1. Wanrong Gao

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    1. Mentioned In 22 Articles

    2. Quantitative depth resolved microcirculation imaging with optical coherence tomography angiography (Part Ι): Blood flow velocity imaging

      Quantitative depth resolved microcirculation imaging with optical coherence tomography angiography (Part Ι): Blood flow velocity imaging
      The research goal of the microvascular network imaging with optical coherence tomography (OCT) angiography is to achieve depth resolved blood flow and vessel imaging in vivo in the clinical management of patents. In this review, we review the main phenomena that have been explored in OCT to image the blood flow velocity vector and the vessels of the microcirculation within living tissues. Parameters that limit the accurate measurements of blood ...
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    3. Quantitative depth resolved microcirculation imaging with optical coherence tomography angiography (Part ΙΙ): Microvascular network imaging

      Quantitative depth resolved microcirculation imaging with optical coherence tomography angiography (Part ΙΙ): Microvascular network imaging
      In this work, we review the main phenomena that have been explored in OCT angiography to image the vessels of the microcirculation within living tissues with the emphasis on how the different processing algorithms were derived to circumvent specific limitations. Parameters are then discussed that can quantitatively describe the depth-resolved microvascular network for possible clinic diagnosis applications. Finally,future directions in continuing OCT development are discussed.
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    4. High speed, wide velocity dynamic range Doppler optical coherence tomography (Part V): Optimal utilization of multi-beam scanning for Doppler and speckle variance microvascular imaging

      High speed, wide velocity dynamic range Doppler optical coherence tomography (Part V): Optimal utilization of multi-beam scanning for Doppler and speckle variance microvascular imaging
      In this paper, a multi-beam scanning technique is proposed to optimize the microvascular images of human skin obtained with Doppler effect based methods and speckle variance processing. Flow phantom experiments were performed to investigate the suitability for combining multi-beam data to achieve enhanced microvascular imaging. To our surprise, the highly variable spot sizes (ranging from 13 to 77 m) encountered in high numerical aperture multi-beam OCT system imaging the same ...
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    5. Multi-beam optical coherence tomography for microvascular imaging of human skin in vivo

      Multi-beam optical coherence tomography for microvascular imaging of human skin in vivo
      In this paper, a multi-beam optical coherence tomography (OCT) was used to reconstruct the microvascular image of human skin in vivo with phase resolved Doppler OCT (PRDOCT), phase resolved Doppler variance (PRDV) and speckle variance OCT (svOCT), in which the blood flow image was calculated by averaging the four blood flow images obtained by the four beams. In PRDOCT method, it is difficult to detect the blood flow perpendicular to ...
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    6. Differential standard deviation of log-scale intensity based optical coherence tomography angiography

      Differential standard deviation of log-scale intensity based optical coherence tomography angiography
      In this paper, a differential standard deviation of log-scale intensity (DSDLI) based optical coherence tomography angiography (OCTA) is presented for calculating microvascular images of human skin. The DSDLI algorithm calculates the variance in difference images of two consecutive log-scale intensity based structural images from the same position along depth direction to contrast blood flow. The en face microvascular images were then generated by calculating the standard deviation of the differential ...
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    7. Dispersion analysis in micron resolution spectral domain optical coherence tomography

      Dispersion analysis in micron resolution spectral domain optical coherence tomography
      One of the main factors that limits the effective axial resolution of spectral domain optical coherence tomography in live tissue imaging is tissue-induced dispersion. In this work, first the methods are reviewed that have been proposed to compensate for the dispersion effects in various applications. Simple formulas are then derived that can be used to estimate the orders of the dispersion that may have significant influences. The formulas are then ...
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    8. Fractal analysis of en face tomographic images obtained with full field optical coherence tomography

      Fractal analysis of en face tomographic images obtained with full field optical coherence tomography
      The quantitative modeling of the imaging signal of pathological areas and healthy areas is necessary to improve the specificity of diagnosis with tomographic en face images obtained with full field optical coherence tomography (FFOCT). In this work, we propose to use the depth-resolved change in the fractal parameter as a quantitative specific biomarker of the stages of disease. The idea is based on the fact that tissue is a random ...
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    9. Imaginary part-based correlation mapping optical coherence tomography for imaging of blood vessels in vivo

      Imaginary part-based correlation mapping optical coherence tomography for imaging of blood vessels in vivo
      We present an imaginary part-based correlation mapping optical coherence tomography (IMcmOCT) technique for in vivo blood vessels imaging. In the conventional correlation mapping optical coherence tomography (cmOCT) method, two adjacent frames of intensity-based structural images are correlated to extract blood flow information and the size of correlation window has to be increased to improve the signal-to-noise ratio of microcirculation maps, which may cause image blur and miss the small blood ...
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    10. Rapid and high-resolution imaging of human liver specimens by full-field optical coherence tomography

      Rapid and high-resolution imaging of human liver specimens by full-field optical coherence tomography
      We report rapid and high-resolution tomographic en face imaging of human liver specimens by full-field optical coherence tomography (FF-OCT). First, the arrangement of the FF-OCT system was described and the performance of the system was measured. The measured axial and lateral resolutions of the system are 0.8 and 0.9 m , respectively. The system has a sensitivity of 60 dB and can achieve an imaging rate of 7 fps ...
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    11. Image contrast reduction mechanism in full-field optical coherence tomography

      Image contrast reduction mechanism in full-field optical coherence tomography
      Correct interpretation of image contrast obtained with full-field optical coherence tomography (FFOCT) technique is required for accurate medical diagnosis applications. In this work, first, the characteristics of microscopic structures of tissue that generate the contrast in en-face tomographic image obtained with FFOCT are discussed. Then an overview is given of the parameters that affect image contrast. Finally, the contrast correction factor for correct image interpretation and the contrast limits to ...
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    12. Stage-based frequency-modulated full-range complex Fourier-domain optical coherence tomography

      Stage-based frequency-modulated full-range complex Fourier-domain optical coherence tomography
      We propose a simple method to modulate spatial interferogram to achieve full-range complex imaging in Fourier-domain optical coherence tomography, in which a sample stage is employed which can be adjusted to introduce a constant carrier frequency into the interference signal during the B-scan by adjusting the stage angle with respect to the normal to the object under test. An additional phase, which is linearly related to the lateral position, is ...
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    13. Fourier spectrum analysis of full-field optical coherence tomography for tissue imaging

      Fourier spectrum analysis of full-field optical coherence tomography for tissue imaging
      We propose a model of the full-field optical coherence tomography (FFOCT) technique for tissue imaging, in which the fractal model of the spatial correlation function of the refractive index of tissue is employed to approximate tissue structure. The results may be helpful for correctly interpreting en face tomographic images obtained with FFOCT.
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    14. The cross-correlation in spectral domain based Doppler optical coherence tomography

      The cross-correlation in spectral domain based Doppler optical coherence tomography
      We propose a cross-correlation method which is based on the cross-correlation of two adjacent A-scans of interferogram fringe for imaging the velocities of the blood flowing in vessels. The method was tested by measurements of the velocities of flowing particles within a glass capillary with known mean velocities. Mean standard deviations of flow velocities of the particles determined through the proposed method were compared to those by the conventional phase ...
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    15. 1-15 of 22 1 2 »
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  2. About Wanrong Gao

    Wanrong Gao is with the Department of Optical Engineering at Nanjing University of Science and Technology.