1. Wen-Chuan Kuo

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    1. Mentioned In 31 Articles

    2. Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging

      Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging
      This study proposed an ultrahigh-resolution multi-contrast optical coherence tomography system integrated with fundus photography for in vivo retinal imaging of rodents. A supercontinuum light source was used in the system, providing an axial resolution of less than 3 m within 1.8 mm (in the tissue). Three types of tissue contrast based on backscattered intensity, phase retardation, and microvasculature at a capillary level can be simultaneously obtained using the proposed ...
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    3. Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model

      Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model
      Incorrect needle placement during an epidural block causes medical complications such as dural puncture or spinal cord injury. We propose a system combining an optical coherence tomography imaging probe with an automatic identification algorithm to objectively identify the epidural needle-tip position and thus reduce complications during epidural needle insertion. Eight quantitative features were extracted from each two-dimensional optical coherence tomography image during insertion of the needle tip from the skin ...
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    4. Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages

      Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages
      Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for diagnosis. We propose the combination of structural and vascular optical coherence tomography (OCT) imaging for the investigation of disease related changes. Progressive thickness changes of epithelium and the destruction of underlying lamina propria was ...
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    5. Label-free, multi-contrast optical coherence tomography for study of skin melanoma mice in vivo

      Label-free, multi-contrast optical coherence tomography for study of skin melanoma mice in vivo
      The lymphatic system plays an important role in inflammation and cancer such as melanoma. Due to the limitations of current developed imaging techniques, visualization of lymphatic vessels within the tissue in vivo has been challenging. Optical imaging of lymphatic vessel is gaining increased interests because it does not involve any radiation and can achieve very high resolution. Here, we developed a multi-contrast, label-free optical coherence tomography (OCT) imaging technology with ...
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    6. Quantitative evaluation of retinal degeneration in royal college of surgeons rats by contrast enhanced ultrahigh resolution optical coherence tomography

      Quantitative evaluation of retinal degeneration in royal college of surgeons rats by contrast enhanced ultrahigh resolution optical coherence tomography
      This study presents a spectral domain optical coherence tomography (SD-OCT) using supercontinuum laser combined with a fundus photography for in vivo high-resolution imaging of retinal degeneration in Royal College of Surgeons (RCS-/- rat). These findings were compared with the Sprague-Dawley (SD) rats and the corresponding histology. Quantitative measurements show that changes in thickness were not significantly different between SD control and young RCS retinas (4 weeks). However, in old RCS ...
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    7. Detection of oral early cancerous lesion by using polarization-sensitive optical coherence tomography: mice model

      Detection of oral early cancerous lesion by using polarization-sensitive optical coherence tomography: mice model
      Oral cancer is the 11th most common cancer worldwide, especially in a male adult. The median age of death in oral cancer was 55 years, 10-20 years earlier than other cancers. Presently, oral cancer is often found in late stage, because the lesion is often flat in early stage and is difficult to diagnose under traditional white light imaging. The only definitive method for determining cancer is an invasive biopsy ...
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    8. A Feasibility Study of Broadband White Light Emitting Diode (WLED) based Full-Field Optical Coherence Microscopy (FF-OCM) using Derivative-based Algorithm

      A Feasibility Study of Broadband White Light Emitting Diode (WLED) based Full-Field Optical Coherence Microscopy (FF-OCM) using Derivative-based Algorithm
      Developing cost-effective and fast detection methods in full-field optical coherence microscopy (FF-OCM) platform for biological applications is of prime focus today. In this paper, we report a cost-effective Linnik type FF-OCM system with a single broadband white light emitting diode (WLED) (470-850nm, 0=630nm) light source in conjunction with a derivative-based image reconstruction algorithm. Sequential two-dimensional (2D) multiple phase-shifted interferograms were obtained by moving the sample stage using piezoelectric transducer ...
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    9. In vivo images of the epidural space with two- and three-dimensional optical coherence tomography in a porcine model

      In vivo images of the epidural space with two- and three-dimensional optical coherence tomography in a porcine model
      Background No reports exist concerning in vivo optical coherence tomography visualization of the epidural space and the blood patch process in the epidural space. In this study, we produced real-time two-dimensional and reconstructed three-dimensional images of the epidural space by using optical coherence tomography in a porcine model. We also aimed to produce three-dimensional optical coherence tomography images of the dura puncture and blood patch process. Methods Two-dimensional and three-dimensional ...
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      Mentions: Wen-Chuan Kuo
    10. En-face sectional imaging using single-shot full-field optical coherence tomography (SS-FF-OCT) based on white light emitting diode (WLED)

      En-face sectional imaging using single-shot full-field optical coherence tomography (SS-FF-OCT) based on white light emitting diode (WLED)
      This work reports a Linnik type single shot full-field optical coherence tomography (SS-FF-OCT), which uses a fast generalized analytic signal based complex Riesz transform scheme to reconstruct wide area en-face OCT images. The OCT interferometer is illuminated using a single broad band white light emitting diode (WLED) (wavelength range 470- 850nm, central wavelength 650nm) and detection unit is a two-dimensional (2D) charge complementary metal oxide semiconductor (CMOS) camera. The measured ...
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      Mentions: Wen-Chuan Kuo
    11. Fiber-needle Swept-source Optical Coherence Tomography System for the Identification of the Epidural Space in Piglets

      Fiber-needle Swept-source Optical Coherence Tomography System for the Identification of the Epidural Space in Piglets
      Background: Epidural needle insertion is traditionally a blind technique whose success depends on the experience of the operator. The authors describe a novel method using a fiber-needle-based swept-source optical coherence tomography (SSOCT) to identify epidural space. Methods: An optical fiber probe was placed into a hollow 18-gauge Tuohy needle. It was then inserted by an experienced anesthesiologist to continuously construct a series of two-dimensional SSOCT images by mechanically rotating the ...
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      Mentions: Wen-Chuan Kuo
    12. Optical Coherence Tomography for Quantitative Diagnosis in Cardiovascular Disease (Book Chapter)

      Optical Coherence Tomography for Quantitative Diagnosis in Cardiovascular Disease (Book Chapter)
      In recent years, biomedical imaging technology has made rapid advances that enable the visualization, quantification, and monitoring of morphology and function. There are several tomography modalities which are currently used in clinics, such as computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), ultrasound (US), etc. These modalities have been developed for in vivo structural and functional imaging in humans, but frequently require large, expensive and complex systems ...
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    13. Balanced-Detection Spectra Domain Optical Coherence Tomography System

      Balanced-Detection Spectra Domain Optical Coherence Tomography System
      A balanced-detection spectra domain optical coherence tomography system is disclosed. A light beam L emitting from the light source module is passed through the second beam splitter, the first beam splitter in series, and then split to the mirror and the sample respectively, and further simultaneously reflected to the first beam splitter, a light beam L 1 and a light beam L 2 are refracted by the first beam splitter ...
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      Mentions: Wen-Chuan Kuo
    14. 1-15 of 31 1 2 »
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  2. About Wen-Chuan Kuo

    Wen-Chuan Kuo

    Wen-Chuan Kuo is an assistant professor at the Institure of Electro-Optical Science and Technology, National Taiwan Normal University.