical diagnostic instruments are expensive, complex and have limited performance. A key reason for this is that the lasers and light sources they use, are adapted from other industrial and scientific applications, and have not been optimized for these new clinical uses. Now in FAMOS, we will develop and demonstrate the next generation of light sources to produce step changes in cost/performance that will trigger development of a whole new world of non-­‐invasive clinical diagnostic tools.
      In European Commission backs biophotonics ‘FAMOS’ consortium with €10.1M for project to develop new lasers for earlier, better diagnosis of major diseases
    5. We've passed acceptance and we're between elation and state of the art...I personally think that OCT will never replace any gold standard like histology or established imaging modalities, but it will be very important at generating information in the future...It provides you with more information for earlier diagnosis.
      In Optical coherence tomography: cellular and functional retinal imaging