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2. Postdoc Position at Vanderbilt University
  
  Explore Optical Coherence Tomography News Jan 2 2019 Jobs & Studentships
  
  Description: The Bowden Laboratory for Biomedical Optics (https://lab.vanderbilt.edu/bowdenlab), as part of the Department of Biomedical Engineering and the Vanderbilt Biophotonics Center, develops optical imaging and sensing technologies for clinical and basic science applications, with additional interest in the development of low-cost and portable technologies for low-resource environments. We seek a new postdoc with expertise in programming and computer vision and an interest in biomedical applications to ...
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  Mentions: Vanderbilt University Stanford University Harvard University
3. Classification of burn injury using Raman spectroscopy and optical coherence tomography: An ex-vivo study on porcine skin
  
  Explore ScienceDirect Nov 1 2018 Dermatology
  
  Accurate depth assessment of burn wounds is a critical task to provide the right treatment and care. Currently, laser Doppler imaging is able to provide better accuracy compared to the standard clinical evaluation. However, its clinical applicability is limited by factors like scanning distance, time, and cost. Precise diagnosis of burns requires adequate structural and functional details. In this work, we evaluated the combined potential of two non-invasive optical modalities ...
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  Mentions: Vanderbilt University Anita Mahadevan-Jansen
4. Enhanced Depth Imaging Optical Coherence Tomography of Ultrasonographically Flat Choroidal Nevi Demonstrates 5 Distinct Patterns
  
  Explore Ophthalmology Retina Oct 13 2018 Ophthalmology
  
  ABSTRACT Purpose To characterize the enhanced-depth imaging optical coherence tomography (EDI-OCT) features of ultrasonographically flat choroidal nevi. Design Retrospective observational study Participants Patients with ultrasonographically flat choroidal nevi identified over 3-year period. Methods Comprehensive eye examinations and multimodal imaging were performed every 6 -12 months. Main Outcome Measures Lesion thickness and features, EDI-OCT findings Results 102 nevi (98 patients) were included. Median follow-up was 9 (range: 0-144) months and 1-8 ...
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  Mentions: Vanderbilt University
5. Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography
  
  Explore TVST Journal Sep 8 2018 Developmental Biology , Ophthalmology
  
  Purpose : To demonstrate and validate that photothermal optical coherence tomography (PT-OCT) can image melanin in the retinal pigment epithelium (RPE) and can observe light-driven melanosome translocation in the zebrafish retina. Methods : A commercial spectral domain OCT system was modified to perform both OCT and PT-OCT. Four adult tyrosinase-mosaic zebrafish with varying levels of melanin expression across their retinas were imaged, and the PT-OCT signal for pigmented and nonpigmented regions were ...
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  Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala
6. NIH taps Bruce J. Tromberg, Ph.D., to lead the National Institute of Biomedical Imaging and Bioengineering
  
  Explore nibib.nih.gov Sep 7 2018
  
  ...4 from Woodrow Wilson High School, Washington, D.C. He earned a B.A. in chemistry and psychology in 1979 from Vanderbilt University, Nashville, Tennessee, and a Ph.D. in chemistry in 1988 from the University of Tennessee...
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  Mentions: National Cancer Institute National Institutes of Health Vanderbilt University
7. Photothermal optical coherence tomography of indocyanine green in ex vivo eyes
  
  Explore OSA | OSA Publishing May 19 2018 Ophthalmology
  
  Indocyanine green (ICG) is routinely used during surgery to stain the inner limiting membrane (ILM) and provide contrast on white light surgical microscopy. While translation of optical coherence tomography (OCT) for intraoperative imaging during ophthalmic surgery has enhanced visualization, the ILM remains difficult to distinguish from underlying retinal structures and ICG does not provide additional OCT contrast. We present photothermal OCT (PT-OCT) for high-specificity detection of ICG on retinal OCT ...
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  Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala
8. Spectrally encoded coherence tomography and reflectometry: Simultaneous en face and cross‐sectional imaging at 2 gigapixels per second
  
  Explore Wiley Online Library Apr 18 2018
  
  Non‐invasive biological imaging is crucial for understanding in vivo structure and function. Optical coherence tomography (OCT) and reflectance confocal microscopy are two of the most widely used optical modalities for exogenous contrast‐free, high‐resolution, three‐dimensional imaging in non‐fluorescent scattering tissues. However, sample motion remains a critical barrier to raster‐scanned acquisition and reconstruction of wide‐field anatomically accurate volumetric datasets. We introduce spectrally encoded coherence tomography ...
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  Mentions: Vanderbilt University Yuankai K. Tao
9. Optical coherence tomography and autofluorescence microscopy of respiratory ciliated epithelia
  
  Explore SPIE Digital Library Mar 20 2018 Pulmonology
  
  Efficient mucociliary clearance is necessary to protect the respiratory tract from infection. Mucociliary dysfunction is common in respiratory diseases including asthma, chronic obstructive pulmonary disease, and cystic fibrosis. Rescuing mucociliary clearance by stimulating the metabolism of respiratory ciliated epithelia could offer new treatments for respiratory diseases. However, the coupling between cellular metabolism and mechanical output in respiratory ciliated epithelia is poorly understood. We propose to study this coupling with autofluorescence ...
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  Mentions: Yale University Vanderbilt University Michael A. Choma
10. Non-destructive geometric and refractive index characterization of single and multi-element lenses using optical coherence tomography
  
  Explore SPIE Digital Library Feb 27 2018
  
  $Non-destructive geometric and refractive index characterization of single and multi-element lenses using optical coherence tomography$
  Design of optical imaging systems requires careful balancing of lens aberrations to optimize the point-spread function (PSF) and minimize field distortions. Aberrations and distortions are a result of both lens geometry and glass material. While most lens manufacturers provide optical models to facilitate system-level simulation, these models are often not reflective of true system performance because of manufacturing tolerances. Optical design can be further confounded when achromatic or proprietary lenses ...
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  Mentions: Vanderbilt University Yuankai K. Tao
11. Resolution and throughput optimized intraoperative spectrally encoded coherence tomography and reflectometry (iSECTR) for multimodal imaging during ophthalmic microsurgery
  
  Explore SPIE Digital Library Feb 27 2018 Ophthalmology
  
  Limited visualization of semi-transparent structures in the eye remains a critical barrier to improving clinical outcomes and developing novel surgical techniques. While increases in imaging speed has enabled intraoperative optical coherence tomography (iOCT) imaging of surgical dynamics, several critical barriers to clinical adoption remain. Specifically, these include (1) static field-of-views (FOVs) requiring manual instrument-tracking; (2) high frame-rates require sparse sampling, which limits FOV; and (3) small iOCT FOV also limits ...
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  Mentions: Vanderbilt University Yuankai K. Tao
12. Multimodal ophthalmic imaging using handheld spectrally encoded coherence tomography and reflectometry (SECTR)
  
  Explore SPIE Digital Library Feb 27 2018
  
  Scanning laser ophthalmoscopy (SLO) provides high-speed, noninvasive en face imaging of the retinal fundus. Optical coherence tomography (OCT) is the current gold-standard for ophthalmic diagnostic imaging and enables depth-resolved visualization of ophthalmic structures and image-based surrogate biomarkers of disease. We present a compact optical and mechanical design for handheld spectrally encoded coherence tomography and reflectometry (SECTR) for multimodality en face spectrally encoded reflectometry (SER) and cross-sectional OCT imaging. We custom-designed ...
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  Mentions: Vanderbilt University Yuankai K. Tao
13. Multimodality optical coherence tomography and fluorescence confocal scanning laser ophthalmoscopy in a zebrafish model of retinal vascular occlusion and remodeling
  
  Explore SPIE Digital Library Feb 27 2018 Developmental Biology
  
  Neovascularization in diabetic retinopathy (DR) and age-related macular degeneration (AMD) result in severe vision-loss and are two of the leading causes of blindness. The structural, metabolic, and vascular changes underlying retinal neovascularization are unknown and, thus, there is an unmet need to identify mechanisms of pathogenesis and novel anti-angiogenic therapies. Zebrafish is a robust ophthalmological model because its retina has comparable structure to the human retina and its fecundity and ...
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  Mentions: Vanderbilt University Yuankai K. Tao
14. Multimodality optical coherence tomography and fluorescence confocal scanning laser ophthalmoscopy for image-guided feedback of intraocular injections in mouse models
  
  Explore SPIE Digital Library Feb 27 2018 Ophthalmology
  
  Rodent models are robust tools for understanding human retinal disease and function because of their similarities with human physiology and anatomy and availability of genetic mutants. Optical coherence tomography (OCT) has been well-established for ophthalmic imaging in rodents and enables depth-resolved visualization of structures and image-based surrogate biomarkers of disease. Similarly, fluorescence confocal scanning laser ophthalmoscopy (cSLO) has demonstrated utility for imaging endogenous and exogenous fluorescence and scattering contrast in ...
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  Mentions: Vanderbilt University Yuankai K. Tao
15. Image-guided intraocular injection using multimodality optical coherence tomography and fluorescence confocal scanning laser ophthalmoscopy in rodent ophthalmological models
  
  Explore SPIE Digital Library Feb 27 2018 Ophthalmology
  
  Intraocular injections are routinely performed for delivery of anti-VEGF and anti-inflammatory therapies in humans. While these injections are also performed in mice to develop novel models of ophthalmic diseases and screen novel therapeutics, the injection location and volume are not well-controlled and reproducible. We overcome limitations of conventional injections methods by developing a multimodality, long working distance, non-contact optical coherence tomography (OCT) and fluorescence confocal scanning laser ophthalmoscopy (cSLO) system ...
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  Mentions: Vanderbilt University Yuankai K. Tao
16. Quantitative biometry of zebrafish retinal vasculature using optical coherence tomographic angiography
  
  Explore OSA | OSA Publishing Feb 27 2018 Developmental Biology , Ophthalmology
  
  The zebrafish is a robust model for studying human ophthalmic function and disease because of its fecundity, life-cycle, and similarities between its retinal structure and the human retina. Here, we demonstrate longitudinal in vivo imaging of retinal structure using optical coherence tomography (OCT) and noninvasive retinal vascular perfusion imaging using OCT angiography (OCT-A) in zebrafish. In addition, we present methods for retinal vascular segmentation and biometry to quantify vessel branch ...
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  Mentions: Vanderbilt University Yuankai K. Tao
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