1. Vadim Backman

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    1. Mentioned In 16 Articles

    2. Biological tissue analysis by inverse spectroscopic optical coherence tomography

      Biological tissue analysis by inverse spectroscopic optical coherence tomography
      A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo .alpha. defined as the ratio of scattering coefficient ...
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    3. Devices, methods, and systems of functional optical coherence tomography

      Devices, methods, and systems of functional optical coherence tomography
      The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide ...
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    4. Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography

      Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography
      In cancer biology, there has been a recent effort to understand tumor formation in the context of the tissue microenvironment. In particular, recent progress has explored the mechanisms behind how changes in the cell-extracellular matrix ensemble influence progression of the disease. The extensive use of in vitro tissue culture models in simulant matrix has proven effective at studying such interactions, but modalities for non-invasively quantifying aspects of these systems are ...
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    5. Devices, Methods, And Systems Of Functional Optical Coherence Tomography

      Devices, Methods, And Systems Of Functional Optical Coherence Tomography
      The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide ...
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    6. Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation

      Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation
      The lack of capability to quantify oxygen metabolism noninvasively impedes both fundamental investigation and clinical diagnosis of a wide spectrum of diseases including all the major blinding diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Using visible light optical coherence tomography (vis-OCT), we demonstrated accurate and robust measurement of retinal oxygen metabolic rate (rMRO 2 ) noninvasively in rat eyes. We continuously monitored the regulatory response of oxygen consumption ...
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    7. Monte Carlo Investigation of Optical Coherence Tomography Retinal Oximetry

      Monte Carlo Investigation of Optical Coherence Tomography Retinal Oximetry
      Optical coherence tomography (OCT) oximetry explores the possibility to measure retinal hemoglobin oxygen saturation level (sO2). We investigated the accuracy of OCT retinal oximetry using Monte Carlo simulation in a commonlyused four-layer retinal model. After we determined the appropriate number of simulated photon packets, we studied the effects of blood vessel diameter, signal sampling position, physiological sO2 level, and the blood packing factor on the accuracy of sO2 estimation in ...
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    8. Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomograph

      Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomograph
      Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolved optical and ultrastructural properties of the mucosa were quantified from histologically normal rectal biopsies from patients with and without colon adenomas ( n = 85 ) as well as from histologically normal ...
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    9. Can OCT be sensitive to nanoscale structural alterations in biological tissue?

      Can OCT be sensitive to nanoscale structural alterations in biological tissue?
      Exploration of nanoscale tissue structures is crucial in understanding biological processes. Although novel optical microscopy methods have been developed to probe cellular features beyond the diffraction limit, nanometer-scale quantification remains still inaccessible forin situtissue. Here we demonstrate that, without actually resolving specific geometrical feature, OCT can be sensitive to tissue structural properties at the nanometer length scale. The statistical mass-density distribution in tissue is quantified by its autocorrelation function modeled ...
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    10. Imaging a full set of optical scattering properties of biological tissue by inverse spectroscopic optical coherence tomography

      Imaging a full set of optical scattering properties of biological tissue by inverse spectroscopic optical coherence tomography
      We here develop a method to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT). Tissue is modelled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. Under the first-order Born approximation, the forward model is established for ISOCT. By measuring optical quantities of tissue including the scattering power of the OCT spectrum ...
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    11. Method for identifying refractive-index fluctuations of a target

      Method for identifying refractive-index fluctuations of a target
      Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations ...
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    12. System for identifying refractive-index fluctuations of a target

      System for identifying refractive-index fluctuations of a target
      Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations ...
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    13. 1-16 of 16
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  2. About Vadim Backman

    Vadim Backman

    Vadim Backman, PhD, is a Professor at Biomedicam Engineering, Northwestern University. Research Interests: Optical imaging, Minimally invasive optical diagnosis and imaging of early cancer, Coherent backscattering spectroscopy for tissue diagnosis, Fractal organization of cells and tissues, Analysis of nano- and micro-architecture of living tissues using light scattering spectroscopy, Light scattering and propagation in random/turbid media.