1. Vanderbilt University

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    1. Mentioned In 57 Articles

    2. Advances in intraoperative optical coherence tomography for surgical guidance

      Advances in intraoperative optical coherence tomography for surgical guidance
      Translation of optical coherence tomography (OCT) technologies for intraoperative visualization enables in vivo micron-resolution imaging of subsurface tissue structures and image-guided clinical decision-making. Over the last decade, intraoperative OCT has evolved from two-dimensional imaging using handheld probes to include biopsy-needles for minimally invasive deep-tissue imaging, surgical instrumentation using optical feedback for tremor dampening and stabilization, and stereomicroscope integrated systems that provide real-time three- and four-dimensional visualization of surgical maneuvers. In ...
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    3. In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye

      In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye
      Optical coherence tomography (OCT) has become a standard-of-care in retinal imaging. OCT allows non-invasive imaging of the tissue structure but lacks specificity to contrast agents that could be used for in vivo molecular imaging. Photothermal OCT (PT-OCT) is a functional OCT-based technique that has been developed to detect absorbers in a sample. We demonstrate in vivo PT-OCT in the eye for the first time on both endogenous (melanin) and exogenous ...
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    4. Multi-Modality Imaging Enables Detailed Hemodynamic Simulations in Dissecting Aneurysms in Mice

      Multi-Modality Imaging Enables Detailed Hemodynamic Simulations in Dissecting Aneurysms in Mice
      A multi-modality imaging-based modeling approach was used to study complex unsteady hemodynamics and lesion growth in a dissecting abdominal aortic aneurysm model. We combined in vivo ultrasound (geometry and flow) and in vitro optical coherence tomography (OCT) (geometry) to obtain the high resolution needed to construct detailed hemodynamic simulations over large portions of the murine vasculature, which include fine geometric complexities. We illustrate this approach for a spectrum of dissecting ...
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    5. Multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography at 400 kHz

      Multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography at 400 kHz
      Multimodal imaging systems that combine scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) have demonstrated the utility of concurrent en face and volumetric imaging for aiming, eye tracking, bulk motion compensation, mosaicking, and contrast enhancement. However, this additional functionality trades off with increased system complexity and cost because both SLO and OCT generally require dedicated light sources, galvanometer scanners, relay and imaging optics, detectors, and control and digitization electronics ...
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    6. Multi-volumetric registration and mosaicking using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Multi-volumetric registration and mosaicking using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
      Ophthalmic diagnostic imaging using optical coherence tomography (OCT) is limited by bulk eye motions and a fundamental trade-off between field-of-view (FOV) and sampling density. Here, we introduced a novel multi-volumetric registration and mosaicking method using our previously described multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and OCT (SS-SESLO-OCT) system. Our SS-SESLO-OCT acquires an entire en face fundus SESLO image simultaneously with every OCT cross-section at 200 frames-per-second. In vivo human ...
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    7. Image-guided feedback for ophthalmic microsurgery using multimodal intraoperative swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Image-guided feedback for ophthalmic microsurgery using multimodal intraoperative swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
      Surgical interventions for ocular diseases involve manipulations of semi-transparent structures in the eye, but limited visualization of these tissue layers remains a critical barrier to developing novel surgical techniques and improving clinical outcomes. We addressed limitations in image-guided ophthalmic microsurgery by using microscope-integrated multimodal intraoperative swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography (iSS-SESLO-OCT). We previously demonstrated in vivo human ophthalmic imaging using SS-SESLO-OCT, which enabled simultaneous acquisition ...
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    8. Automated feature extraction for retinal vascular biometry in zebrafish using OCT angiography

      Automated feature extraction for retinal vascular biometry in zebrafish using OCT angiography
      Zebrafish have been identified as an ideal model for angiogenesis because of anatomical and functional similarities with other vertebrates. The scale and complexity of zebrafish assays are limited by the need to manually treat and serially screen animals, and recent technological advances have focused on automation and improving throughput. Here, we use optical coherence tomography (OCT) and OCT angiography (OCT-A) to perform noninvasive, in vivo imaging of retinal vasculature in ...
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    9. Modular multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography scan-head for surgical microscope-integrated and slit-lamp imaging

      Modular multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography scan-head for surgical microscope-integrated and slit-lamp imaging
      anning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) enable noninvasive in vivo diagnostic imaging and provide complementary en face and depth-resolved visualization of ophthalmic structures, respectively. We previously demonstrated concurrent multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and OCT (SS-SESLO-OCT) at 1060 nm using a swept-source and double clad fiber coupler. Here, we present system enhancements and novel designs for a modular SS-SESLO-OCT scan-head that can be coupled to ...
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    10. Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
      Scanning laser ophthalmoscopy (SLO) benefits diagnostic imaging and therapeutic guidance by allowing for high-speeden faceimaging of retinal structures. When combined with optical coherence tomography (OCT), SLO enables real-time aiming and retinal tracking and provides complementary information for post-acquisition volumetric co-registration, bulk motion compensation, and averaging. However, multimodality SLO-OCT systems generally require dedicated light sources, scanners, relay optics, detectors, and additional digitization and synchronization electronics, which increase system complexity. Here, we ...
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    11. Depth-resolved analytical model and correction algorithm for photothermal optical coherence tomography

      Depth-resolved analytical model and correction algorithm for photothermal optical coherence tomography
      Photothermal OCT (PT-OCT) is an emerging molecular imaging technique that occupies a spatial imaging regime between microscopy and whole body imaging. PT-OCT would benefit from a theoretical model to optimize imaging parameters and test image processing algorithms. We propose the first analytical PT-OCT model to replicate an experimental A-scan in homogeneous and layered samples. We also propose the PT-CLEAN algorithm to reduce phase-accumulation and shadowing, two artifacts found in PT-OCT ...
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    12. Development of Photothermal Optical Coherence Tomography for In Vivo Imaging of Contrast Agents (Thesis)

      Development of Photothermal Optical Coherence Tomography for In Vivo Imaging of Contrast Agents (Thesis)
      Sensitive and specific noninvasive in vivo imaging of contrast agents and endogenous molecules can supply molecular and functional information in animal models, providing essential insight into mechanisms of disease formation and progression, drug delivery, and treatment response. In cancer in particular, high resolution imaging is essential for capturing spatial heterogeneities in molecular expression and the tumor microenvironment that cause significant barriers to treatment efficacy and drug delivery. Optical coherence tomography ...
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    13. Photothermal optical lock-in optical coherence tomography for in vivo imaging

      Photothermal optical lock-in optical coherence tomography for in vivo imaging
      Photothermal OCT (PTOCT) provides high sensitivity to molecular targets in tissue, and occupies a spatial imaging regime that is attractive for small animal imaging. However, current implementations of PTOCT require extensive temporal sampling, resulting in slow frame rates and a large data burden that limit its in vivo utility. To address these limitations, we have implemented optical lock-in techniques for photothermal optical lock-in OCT (poli-OCT), and demonstrated the in vivo ...
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  2. About Vanderbilt University

    Vanderbilt University

    Vanderbilt University is a private, nonsectarian, coeducational research university in Nashville, Tennessee, USA. Founded in 1873, the university is named for shipping and rail magnate "Commodore" Cornelius Vanderbilt, who provided Vanderbilt its initial $1 million endowment despite having never been to the South. The Commodore hoped that his gift and the greater work of the university would help to heal the sectional wounds inflicted by the Civil War.