1. Wihan Kim

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    1. Mentioned In 9 Articles

    2. Dual-modality optical coherence tomography and frequency-domain fluorescence lifetime imaging microscope system for intravascular imaging

      Dual-modality optical coherence tomography and frequency-domain fluorescence lifetime imaging microscope system for intravascular imaging
      Significance: Detailed biochemical and morphological imaging of the plaque burdened coronary arteries holds the promise of improved understanding of atherosclerosis plaque development, ultimately leading to better diagnostics and therapies. Aim: Development of a dual-modality intravascular catheter supporting swept-source optical coherence tomography (OCT) and frequency-domain fluorescence lifetime imaging (FD-FLIM) of endogenous fluorophores with UV excitation. Approach: We instituted a refined approach to endoscope development that combines simulation in a commercial ray ...
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    3. Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography

      Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography
      Optical coherence tomography (OCT) images largely lack molecular information or molecular contrast. We address that issue here, reporting on the development of biodegradable micro and nano-spheres loaded with methylene blue (MB) as molecular contrast agents for OCT. MB is a constituent of FDA approved therapies and widely used as a dye in off-label clinical applications. The sequestration of MB within the polymer reduced toxicity and improved signal strength by drastically ...
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    4. Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system

      Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system
      We have developed a highly phase stable optical coherence tomography and vibrometry system that attaches directly to the accessory area of a surgical microscope common to both the otology clinic and operating room. Careful attention to minimizing sources of phase noise has enabled a system capable of measuring vibrations of the middle ear with a sensitivity of 5 pm in an awake human patient. The system is shown to be ...
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    5. Endoscopic optical coherence tomography enables morphological and subnanometer vibratory imaging of the porcine cochlea through the round window

      Endoscopic optical coherence tomography enables morphological and subnanometer vibratory imaging of the porcine cochlea through the round window
      A highly phase stable hand-held (HH) endoscopic system has been developed for optical coherence tomography and vibrometry. Designed to transit the ear canal to the middle ear space and peer through the round window (RW), it is capable of imaging the vibratory function of the cochlear soft tissues with subnanometer scale sensitivity. A side-looking, 9 cm long rigid endoscope with a distal diameter of 1.2 mm, was able to ...
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    6. Contrast enhancement of pump-probe optical coherence tomography (PP-OCT) based molecular imaging using methylene blue loaded PLGA particles

      Contrast enhancement of pump-probe optical coherence tomography (PP-OCT) based molecular imaging using methylene blue loaded PLGA particles
      Atherosclerosis, a condition in which plaque accumulates on the inner wall of arteries, is often recognized as a precursor to cardiovascular diseases (CVDs), the most common causes of death in the US. Optical Coherence Tomography (OCT) is an intravascular optical diagnosis tool, which can be used to obtain high resolution morphological images of atherosclerotic plaque. However, atherosclerotic plaque components, such as macrophages, can be misclassified due to their signal similarities ...
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    7. Feature Of The Week 2/23/14: Texas A&M University Reports on In vivo Pump-Probe Optical Coherence Tomography Imaging in Xenopus Laevis

      Feature Of The Week 2/23/14: Texas A&M University Reports on In vivo Pump-Probe Optical Coherence Tomography Imaging in Xenopus Laevis
      Currently, optical coherence tomography (OCT), is not capable of obtaining molecular information often crucial for identification of disease. To enable molecular imaging with OCT, we have further developed a technique that harnesses transient changes in light absorption in the sample to garner molecular information. A Fourier-domain Pump-Probe OCT (PPOCT) system utilizing a 532 nm pump and 830 nm probe has been developed for imaging hemoglobin. Methylene blue, a biological dye ...
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  2. About Wihan Kim

    Wihan Kim

    Wihan Kim received his B.S. degree in Mechanical engineering from Kyoungpook National University at South Korea where he researched the developing of the confocal and multiphoton microscopy. He works on Pump-probe Optical Coherence Tomography and Microscopy. His current research focuses on the development of applications of the Pump-probe imaging