1. William R. Freeman

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    1. Mentioned In 28 Articles

    2. Fluorescein Angiography Versus Optical Coherence Tomography-Guided Planning for Macular Laser Photocoagulation in Diabetic Macular Edema

      Fluorescein Angiography Versus Optical Coherence Tomography-Guided Planning for Macular Laser Photocoagulation in Diabetic Macular Edema

      Purpose: To compare laser photocoagulation plans for diabetic macular edema (DME) using fluorescein angiography (FA) versus optical coherence tomography (OCT) thickness map superimposed on the retina. Methods: Fourteen eyes with DME undergoing navigated laser photocoagulation with navigated photocoagulator had FA taken using the same instrument. Optical coherence tomography central retinal thickness map was imported to the photocoagulator and with same magnification aligned onto the retina. Three retina specialists placed laser spot marks separately on FA and OCT image in a masked fashion. The spots placed by each physician were compared between FA and OCT and among physicians. The area of ...

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    3. Optical Coherence Tomography Findings of the Vitreoretinal Interface in Asymptomatic Fellow Eyes of Patients With Acute Posterior Vitreous Detachment

      Optical Coherence Tomography Findings of the Vitreoretinal Interface in Asymptomatic Fellow Eyes of Patients With Acute Posterior Vitreous Detachment

      Purpose: To describe the vitreoretinal interface of the asymptomatic fellow eyes of patients with acute unilateral posterior vitreous detachment (PVD) based on biomicroscopic examination and spectral domain optical coherence tomography. Methods: Sixty-five eyes of 65 consecutive patients with acute unilateral PVD were examined by slit-lamp, indirect ophthalmoscopy, and spectral domain optical coherence tomography. The state of PVD in different retinal locations and premacular pocket were assessed and graded using spectral domain optical coherence tomography. Results: Nine eyes (13.85%) had no PVD, 15 (23.08%) had extrafoveal vitreous separation (Stage 1), 18 (27.69%) had partial foveal vitreous separation (Stage ...

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    4. Safety and Efficacy of Oral Fluorescein Angiography in Detecting Macular Edema in Comparison With Spectral-Domain Optical Coherence Tomography

      Safety and Efficacy of Oral Fluorescein Angiography in Detecting Macular Edema in Comparison With Spectral-Domain Optical Coherence Tomography

      Purpose: To evaluate the safety of oral fluorescein angiography (FA) and to compare its efficacy in detection of macular edema (ME) with spectral-domain optical coherence tomography (SD-OCT). Methods: Results of imaging studies for 1,928 eyes of 1,019 patients who had simultaneously undergone both oral FA and SD-OCT by a confocal laser ophthalmoscope were reviewed. Sensitivity in detecting ME, discrepancy rate, and "kappa" agreement were determined for both the techniques and with eyes stratified by disease diagnosis. Results: No allergic reactions occurred after oral FA. Mild gastric discomfort was noted in <1% of the patients; 1,840 eyes (95 ...

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    5. Correlation of Spectral Domain Optical Coherence Tomography Characteristics With Visual Acuity in Eyes With Subfoveal Scarring After Treatment for Wet Age-Related Macular Degeneration

      Correlation of Spectral Domain Optical Coherence Tomography Characteristics With Visual Acuity in Eyes With Subfoveal Scarring After Treatment for Wet Age-Related Macular Degeneration

      Purpose: Correlating spectral domain optical coherence tomography characteristics with final best-corrected visual acuity (BCVA) in eyes with subfoveal scarring after treatment for wet age-related macular degeneration. Methods: Seventy-nine eyes from 64 subjects, who developed subfoveal scarring after treatment of wet age-related macular degeneration, were retrospectively studied. Spectral domain optical coherence tomography characteristics were analyzed, including percentage disruption of inner segment/outer segment junction and external limiting membrane, central macular thickness, subfoveal scar thickness, subretinal scar area, and proximity of retina with intact outer structures to the fovea. A multivariate stepwise regression analysis was performed with the final BCVA logarithm of ...

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    6. Repeatability and reproducibility of manual choroidal volume measurements using enhanced depth imaging optical coherence tomography

      Repeatability and reproducibility of manual choroidal volume measurements using enhanced depth imaging optical coherence tomography

      Purpose: To evaluate the repeatability and reproducibility of manual choroidal volume (CV) measurements on spectral-domain optical coherence tomography (SD-OCT) using enhanced depth imaging (EDI). Methods: Sixty eyes of 32 patients with or without any ocular chorio-retinal diseases were enrolled prospectively. Thirty-one choroidal scans were performed on each eye centered at the fovea using a raster protocol. Two masked observers demarcated choroidal boundaries using the built-in automated retinal segmentation software on two separate sessions. The observers were masked to each other's and their own previous readings. A standardized grid centered on the fovea was positioned automatically by the Spectralis OCT ...

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    7. Characterization of Diabetic Microaneurysms by Simultaneous Fluorescein Angiography and Spectral-Domain Optical Coherence Tomography

      Characterization of Diabetic Microaneurysms by Simultaneous Fluorescein Angiography and Spectral-Domain Optical Coherence Tomography

      Purpose To correlate spectral-domain optical coherence tomography (SD-OCT) findings of perfused diabetic microaneurysms with leakage status on fluorescein angiography (FA) using simultaneous FA and SD-OCT. Design Retrospective, observational case series. Methods A total of 173 microaneurysms were analyzed in 50 eyes (14 mild nonproliferative diabetic retinopathy [NPDR]; 22 moderate NPDR; 9 severe NPDR; 5 proliferative diabetic retinopathy) of 40 diabetic patients using simultaneous FA and SD-OCT. The characteristics of microaneurysms were evaluated by 2 masked observers using SD-OCT and correlated with leakage status on FA. Results External diameter of microaneurysms averaged 104 μm (range 43-266 μm). Some microaneurysm centers (15 ...

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    8. Spectral-Domain Optical Coherence Tomography Imaging of Postoperative Scleral Buckles

      Spectral-Domain Optical Coherence Tomography Imaging of Postoperative Scleral Buckles
      Purpose: To describe the appearance on spectral domain optical coherence tomography of the peripheral retina and overlying vitreous after scleral buckling surgery. Methods: Retrospective case series of patients who underwent scleral buckle surgery and had subsequent scanning laser ophthalmoscopy/spectral-domain optical coherence tomography images over the area of buckled retina. Twelve eyes from 11 patients were identified and show a variety of retinal anatomies, vitreous configurations, and clinical applications. Results: Twelve eyes from 11 patients were studied, and in all eyes, the peripheral retina could be visualized with 10 cases of successful retinal reattachment and 2 cases of scleral buckle ...
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    9. Long-Term SD-OCT/SLO Imaging of Neuroretina and Retinal Pigment Epithelium After Subthreshold Infrared Laser Treatment of Drusen

      Long-Term SD-OCT/SLO Imaging of Neuroretina and Retinal Pigment Epithelium After Subthreshold Infrared Laser Treatment of Drusen
      Purpose: The purpose of this study was to determine the long-term effect of subthreshold diode laser treatment for drusen in patients with nonexudative age-related macular degeneration with spectral domain optical coherence tomography combined with simultaneous scanning laser ophthalmoscope. Methods: Eight eyes of four consecutive age-related macular degeneration patients with bilateral drusen previously treated with subthreshold diode laser were imaged with spectral domain optical coherence tomography/scanning laser ophthalmoscope. Abnormalities in the outer retinal layers' reflectivity as seen with spectral domain optical coherence tomography/scanning laser ophthalmoscope were retrospectively analyzed and compared with color fundus pictures, and autofluorescence images were acquired ...
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    10. Dynamics of the Macular Hole-Silicone Oil Tamponade Interface With Patient Positioning As Imaged By Spectral Domain-Optical Coherence Tomography

      Dynamics of the Macular Hole-Silicone Oil Tamponade Interface With Patient Positioning As Imaged By Spectral Domain-Optical Coherence Tomography
      Purpose: The purposes of this study were to evaluate with spectral domain-optical coherence tomography the relationship between the retina and overlying silicone oil tamponade after macular hole surgery and to evaluate how this relationship changes with patient positioning. Methods: We studied a retrospective consecutive case series of 10 eyes from 9 patients who underwent macular hole surgery with silicone oil tamponade and subsequent spectral domain-optical coherence tomography scans. Four of the included eyes were also imaged with patients in face-down posture to determine whether the silicone-retina apposition changes with prone positioning. Finally, a single patient was also scanned in the ...
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    11. Correlation Between Morphologic Features on Spectral-Domain Optical Coherence Tomography and Angiographic Leakage Patterns in Macular Edema

      Purpose: The purpose of this study was to determine the morphologic patterns of angiographic macular edema using simultaneous colocalization of fluorescein angiography and spectral-domain optical coherence tomography (SD-OCT) images in diabetes, epiretinal membrane, uveitic and pseudophakic cystoid macular edema, and vein occlusion. Methods: Eighty-seven consecutive patients (107 eyes) with macular edema from 5 different etiologies were imaged by simultaneous scanning laser ophthalmoscopy/OCT to study the morphologic patterns of edema on SD-OCT and then correlated/colocalized with the fluorescein angiographic patterns of leakage. Statistical analysis was done to analyze the differences in the morphologic OCT pattern by different diseases. Results ...
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    12. Observations by Spectral-Domain Optical Coherence Tomography Combined with Simultaneous Scanning Laser Ophthalmoscopy: Imaging of the Vitreous

      ...f the vitreoretinal interface, and it is particularly useful for defining focal changes and PVD. Inquiries to William R. Freeman, Department of Ophthalmology, Shiley Eye Center, 0946, University of California, San Diego,...
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    13. 1-15 of 28 1 2 »
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  2. About William R. Freeman

    William R. Freeman

    William R. Freeman, M.D. is an internationally acclaimed scientific researcher and Director of the Jacobs Retina Research Center, adjoining the UCSD Shiley Eye Center. The clinical research center at the Jacobs Center will enable patients to benefit from the latest advances in diagnostic equipment and therapies. Researchers working in the Center's laboratories will focus on advancing promising therapies for macular degeneration, tumors, inherited retinal disease, retinal detachment, macular holes, and other important retinal diseases. Dr. Freeman is Professor of Ophthalmology at UCSD and has built a clinical and research enterprise of excellence since he came to UCSD in 1986. The new Jacobs Retina Center has allowed him to continue to build a research team dedicated to attacking retinal diseases that cause blindness and vision loss.