1. VU University Amsterdam

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    1. Mentioned In 110 Articles

    2. In Vivo 3D Determination of Peripapillary Scleral and Retinal Layer Architecture Using Polarization-Sensitive Optical Coherence Tomography

      In Vivo 3D Determination of Peripapillary Scleral and Retinal Layer Architecture Using Polarization-Sensitive Optical Coherence Tomography
      Purpose : The purpose of this paper was to determine the architecture of the collagen fibers of the peripapillary sclera, the retinal nerve fiber layer (RNFL), and Henle's fiber layer in vivo in 3D using polarization-sensitive optical coherence tomography (PS-OCT). Methods : Seven healthy volunteers were imaged with our in-house built PS-OCT system. PS-OCT imaging included intensity, local phase retardation, relative optic axis, and optic axis uniformity (OAxU). Differential Mueller matrix ...
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    3. Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography

      Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography
      Purpose : To compare the rates of clinically significant artifacts for two-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness versus three-dimensional (3D) neuroretinal rim thickness using spectral-domain optical coherence tomography (SD-OCT). Methods : Only one eye per patient was used for analysis of 120 glaucoma patients and 114 normal patients. For RNFL scans and optic nerve scans, 15 artifact types were calculated per B-scan and per eye. Neuroretinal rim tissue was quantified ...
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    4. Subretinal Fibrosis Detection Using Polarization Sensitive Optical Coherence Tomography

      Subretinal Fibrosis Detection Using Polarization Sensitive Optical Coherence Tomography
      Purpose : Subretinal fibrosis (SRFib) is an important cause of permanent loss-of-vision diseases with submacular neovascularization, but a reliable diagnostic method is currently missing. This study uses polarization-sensitive optical coherence tomography (PS-OCT) to detect SRFib within retinal lesions by measurement of its birefringent collagen fibers. Methods : Twenty-five patients were enrolled with retinal pathology in one or both eyes containing (1) suspected SRFib, (2) lesions suspected not to be fibrotic, or (3 ...
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    5. Toward clinical elastography of dermal tissues: A medical device to probe skin’s elasticity through suction, with subsurface imaging via optical coherence tomography

      Toward clinical elastography of dermal tissues: A medical device to probe skin’s elasticity through suction, with subsurface imaging via optical coherence tomography
      ABSTRACT The mechanical behavior of dermal tissues is unarguably recognized for its diagnostic ability and in the last decades received a steadily increasing interest in dermatology practices. Among the various methods to investigate the mechanics of skin in clinical environments, suction-based ones are especially noteworthy, thanks to their qualities of minimal invasiveness and relative simplicity of setups and data analysis. In such experiments, structural visualization of the sample is highly ...
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    6. Detailed optical coherence tomography angiographic short‐term response of type 3 neovascularization to combined treatment with photodynamic therapy and intravitreal bevacizumab

      Detailed optical coherence tomography angiographic short‐term response of type 3 neovascularization to combined treatment with photodynamic therapy and intravitreal bevacizumab
      Purpose To explore the short‐term vascular and structural changes of type 3 neovascularization using optical coherence tomography angiography (OCT‐A) when treated with a combination of photodynamic therapy (PDT) and intravitreal bevacizumab (IVB), and to evaluate the course of different sequences of the combined therapies. Methods Thirty eyes of 29 treatment‐nave patients with a type 3 neovascularization were included in this prospective observational cohort study. They were all ...
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    7. In vivo characterization of chick embryo mesoderm by optical coherence tomography assisted microindentation

      In vivo characterization of chick embryo mesoderm by optical coherence tomography assisted microindentation
      Embryos are growing organisms with highly heterogeneous properties in space and time. Understanding the mechanical properties is a crucial prerequisite for the investigation of morphogenesis. During the last ten years, new techniques have been developed to evaluate the mechanical properties of biological tissues in vivo . To address this need, we employed a new instrument that, via the combination of micro-indentation with Optical Coherence Tomography (OCT), allows us to determine both ...
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    8. Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Retinal Nerve Fiber Layer Volume

      Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Retinal Nerve Fiber Layer Volume
      Purpose : To compare artifact rates in two-dimensional (2D) versus three-dimensional (3D) retinal nerve fiber layer (RNFL) scans using Spectralis optical coherence tomography (OCT) Methods : Thirteen artifact types in 2D and 3D RNFL scans were identified in 106 glaucomatous eyes and 95 normal eyes. Artifact rates were calculated per B-scan and per eye. In 3D volume scans, artifacts were counted only for the 97 B-scans used to calculate RNFL parameters for ...
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    9. Computational-imaging-based optical coherence tomography in time- and frequency-domain

      Computational-imaging-based optical coherence tomography in time- and frequency-domain
      A computational 3D imaging system is developed that enables polychromatic, depth-resolved, diffraction-limited imaging of semi-transparent objects. By combining coherent diffractive imaging (CDI) and optical coherence tomography (OCT), we reconstruct tomographic images of 3D objects from a set of wavelength- and phase-resolved diffraction patterns, using numerical methods to achieve image quality beyond the hardware limits of the optical systems used. We implement both time- and frequency-domain versions of full-field OCT systems ...
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    10. Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography

      Analysis of Neuroretinal Rim by Age, Race, and Sex Using High-Density 3-Dimensional Spectral-Domain Optical Coherence Tomography
      rcis: Neuroretinal rim minimum distance band (MDB) thickness is significantly lower in older subjects and African Americans compared with whites. It is similar in both sexes. Purpose: To evaluate the relationship between age, race, and sex with the neuroretinal rim using high-density spectral-domain optical coherence tomography optic nerve volume scans of normal eyes. Methods: A total of 256 normal subjects underwent Spectralis spectral-domain optical coherence tomography optic nerve head volume ...
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    11. Analysis of Neuroretinal Rim by Age, Race, and Gender Using High-Density Three-Dimensional Spectral Domain Optical Coherence Tomography

      Analysis of Neuroretinal Rim by Age, Race, and Gender Using High-Density Three-Dimensional Spectral Domain Optical Coherence Tomography
      Prcis: Neuroretinal rim minimum distance band thickness is significantly lower in older subjects and African Americans compared to Caucasians. It is similar in both genders. Purpose: To evaluate the relationship between age, race, and gender with the neuroretinal rim using high-density spectral domain optical coherence tomography (SD-OCT) optic nerve volume scans of normal eyes. Methods: 256 normal subjects underwent Spectralis (Heidelberg Engineering, Heidelberg, Germany) SD-OCT optic nerve head volume scans ...
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    12. Optical coherence tomography velocimetry based on decorrelation estimation of phasor pair ratios (DEPPAIR)

      Optical coherence tomography velocimetry based on decorrelation estimation of phasor pair ratios (DEPPAIR)
      Quantitative velocity estimations in optical coherence tomography requires the estimation of the axial and lateral flow components. Optical coherence tomography measures the depth resolved complex field reflected from a sample. While the axial velocity component can be determined from the Doppler shift or phase shift between a pair of consecutive measurements at the same location, the estimation of the lateral component for in vivo applications is still challenging. One approach ...
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    13. Optic axis uniformity as a metric to improve the contrast of birefringent structures and analyze the retinal nerve fiber layer in polarization-sensitive optical coherence tomography

      Optic axis uniformity as a metric to improve the contrast of birefringent structures and analyze the retinal nerve fiber layer in polarization-sensitive optical coherence tomography
      A new metric is used to improve the contrast of birefringent structures in biological tissue using polarization-sensitive optical coherence tomography. This metric, optic axis uniformity (OAxU), is based on the optic axis of birefringence and quantifies the uniformity of the optic axis direction. OAxU provides surprisingly strong contrast for fibrous structures such as muscle and the retinal nerve fiber layer (RNFL). We used OAxU for automatic segmentation of the RNFL ...
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    14. Three-Dimensional Optical Coherence Tomography Imaging for Glaucoma Associated with Boston Keratoprosthesis Type I and II

      Three-Dimensional Optical Coherence Tomography Imaging for Glaucoma Associated with Boston Keratoprosthesis Type I and II
      Precis: 3D spectral domain OCT volume scans of the optic nerve head and the peripapillary area are useful in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro). Purpose: To report the use of spectral domain optical coherence tomography (OCT) in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro). Methods: Observational case series. Four consecutive patients with ...
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    15. Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software

      Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software
      Prcis: The diagnostic capability of peripapillary retinal volume is similar to peripapillary retinal nerve fiber layer thickness for diagnosing glaucoma, but with fewer artifacts. Purpose: To compare the diagnostic capability of three-dimensional (3D) peripapillary retinal volume (RV) versus two-dimensional (2D) peripapillary retinal nerve fiber layer (RNFL) thickness for open-angle glaucoma . Patients and Methods: A retrospective cross-sectional analysis was conducted. A total of 180 subjects [113 open-angle glaucomas (OAG), 67 normal ...
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  2. About VU University Amsterdam

    VU University Amsterdam

    VU University Amsterdam (Vriju Universiteit) aims to be inspiring, innovative and involved. Inspiring: VU University Amsterdam is working hard to ensure that all of its courses rank among the best in the country. VU University Amsterdam offers an inspiring study environment capable of providing students with the most suitable course for their needs.

    Innovative: VU University Amsterdam stands for high quality, fundamental, innovative and socially oriented research. The university has several leading research groups, all of which enjoy international recognition. In recent years, capacity and expertise have been pooled in large-scale programmes, enabling interactions between different disciplines to be exploited to the full.

    Involved: VU's origins are rooted in the Christian faith. This is why we attach such great importance to our social role. We take the view that academic work cannot be divorced from the concerns of society, in terms of standards, values, philosophy and religio