1. Washington University in St. Louis

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    1. Mentioned In 100 Articles

    2. Developing Drosophila melanogaster Models for Imaging and Optogenetic Control of Cardiac Function

      Developing Drosophila melanogaster Models for Imaging and Optogenetic Control of Cardiac Function
      Using Drosophila melanogaster (fruit fly) as a model organism has ensured significant progress in many areas of biological science, from cellular organization and genomic investigations to behavioral studies. Due to the accumulated scientific knowledge, in recent years, Drosophila was brought to the field of modeling human diseases, including heart disorders. The presented work describes the experimental system for monitoring and manipulating the heart function in the context of a whole ...
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    3. Longitudinal morphological and functional characterization of human heart organoids using optical coherence tomography

      Longitudinal morphological and functional characterization of human heart organoids using optical coherence tomography
      Organoids play an increasingly important role as in vitro models for studying organ development , disease mechanisms, and drug discovery. Organoids are self-organizing, organ-like three-dimensional (3D) cell cultures developing organ-specific cell types and functions. Recently, three groups independently developed self-assembling human heart organoids (hHOs) from human pluripotent stem cells (hPSCs). In this study, we utilized a customized spectral-domain optical coherence tomography (SD-OCT) system to characterize the growth of hHOs. Development of ...
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    4. Human Colorectal Cancer Tissue Assessment Using Optical Coherence Tomography Catheter and Deep Learning

      Human Colorectal Cancer Tissue Assessment Using Optical Coherence Tomography Catheter and Deep Learning
      Optical coherence tomography (OCT) can differentiate normal colonic mucosa from neoplasia, potentially offering a new mechanism of endoscopic tissue assessment and biopsy targeting, with a high optical resolution and an imaging depth of ~1 mm. Recent advances in convolutional neural networks (CNN) have enabled application in ophthalmology, cardiology, and gastroenterology malignancy detection with high sensitivity and specificity. Here we describe a miniaturized OCT catheter and a residual neural network (ResNet ...
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    5. Endoscopic Optical Coherence Tomography for Screening and Diagnosis of Colorectal Precancerous and Malignant Polyps

      Endoscopic Optical Coherence Tomography for Screening and Diagnosis of Colorectal Precancerous and Malignant Polyps
      Colorectal cancer arises from the mucosal layer of the colon. Current screening is performed by flexible endoscopy, which involves visual inspection of the mucosal lining of the colon and rectum with an optical camera mounted on the endoscope, with abnormal areas being biopsied. This method is somewhat limited in that there are no readily available surface pattern or morphological classification systems with adequate sensitivity or specificity to evaluate extent of ...
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    6. Washington University Receives NIH Grant for High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart

      Washington University Receives NIH Grant for High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart
      ...logist) and Dr. Jeanne Nerbonne (cardiac electrophysiologist) and Dr. Kenneth Schechtman (biostatistician) at Washington University, we propose to develop a high-throughput integrated OCT imaging and dual-color optogenet...
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    7. Optical Coherence Tomography in Biomedicine (Book Chapter)

      Optical Coherence Tomography in Biomedicine (Book Chapter)
      In this chapter, we first introduce the basic working principles of optical coherence tomography (OCT). Three types of OCT, including time-domain, spectral-domain, and swept-source OCT are discussed. Functional OCT methods, including polarization sensitive OCT (PS-OCT), spectroscopic OCT (S-OCT), optical coherence elastography (OCE), and OCT angiography (OCTA) are also described. Furthermore, recent advances in high-speed and high-resolution OCT technologies are reviewed. We also highlight several OCT applications in biomedicine, including ophthalmology ...
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    8. Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution

      Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution
      The surface of the human cerebellar cortex is much more tightly folded than the cerebral cortex. Volumetric analysis of cerebellar morphometry in magnetic resonance imaging studies suffers from insufficient resolution, and therefore has had limited impact on disease assessment. Automatic serial polarization-sensitive optical coherence tomography (as-PSOCT) is an emerging technique that offers the advantages of microscopic resolution and volumetric reconstruction of large-scale samples. In this study, we reconstructed multiple cubic ...
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    9. Using Optical Coherence Tomography and Intravascular Ultrasound Imaging to Quantify Coronary Plaque Cap Stress/Strain and Progression: A Follow-Up Study Using 3D Thin-Layer Models

      Using Optical Coherence Tomography and Intravascular Ultrasound Imaging to Quantify Coronary Plaque Cap Stress/Strain and Progression: A Follow-Up Study Using 3D Thin-Layer Models
      Accurate plaque cap thickness quantification and cap stress/strain calculations are of fundamental importance for vulnerable plaque research. To overcome uncertainties due to intravascular ultrasound (IVUS) resolution limitation, IVUS and optical coherence tomography (OCT) coronary plaque image data were combined together to obtain accurate and reliable cap thickness data, stress/strain calculations, and reliable plaque progression predictions. IVUS, OCT, and angiography baseline and follow-up data were collected from nine patients ...
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    10. Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease | Nature Communications

      Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease | Nature Communications
      Congenital heart defects constitute the most common human birth defect, however understanding of how these disorders originate is limited by our ability to model the human heart accurately in vitro. Here we report a method to generate developmentally relevant human heart organoids by self-assembly using human pluripotent stem cells. Our procedure is fully defined, efficient, reproducible, and compatible with high-content approaches. Organoids are generated through a three-step Wnt signaling modulation ...
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    11. Washington University Receives NIH Grant for High throughput optical coherence tomography (OCT)-based imaging platform for label-free, non-invasive characterization of 3D tumor spheroids

      Washington University Receives NIH Grant for High throughput optical coherence tomography (OCT)-based imaging platform for label-free, non-invasive characterization of 3D tumor spheroids
      ...eroids, being developed for regenerative medicine and drug discovery studies.

      Washington University Receives a 2021 NIH Grant for $347,287 for High throughput optical coherence tomography ...

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  2. About Washington University in St. Louis

    Washington University in St. Louis

    Washington University in St. Louis is a private research university located in St. Louis, Missouri. Founded in 1853 and named for George Washington. Twenty-two Nobel laureates have been associated with Washington University, nine doing the major part of their pioneering research at the university Washington University.

    Optical Imaging Laboratory at Washington University in St. Louis, a research laboratory dedicated to the development of novel non-ionizing imaging technologies with biomedical applications directed by Lihong Wang, Ph.D.