1. UT Southwestern Medical Center

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    1. Mentioned In 75 Articles

    2. Evaluation and characterization of facial skin aging using optical coherence tomography

      Evaluation and characterization of facial skin aging using optical coherence tomography
      Objectives: The skin aging exposome encompasses internal and external factors that contribute to clinical signs of facial aging. Aging skin can be characterized by distinctive features such as wrinkles, lentigines, elastosis, and roughness. Optical coherence tomography (OCT) is capable of noninvasively measuring skin characteristics. This study aimed to assess bilateral features using OCT to explore temporal skin changes among decades and potential changes in facial skin aging based on laterality ...
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    3. Glaucoma Diagnosis Through the Integration of Optical Coherence Tomography/Angiography and Machine Learning Diagnostic Models

      Glaucoma Diagnosis Through the Integration of Optical Coherence Tomography/Angiography and Machine Learning Diagnostic Models
      ...ective study were obtained from electronic medical records of 887 patients seen in the Glaucoma Clinic at the University of Texas Southwestern Medical Center (UTSW) from January 2017 through July 2019. Institutional Revi...
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    4. Performance of Deep Learning Models in Automatic Measurement of Ellipsoid Zone Area on Baseline Optical Coherence Tomography (OCT) Images From the Rate of Progression of USH2A-Related Retinal Degeneration (RUSH2A) Study

      Performance of Deep Learning Models in Automatic Measurement of Ellipsoid Zone Area on Baseline Optical Coherence Tomography (OCT) Images From the Rate of Progression of USH2A-Related Retinal Degeneration (RUSH2A) Study
      Purpose: Previously, we have shown the capability of a hybrid deep learning (DL) model that combines a U-Net and a sliding-window (SW) convolutional neural network (CNN) for automatic segmentation of retinal layers from OCT scan images in retinitis pigmentosa (RP). We found that one of the shortcomings of the hybrid model is that it tends to underestimate ellipsoid zone (EZ) width or area, especially when EZ extends toward or beyond ...
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    5. Nail-Patella Syndrome: Optical Coherence Tomography Angiography Findings

      Nail-Patella Syndrome: Optical Coherence Tomography Angiography Findings
      We describe a 51-year-old Hispanic female with nail-patella syndrome (NPS), a rare genetic disease with a wide range of systemic features such as nail dysplasia and finger abnormalities, elbow webbing, iliac horn, patellar subluxation, and proteinuria. Some patients additionally have a history of glaucoma and other ocular features such as thick central corneal thickness, Lesters sign, prominent iris processes, and optic nerve cupping. Our patient had a history of glaucoma ...
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    6. A Hybrid Model Composed of Two Convolutional Neural Networks (CNNs) for Automatic Retinal Layer Segmentation of OCT Images in Retinitis Pigmentosa (RP)

      A Hybrid Model Composed of Two Convolutional Neural Networks (CNNs) for Automatic Retinal Layer Segmentation of OCT Images in Retinitis Pigmentosa (RP)
      Purpose: We propose and evaluate a hybrid model composed of two convolutional neural networks (CNNs) with different architectures for automatic segmentation of retina layers in spectral domain optical coherence tomography (SD-OCT) B-scans of retinitis pigmentosa (RP). Methods: The hybrid model consisted of a U-Net for initial semantic segmentation and a sliding-window (SW) CNN for refinement by correcting the segmentation errors of U-Net. The U-Net construction followed Ronneberger et al. (2015 ...
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    7. Coronary Stent Healing in Cancer Patients—An Optical Coherence Tomography Perspective

      Coronary Stent Healing in Cancer Patients—An Optical Coherence Tomography Perspective
      Objective: This study assessed stent healing patterns and cardiovascular outcomes by optical coherence tomography (OCT) in cancer patients after drug-eluting stent (DES) placement. Background: Cancer treatment, owing to its cytotoxic and antiproliferative effects, could delay stent healing and increase stent thrombosis risk, especially when dual antiplatelet therapy (DAPT) is discontinued early for oncological treatment. OCT can assess stent endothelialization and other healing parameters, which may provide clinical guidance in these ...
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    8. Comprehensive review of surgical microscopes: technology development and medical applications

      Comprehensive review of surgical microscopes: technology development and medical applications
      Significance: Surgical microscopes provide adjustable magnification, bright illumination, and clear visualization of the surgical field and have been increasingly used in operating rooms. State-of-the-art surgical microscopes are integrated with various imaging modalities, such as optical coherence tomography (OCT), fluorescence imaging, and augmented reality (AR) for image-guided surgery. Aim: This comprehensive review is based on the literature of over 500 papers that cover the technology development and applications of surgical microscopy ...
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    9. Acute Bilateral Uveitis, Hypotony, and Cataracts Associated with Ipilimumab and Nivolumab Therapy: Optical Coherence Tomography Angiography Findings

      Acute Bilateral Uveitis, Hypotony, and Cataracts Associated with Ipilimumab and Nivolumab Therapy: Optical Coherence Tomography Angiography Findings
      Immune checkpoint inhibitors are increasingly being used for the treatment of several malignancies. In rare cases, patients develop disabling ophthalmic side effects such as dry eyes, episcleritis, keratitis, uveitis, inflammatory orbitopathy, myasthenia gravis, macular edema, and serous retinal detachment. We present a case of acute bilateral anterior uveitis, prolonged hypotony, and cataracts following the use of dual therapy ipilimumab and nivolumab.
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    10. Application of a Deep Machine Learning Model for Automatic Measurement of EZ Width in SD-OCT Images of RP

      Application of a Deep Machine Learning Model for Automatic Measurement of EZ Width in SD-OCT Images of RP
      Purpose : We applied a deep convolutional neural network model for automatic identification of ellipsoid zone (EZ) in spectral domain optical coherence tomography B-scans of retinitis pigmentosa (RP). Methods : Midline B-scans having visible EZ from 220 patients with RP and 20 normal subjects were manually segmented for inner limiting membrane, inner nuclear layer, EZ, retinal pigment epithelium, and Bruch's membrane. A total of 2.87 million labeled image patches (33 ...
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    11. Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice

      Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice
      Retinal disease and loss of vision can result from any disruption of the complex pathways controlling retinal development and homeostasis. Forward genetics provides an excellent tool to find, in an unbiased manner, genes that are essential to these processes. Using N -ethyl- N -nitrosourea mutagenesis in mice in combination with a screening protocol using optical coherence tomography (OCT) and automated meiotic mapping, we identified 11 mutations presumably causative of retinal ...
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    12. An assessment of the quality of optical coherence tomography image acquisition

      An assessment of the quality of optical coherence tomography image acquisition
      Optical coherence tomography (OCT) provides excellent image resolution, however OCT optimal acquisition is essential but could be challenging owing to several factors. We sought to assess the quality of OCT pullbacks and identify the causes of suboptimal image acquisition. We evaluated 784 (404 pre-PCI; 380 post-PCI) coronary pullbacks from an anonymized OCT database from our Cardiovascular Imaging Core Laboratory. Imaging of the region-of-interest (ROIlesion or stented segment plus references) was ...
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    13. Use of Optical Coherence Tomography (OCT) in Aesthetic Skin Assessment—A Short Review

      Use of Optical Coherence Tomography (OCT) in Aesthetic Skin Assessment—A Short Review
      Assessments of non‐surgical office‐based aesthetic treatments' efficacy including lasers are mostly based on subjective evaluation of clinical photography. Accumulating evidence suggest that non‐invasive skin imaging such as optical coherence tomography (OCT) can be effectively used to assess not only the skin surface but also the underlying epidermis and dermis, providing objective and clinically relevant data. In this review, we highlight the potential of OCT imaging for the ...
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    14. Unique characteristics of optical coherence tomography (OCT) results and visual acuity testing in myelin oligodendrocyte glycoprotein (MOG) antibody positive pediatric patients

      Unique characteristics of optical coherence tomography (OCT) results and visual acuity testing in myelin oligodendrocyte glycoprotein (MOG) antibody positive pediatric patients
      Background Optic nerve involvement in anti-myelin oligodendrocyte glycoprotein antibody associated syndrome (MOG ab syndrome) tends to have unique features. Few studies have reported optical coherence tomography (OCT) measures like retinal nerve fiber layer thickness findings in the setting of pediatric MOG ab syndrome. Objectives The aim of this study is to compare visual acuity between MOG ab positive and MOG ab negative pediatric cohorts and examine correlations with OCT findings ...
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  2. About UT Southwestern Medical Center

    UT Southwestern Medical Center

    University of Texas Southwestern Medical Center. Part of The University of Texas System, UT Southwestern is governed by the UT Board of Regents. President Dr. Daniel K. Podolsky leads the medical center which includes three degree-granting institutions: UT Southwestern Medical School, UT Southwestern Graduate School of Biomedical Sciences and UT Southwestern School of Health Professions. These three schools train nearly 4,200 medical, graduate and health professions students, residents and postdoctoral fellows each year.