Optical coherence tomography (OCT) is a high-resolution intracoronary arterial imaging modality. We describe two patients who were admitted to undergo coronary angiography (CAG) and OCT for follow-up of Kawasaki disease (KD) with coronary artery aneurysms. OCT clearly demonstrated thrombus, stenosis, fibrotic intimal thickening with lamellar calcification and partial disappearance of the tunica media at the aneurysm site. In addition, focal calcification, intimal thickening and medial irregularity were observed even in regions of coronary arterial walls that appeared to be normal by CAG. OCT is useful for evaluating coronary arterial sequelae of KD.

Objective Although monocytes appear to be actively involved in the onset of acute coronary syndrome (ACS), they are heterogenous in human peripheral blood. How up-regulation of monocyte subsets leads to coronary plaque rupture followed by thrombus formation remains unclear. Recent studies have shown that P-selectin glycoprotein ligand-1 (PSGL-1) is involved in monocyte activation in patients with thrombus formation. We therefore investigated the relationship between the expression of PSGL-1 on monocyte subsets and thrombus formation using frequency-domain optical coherence tomography (FD-OCT) in patients with ACS. Methods We enrolled a total of 100 individuals in this study: patients with acute myocardial infarction ...

IVUS Versus Angiography Guidance for DES PlacementFirst Author/Study (Ref. #), Year (Study)nStudy PopulationStudy DesignIVUS Criteria for Optimal ExpansionCriteria FulfilledMain Outcome MeasuresResultsRoy et al. (2), 20081,768De novo native coronary lesions, restenotic and SVG lesionsSingle-center registryDiscretion of the treating operator—Definite stent thrombosis and MACE at 12 monthsIVUS better (stent thrombosis and TLR)Classen et al. (3), 2011 (MATRIX)1,504 (SES)De novo native coronary and restenotic lesionsMulticenter registryDiscretion of the treating operator—30-day, 1-yr, and 2-yr rates of death/MI, MACE, and stent thrombosisIVUS betterPark et al. (4), 2009682Left main lesionsMulticenter registryDiscretion of the treating operator3-yr mortalityIVUS betterChieffo ...

We have grown monolithic multi-color InAs quantum dots (QDs) for use as a near-infrared (NIR) broadband light source. Our previously developed rotational metal mask enables selective-area growth of QD ensembles with emission peak wavelengths controlled by strain-reducing layers thicknesses, varying the emission approximately 1.2–1.3  μ m. The peak shift value was up to 120 nm, and a combined 160-nm-bandwidth emission spectrum was achieved. Further, the emission spectra shapes were controlled using specific optical excitation powers for each QD ensemble. These results demonstrate the effectiveness of multi-color QDs as a spectrum-shape-controllable NIR broadband light source, particularly suited for optical ...

Frequency-domain optical coherence tomography (FD-OCT) is a novel technology which provides high-resolution cross-sectional images of coronary arteries. The aim of this study was to evaluate the inter-scan reproducibility of geometric FD-OCT measurements in the clinical setting. We examined 20 coronary lesions using FD-OCT. Following the FD-OCT image acquisition (1 st pullback), and after the disengagement and re-engagement of the guiding catheter, an additional acquisition (2 nd pullback) was performed using a new FD-OCT catheter. There was excellent correlation for minimum lumen area ( r = 0.99, P < 0.001), lesion length ( r = 0.99, P < 0.001) and lumen volume ( r ...

St. Jude Medical Press Release - St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced the launch of its ILUMIEN ™ OPTIS ™ System, a next-generation technology designed to help physicians make personalized stenting decisions based on each patient’s unique anatomy and disease state. The new ILUMIEN OPTIS system remains the only combined Fractional Flow Reserve (FFR) and intravascular Optical Coherence Tomography (OCT) imaging technology platform. Together, FFR and OCT offer physicians a physiological and anatomical view of the coronary vessels to help diagnose and treat coronary artery disease. The ILUMIEN OPTIS system provides enhancements to the ILUMIEN ...