1. Wang Yuhl Oh

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    1. Mentioned In 46 Articles

    2. High-speed optical coherence tomography angiography for the measurement of stimulus-induced retrograde vasodilation of cerebral pial arteries in awake mice

      High-speed optical coherence tomography angiography for the measurement of stimulus-induced retrograde vasodilation of cerebral pial arteries in awake mice
      Significance: Having a clear understanding of functional hyperemia is crucial for functional brain imaging and neurological disease research. Vasodilation induced by sensory stimulus propagates from the arterioles to the upstream pial arteries in a retrograde fashion. As retrograde vasodilation occurs briefly in the early stage of functional hyperemia, an imaging technique with a high temporal resolution is required for its measurement. Aim: We aimed to present an imaging method to ...
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    3. In vivo imaging of the hyaloid vascular regression and retinal and choroidal vascular development in rat eyes using optical coherence tomography angiography

      In vivo imaging of the hyaloid vascular regression and retinal and choroidal vascular development in rat eyes using optical coherence tomography angiography
      This study investigates the hyaloid vascular regression and its relationship to the retinal and choroidal vascular developments using optical coherence tomography angiography (OCTA). Normal and oxygen-induced retinopathy (OIR) rat eyes at postnatal day 15, 18, 21, and 24 were longitudinally imaged using OCTA. At each day, two consecutive imaging for visualizing the hyaloid vasculature and the retinal and choroidal vasculatures were conducted. The hyaloid vessel volume and the retinal and ...
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    4. 9.4 MHz A-line rate optical coherence tomography at 1300 nm using a wavelength-swept laser based on stretched-pulse active mode-locking

      9.4 MHz A-line rate optical coherence tomography at 1300 nm using a wavelength-swept laser based on stretched-pulse active mode-locking
      In optical coherence tomography (OCT), high-speed systems based at 1300nm are among the most broadly used. Here, we present 9.4 MHz A-line rate OCT system at 1300nm. A wavelength-swept laser based on stretched-pulse active mode locking (SPML) provides a continuous and linear-in-wavenumber sweep from 1240nm to 1340nm, and the OCT system using this light source provides a sensitivity of 98dB and a single-sided 6-dB roll-off depth of 2.5mm ...
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    5. Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix

      Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix
      ...scattering media systems,” IEEE Photonics J. 10(2), 1–12 (2018). [Crossref] N. Lippok, B. Braaf, M. Villiger, W. Y. Oh, B. J. Vakoc, and B. E. Bouma, “Quantitative depolarization measurements for fiber-based polarization...
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    6. Retinal Blood Vessel Caliber Estimation for Optical Coherence Tomography Angiography Images Based on 3D Superellipsoid Modeling

      Retinal Blood Vessel Caliber Estimation for Optical Coherence Tomography Angiography Images Based on 3D Superellipsoid Modeling
      Changes of retinal blood vessel calibers may reflect various retinal diseases and even several non-retinal diseases. We propose a new method to estimate retinal vessel calibers from 3D optical coherence tomography angiography (OCTA) images based on 3D modeling using superellipsoids. Taking advantage of 3D visualization of the retinal tissue microstructures in vivo provided by OCTA, our method can detect retinal blood vessels precisely, estimate their calibers reliably, and show the ...
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    7. Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

      Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration
      Choriocapillary loss is a major cause of neovascular age-related macular degeneration (NV-AMD). Although vascular endothelial growth factor (VEGF) blockade for NV-AMD has shown beneficial outcomes, unmet medical needs for patients refractory or tachyphylactic to anti-VEGF therapy exist. In addition, the treatment could exacerbate choriocapillary rarefaction, necessitating advanced treatment for fundamental recovery from NV-AMD. In this study, Tie2 activation by angiopoietin-2binding and Tie2-activating antibody (ABTAA) presents a therapeutic strategy for NV-AMD ...
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    8. Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging

      Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging
      Comprehensive imaging of both the structural and biochemical characteristics of atherosclerotic plaque is essential for the diagnosis and study of coronary artery disease because both a plaques morphology and its biochemical composition affect the level of risk it poses. Optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIm) are promising optical imaging methods for characterizing coronary artery plaques morphologically and biochemically, respectively. In this study, we present a hybrid intravascular ...
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    9. Quantitative depolarization measurements for fiber‐based polarization‐sensitive optical frequency domain imaging of the retinal pigment epithelium

      Quantitative depolarization measurements for fiber‐based polarization‐sensitive optical frequency domain imaging of the retinal pigment epithelium
      A full quantitative evaluation of the depolarization of light may serve to assess concentrations of depolarizing particles in the retinal pigment epithelium and to investigate their role in retinal diseases in the human eye. Optical coherence tomography (OCT) and optical frequency domain imaging (OFDI) use spatial incoherent averaging to compute depolarization. Depolarization depends on accurate measurements of the polarization states at the receiver but also on the polarization state incident ...
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    10. Wide dynamic range high-speed three-dimensional quantitative OCT angiography with a hybrid-beam scan

      Wide dynamic range high-speed three-dimensional quantitative OCT angiography with a hybrid-beam scan
      We demonstrate a novel hybrid-beam scanning-based quantitative optical coherence tomography angiography (OCTA) that provides high-speed wide dynamic range blood flow speed imaging. The hybrid-beam scanning scheme enables multiple OCTA image acquisitions with a wide range of multiple time intervals simultaneously providing wide dynamic range blood flow speed imaging independent of the blood vessel orientation, which was quantified over a speed range of 0.6 104 mm / s 0.6104mm/s ...
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    11. Multispectral analog-mean-delay fluorescence lifetime imaging combined with optical coherence tomography

      Multispectral analog-mean-delay fluorescence lifetime imaging combined with optical coherence tomography
      The pathophysiological progression of chronic diseases, including atherosclerosis and cancer, is closely related to compositional changes in biological tissues containing endogenous fluorophores such as collagen, elastin, and NADH, which exhibit strong autofluorescence under ultraviolet excitation. Fluorescence lifetime imaging (FLIm) provides robust detection of the compositional changes by measuring fluorescence lifetime, which is an inherent property of a fluorophore. In this paper, we present a dual-modality system combining a multispectral analog-mean-delay ...
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    12. Comparison of Accuracy of One Use Methods for Calculating Fractional Flow Reserve by Intravascular Optical Coherence Tomography to That Determined by the Pressure-Wire Method

      Comparison of Accuracy of One Use Methods for Calculating Fractional Flow Reserve by Intravascular Optical Coherence Tomography to That Determined by the Pressure-Wire Method
      While identification of hemodynamic significance of coronary lesions becomes important for revascularization strategy, the potential role of three-dimensional high-resolution intracoronary Optical coherence tomography (OCT) for predicting functional significance of coronary lesions remains unclear. We assessed the diagnostic performance of two computational approaches for deriving fractional flow reserve (FFR) from intravascular OCT images. We developed two methods to derive FFR from volumetric OCT images by applying analytical fluid dynamics (FFR-OCTAFD) and ...
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    13. Intravascular optical coherence tomography [Invited]

      Intravascular optical coherence tomography [Invited]
      Shortly after the first demonstration of optical coherence tomography for imaging the microstructure of the human eye, work began on developing systems and catheters suitable for intravascular imaging in order to diagnose and investigate atherosclerosis and potentially to monitor therapy. This review covers the driving considerations of the clinical application and its constraints, the major engineering milestones that enabled the current, high-performance commercial imaging systems, the key studies that laid ...
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    14. Plasma treatment effect on angiogenesis in wound healing process evaluated in vivo using angiographic optical coherence tomography

      Plasma treatment effect on angiogenesis in wound healing process evaluated in vivo using angiographic optical coherence tomography
      Non-thermal atmospheric pressure plasma holds promise for promoting wound healing. However, plasma-induced angiogenesis, which is important to better understand the underlying physics of plasma treatment effect on wound healing, remains largely unknown. We therefore evaluated the effect of non-thermal plasma on angiogenesis during wound healing through longitudinal monitoring over 30 days using non-invasive angiographic optical coherence tomography imaging in vivo . We demonstrate that the plasma-treated vascular wound area of mouse ...
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    15. Imaging Laser-Induced Choroidal Neovascularization in the Rodent Retina Using Optical Coherence Tomography Angiography

      Imaging Laser-Induced Choroidal Neovascularization in the Rodent Retina Using Optical Coherence Tomography Angiography
      Purpose : The purpose of this study was to evaluate the performance of optical coherence tomography angiography (OCTA) in visualizing laser-induced choroidal neovascularization (CNV) in the rodent retina. Methods : Choroidal neovascularization was induced via laser photocoagulation in 2 male Brown Norway rats and 2 male C57BL/6 mice. For qualitative comparison, the animals were imaged in vivo with OCTA, indocyanine green angiography (ICGA), and fluorescein angiography (FA), and ex vivo with ...
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    16. 1-15 of 46 1 2 3 »
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  2. About Wang Yuhl Oh

    Wang Yuhl Oh

    Wang Yuhl Oh is an Associate Professor Dept. of Mechanical Engineering, KAIST.

  3. Quotes

    1. The newly-developed system proved to be a world-class blood vessel endoscope system, since we succeeded in scanning a blood vessel of a rabbit, which is similar to that of a human.” He added, “We will do our best to make sure that this technology can be used in patients within a few years through further research. For example, we are planning to scan the coronary arteries of a certain animal, whose heart is similar in size vis-à-vis the human heart, during the first half of this year.
      In Korea Research Team Develops Tech for 3D Blood Vessel Endoscope