1. Johns Hopkins University

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    1. Mentioned In 434 Articles

    2. Optical flow optical coherence tomography for determining accurate velocity fields

      Optical flow optical coherence tomography for determining accurate velocity fields
      Determining micron-scale fluid flow velocities using optical coherence tomography (OCT) is important in both biomedical research and clinical diagnosis. Numerous methods have been explored to quantify the flow information, which can be divided into either phase-based or amplitude-based methods. However, phase-based methods, such as Doppler methods, are less sensitive to transverse velocity components and suffer from wrapped phase and phase instability problems for axial velocity components. On the other hand ...
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    3. Machine Learning Techniques for Ophthalmic Data Processing: A Review

      Machine Learning Techniques for Ophthalmic Data Processing: A Review
      Machine learning and especially deep learning techniques are dominating medical image and data analysis. This article reviews machine learning approaches proposed for diagnosing ophthalmic diseases during the last four years. Three diseases are addressed in this survey, namely diabetic retinopathy, age-related macular degeneration, and glaucoma. The review covers over 60 publications and 25 public datasets and challenges related to the detection, grading, and lesion segmentation of the three considered diseases ...
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    4. In vivo assessment of vascular-targeted photodynamic therapy effects on tumor microvasculature using ultrahigh-resolution functional optical coherence tomography

      In vivo assessment of vascular-targeted photodynamic therapy effects on tumor microvasculature using ultrahigh-resolution functional optical coherence tomography
      Abstract Vascular-targeted photodynamic therapy (VTP) is an emerging treatment for tumors. The change of tumor vasculatures, including a newly-formed microvascular, in response to VTP, is a key assessment parameter for optimizing the treatment effect. However, an accurate assessment of vasculature, particularly the microvasculatures changes in vivo , remains challenging due to the limited resolution afforded by existing imaging modalities. In this study, we demonstrated the in vivo imaging of VTP effects ...
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    5. Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy

      Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy
      Aims To compare widefield swept-source optical coherence tomography angiography (WF SS-OCTA) with ultra-widefield colour fundus photography (UWF CFP) and fluorescein angiography (UWF FA) for detecting diabetic retinopathy (DR) lesions. Methods This prospective, observational study was conducted at Massachusetts Eye and Ear from December 2018 to October 2019. Proliferative DR, non-proliferative DR and diabetic patients with no DR were included. All patients were imaged with a WF SS-OCTA using a Montage ...
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    6. Outer retina changes on optical coherence tomography in vitamin A deficiency

      Outer retina changes on optical coherence tomography in vitamin A deficiency
      Background Vitamin A deficiency is rare in the United States and can be missed in patients with malabsorption syndromes without a high dose of suspicion. Ocular complications of hypovitaminosis A include xerosis and nyctalopia, and to a lesser extent reduction in visual acuity and color vision. Outer retinal changes, as seen on spectral domain optic coherence tomography (SD-OCT), in patients with vitamin A deficiency have previously not been documented. Case ...
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    7. Accuracy of optical coherence tomography for diagnosing glaucoma: an overview of systematic reviews

      Accuracy of optical coherence tomography for diagnosing glaucoma: an overview of systematic reviews
      Aims To assess the diagnostic accuracy (DTA) of optical coherence tomography (OCT) for detecting glaucoma by systematically searching and appraising systematic reviews (SRs) on this issue. Methods We searched a database of SRs in eyes and vision maintained by the Cochrane Eyes and Vision United States on the DTA of OCT for detecting glaucoma. Two authors working independently screened the records, abstracted data and assessed the risk of bias using ...
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    8. Device and methods for color corrected OCT imaging endoscope/catheter to achieve high-resolution

      Device and methods for color corrected OCT imaging endoscope/catheter to achieve high-resolution
      The present invention is directed to an achromatic endoscope which employs a diffractive microlens. Along with a broadband rotary joint and a custom 800 nm SD-OCT system, ultrahigh-resolution 3D volumetric imaging over a large area becomes possible. The diffractive microlens can be used directly with a GRIN lens, making the endoscope design simpler and cost effective. Preliminary ex vivo 3D intraluminal imaging was performed with the endoscope in conjunction with ...
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    9. Automatic intraoperative optical coherence tomography positioning

      Automatic intraoperative optical coherence tomography positioning
      Purpose Intraoperative optical coherence tomography (iOCT) was recently introduced as a new modality for ophthalmic surgeries. It provides real-time cross-sectional information at a very high resolution. However, properly positioning the scan location during surgery is cumbersome and time-consuming, as a surgeon needs both his hands for surgery. The goal of the present study is to present a method to automatically position an iOCT scan on an anatomy of interest in ...
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    10. Use of En Face Optical Coherence Tomography to Monitor Papilledema in Idiopathic Intracranial Hypertension: A Pilot Study

      Use of En Face Optical Coherence Tomography to Monitor Papilledema in Idiopathic Intracranial Hypertension: A Pilot Study
      Background: En face optical coherence tomography (OCT) uses the data acquired during OCT of the optic disc, which typically is used to determine measurements of the peripapillary retinal nerve fiber layer (ppRNFL), to generate a coronal composite fundus image rather than a cross-sectional image. En face OCT has been reported to identify retinal changes related to papilledema in idiopathic intracranial hypertension (IIH) but has not been evaluated for monitoring papilledema ...
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    11. Selective retina therapy monitoring by speckle variance optical coherence tomography for dosimetry control

      Selective retina therapy monitoring by speckle variance optical coherence tomography for dosimetry control
      Significance: Selective retina therapy (SRT) selectively targets the retinal pigment epithelium (RPE) and reduces negative side effects by avoiding thermal damages of the adjacent photoreceptors, the neural retina, and the choroid. However, the selection of proper laser energy for the SRT is challenging because of ophthalmoscopically invisible lesions in the RPE and different melanin concentrations among patients or even regions within an eye. Aim: We propose and demonstrate SRT monitoring ...
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    12. Ultra-sensitive optical coherence elastography using a high-dynamic-range force loading scheme for cervical rigidity assessment

      Ultra-sensitive optical coherence elastography using a high-dynamic-range force loading scheme for cervical rigidity assessment
      An ultra-sensitive, wide-range force loading scheme is proposed for compression optical coherence elastography (OCE) that allows for the quantitative analysis of cervical tissue elasticity ex vivo . We designed a force loading apparatus featuring a water sink for minuscule incremental loading through a volume-controlled water droplet, from which the Youngs modulus can be calculated by fitting the stress-strain curve. We validated the performance of the proposed OCE system on homogenous agar ...
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    13. Robust, accurate depth-resolved attenuation characterization in optical coherence tomography

      Robust, accurate depth-resolved attenuation characterization in optical coherence tomography
      Depth-resolved optical attenuation coefficient is a valuable tissue parameter that complements the intensity-based structural information in optical coherent tomography (OCT) imaging. Herein we systematically analyzed the under- and over-estimation bias of existing depth-resolved methods when applied to real biological tissues, and then proposed a new algorithm that remedies these issues and accommodates general OCT data that contain incomplete decay and noise floor, thereby affording consistent estimation accuracy for practical biological ...
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  2. About Johns Hopkins University

    Johns Hopkins University

    John Hopkins University mission is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.  Hopkins now uses one overarching name - Johns Hopkins Medicine -to identify its whole medical enterprise. This $4 billion virtual organization unites the physicians and scientists of The Johns Hopkins University School of Medicine with the health professionals and facilities that make up the broad Johns Hopkins Health System.  The Wilmer Eye Institute at Johns Hopkins has long been recognized for bringing together ophthalmologists consistently ranked by their peers as among the finest internationally, with a specially trained and highly experienced team of nurses cited by patients for their knowledge, responsiveness, and sensitivity. Johns Hopkins Multiple Sclerosis Center is one of the largest clinical and research MS centers in the world.