1. William J. Brown

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    1. Mentioned In 25 Articles

    2. Ophthalmoscope

      Ophthalmoscope
      A scanning laser ophthalmoscope (SLO) for imaging the retina of an eye comprises a source (12) of collimated light, a scanning device (14, 16, 1328, 1319), a scan transfer device (20) and a detector (1310). The scan transfer device has a first focus (16) at which an apparent point source is provided and a second focus (24) at which an eye (524, 1324) may be accommodated. The scan transfer device ...
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    3. Design and implementation of a low-cost, portable OCT system

      Design and implementation of a low-cost, portable OCT system
      Optical coherence tomography (OCT) is a widely used biomedical imaging tool, primarily in ophthalmology to diagnose and stage retinal diseases. In order to increase access for a wider range of applications and in low resource settings, we developed a portable, low-cost OCT system that has comparable imaging performance to commercially available systems. Here, we present the system design and characterization and compare the system performance to other commercially available OCT ...
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    4. Systems and methods for deep spectroscopic imaging of biological samples with use of an interferometer and spectrometer

      Systems and methods for deep spectroscopic imaging of biological samples with use of an interferometer and spectrometer
      Disclosed herein are systems and methods for deep spectroscopic imaging of a biological sample. In an aspect, a system includes a broad bandwidth light source configured to generate an illumination beam, an interferometer, and a spectrometer. The interferometer includes a first beam splitter configured to split the illumination beam into an incident beam and a reference beam; an optical lens directs the incident beam onto a biological sample at a ...
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    5. Optical coherence tomography imaging systems and methods

      Optical coherence tomography imaging systems and methods
      Optical coherence tomography imaging systems and methods are disclosed. According to an aspect, an optical coherence tomography imaging system includes a scanner configured to obtain images and to convert the images to electrical signals. The system also includes a computing device comprising an OCT module configured to receive the electrical signals, to apply an OCT imaging technique, and to generate imaging data.
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      Mentions: William J. Brown
    6. Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography

      Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography
      Angle-resolved low coherence interferometry (a/LCI) is an optical technique used to measure nuclear morphology in situ . However, a/LCI is not an imaging modality and can produce ambiguous results when the measurements are not properly oriented to the tissue architecture. Here we present a 2D a/LCI system which incorporates optical coherence tomography imaging to guide the measurements. System design and characterization are presented, along with example cases which ...
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    7. Portable optical coherence tomography (OCT) systems

      Portable optical coherence tomography (OCT) systems
      Portable optical coherence tomography (OCT) devices including at least one mirror configured to scan at least two directions are provided. The portable OCT devices are configured to provide a portable interface to a sample that can be aligned to the sample without repositioning the sample. Related systems are also provided.
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    8. Scanning Laser Ophthalmoscopes

      Scanning Laser Ophthalmoscopes
      A scanning laser ophthalmoscope (SLO) for imaging the retina of an eye comprises a source ( 12 ) of collimated light, a scanning device ( 14, 16, 1328, 1319 ), a scan transfer device ( 20 ) and a detector ( 1310 ). The scan transfer device has a first focus ( 16 ) at which an apparent point source is provided and a second focus ( 24 ) at which an eye ( 524, 1324 ) may be accommodated. The scan transfer device ...
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    9. Functional optical coherence tomography: principles and progress

      Functional optical coherence tomography: principles and progress
      In the past decade, several functional extensions of optical coherence tomography (OCT) have emerged, and this review highlights key advances in instrumentation, theoretical analysis, signal processing and clinical application of these extensions. We review five principal extensions: Doppler OCT (DOCT), polarization-sensitive OCT (PS-OCT), optical coherence elastography (OCE), spectroscopic OCT (SOCT), and molecular imaging OCT. The former three have been further developed with studies in both ex vivo and in vivo ...
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    10. Optical Coherence Tomography Imaging Systems And Methods

      Optical Coherence Tomography Imaging Systems And Methods
      Optical coherence tomography imaging systems and methods are disclosed. According to an aspect, an optical coherence tomography imaging system includes a scanner configured to obtain images and to convert the images to electrical signals. The system also includes a computing device comprising an OCT module configured to receive the electrical signals, to apply an OCT imaging technique, and to generate imaging data.
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    11. Feature Of The Week 11/16/14: In Vivo Analysis of Burns in a Mouse Model using Spectroscopic OCT

      Feature Of The Week 11/16/14: In Vivo Analysis of Burns in a Mouse Model using Spectroscopic OCT
      Evaluation of burn severity is a significant clinical problem with over 2 million burns reported each year in the United States [1]. The magnitude of this clinical need has inspired the development of many technologies to assess burn depth, but none of these have been widely adopted as clinical judgment still relies primarily on visual inspection, with an accuracy of about 70% [2]. A recent study by researchers at Duke ...
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    12. Improvements In Or Relating To Scanning Laser Ophthalmoscopes

      Improvements In Or Relating To Scanning Laser Ophthalmoscopes
      A scanning laser ophthalmoscope (SLO) for imaging the retina of an eye comprises a source (12) of collimated light, a scanning device (14, 16, 1328, 1319), a scan transfer device (20) and a detector (1310). The scan transfer device has a first focus (16) at which an apparent point source is provided and a second focus (24) at which an eye (524, 1324) may be accommodated. The scan transfer device ...
      Read Full Article
    13. 1-15 of 25 1 2 »
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      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
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  2. About William J. Brown

    William J. Brown

    William Brown joined the Biomedical Interferometry and Optical Spectroscopy group at Duke University in September 2013 after spending time in industry at Oncoscope, Inc. and Wasatch Photonics. His areas of research focus include low coherence interferometry, novel microscopy, and medical imaging. In addition he supports the commercial translation of lab developed technologies with clinical markets. He received his PhD from the Department of Physics at Duke University in quantum optics.

  3. Quotes

    1. Spark OCT has a deeper imaging range and higher speed compared to other OCT systems on the market...Further clinical development aims to provide physicians with images to support diagnosis and treatment of patients in many health-care sectors...The 1310 nm wavelength provides better penetration into samples such as skin, and sees through materials such as silicon that are opaque at visible wavelengths," he said. "This system has an imaging range of 10 millimeters with a resolution of 15 microns.
      In Wasatch Photonics to attend The Innovation Showcase, launch new OCT imaging system
    2. This disease affects an estimated 16 million Americans and is a primary cause of heart attacks and strokes. Identifying and treating plaque buildup and other intravascular conditions could reduce the morbidity and mortality rates from coronary artery disease,...Our technology, called intravascular optical coherence tomography, provides detailed imaging information for physicians to use in plaque assessment and stent implantation and monitoring. Our system, with its increased image resolution capability and competitive cost, will provide a significant improvement over the current systems..."The National Science Foundation has a long history of funding both basic research and, via the SBIR program, commercialization of innovation at small companies.
      In Imaging technology could lower coronary disease mortality rate
    3. We're really excited about this tool, especially the 3-D and chemical analysis and that it's right down the road.
      In How Lasers Are Changing the Study of Art