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2. Handheld spectrally encoded coherence tomography and reflectometry for motion-corrected ophthalmic optical coherence tomography and optical coherence tomography angiography
  
  Explore SPIE Digital Library Jul 7 2019
  
  Optical coherence tomography (OCT) is the gold standard for quantitative ophthalmic imaging. The majority of commercial and research systems require patients to fixate and be imaged in a seated upright position, which limits the ability to perform ophthalmic imaging in bedridden or pediatric patients. Handheld OCT devices overcome this limitation, but image quality often suffers due to a lack of real-time aiming and patient eye and photographer motion. We describe ...
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  Mentions: Vanderbilt University Yuankai K. Tao
3. Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents
  
  Explore TVST Journal May 23 2019 Ophthalmology
  
  Purpose : Optical coherence tomography (OCT) is widely used for ocular imaging in clinical and research settings. OCT natively provides structural information based on the reflectivity of the tissues it images. We demonstrate the utility of photothermal OCT (PTOCT) imaging of gold nanorods (GNR) in the mouse retina in vivo in the laser-induced choroidal neovascularization (LCNV) model to provide additional image contrast within the lesion. Methods : Wild-type C57BL/6 mice were ...
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  Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala
4. Vanderbilt University Receives NIH Grant for In Vivo Molecular Imaging of Vascular Disease of the Retina
  
  Explore Optical Coherence Tomography News Mar 6 2019 Ophthalmology , Funding
  
  ...al settings, and to establish a novel method to investigate hypoxia as a component of retinal vasculopathies. Vanderbilt University Receives a 2019 NIH Grant for $431,513 for In Vivo Molecular Imaging of Vascular Disease...
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  Mentions: National Institutes of Health Vanderbilt University
5. BiOS Hot Topics: Changing of the Guard
  
  Explore Home: SPIE.org Feb 21 2019
  
  ...n in the world who are scarred or disfigured in need of this help," Rochford added. Anita Mahadevan-Jansen of Vanderbilt University paid tribute to the late Warren S. Grundfest, professor of bioengineering and electrical...
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  Mentions: James G. Fujimoto Wolfgang Drexler Leiden University
6. Postdoc Position at Vanderbilt University
  
  Explore Optical Coherence Tomography News Jan 2 2019 Jobs & Studentships
  
  Description: The Bowden Laboratory for Biomedical Optics (https://lab.vanderbilt.edu/bowdenlab), as part of the Department of Biomedical Engineering and the Vanderbilt Biophotonics Center, develops optical imaging and sensing technologies for clinical and basic science applications, with additional interest in the development of low-cost and portable technologies for low-resource environments. We seek a new postdoc with expertise in programming and computer vision and an interest in biomedical applications to ...
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  Mentions: Vanderbilt University Stanford University Harvard University
7. Classification of burn injury using Raman spectroscopy and optical coherence tomography: An ex-vivo study on porcine skin
  
  Explore ScienceDirect Nov 1 2018 Dermatology
  
  Accurate depth assessment of burn wounds is a critical task to provide the right treatment and care. Currently, laser Doppler imaging is able to provide better accuracy compared to the standard clinical evaluation. However, its clinical applicability is limited by factors like scanning distance, time, and cost. Precise diagnosis of burns requires adequate structural and functional details. In this work, we evaluated the combined potential of two non-invasive optical modalities ...
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  Mentions: Vanderbilt University Anita Mahadevan-Jansen
8. Enhanced Depth Imaging Optical Coherence Tomography of Ultrasonographically Flat Choroidal Nevi Demonstrates 5 Distinct Patterns
  
  Explore Ophthalmology Retina Oct 13 2018 Ophthalmology
  
  ABSTRACT Purpose To characterize the enhanced-depth imaging optical coherence tomography (EDI-OCT) features of ultrasonographically flat choroidal nevi. Design Retrospective observational study Participants Patients with ultrasonographically flat choroidal nevi identified over 3-year period. Methods Comprehensive eye examinations and multimodal imaging were performed every 6 -12 months. Main Outcome Measures Lesion thickness and features, EDI-OCT findings Results 102 nevi (98 patients) were included. Median follow-up was 9 (range: 0-144) months and 1-8 ...
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  Mentions: Vanderbilt University
9. Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography
  
  Explore TVST Journal Sep 8 2018 Developmental Biology , Ophthalmology
  
  Purpose : To demonstrate and validate that photothermal optical coherence tomography (PT-OCT) can image melanin in the retinal pigment epithelium (RPE) and can observe light-driven melanosome translocation in the zebrafish retina. Methods : A commercial spectral domain OCT system was modified to perform both OCT and PT-OCT. Four adult tyrosinase-mosaic zebrafish with varying levels of melanin expression across their retinas were imaged, and the PT-OCT signal for pigmented and nonpigmented regions were ...
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  Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala
10. NIH taps Bruce J. Tromberg, Ph.D., to lead the National Institute of Biomedical Imaging and Bioengineering
  
  Explore nibib.nih.gov Sep 7 2018
  
  ...4 from Woodrow Wilson High School, Washington, D.C. He earned a B.A. in chemistry and psychology in 1979 from Vanderbilt University, Nashville, Tennessee, and a Ph.D. in chemistry in 1988 from the University of Tennessee...
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  Mentions: National Cancer Institute National Institutes of Health Vanderbilt University
11. Photothermal optical coherence tomography of indocyanine green in ex vivo eyes
  
  Explore OSA | OSA Publishing May 19 2018 Ophthalmology
  
  Indocyanine green (ICG) is routinely used during surgery to stain the inner limiting membrane (ILM) and provide contrast on white light surgical microscopy. While translation of optical coherence tomography (OCT) for intraoperative imaging during ophthalmic surgery has enhanced visualization, the ILM remains difficult to distinguish from underlying retinal structures and ICG does not provide additional OCT contrast. We present photothermal OCT (PT-OCT) for high-specificity detection of ICG on retinal OCT ...
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  Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala
12. Spectrally encoded coherence tomography and reflectometry: Simultaneous en face and cross‐sectional imaging at 2 gigapixels per second
  
  Explore Wiley Online Library Apr 18 2018
  
  Non‐invasive biological imaging is crucial for understanding in vivo structure and function. Optical coherence tomography (OCT) and reflectance confocal microscopy are two of the most widely used optical modalities for exogenous contrast‐free, high‐resolution, three‐dimensional imaging in non‐fluorescent scattering tissues. However, sample motion remains a critical barrier to raster‐scanned acquisition and reconstruction of wide‐field anatomically accurate volumetric datasets. We introduce spectrally encoded coherence tomography ...
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  Mentions: Vanderbilt University Yuankai K. Tao
13. Optical coherence tomography and autofluorescence microscopy of respiratory ciliated epithelia
  
  Explore SPIE Digital Library Mar 20 2018 Pulmonology
  
  Efficient mucociliary clearance is necessary to protect the respiratory tract from infection. Mucociliary dysfunction is common in respiratory diseases including asthma, chronic obstructive pulmonary disease, and cystic fibrosis. Rescuing mucociliary clearance by stimulating the metabolism of respiratory ciliated epithelia could offer new treatments for respiratory diseases. However, the coupling between cellular metabolism and mechanical output in respiratory ciliated epithelia is poorly understood. We propose to study this coupling with autofluorescence ...
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  Mentions: Yale University Vanderbilt University Michael A. Choma
14. Non-destructive geometric and refractive index characterization of single and multi-element lenses using optical coherence tomography
  
  Explore SPIE Digital Library Feb 27 2018
  
  $Non-destructive geometric and refractive index characterization of single and multi-element lenses using optical coherence tomography$
  Design of optical imaging systems requires careful balancing of lens aberrations to optimize the point-spread function (PSF) and minimize field distortions. Aberrations and distortions are a result of both lens geometry and glass material. While most lens manufacturers provide optical models to facilitate system-level simulation, these models are often not reflective of true system performance because of manufacturing tolerances. Optical design can be further confounded when achromatic or proprietary lenses ...
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  Mentions: Vanderbilt University Yuankai K. Tao
15. Resolution and throughput optimized intraoperative spectrally encoded coherence tomography and reflectometry (iSECTR) for multimodal imaging during ophthalmic microsurgery
  
  Explore SPIE Digital Library Feb 27 2018 Ophthalmology
  
  Limited visualization of semi-transparent structures in the eye remains a critical barrier to improving clinical outcomes and developing novel surgical techniques. While increases in imaging speed has enabled intraoperative optical coherence tomography (iOCT) imaging of surgical dynamics, several critical barriers to clinical adoption remain. Specifically, these include (1) static field-of-views (FOVs) requiring manual instrument-tracking; (2) high frame-rates require sparse sampling, which limits FOV; and (3) small iOCT FOV also limits ...
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  Mentions: Vanderbilt University Yuankai K. Tao
16. Multimodal ophthalmic imaging using handheld spectrally encoded coherence tomography and reflectometry (SECTR)
  
  Explore SPIE Digital Library Feb 27 2018
  
  Scanning laser ophthalmoscopy (SLO) provides high-speed, noninvasive en face imaging of the retinal fundus. Optical coherence tomography (OCT) is the current gold-standard for ophthalmic diagnostic imaging and enables depth-resolved visualization of ophthalmic structures and image-based surrogate biomarkers of disease. We present a compact optical and mechanical design for handheld spectrally encoded coherence tomography and reflectometry (SECTR) for multimodality en face spectrally encoded reflectometry (SER) and cross-sectional OCT imaging. We custom-designed ...
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  Mentions: Vanderbilt University Yuankai K. Tao
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