1. Valery V. Tuchin

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    1. Mentioned In 63 Articles

    2. Optical monitoring of adipose tissue destruction under encapsulated lipase action

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      Optical monitoring of adipose tissue destruction under encapsulated lipase action
      Enzymatic destruction of adipose tissue has been achieved by encapsulation of lipase into the polymeric microcapsules. Adipose tissue destruction was delayed while lipase is encapsulated comparing with the direct lipase action as demonstrated by optical microscopy and optical coherence tomography in in vitro studies. Raman spectroscopy confirms that triglycerides in fat tissue were cleaved into free fatty acids, glycerol, and possible di‐ and monoglyceride residues. The results underpin the concept ...
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      Mentions: Valery V. Tuchin

    3. A robust model of an OCT signal in a spectral domain

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      A robust model of an OCT signal in a spectral domain
      Optical coherence tomography (OCT) relies on ballistic back scattered photons to construct depth resolved optical slices of a specimen. However, the theory of OCT is generally math heavy and unintuitive. In this paper, we propose an approach, and show as many aspects of the OCT signal formation that can be described by using simple math and intuitive physics. The model allowing for simulating a semi-ideal OCT signal from an object ...
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      Mentions: Saratov State University Valery V. Tuchin

    4. Nanoparticle-enabled experimentally trained wavelet-domain denoising method for optical coherence tomography

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      Nanoparticle-enabled experimentally trained wavelet-domain denoising method for optical coherence tomography
      We present the nanoparticle-enabled experimentally trained wavelet-domain denoising method for optical coherence tomography (OCT). It employs an experimental training algorithm based on imaging of a test-object, made of the colloidal suspension of the monodisperse nanoparticles and contains the microscale inclusions. The geometry and the scattering properties of the test-object are known a priori allowing us to set the criteria for the training algorithm. Using a wide set of the wavelet ...
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      Mentions: Valery V. Tuchin

    5. Photodynamic opening of the blood-brain barrier and pathways of brain clearing

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      Photodynamic opening of the blood-brain barrier and pathways of brain clearing
      A new application of the photodynamic treatment (PDT) is presented for the opening of blood-brain barrier (BBB) and the brain clearing activation that is associated with it, including the use of gold nanoparticles as emerging photosensitizer carriers in PDT. The obtained results clearly demonstrate two pathways for the brain clearing: 1) using PDT-opening of BBB and intravenous injection of FITC-dextran we showed a clearance of this tracer via the meningeal ...
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      Mentions: Saratov State University Valery V. Tuchin

    6. Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry

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      Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry
      Observation of temperature-mediated phase transitions between lipid components of the adipose tissues has been performed by combined use of the Abbe refractometry and optical coherence tomography. The phase transitions of the lipid components were clearly observed in the range of temperatures from 24C to 60C, and assessed by quantitatively monitoring the changes of the refractive index of 1- to 2-mm-thick porcine fat tissue slices. The developed approach has a great ...
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      Mentions: Saratov State University Valery V. Tuchin Igor V. Meglinski

    7. Application of optical coherence tomography for in vivo monitoring of the meningeal lymphatic vessels during opening of blood–brain barrier: mechanisms of brain clearing

      Explore SPIE Digital Library Neurology
      Application of optical coherence tomography for in vivo monitoring of the meningeal lymphatic vessels during opening of blood–brain barrier: mechanisms of brain clearing
      The meningeal lymphatic vessels were discovered 2 years ago as the drainage system involved in the mechanisms underlying the clearance of waste products from the brain. The bloodbrain barrier (BBB) is a gatekeeper that strongly controls the movement of different molecules from the blood into the brain. We know the scenarios during the opening of the BBB, but there is extremely limited information on how the brain clears the substances ...
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      Mentions: Saratov State University Valery V. Tuchin

    8. Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography

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      Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography
      Developing a deep-tissue imaging tool with good optical resolution is one of the important goals of biophotonics because medical diagnosis usually requires imaging of fine details of whole tissue structures. Optical coherence tomography (OCT) is an extensively developed imaging tool for biological tissues. Based on low-coherence interferometry, OCT provides micrometer scale resolution and enables non-invasive high-speed imaging1 . OCT is widely used in ophthalmology because it can fully access retina, choroid ...
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      Mentions: Institute of Applied Physics Saratov State University Valery V. Tuchin

    10. Optical clearing of articular cartilage: a comparison of clearing agents

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      Optical clearing of articular cartilage: a comparison of clearing agents
      Optical clearing technique was applied to the problem of OCT imaging of articular cartilage and subchondral bone. We show that optical clearing significantly enhances visualization of articular cartilage and cartilage-bone interface. The effect of different clearing agents was analyzed. For the clearing, iohexol solution and propylene glycol (PG) were used. Clearing was performed in vitro at room temperature by immersion method. Cylindrical osteochondral samples (d=4.8mm) were drilled from ...
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      Mentions: Matti Kinnunen University of Oulu Valery V. Tuchin

    11. Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage

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      Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage
      Optical clearing is an effective method to reduce light scattering of biological tissues that provides significant enhancement of light penetration into the biological tissues making non-invasive diagnosis more feasible. In current report Optical Coherence Tomography (OCT) in conjunction with optical clearing is applied for assessment of deep cartilage layers and cartilage-bone interface. The solution of Iohexol in water has been used as an optical clearing agent. The cartilage-bone boundary becomes ...
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      Mentions: Matti Kinnunen University of Oulu Saratov State University

    12. OCT/LCT monitoring the drug effect on the human cornea structure in vivo

      Explore Журналы СГАУ Ophthalmology
      OCT/LCT monitoring the drug effect on the human cornea structure in vivo
      The effect of anti-glaucoma drugs on the structure components of human eye cornea are studied. The eye drops Timolol-AKOS 0.5% and Kosopt were used as the object of study. 10 voluntary patients of the Eye Disease Clinic aged from 70 to 75 suffering from glaucoma took part in the studies. The study of cornea in vivo was carried out using the methods of laser scanning confocal tomography (LCT) and ...
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      Mentions: Saratov State University Valery V. Tuchin
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  4. About Valery V. Tuchin

    Valery V. Tuchin

    Valery V. Tuchin, PhD, holds the Optics and Biophotonics Chair and is a Director of Research-Educational Institute of Optics and Biophotonics at Saratov State University, Head of Laboratory on Laser Diagnostics of Technical and Living Systems, Inst. of Precise Mechanics and Control, RAS. His research interests include biophotonics, biomedical optics and laser medicine, physics of optical and laser measurements. He has authored more than 300 peer-reviewed papers and books. He has been awarded Honored Science Worker of the Russian Federation and SPIE Fellow; he is a Vice-President of Russian Photobiology Society. In 2007 he was awarded the SPIE Educator Award. He is a FiDiPro Professor of University of Oulu (Finland).

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