1. Vanderbilt University

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    1. Mentioned In 83 Articles

    2. Researchers advance image-guided robotic surgical tools for delicate eye procedures

      Researchers advance image-guided robotic surgical tools for delicate eye procedures
      Molecular, gene and cell-based therapies targeting eye diseases could prevent and potentially reverse cell degeneration that leads to loss of sight. However, delivering injections safely and accurately into targeted ocular layers remain concerns that affect the advancement of life-changing new treatments. To address the safety and reliability challenges, researchers in the Vanderbilt Institute for Surgery and Engineering are joining their expertise to enable the use of optical coherence tomography (OCT ...
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    3. Review of methods and applications of attenuation coefficient measurements with optical coherence tomography

      Review of methods and applications of attenuation coefficient measurements with optical coherence tomography
      The optical attenuation coefficient (AC), an important tissue parameter that measures how quickly incident light is attenuated when passing through a medium, has been shown to enable quantitative analysis of tissue properties from optical coherence tomography (OCT) signals. Successful extraction of this parameter would facilitate tissue differentiation and enhance the diagnostic value of OCT. In this review, we discuss the physical and mathematical basis of AC extraction from OCT data ...
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    4. Handheld spectrally encoded coherence tomography and reflectometry for motion-corrected ophthalmic optical coherence tomography and optical coherence tomography angiography

      Handheld spectrally encoded coherence tomography and reflectometry for motion-corrected ophthalmic optical coherence tomography and optical coherence tomography angiography
      Optical coherence tomography (OCT) is the gold standard for quantitative ophthalmic imaging. The majority of commercial and research systems require patients to fixate and be imaged in a seated upright position, which limits the ability to perform ophthalmic imaging in bedridden or pediatric patients. Handheld OCT devices overcome this limitation, but image quality often suffers due to a lack of real-time aiming and patient eye and photographer motion. We describe ...
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    5. Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents

      Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents
      Purpose : Optical coherence tomography (OCT) is widely used for ocular imaging in clinical and research settings. OCT natively provides structural information based on the reflectivity of the tissues it images. We demonstrate the utility of photothermal OCT (PTOCT) imaging of gold nanorods (GNR) in the mouse retina in vivo in the laser-induced choroidal neovascularization (LCNV) model to provide additional image contrast within the lesion. Methods : Wild-type C57BL/6 mice were ...
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    6. Postdoc Position at Vanderbilt University

      Postdoc Position at Vanderbilt University
      Description: The Bowden Laboratory for Biomedical Optics (https://lab.vanderbilt.edu/bowdenlab), as part of the Department of Biomedical Engineering and the Vanderbilt Biophotonics Center, develops optical imaging and sensing technologies for clinical and basic science applications, with additional interest in the development of low-cost and portable technologies for low-resource environments. We seek a new postdoc with expertise in programming and computer vision and an interest in biomedical applications to ...
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    7. Classification of burn injury using Raman spectroscopy and optical coherence tomography: An ex-vivo study on porcine skin

      Classification of burn injury using Raman spectroscopy and optical coherence tomography: An ex-vivo study on porcine skin
      Accurate depth assessment of burn wounds is a critical task to provide the right treatment and care. Currently, laser Doppler imaging is able to provide better accuracy compared to the standard clinical evaluation. However, its clinical applicability is limited by factors like scanning distance, time, and cost. Precise diagnosis of burns requires adequate structural and functional details. In this work, we evaluated the combined potential of two non-invasive optical modalities ...
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    8. Enhanced Depth Imaging Optical Coherence Tomography of Ultrasonographically Flat Choroidal Nevi Demonstrates 5 Distinct Patterns

      Enhanced Depth Imaging Optical Coherence Tomography of Ultrasonographically Flat Choroidal Nevi Demonstrates 5 Distinct Patterns
      ABSTRACT Purpose To characterize the enhanced-depth imaging optical coherence tomography (EDI-OCT) features of ultrasonographically flat choroidal nevi. Design Retrospective observational study Participants Patients with ultrasonographically flat choroidal nevi identified over 3-year period. Methods Comprehensive eye examinations and multimodal imaging were performed every 6 -12 months. Main Outcome Measures Lesion thickness and features, EDI-OCT findings Results 102 nevi (98 patients) were included. Median follow-up was 9 (range: 0-144) months and 1-8 ...
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    9. Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography

      Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography
      Purpose : To demonstrate and validate that photothermal optical coherence tomography (PT-OCT) can image melanin in the retinal pigment epithelium (RPE) and can observe light-driven melanosome translocation in the zebrafish retina. Methods : A commercial spectral domain OCT system was modified to perform both OCT and PT-OCT. Four adult tyrosinase-mosaic zebrafish with varying levels of melanin expression across their retinas were imaged, and the PT-OCT signal for pigmented and nonpigmented regions were ...
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    10. Photothermal optical coherence tomography of indocyanine green in ex vivo eyes

      Photothermal optical coherence tomography of indocyanine green in ex vivo eyes
      Indocyanine green (ICG) is routinely used during surgery to stain the inner limiting membrane (ILM) and provide contrast on white light surgical microscopy. While translation of optical coherence tomography (OCT) for intraoperative imaging during ophthalmic surgery has enhanced visualization, the ILM remains difficult to distinguish from underlying retinal structures and ICG does not provide additional OCT contrast. We present photothermal OCT (PT-OCT) for high-specificity detection of ICG on retinal OCT ...
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    11. Spectrally encoded coherence tomography and reflectometry: Simultaneous en face and cross‐sectional imaging at 2 gigapixels per second

      Spectrally encoded coherence tomography and reflectometry: Simultaneous en face and cross‐sectional imaging at 2 gigapixels per second
      Non‐invasive biological imaging is crucial for understanding in vivo structure and function. Optical coherence tomography (OCT) and reflectance confocal microscopy are two of the most widely used optical modalities for exogenous contrast‐free, high‐resolution, three‐dimensional imaging in non‐fluorescent scattering tissues. However, sample motion remains a critical barrier to raster‐scanned acquisition and reconstruction of wide‐field anatomically accurate volumetric datasets. We introduce spectrally encoded coherence tomography ...
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  2. About Vanderbilt University

    Vanderbilt University

    Vanderbilt University is a private, nonsectarian, coeducational research university in Nashville, Tennessee, USA. Founded in 1873, the university is named for shipping and rail magnate "Commodore" Cornelius Vanderbilt, who provided Vanderbilt its initial $1 million endowment despite having never been to the South. The Commodore hoped that his gift and the greater work of the university would help to heal the sectional wounds inflicted by the Civil War.