1. Wolfgang Drexler

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    1. Mentioned In 136 Articles

    2. In vivo three dimensional dual wavelength photoacoustic tomography imaging of the far red fluorescent protein E2-Crimson expressed in adult zebrafish

      In vivo three dimensional dual wavelength photoacoustic tomography imaging of the far red fluorescent protein E2-Crimson expressed in adult zebrafish
      For the first time the far red fluorescent protein (FP) E2-Crimson genetically expressed in the exocrine pancreas of adult zebrafish has been non-invasively mapped in 3D in vivo using photoacoustic tomography (PAT). The distribution of E2-Crimson in the exocrine pancreas acquired by PAT was confirmed using epifluorescence imaging and histology, with optical coherence tomography (OCT) providing complementary structural information. This work demonstrates the depth advantage of PAT to resolve FP ...
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    3. Measurement of Tear Film Thickness Using Ultrahigh Resolution Optical Coherence Tomography

      Measurement of Tear Film Thickness Using Ultrahigh Resolution Optical Coherence Tomography
      Purpose: To visualize the pre-corneal tear film with high resolution spectral domain optical coherence tomography, enabling quantification of tear film thickness in healthy subjects. Methods: A custom built spectral domain optical coherence tomography system comprising a broad band Ti:Sapphire laser operating at 800 nm and a high speed CCD camera with a read out rate of 47 kHz was used for measurement of pre-corneal tear film thickness. The system ...
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    4. Miniature spectrometer and beam splitter for an optical coherence tomography on a silicon chip

      Miniature spectrometer and beam splitter for an optical coherence tomography on a silicon chip
      Optical coherence tomography (OCT) has enabled clinical applications that revolutionized in vivo medical diagnostics. Nevertheless, its current limitations owing to cost, size, complexity, and the need for accurate alignment must be overcome by radically novel approaches. Exploiting integrated optics, we assemble the central components of a spectral-domain OCT system on a silicon chip. The spectrometer comprises an arrayed-waveguide grating with 136-nm free spectral range and 0.21-nm wavelength resolution. The ...
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    5. OCT Pioneer Professor Wolfgang Drexler to Teach Short Course on OCT at Biophotonics ’13 at Island of Ven, Sweden

      OCT Pioneer Professor Wolfgang Drexler to Teach Short Course on OCT at Biophotonics ’13 at Island of Ven, Sweden
      The 6 th International Graduate Summer School Biophotonics '13 will take place 8-15 June 2013 at Backafallsbyn on the Island of Ven, Sweden. The registration to apply to attend Biophotonics '13 is now open. Please take a moment to read the instructions below carefully before starting to fill out the online application form. Application form In order to apply by filling out the online form, you need to provide the ...
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    6. European Commission backs biophotonics ‘FAMOS’ consortium with €10.1M for project to develop new lasers for earlier, better diagnosis of major diseases

      European Commission backs biophotonics ‘FAMOS’ consortium with €10.1M for project to develop new lasers for earlier, better diagnosis of major diseases
      ...estors to get in touch and get involved in this exciting project! The primary contact for FAMOS is Professor Wolfgang Drexler, Medical University of Vienna: Wolfgang.Drexler@meduniwien.ac.at +43 1 40400 1984 (Mrs. Pich...
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    7. Choroidal Thinning in Diabetes Type 1 Detected by 3-Dimensional 1060 nm Optical Coherence Tomography

      Choroidal Thinning in Diabetes Type 1 Detected by 3-Dimensional 1060 nm Optical Coherence Tomography
      Purpose. To map choroidal (ChT) and retinal thickness (RT) in patients with diabetes type 1 with and without maculopathy and retinopathy in order to compare them with healthy subjects using high speed 3-dimensional (3D) 1060 nm optical coherence tomography (OCT). Methods. Thirty-three eyes from 33 diabetes type 1 subjects (23–57 years, 15 male) divided into groups of without pathology (NDR) and with pathology (DR; including microaneurysms, exudates, clinically significant ...
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    8. In situ structural and microangiographic assessment of human skin lesions with high-speed OCT

      In situ structural and microangiographic assessment of human skin lesions with high-speed OCT
      We demonstrate noninvasive structural and microvascular contrast imaging of different human skin diseasesin vivousing an intensity difference analysis of OCT tomograms. The high-speed swept source OCT system operates at 1310 nm with 220 kHz A-scan rate. It provides an extended focus by employing a Bessel beam. The studied lesions were two cases of dermatitis and two cases of basal cell carcinoma. The lesions show characteristic vascular patterns that are significantly ...
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    9. Three-dimensional multiphoton/optical coherence tomography for diagnostic applications in dermatology

      Three-dimensional multiphoton/optical coherence tomography for diagnostic applications in dermatology
      A preliminary clinical trial using state-of-the-art multiphoton tomography (MPT) and optical coherence tomography (OCT) for three-dimensional (3D) multimodal in vivo imaging of normal skin, nevi, scars and pathologic skin lesions has been conducted. MPT enabled visualization of sub-cellular details with axial and transverse resolutions of 2 m and 0.5 m, respectively, from a volume of 0.35 0.35 0.2 mm3 at a frame rate of 0.14 ...
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    10. 61-75 of 136 « 1 2 3 4 5 6 7 8 9 »
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  2. About Wolfgang Drexler

    Wolfgang Drexler

    Wolfgang Drexler was a Full Professor of Biomedical Imaging at the School of Optometry and Vision Sciences at Cardiff University, Wales, UK from 2006 to 2009. Since October 2009 he is a Full Professor of Medical Physics and the Head of the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna, Austria, Honorary Distinguished Professor at Cardiff University and is also Director of the Christian Doppler Laboratory. He is a member of the Austrian Academy of Science and has published more than 150 publications (including Nature Medicine and PNAS).

  3. Quotes

    1. State-of-the-art OCT technology has its limitations: it is bulky, the size of a desk top and quite expensive, costing anything in the region of €100, 000 per unit. It can detect abnormalities but at the present moment, compact, cost effective versions that can be used outside of hospitals and in private practice in a hand held mode do not exist...The core component of our OCTChip project targets the size of a 1 cent coin. It will reduce costs and is maintenance free. Hence retinal diseases like Diabetic Retinopathy and Glaucoma as well as other retina diseases that are worldwide leading causes for blindness might be diagnosed via screening with this cost-effective compact point-of-care version of OCT...OCTChip fosters wide spread use to visualise and quantify the retina in more definition, so we can diagnose diseases better, quicker, and cheaper.
      In Coin-Sized Scanner to Target Blindness
    2. Miniaturization of OCT-based imaging technology on integrated photonics enables a novel, unique generation of not only cost-effective, but also compact, robust and nearly maintenance-free handheld OCT systems...The partners of the BiopsyPen Project have exquisite complementary expertise to accomplish a significant step towards this ambitious goal.”
      In MedLumics Announces “BiopsyPen Project” with €3.6M EU in Funding; Initiative Aimed at New Clinical Applications for Optical Coherence Tomography
    3. Swept-source technology from Insight has the potential to revolutionize OCT in the future, especially regarding ease of use, flexibility, and unique OCT performance.
      In Akinetic all-semiconductor swept lasers boost OCT image quality
    4. Lasers and light-­‐based methods have long promised to deliver benefits to clinicians through faster, more accurate, more sensitive, and more cost-­‐effective diagnosis of cancer and other important diseases, but so far most optical diagnostic instruments are expensive, complex and have limited performance. A key reason for this is that the lasers and light sources they use, are adapted from other industrial and scientific applications, and have not been optimized for these new clinical uses. Now in FAMOS, we will develop and demonstrate the next generation of light sources to produce step changes in cost/performance that will trigger development of a whole new world of non-­‐invasive clinical diagnostic tools.
      In European Commission backs biophotonics ‘FAMOS’ consortium with €10.1M for project to develop new lasers for earlier, better diagnosis of major diseases
    5. We've passed acceptance and we're between elation and state of the art...I personally think that OCT will never replace any gold standard like histology or established imaging modalities, but it will be very important at generating information in the future...It provides you with more information for earlier diagnosis.
      In Optical coherence tomography: cellular and functional retinal imaging