1. Valery V. Tuchin

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    1. Mentioned In 61 Articles

    2. Nanoparticle-enabled experimentally trained wavelet-domain denoising method for optical coherence tomography

      Nanoparticle-enabled experimentally trained wavelet-domain denoising method for optical coherence tomography
      We present the nanoparticle-enabled experimentally trained wavelet-domain denoising method for optical coherence tomography (OCT). It employs an experimental training algorithm based on imaging of a test-object, made of the colloidal suspension of the monodisperse nanoparticles and contains the microscale inclusions. The geometry and the scattering properties of the test-object are known a priori allowing us to set the criteria for the training algorithm. Using a wide set of the wavelet ...
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      Mentions: Valery V. Tuchin
    3. Photodynamic opening of the blood-brain barrier and pathways of brain clearing

      Photodynamic opening of the blood-brain barrier and pathways of brain clearing
      A new application of the photodynamic treatment (PDT) is presented for the opening of blood-brain barrier (BBB) and the brain clearing activation that is associated with it, including the use of gold nanoparticles as emerging photosensitizer carriers in PDT. The obtained results clearly demonstrate two pathways for the brain clearing: 1) using PDT-opening of BBB and intravenous injection of FITC-dextran we showed a clearance of this tracer via the meningeal ...
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    4. Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry

      Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry
      Observation of temperature-mediated phase transitions between lipid components of the adipose tissues has been performed by combined use of the Abbe refractometry and optical coherence tomography. The phase transitions of the lipid components were clearly observed in the range of temperatures from 24C to 60C, and assessed by quantitatively monitoring the changes of the refractive index of 1- to 2-mm-thick porcine fat tissue slices. The developed approach has a great ...
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    5. Application of optical coherence tomography for in vivo monitoring of the meningeal lymphatic vessels during opening of blood–brain barrier: mechanisms of brain clearing

      Application of optical coherence tomography for in vivo monitoring of the meningeal lymphatic vessels during opening of blood–brain barrier: mechanisms of brain clearing
      The meningeal lymphatic vessels were discovered 2 years ago as the drainage system involved in the mechanisms underlying the clearance of waste products from the brain. The bloodbrain barrier (BBB) is a gatekeeper that strongly controls the movement of different molecules from the blood into the brain. We know the scenarios during the opening of the BBB, but there is extremely limited information on how the brain clears the substances ...
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    6. Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography

      Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography
      Developing a deep-tissue imaging tool with good optical resolution is one of the important goals of biophotonics because medical diagnosis usually requires imaging of fine details of whole tissue structures. Optical coherence tomography (OCT) is an extensively developed imaging tool for biological tissues. Based on low-coherence interferometry, OCT provides micrometer scale resolution and enables non-invasive high-speed imaging1 . OCT is widely used in ophthalmology because it can fully access retina, choroid ...
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    7. Optical clearing of articular cartilage: a comparison of clearing agents

      Optical clearing of articular cartilage: a comparison of clearing agents
      Optical clearing technique was applied to the problem of OCT imaging of articular cartilage and subchondral bone. We show that optical clearing significantly enhances visualization of articular cartilage and cartilage-bone interface. The effect of different clearing agents was analyzed. For the clearing, iohexol solution and propylene glycol (PG) were used. Clearing was performed in vitro at room temperature by immersion method. Cylindrical osteochondral samples (d=4.8mm) were drilled from ...
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    8. Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage

      Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage
      Optical clearing is an effective method to reduce light scattering of biological tissues that provides significant enhancement of light penetration into the biological tissues making non-invasive diagnosis more feasible. In current report Optical Coherence Tomography (OCT) in conjunction with optical clearing is applied for assessment of deep cartilage layers and cartilage-bone interface. The solution of Iohexol in water has been used as an optical clearing agent. The cartilage-bone boundary becomes ...
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    9. OCT/LCT monitoring the drug effect on the human cornea structure in vivo

      OCT/LCT	monitoring	the	drug 	effect	on	the	human	cornea	 structure	in	vivo
      The effect of anti-glaucoma drugs on the structure components of human eye cornea are studied. The eye drops Timolol-AKOS 0.5% and Kosopt were used as the object of study. 10 voluntary patients of the Eye Disease Clinic aged from 70 to 75 suffering from glaucoma took part in the studies. The study of cornea in vivo was carried out using the methods of laser scanning confocal tomography (LCT) and ...
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    10. In vivo microvascular imaging of human oral and nasal cavities using swept-source optical coherence tomography with a single forward/side viewing probe

      In vivo microvascular imaging of human oral and nasal cavities using swept-source optical coherence tomography with a single forward/side viewing probe
      ...rence Tomography and Coherence Domain Optical Methods in Biomedicine XIX James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin San Francisco, California, United States | February 07, 2015 We report three-dimensional (3...
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  2. About Valery V. Tuchin

    Valery V. Tuchin

    Valery V. Tuchin, PhD, holds the Optics and Biophotonics Chair and is a Director of Research-Educational Institute of Optics and Biophotonics at Saratov State University, Head of Laboratory on Laser Diagnostics of Technical and Living Systems, Inst. of Precise Mechanics and Control, RAS. His research interests include biophotonics, biomedical optics and laser medicine, physics of optical and laser measurements. He has authored more than 300 peer-reviewed papers and books. He has been awarded Honored Science Worker of the Russian Federation and SPIE Fellow; he is a Vice-President of Russian Photobiology Society. In 2007 he was awarded the SPIE Educator Award. He is a FiDiPro Professor of University of Oulu (Finland).