1. VU University Amsterdam

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    1. Mentioned In 103 Articles

    2. Computational-imaging-based optical coherence tomography in time- and frequency-domain

      Computational-imaging-based optical coherence tomography in time- and frequency-domain
      A computational 3D imaging system is developed that enables polychromatic, depth-resolved, diffraction-limited imaging of semi-transparent objects. By combining coherent diffractive imaging (CDI) and optical coherence tomography (OCT), we reconstruct tomographic images of 3D objects from a set of wavelength- and phase-resolved diffraction patterns, using numerical methods to achieve image quality beyond the hardware limits of the optical systems used. We implement both time- and frequency-domain versions of full-field OCT systems ...
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    3. Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography

      Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography
      rcis: Neuroretinal rim minimum distance band (MDB) thickness is significantly lower in older subjects and African Americans compared with whites. It is similar in both sexes. Purpose: To evaluate the relationship between age, race, and sex with the neuroretinal rim using high-density spectral-domain optical coherence tomography optic nerve volume scans of normal eyes. Methods: A total of 256 normal subjects underwent Spectralis spectral-domain optical coherence tomography optic nerve head volume ...
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    4. Analysis of Neuroretinal Rim by Age, Race, and Gender Using High-Density Three-Dimensional Spectral Domain Optical Coherence Tomography

      Analysis of Neuroretinal Rim by Age, Race, and Gender Using High-Density Three-Dimensional Spectral Domain Optical Coherence Tomography
      Prcis: Neuroretinal rim minimum distance band thickness is significantly lower in older subjects and African Americans compared to Caucasians. It is similar in both genders. Purpose: To evaluate the relationship between age, race, and gender with the neuroretinal rim using high-density spectral domain optical coherence tomography (SD-OCT) optic nerve volume scans of normal eyes. Methods: 256 normal subjects underwent Spectralis (Heidelberg Engineering, Heidelberg, Germany) SD-OCT optic nerve head volume scans ...
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    5. Optical coherence tomography velocimetry based on decorrelation estimation of phasor pair ratios (DEPPAIR)

      Optical coherence tomography velocimetry based on decorrelation estimation of phasor pair ratios (DEPPAIR)
      Quantitative velocity estimations in optical coherence tomography requires the estimation of the axial and lateral flow components. Optical coherence tomography measures the depth resolved complex field reflected from a sample. While the axial velocity component can be determined from the Doppler shift or phase shift between a pair of consecutive measurements at the same location, the estimation of the lateral component for in vivo applications is still challenging. One approach ...
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    6. Optic axis uniformity as a metric to improve the contrast of birefringent structures and analyze the retinal nerve fiber layer in polarization-sensitive optical coherence tomography

      Optic axis uniformity as a metric to improve the contrast of birefringent structures and analyze the retinal nerve fiber layer in polarization-sensitive optical coherence tomography
      A new metric is used to improve the contrast of birefringent structures in biological tissue using polarization-sensitive optical coherence tomography. This metric, optic axis uniformity (OAxU), is based on the optic axis of birefringence and quantifies the uniformity of the optic axis direction. OAxU provides surprisingly strong contrast for fibrous structures such as muscle and the retinal nerve fiber layer (RNFL). We used OAxU for automatic segmentation of the RNFL ...
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    7. Three-Dimensional Optical Coherence Tomography Imaging for Glaucoma Associated with Boston Keratoprosthesis Type I and II

      Three-Dimensional Optical Coherence Tomography Imaging for Glaucoma Associated with Boston Keratoprosthesis Type I and II
      Precis: 3D spectral domain OCT volume scans of the optic nerve head and the peripapillary area are useful in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro). Purpose: To report the use of spectral domain optical coherence tomography (OCT) in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro). Methods: Observational case series. Four consecutive patients with ...
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    8. Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software

      Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software
      Prcis: The diagnostic capability of peripapillary retinal volume is similar to peripapillary retinal nerve fiber layer thickness for diagnosing glaucoma, but with fewer artifacts. Purpose: To compare the diagnostic capability of three-dimensional (3D) peripapillary retinal volume (RV) versus two-dimensional (2D) peripapillary retinal nerve fiber layer (RNFL) thickness for open-angle glaucoma . Patients and Methods: A retrospective cross-sectional analysis was conducted. A total of 180 subjects [113 open-angle glaucomas (OAG), 67 normal ...
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    9. In vivo multifunctional optical coherence tomography at the periphery of the lungs

      In vivo multifunctional optical coherence tomography at the periphery of the lungs
      Remodeling of tissue, such as airway smooth muscle (ASM) and extracellular matrix, is considered a key feature of airways disease. No clinically accepted diagnostic method is currently available to assess airway remodeling or the effect of treatment modalities such as bronchial thermoplasty in asthma, other than invasive airway biopsies. Optical coherence tomography (OCT) generates cross-sectional, near-histological images of airway segments and enables identification and quantification of airway wall layers based ...
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    10. Classification and treatment follow-up of a juxtapapillary retinal hemangioblastoma with optical coherence tomography angiography

      Classification and treatment follow-up of a juxtapapillary retinal hemangioblastoma with optical coherence tomography angiography
      Purpose Only an endophytic growth pattern in juxtapapillary retinal hemangioblastoma (JRH) is an indication for surgical treatment, but classification of growth types is difficult using conventional imaging techniques. This case report describes the use of optical coherence tomography angiography (OCT-A) features for classification and treatment follow-up in a case with JRH. Observations The JRH of this patient was easily detected with two different OCT-A methods in both en-face and cross-sectional ...
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    11. Optical coherence tomography to detect acute esophageal radiation-induced damage in mice: a validation study

      Optical coherence tomography to detect acute esophageal radiation-induced damage in mice: a validation study
      Radiation therapy for patients with non-small-cell lung cancer is hampered by acute radiation-induced toxicity in the esophagus. This study aims to validate that optical coherence tomography (OCT), a minimally invasive imaging technique with high resolution (~10 m), is able to visualize and monitor acute radiation-induced esophageal damage (ARIED) in mice. We compare our findings with histopathology as the gold standard. Irradiated mice receive a single dose of 40 Gy at ...
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    12. Micro-indentation and optical coherence tomography for the mechanical characterization of embryos: Experimental setup and measurements on fixed chicken embryos.

      Micro-indentation and optical coherence tomography for the mechanical characterization of embryos: Experimental setup and measurements on fixed chicken embryos.
      The investigation of the mechanical properties of embryos is expected to provide valuable information on the phenomenology of morphogenesis. It is thus believed that, by mapping the viscoelastic features of an embryo at different stages of growth, it may be possible to shed light on the role of mechanics in embryonic development. To contribute to this field, we present a new instrument that can determine spatiotemporal distributions of mechanical properties ...
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    13. Precision analysis and optimization in phase decorrelation OCT velocimetry

      Precision analysis and optimization in phase decorrelation OCT velocimetry
      Quantitative flow velocimetry in Optical Coherence Tomography is used to determine both the axial and lateral flow component at the level of individual voxels. The lateral flow is determined by analyzing the statistical properties of reflected electro-magnetic fields for repeated measurements at (nearly) the same location. The precision or statistical fluctuation of the quantitative velocity estimation depends on the number of repeated measurements and the method to determine quantitative flow ...
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    14. Micro-indentation and optical coherence tomography for the mechanical characterization of embryos

      Micro-indentation and optical coherence tomography for the mechanical characterization of embryos
      The investigation of the mechanical properties of embryos is expected to provide valuable information on the phenomenology of morphogenesis. It is thus believed that, by mapping the viscoelastic features of an embryo at different stages of growth, it may be possible to shed light on the role of mechanics in embryonic development. To contribute to this field, we present a new instrument that can determine spatiotemporal distributions of mechanical properties ...
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    15. On-chip polarization beam splitter design for optical coherence tomography

      On-chip polarization beam splitter design for optical coherence tomography
      Polarization beam splitters (PBSs) are central elements for polarization handling. Here, we present the design of an ultra-broadband, low-loss, and easy-to-fabricate PBS based on a silicon nitride asymmetrical directional coupler for polarization-sensitive optical coherence tomography systems. The phase difference between transverse electric and transverse magnetic modes is introduced by using straight waveguides with different widths and an offset between them. A bent waveguide is placed close to the end of ...
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  2. About VU University Amsterdam

    VU University Amsterdam

    VU University Amsterdam (Vriju Universiteit) aims to be inspiring, innovative and involved. Inspiring: VU University Amsterdam is working hard to ensure that all of its courses rank among the best in the country. VU University Amsterdam offers an inspiring study environment capable of providing students with the most suitable course for their needs.

    Innovative: VU University Amsterdam stands for high quality, fundamental, innovative and socially oriented research. The university has several leading research groups, all of which enjoy international recognition. In recent years, capacity and expertise have been pooled in large-scale programmes, enabling interactions between different disciplines to be exploited to the full.

    Involved: VU's origins are rooted in the Christian faith. This is why we attach such great importance to our social role. We take the view that academic work cannot be divorced from the concerns of society, in terms of standards, values, philosophy and religio