1. Utkarsh Sharma

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    1. Mentioned In 31 Articles

    2. Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology

      Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology
      Artifacts introduced by eye motion in optical coherence tomography angiography (OCTA) affect the interpretation of images and the quantification of parameters with clinical value. Eradication of such artifacts in OCTA remains a technical challenge. We developed an algorithm that recognizes five different types of motion artifacts and used it to evaluate the performance of three motion removal technologies. On en face maximum projection of flow images, the summed flow signal ...
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    3. Analysis and visualization of OCT angiography data

      Analysis and visualization of OCT angiography data
      Methods for analyzing and visualizing OCT angiography data are presented. In one embodiment, an automated method for identifying the foveal avascular zone in a two dimensional en face image generated from motion contrast data is presented. Several 3D visualization techniques are presented including one in which a particular vessel is selected in a motion contrast image and all connected vessels are highlighted. A further embodiment includes a stereoscopic visualization method ...
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    4. Wide-field optical coherence tomography based microangiography for retinal imaging

      Wide-field optical coherence tomography based microangiography for retinal imaging
      Optical coherence tomography angiography (OCTA) allows for the evaluation of functional retinal vascular networks without a need for contrast dyes. For sophisticated monitoring and diagnosis of retinal diseases, OCTA capable of providing wide-field and high definition images of retinal vasculature in a single image is desirable. We report OCTA with motion tracking through an auxiliary real-time line scan ophthalmoscope that is clinically feasible to image functional retinal vasculature in patients ...
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    5. Split integration mode acquisition for optimized OCT imaging at multiple speeds

      Split integration mode acquisition for optimized OCT imaging at multiple speeds
      Split Integration Mode (SIM) acquisition schemes are presented that enable optical coherence tomography (OCT) imaging at multiple rates. SIM enables a system and method of operation having a first mode and a second mode, wherein the fundamental acquisition rate of the detector is the same in the two modes, but wherein the generated signals in the second mode are digitally combined prior to signal processing to create a data set ...
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    6. Systems and methods for improved acquisition of ophthalmic optical coherence tomography data

      Systems and methods for improved acquisition of ophthalmic optical coherence tomography data
      Systems and methods for improved acquisition of ophthalmic optical coherence tomography data are presented, allowing for enhanced ease of use and higher quality data and analysis functionality. Embodiments include automated triggering for detecting and initiating collection of OCT ophthalmic data, an automated technique for determining the optimal number of B-scans to be collected to create the highest quality image and optimize speckle reduction, automated review of fundus images collected with ...
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    7. Systems and methods for faster optical coherence tomography acquisition and processing

      Systems and methods for faster optical coherence tomography acquisition and processing
      Systems and methods for faster acquisition and processing of OCT image data are presented. In one embodiment of the present invention, an OCT system is operated in two different acquisition modes of different axial resolutions to allow for efficient collection of OCT Angiography data while also collecting high resolution OCT data. In another embodiment, a reduced subset of a collected data set is used for OCT Angiography data analysis. In ...
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    8. SWEPT SOURCE OCT ANGIOGRAPHY OF NEOVASCULAR MACULAR TELANGIECTASIA TYPE 2

      SWEPT SOURCE OCT ANGIOGRAPHY OF NEOVASCULAR MACULAR TELANGIECTASIA TYPE 2
      Background/Purpose: To image subretinal neovascularization in proliferative macular telangiectasia Type 2 (MacTel2) using swept source optical coherence tomography based microangiography (OMAG). Methods: Patients with macular telangiectasia Type 2 were enrolled in a prospective, observational study known as the MacTel Project and evaluated using a high-speed 1,050 nm swept-source OCT prototype system. The OMAG algorithm generated en face flow images from three retinal layers, and the region bounded by ...
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    9. Systems and methods for enhanced accuracy in OCT imaging of the cornea

      Systems and methods for enhanced accuracy in OCT imaging of the cornea
      Systems and methods for enhanced accuracy in optical coherence tomography imaging of the cornea are presented, including approaches for more accurate corneal surface modeling, pachymetry maps, keratometric values, and corneal power. These methods involve new scan patterns, an eye tracking mechanism for transverse motion feedback, and advanced motion correction algorithms. In one embodiment the methods comprise acquiring a first sparse set of data, using that data to create a corneal ...
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    10. Segmentation and enhanced visualization techniques for full-range fourier domain optical coherence tomography

      Segmentation and enhanced visualization techniques for full-range fourier domain optical coherence tomography
      Presented here are new processing techniques for optical coherence tomography (OCT) data that allow for improved visualization and use of full-range OCT images. These techniques minimize the central line artifact and the complex conjugate artifact without requiring additional system hardware or significantly increasing post-processing time. The central line artifact is minimized by normalizing each A-scan to account for ripples at the zero-delay position. The complex conjugate artifact is minimized by ...
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    11. Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking.

      Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking.
      Optical coherence tomography (OCT)-based optical microangiography (OMAG) is a high-resolution, noninvasive imaging technique capable of providing three-dimensionalin vivoblood flow visualization within microcirculatory tissue beds in the eye. Although the technique has demonstrated early clinical utility by imaging diseased eyes, its limited field of view (FOV) and the sensitivity to eye motion remain the two biggest challenges for the widespread clinical use of the technology. Here, we report the results ...
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    12. Swept-Source OCT Angiography of Macular Telangiectasia Type 2

      Swept-Source OCT Angiography of Macular Telangiectasia Type 2
      BACKGROUND AND OBJECTIVE: To evaluate the central macular microvascular network in patients with macular telangiectasia type 2 (MacTel2) using optical coherence tomography (OCT)-based microangiography (OMAG). PATIENTS AND METHODS: Prospective, observational study of patients with MacTel2 evaluated using a swept-source OCT (SS-OCT) prototype. OMAG was performed using a 3 mm 3 mm central foveal raster scan. The algorithm segmented the retina into three layers. Microvascular distribution was depicted as en ...
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    13. Swept-Source OCT Angiography of the Retinal Vasculature Using Intensity Differentiation-based Optical Microangiography Algorithms

      Swept-Source OCT Angiography of the Retinal Vasculature Using Intensity Differentiation-based Optical Microangiography Algorithms
      To demonstrate the feasibility of using a 1,050-nm swept-source optical coherence tomography (SS-OCT) system to achieve noninvasive retinal vasculature imaging in human eyes. MATERIALS AND METHODS: Volumetric data sets were acquired using a 1-m SS-OCT prototype that operated at a 100-kHz A-line rate. A scanning protocol designed to allow for motion contrast processing, referred to as OCT angiography or optical microangiography (OMAG), was used to scan an approximately 3 ...
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    14. Segmentation And Enhanced Visualization Techniques For FULL-RANGE Fourier Domain Optical Coherence Tomography

      Segmentation And Enhanced Visualization Techniques For FULL-RANGE Fourier Domain Optical Coherence Tomography
      Presented here are new processing techniques for optical coherence tomography (OCT) data that allow for improved visualization and use of full-range OCT images. These techniques minimize the central line artifact and the complex conjugate artifact without requiring additional system hardware or significantly increasing post-processing time. The central line artifact is minimized by normalizing each A-scan to account for ripples at the zero-delay position.
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    15. Data Acquisition Methods For Reduced Motion Artifacts And Applications In Oct Angiography

      Data Acquisition Methods For Reduced Motion Artifacts And Applications In Oct Angiography
      Systems and methods for reducing the effects of motion on functional optical coherence tomography (OCT) imaging are described. Embodiments including post-processing and motion tracking are presented. A preferred embodiment in which functional OCT data is collected and analyzed for motion as a multiple scan unit is described. An extension of the invention to the collection of large field of view or montaged functional OCT data sets is also presented.
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    16. 1-15 of 31 1 2 »
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  2. About Utkarsh Sharma

    Utkarsh Sharma

    Utkarsh Sharma has over 15 years of experience in development of innovative optical imaging systems, medical devices, lasers and sensors. He obtained his PhD in Electrical and Computer Engineering at the Johns Hopkins University and BS in Engineering Physics from Indian Institute of Technology (IIT-Bombay). During his doctoral research, he developed novel optical imaging systems and fiber lasers. Post PhD, he worked as research fellow at Harvard Medical School and later at Beckman Institute at the University of Illinois (UIUC), where he continued working towards developing high-speed and high-sensitivity optical imaging systems and laser sources for applications in bio-imaging. Thereafter he worked at Carl Zeiss Meditec, Inc. (Dublin, CA) where he led the projects for developing next generation ophthalmic imaging systems and technologies including development and commercialization of OCT angiography. Currently he is leading the Advanced Technology Development Group at Optovue Inc. (Fremont, CA).

    Dr. Sharma has authored more than 45 research publications including peer-reviewed journal articles, book chapters, and articles in conference proceedings. His work has resulted in 23 issued/pending patents in the field of optical imaging and lasers. He has delivered over 12 invited talks at international conferences and technical events. He has been serving as a technical committee planning member for CLEO 2015-17.