1. Vanderbilt University

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    1. Mentioned In 102 Articles

    2. New laser technique, backscattering interferometer, opens doors for drug discovery

      New laser technique, backscattering interferometer, opens doors for drug discovery
      A new laser technique has demonstrated it can measure the interactions between proteins tangled in a cell’s membrane and a variety of other biological molecules. These extremely difficult measurements can aid the process of drug discovery. Scientists estimate that about 30 percent of the 7,000 proteins in a human cell reside in the cell’s membrane, and that these membrane proteins initiate 60 to 70 percent of the ...
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    3. A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers

      A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers
      ...Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37212 College of Arts and Sciences, Vanderbilt University, Nashville, Tennessee 37235 Division of Dermatology, Department of Medicine, Vanderbilt ...
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    4. Integrated system for combined Raman spectroscopy–spectral domain optical coherence tomography

      Integrated system for combined Raman spectroscopy–spectral domain optical coherence tomography
      Raman spectroscopy (RS) and optical coherence tomography (OCT) are powerful tools for optical analysis of tissues with mutually complementary strengths and limitations. OCT excels at visualizing tissue microstructure but lacks molecular specificity, while RS can relay tissue biochemical composition but typically cannot relate microstructure. Previous implementations of combined RS-OCT have utilized a common sample arm while maintaining independent RS and OCT detection arms. We present the design and application of ...
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    5. Longitudinal optical imaging of tumor metabolism and hemodynamics

      Longitudinal optical imaging of tumor metabolism and hemodynamics
      An important feature of tumor hypoxia is its temporal instability, or “cycling hypoxia.” The primary consequence of cycling hypoxia is increased tumor aggressiveness and treatment resistance beyond that of chronic hypoxia. Longitudinal imaging of tumor metabolic demand, hemoglobin oxygen saturation, and blood flow would provide valuable insight into the mechanisms and distribution of cycling hypoxia in tumors. Fluorescence imaging of metabolic demand via the optical redox ratio (fluorescence intensity of ...
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    6. Structural and biochemical characterization of the rat retina with combined Raman spectroscopy-optical coherence tomography (RS-SDOCT)

      Structural and biochemical characterization of the rat retina with combined Raman spectroscopy-optical coherence tomography (RS-SDOCT)
      Raman spectroscopy (RS) and Optical Coherence Tomography (OCT) are powerful tools for optical analysis of tissues with complimentary strengths. OCT excels and visualizing tissue microstructure while RS can relay tissue biochemical composition. Both instruments have significant potential to serve as valuable tools in non-invasive characterization of the rodent models of retinal disease. In this abstract we present the design and application of a common detector combined RS-OCT instrument for evaluating ...
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    7. A clinical probe for combined Raman spectroscopy/optical coherence tomography (RS-OCT) of the skin cancers

      A clinical probe for combined Raman spectroscopy/optical coherence tomography (RS-OCT) of the skin cancers
      Skin cancer is the most commonly occurring cancer, with incidence rates rising annually. Realizing favorable outcomes requires early diagnosis, for which the current standard is biopsy followed by histopathology. This process can be invasive, subjective, time consuming, and costly. Optical techniques, including Optical Coherence Tomography (OCT) and Raman Spectroscopy (RS), have been developed to perform non-invasive characterization of skin lesions, however neither is without limitation. Here, we demonstrate a clinical ...
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    8. Calibration protocol for Fourier-domain OCT using optical fiber gratings

      Calibration protocol for Fourier-domain OCT using optical fiber gratings
      We present a calibration protocol to get the alignment factors of a custom-made spectrometer and the nonlinear fitting function between the measured CCD pixel domain and the wavelength domain to apply the Fourier-domain optical coherence tomography (FD-OCT) using optical fiber gratings. We have used 5 different center wavelength gratings covered the broadband source spectral range with a narrow spectral bandwidth (92 %) to calibrate and align the custom-made spectrometer. The implemented ...
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    9. New biophotonics techniques hold promise but need translation, say researchers at NIH-SPIE 'Bench to Bedside' workshop

      BETHESDA, Maryland, USA, and BELLINGHAM, Washington, USA -- Leading-edge advances such as a revolutionary cardiology treatment and noninvasive optical techniques for studying the brain combined with pragmatic discussions on research focus and funding highlighted a two-day inter-institute workshop last week at the National Institutes of Health (NIH) in Bethesda, Maryland. Approximately 350 preeminent researchers in biophotonics attended the workshop, titled "Optical Diagnostics and Biophotonic Methods from Bench to Bedside." Amir Gandjbakhche ...
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    10. Photothermal optical coherence tomography of epidermal growth factor receptor in live cells using immunotargeted gold nanospheres

      Molecular imaging is a powerful tool for investigating disease processes and potential therapies in both in vivo and in vitro systems. However, high resolution molecular imaging has been limited to relatively shallow penetration depths that can be accessed with microscopy. Optical coherence tomograp ... [Proc. SPIE 7168, 71680S (2009)] published Thu Feb 19, 2009.
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    11. Combined hyperspectral and spectral domain optical coherence tomography microscope for non-invasive hemodynamic imaging

      Melissa C. Skala, Hansford Hendargo, Andrew Fontanella et al. We have combined hyperspectral imaging with spectral domain optical coherence tomography (SDOCT) to non-invasively image changes in hemoglobin saturation, blood flow, microvessel morphology and sheer rate on the vessel wall with tumor growth. Changes in these hemodynamic variables were measured over ... [Proc. SPIE 7174, 71740I (2009)] published Thu Feb 12, 2009.
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    12. Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

      Combined Raman spectroscopy and optical coherence tomography device for tissue characterization
      We report a dual-modal device capable of sequential acquisition of Raman spectroscopy (RS) and optical coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous ...
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    13. 91-102 of 102 « 1 2 3 4 5 6 7
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  2. About Vanderbilt University

    Vanderbilt University

    Vanderbilt University is a private, nonsectarian, coeducational research university in Nashville, Tennessee, USA. Founded in 1873, the university is named for shipping and rail magnate "Commodore" Cornelius Vanderbilt, who provided Vanderbilt its initial $1 million endowment despite having never been to the South. The Commodore hoped that his gift and the greater work of the university would help to heal the sectional wounds inflicted by the Civil War.