1. Wolfgang Drexler

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    1. Mentioned In 136 Articles

    2. Comparison of optical coherence tomography angiography and narrow-band imaging using a bimodal endoscope

      Comparison of optical coherence tomography angiography and narrow-band imaging using a bimodal endoscope
      We present coregistered images of tissue vasculature that allow a direct comparison between the performance of narrow-band imaging (NBI) and optical coherence tomography angiography (OCTA). Images were generated with a bimodal endomicroscope having a size of 152.43.3mm 3 ( l , w , h ) that combines two imaging channels. The white light imaging channel was used to perform NBI, the current gold standard for endoscopic visualization of vessels. The second channel ...
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    3. Histologic Correlation of Pig Retina Radial Stratification with Ultrahigh-Resolution Optical Coherence Tomography

      Histologic Correlation of Pig Retina Radial Stratification with Ultrahigh-Resolution Optical Coherence Tomography
      purpose. To compare ultrahigh-resolution optical coherence tomography (OCT) cross-sectional images of the pig retina with histology, to evaluate the potential of ultrahigh-resolution OCT for enhanced visualization of intra- and subretinal structures. methods. Ultrahigh-resolution OCT images were acquired with 1.4-m axial 3-m transverse resolution from in vitro posterior eyecup preparations of the domestic pig. Frozen sections were obtained in precise alignment with OCT tomograms, by using major blood vessels as ...
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    4. Feature Of The Week 03/31/2019: Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

      Feature Of The Week 03/31/2019: Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue
      We have developed a multimodal laser scanning microscope (LSM) platform combining optical coherence tomography (OCT), spectral focusing coherent anti-Stokes Raman scattering (SF-CARS), second harmonic generation (SHG) and two-photon excited fluorescence (TPF). Morphological, molecular and biochemical information from tissues can be collected in a non-invasive and label-free manner by merging ultra-fast Ti:sapphire lasers with well-developed optical imaging techniques. The combination of the proposed imaging modalities enables increased sensitivity and specificity ...
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    5. Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

      Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue
      Multimodal imaging platforms offer a vast array of tissue information in a single image acquisition by combining complementary imaging techniques. By merging different systems, better tissue characterization can be achieved than is possible by the constituent imaging modalities alone. The combination of optical coherence tomography (OCT) with non-linear optical imaging (NLOI) techniques such as two-photon excited fluorescence (TPEF), second harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS) provides access ...
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    6. Summary of 6th International Meeting on OCT Angiography & Advances in OCT in Rome December 2018: A Tremendous Success

      Summary of 6th International Meeting on OCT Angiography & Advances in OCT in Rome December 2018: A Tremendous Success
      ...Nadia Waheed, Caroline Baumal, (USA), Albert Augustin, Daniel Pauleikhoff, (Germany), Ursula Schmidt-Erfurth, Wolfgang Drexler (Austria), Anat Loewenstein, Ethan Priel (Israel), Alain Gaudric, Eric Souied, Francine Behar...
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    7. Optical coherence tomography angiography and photoacoustic imaging in dermatology

      Optical coherence tomography angiography and photoacoustic imaging in dermatology
      Optical coherence tomography angiography (OCTA) is a relatively novel functional extension of the widely accepted ophthalmic imaging tool named optical coherence tomography (OCT). Since OCTAs debut in ophthalmology, researchers have also been trying to expand its translational application into dermatology. The ability of OCTA in resolving microvasculature has shown promising results in imaging skin diseases. Meanwhile, photoacoustic imaging (PAI), which uses laser pulse induced ultrasound waves as the signal, has ...
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    8. Dynamic Changes of Retinal Microaneurysms in Diabetes Imaged With In Vivo Adaptive Optics Optical Coherence Tomography

      Dynamic Changes of Retinal Microaneurysms in Diabetes Imaged With In Vivo Adaptive Optics Optical Coherence Tomography
      Purpose : To prospectively monitor microaneurysms (MAs) in three dimensions using adaptive optics optical coherence tomography (AOOCT). Methods : Patients with diabetes mellitus and parafoveal MAs were included in this longitudinal study. At baseline, MAs were identified in standard fluorescein angiography (FA) and subsequently imaged with an AOOCT prototype, incorporated into an AO fundus camera (RTX1, Imagine Eyes) device. Imaging was repeated every 3 months in each patient to explore the potential ...
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    9. Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer
      We present a combination of optical coherence tomography (OCT) and Raman spectroscopy (RS) for improved diagnosis and discrimination of different stages and grades of bladder cancer ex vivo by linking the complementary information provided by these two techniques. Bladder samples were obtained from biopsies dissected via transurethral resection of the bladder tumor (TURBT). As OCT provides structural information rapidly, it was used as a red-flag technology to scan the bladder ...
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    10. Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography

      Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography
      A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy (EM) is presented. The two modalities are physically co‐registered in a common‐path configuration. The instrument is enabled by a dedicated planar lightwave circuit with a footprint of only 1.1 x 19.5 mm 2 that provides akinetic axial OCT scanning at speeds up to 24 kHz. Lateral scanning is ...
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    11. Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye

      Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye
      Imaging of the human retina with high resolution is an essential step towards improved diagnosis and treatment control. In this paper, we introduce a compact, clinically user-friendly instrument based on swept source optical coherence tomography (SS-OCT). A key feature of the system is the realization of two different operation modes. The first operation mode is similar to conventional OCT imaging and provides large field of view (FoV) images (up to ...
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    12. PhD Student Opening in Functional Optical Imaging Employing Contrast Agents at the Medical University of Vienna

      PhD Student Opening in Functional Optical Imaging Employing Contrast Agents at the Medical University of Vienna
      A funded PhD student position at the Drexler Lab is open for application immediately. Enrollment is on a rolling basis. The project for this position is multimodal imaging combining optical coherence microscopy and photoacoustic microscopy for preclinical small animal imaging. Both endogenous and exogenous contrast agents should be used to explore molecular contrast. The addition of spectroscopic photoacoustic imaging and functional optical coherence microscopy gives access to the metabolism of ...
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    13. Post Doc Position for retinal imaging using adaptive optics technology at the Medical University Vienna

      Post Doc Position for retinal imaging using adaptive optics technology at the Medical University Vienna
      ... publication record, your motivation letter, and names and e-mails of at least two references to Univ. Prof. Wolfgang Drexler The host university is the Medical University of Vienna which is one of the leading institut...
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    14. Optophysiological Characterisation of Inner Retina Responses with High-Resolution Optical Coherence Tomography

      Optophysiological Characterisation of Inner Retina Responses with High-Resolution Optical Coherence Tomography
      Low coherence laser interferometry has revolutionised quantitative biomedical imaging of optically transparent structures at cellular resolutions. We report the first optical recording of neuronal excitation at cellular resolution in the inner retina by quantifying optically recorded stimulus-evoked responses from the retinal ganglion cell layer and comparing them with an electrophysiological standard. We imaged anaesthetised paralysed tree shrews, gated image acquisition, and used numerical filters to eliminate noise arising from retinal ...
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    15. 1-15 of 136 1 2 3 4 5 6 7 8 9 »
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  2. About Wolfgang Drexler

    Wolfgang Drexler

    Wolfgang Drexler was a Full Professor of Biomedical Imaging at the School of Optometry and Vision Sciences at Cardiff University, Wales, UK from 2006 to 2009. Since October 2009 he is a Full Professor of Medical Physics and the Head of the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna, Austria, Honorary Distinguished Professor at Cardiff University and is also Director of the Christian Doppler Laboratory. He is a member of the Austrian Academy of Science and has published more than 150 publications (including Nature Medicine and PNAS).

  3. Quotes

    1. State-of-the-art OCT technology has its limitations: it is bulky, the size of a desk top and quite expensive, costing anything in the region of €100, 000 per unit. It can detect abnormalities but at the present moment, compact, cost effective versions that can be used outside of hospitals and in private practice in a hand held mode do not exist...The core component of our OCTChip project targets the size of a 1 cent coin. It will reduce costs and is maintenance free. Hence retinal diseases like Diabetic Retinopathy and Glaucoma as well as other retina diseases that are worldwide leading causes for blindness might be diagnosed via screening with this cost-effective compact point-of-care version of OCT...OCTChip fosters wide spread use to visualise and quantify the retina in more definition, so we can diagnose diseases better, quicker, and cheaper.
      In Coin-Sized Scanner to Target Blindness
    2. Miniaturization of OCT-based imaging technology on integrated photonics enables a novel, unique generation of not only cost-effective, but also compact, robust and nearly maintenance-free handheld OCT systems...The partners of the BiopsyPen Project have exquisite complementary expertise to accomplish a significant step towards this ambitious goal.”
      In MedLumics Announces “BiopsyPen Project” with €3.6M EU in Funding; Initiative Aimed at New Clinical Applications for Optical Coherence Tomography
    3. Swept-source technology from Insight has the potential to revolutionize OCT in the future, especially regarding ease of use, flexibility, and unique OCT performance.
      In Akinetic all-semiconductor swept lasers boost OCT image quality
    4. Lasers and light-­‐based methods have long promised to deliver benefits to clinicians through faster, more accurate, more sensitive, and more cost-­‐effective diagnosis of cancer and other important diseases, but so far most optical diagnostic instruments are expensive, complex and have limited performance. A key reason for this is that the lasers and light sources they use, are adapted from other industrial and scientific applications, and have not been optimized for these new clinical uses. Now in FAMOS, we will develop and demonstrate the next generation of light sources to produce step changes in cost/performance that will trigger development of a whole new world of non-­‐invasive clinical diagnostic tools.
      In European Commission backs biophotonics ‘FAMOS’ consortium with €10.1M for project to develop new lasers for earlier, better diagnosis of major diseases
    5. We've passed acceptance and we're between elation and state of the art...I personally think that OCT will never replace any gold standard like histology or established imaging modalities, but it will be very important at generating information in the future...It provides you with more information for earlier diagnosis.
      In Optical coherence tomography: cellular and functional retinal imaging