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    1. Mentioned In 78 Articles

    2. Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents

      Explore TVST Journal Ophthalmology
      Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents
      Purpose : Optical coherence tomography (OCT) is widely used for ocular imaging in clinical and research settings. OCT natively provides structural information based on the reflectivity of the tissues it images. We demonstrate the utility of photothermal OCT (PTOCT) imaging of gold nanorods (GNR) in the mouse retina in vivo in the laser-induced choroidal neovascularization (LCNV) model to provide additional image contrast within the lesion. Methods : Wild-type C57BL/6 mice were ...
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      Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala

    5. Postdoc Position at Vanderbilt University

      Explore Optical Coherence Tomography News Jobs & Studentships
      Postdoc Position at Vanderbilt University
      Description: The Bowden Laboratory for Biomedical Optics (https://lab.vanderbilt.edu/bowdenlab), as part of the Department of Biomedical Engineering and the Vanderbilt Biophotonics Center, develops optical imaging and sensing technologies for clinical and basic science applications, with additional interest in the development of low-cost and portable technologies for low-resource environments. We seek a new postdoc with expertise in programming and computer vision and an interest in biomedical applications to ...
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      Mentions: Vanderbilt University Stanford University Harvard University

    6. Classification of burn injury using Raman spectroscopy and optical coherence tomography: An ex-vivo study on porcine skin

      Explore ScienceDirect Dermatology
      Classification of burn injury using Raman spectroscopy and optical coherence tomography: An ex-vivo study on porcine skin
      Accurate depth assessment of burn wounds is a critical task to provide the right treatment and care. Currently, laser Doppler imaging is able to provide better accuracy compared to the standard clinical evaluation. However, its clinical applicability is limited by factors like scanning distance, time, and cost. Precise diagnosis of burns requires adequate structural and functional details. In this work, we evaluated the combined potential of two non-invasive optical modalities ...
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      Mentions: Vanderbilt University Anita Mahadevan-Jansen

    7. Enhanced Depth Imaging Optical Coherence Tomography of Ultrasonographically Flat Choroidal Nevi Demonstrates 5 Distinct Patterns

      Explore Ophthalmology Retina Ophthalmology
      Enhanced Depth Imaging Optical Coherence Tomography of Ultrasonographically Flat Choroidal Nevi Demonstrates 5 Distinct Patterns
      ABSTRACT Purpose To characterize the enhanced-depth imaging optical coherence tomography (EDI-OCT) features of ultrasonographically flat choroidal nevi. Design Retrospective observational study Participants Patients with ultrasonographically flat choroidal nevi identified over 3-year period. Methods Comprehensive eye examinations and multimodal imaging were performed every 6 -12 months. Main Outcome Measures Lesion thickness and features, EDI-OCT findings Results 102 nevi (98 patients) were included. Median follow-up was 9 (range: 0-144) months and 1-8 ...
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      Mentions: Vanderbilt University

    8. Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography

      Explore TVST Journal Developmental Biology , Ophthalmology
      Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography
      Purpose : To demonstrate and validate that photothermal optical coherence tomography (PT-OCT) can image melanin in the retinal pigment epithelium (RPE) and can observe light-driven melanosome translocation in the zebrafish retina. Methods : A commercial spectral domain OCT system was modified to perform both OCT and PT-OCT. Four adult tyrosinase-mosaic zebrafish with varying levels of melanin expression across their retinas were imaged, and the PT-OCT signal for pigmented and nonpigmented regions were ...
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      Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala

    10. Photothermal optical coherence tomography of indocyanine green in ex vivo eyes

      Explore OSA | OSA Publishing Ophthalmology
      Photothermal optical coherence tomography of indocyanine green in ex vivo eyes
      Indocyanine green (ICG) is routinely used during surgery to stain the inner limiting membrane (ILM) and provide contrast on white light surgical microscopy. While translation of optical coherence tomography (OCT) for intraoperative imaging during ophthalmic surgery has enhanced visualization, the ILM remains difficult to distinguish from underlying retinal structures and ICG does not provide additional OCT contrast. We present photothermal OCT (PT-OCT) for high-specificity detection of ICG on retinal OCT ...
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      Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala

    11. Spectrally encoded coherence tomography and reflectometry: Simultaneous en face and cross‐sectional imaging at 2 gigapixels per second

      Explore Wiley Online Library
      Spectrally encoded coherence tomography and reflectometry: Simultaneous en face and cross‐sectional imaging at 2 gigapixels per second
      Non‐invasive biological imaging is crucial for understanding in vivo structure and function. Optical coherence tomography (OCT) and reflectance confocal microscopy are two of the most widely used optical modalities for exogenous contrast‐free, high‐resolution, three‐dimensional imaging in non‐fluorescent scattering tissues. However, sample motion remains a critical barrier to raster‐scanned acquisition and reconstruction of wide‐field anatomically accurate volumetric datasets. We introduce spectrally encoded coherence tomography ...
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      Mentions: Vanderbilt University Yuankai K. Tao

    12. Optical coherence tomography and autofluorescence microscopy of respiratory ciliated epithelia

      Explore SPIE Digital Library Pulmonology
      Optical coherence tomography and autofluorescence microscopy of respiratory ciliated epithelia
      Efficient mucociliary clearance is necessary to protect the respiratory tract from infection. Mucociliary dysfunction is common in respiratory diseases including asthma, chronic obstructive pulmonary disease, and cystic fibrosis. Rescuing mucociliary clearance by stimulating the metabolism of respiratory ciliated epithelia could offer new treatments for respiratory diseases. However, the coupling between cellular metabolism and mechanical output in respiratory ciliated epithelia is poorly understood. We propose to study this coupling with autofluorescence ...
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      Mentions: Yale University Vanderbilt University Michael A. Choma

    13. Non-destructive geometric and refractive index characterization of single and multi-element lenses using optical coherence tomography

      Explore SPIE Digital Library
      Non-destructive geometric and refractive index characterization of single and multi-element lenses using optical coherence tomography
      Design of optical imaging systems requires careful balancing of lens aberrations to optimize the point-spread function (PSF) and minimize field distortions. Aberrations and distortions are a result of both lens geometry and glass material. While most lens manufacturers provide optical models to facilitate system-level simulation, these models are often not reflective of true system performance because of manufacturing tolerances. Optical design can be further confounded when achromatic or proprietary lenses ...
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      Mentions: Vanderbilt University Yuankai K. Tao

    14. Resolution and throughput optimized intraoperative spectrally encoded coherence tomography and reflectometry (iSECTR) for multimodal imaging during ophthalmic microsurgery

      Explore SPIE Digital Library Ophthalmology
      Resolution and throughput optimized intraoperative spectrally encoded coherence tomography and reflectometry (iSECTR) for multimodal imaging during ophthalmic microsurgery
      Limited visualization of semi-transparent structures in the eye remains a critical barrier to improving clinical outcomes and developing novel surgical techniques. While increases in imaging speed has enabled intraoperative optical coherence tomography (iOCT) imaging of surgical dynamics, several critical barriers to clinical adoption remain. Specifically, these include (1) static field-of-views (FOVs) requiring manual instrument-tracking; (2) high frame-rates require sparse sampling, which limits FOV; and (3) small iOCT FOV also limits ...
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      Mentions: Vanderbilt University Yuankai K. Tao

    15. Multimodal ophthalmic imaging using handheld spectrally encoded coherence tomography and reflectometry (SECTR)

      Explore SPIE Digital Library
      Multimodal ophthalmic imaging using handheld spectrally encoded coherence tomography and reflectometry (SECTR)
      Scanning laser ophthalmoscopy (SLO) provides high-speed, noninvasive en face imaging of the retinal fundus. Optical coherence tomography (OCT) is the current gold-standard for ophthalmic diagnostic imaging and enables depth-resolved visualization of ophthalmic structures and image-based surrogate biomarkers of disease. We present a compact optical and mechanical design for handheld spectrally encoded coherence tomography and reflectometry (SECTR) for multimodality en face spectrally encoded reflectometry (SER) and cross-sectional OCT imaging. We custom-designed ...
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      Mentions: Vanderbilt University Yuankai K. Tao

    16. Multimodality optical coherence tomography and fluorescence confocal scanning laser ophthalmoscopy in a zebrafish model of retinal vascular occlusion and remodeling

      Explore SPIE Digital Library Developmental Biology
      Multimodality optical coherence tomography and fluorescence confocal scanning laser ophthalmoscopy in a zebrafish model of retinal vascular occlusion and remodeling
      Neovascularization in diabetic retinopathy (DR) and age-related macular degeneration (AMD) result in severe vision-loss and are two of the leading causes of blindness. The structural, metabolic, and vascular changes underlying retinal neovascularization are unknown and, thus, there is an unmet need to identify mechanisms of pathogenesis and novel anti-angiogenic therapies. Zebrafish is a robust ophthalmological model because its retina has comparable structure to the human retina and its fecundity and ...
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      Mentions: Vanderbilt University Yuankai K. Tao
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  4. About Vanderbilt University

    Vanderbilt University

    Vanderbilt University is a private, nonsectarian, coeducational research university in Nashville, Tennessee, USA. Founded in 1873, the university is named for shipping and rail magnate "Commodore" Cornelius Vanderbilt, who provided Vanderbilt its initial $1 million endowment despite having never been to the South. The Commodore hoped that his gift and the greater work of the university would help to heal the sectional wounds inflicted by the Civil War.

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