1. UT Southwestern Medical Center

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    1. Mentioned In 66 Articles

    2. Optic coherence tomography as a potential readout in clinical trials

      Optic coherence tomography as a potential readout in clinical trials
      Optical coherence tomography (OCT) is a noninvasive tool used for measuring tissue at micrometer resolution. It has been extensively applied to ocular pathologies and is now being studied as a biomarker in various neurologic conditions. The retina represents a unique environment for study, with unmyelinated axons that directly synapse into the central nervous system. When trying to quantify axonal degradation in neurologic disease, the currently used imaging modalities are limited ...
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    3. A Comparison of Visual Field Sensitivity to Photoreceptor Thickness in Retinitis Pigmentosa

      Purpose: To explore the relationship between visual field sensitivity and photoreceptor layer thickness in patients with retinitis pigmentosa (RP). Methods: Static automated perimetry with Humphrey Field Analyzer (central 30-2 threshold program with spot size III) and frequency domain optical coherence tomography (fd-OCT) scans with Spectralis HRA+OCT were obtained from 10 age-matched normal controls and 20 patients with RP retaining good central vision (better than 20/32). The OS+ thickness ...
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    4. Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis

      Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis
      Objective Cross-sectional studies of optical coherence tomography (OCT) show that retinal nerve fiber layer (RNFL) thickness is reduced in multiple sclerosis (MS) and correlates with visual function. We determined how longitudinal changes in RNFL thickness relate to visual loss. We also examined patterns of RNFL thinning over time in MS eyes with and without a prior history of acute optic neuritis (ON). Methods Patients underwent OCT measurement of RNFL thickness ...
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    5. Macular Atrophy in Birdshot Retinochoroidopathy: An Optical Coherence Tomography and Multifocal Electroretinography Analysis

      Purpose: The purpose of this study was to evaluate macular atrophy by frequency-domain optical coherence tomography (OCT) in patients with birdshot retinochoroidopathy and to compare the resulting thickness measures with visual acuity and multifocal electroretinography (mfERG). Methods: Measures were obtained from 14 eyes of 7 patients with birdshot retinochoroidopathy and 23 normal eyes. Optical coherence tomography-3 measures of macular thinning were related to visual acuity, mfERG response density, and time ...
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    6. Macular Volume Determined by Optical Coherence Tomography as a Measure of Neuronal Loss in Multiple Sclerosis

      Macular Volume Determined by Optical Coherence Tomography as a Measure of Neuronal Loss in Multiple Sclerosis
      ...delphia; Departments of Neurology (Mss Frohman and Conger and Dr Frohman) and Ophthalmology (Dr Frohman), The University of Texas Southwestern Medical Center, Dallas; Departments of Ophthalmology (Dr Burkholder) and Neur...
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    7. Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: A pilot study

      BackgroundMeasurement of retinal nerve fiber layer (RNFL) thickness in multiple sclerosis (MS) is gaining increasing attention.ObjectivesTo explore the relationship between RNFL thickness as measured by optical coherence tomography (OCT) and scanning laser polarimetry with variable corneal compensation (GDx), and conventional and non-conventional optic nerve and brain MRI measures.MethodsTwelve relapsing–remitting (RR) MS patients (12 affected and 12 unaffected eyes) and 4 age- and sex-matched normal controls (NC) (8 ...
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    8. Corneal Deturgescence after Descemet Stripping Automated Endothelial Keratoplasty Evaluated by Visante Anterior Segment Optical Coherence Tomography

      Purpose: To evaluate postoperative corneal deturgescence after Descemet stripping endothelial keratoplasty (DSAEK) using the Visante anterior segment optical coherence tomography (OCT) system (Carl Zeiss Meditec Inc, Dublin, California, USA).Design: Retrospective case series. Methods: We included 21 eyes (9 males and 12 females; mean age ± standard deviation, 76.3 ± 12 years). The Visante OCT system was used to determine the central and peripheral endothelial keratoplasty graft thickness and total central ...
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    9. Thickness of Receptor and Post-receptor Retinal Layers in Patients with Retinitis Pigmentosa Measured with Frequency-Domain Optical Coherence Tomography (fdOCT)

      PURPOSE: To better understand the effects of retinitis pigmentosa (RP) on post-receptor anatomy by measuring the thickness of the receptor, inner nuclear, retinal ganglion cell (RGC), and retinal nerve fiber layers (RNFL) with frequency-domain optical coherence tomography (fdOCT). METHODS: FdOCT scans were obtained from the horizontal midline in 30 patients with RP and 23 comparable age control subjects. Raw images were exported and the thickness of photoreceptor/RPE, inner nuclear ...
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    10. 46-60 of 66 « 1 2 3 4 5 »
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  2. About UT Southwestern Medical Center

    UT Southwestern Medical Center

    University of Texas Southwestern Medical Center. Part of The University of Texas System, UT Southwestern is governed by the UT Board of Regents. President Dr. Daniel K. Podolsky leads the medical center which includes three degree-granting institutions: UT Southwestern Medical School, UT Southwestern Graduate School of Biomedical Sciences and UT Southwestern School of Health Professions. These three schools train nearly 4,200 medical, graduate and health professions students, residents and postdoctoral fellows each year.