1. University of Wisconsin

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    1. Mentioned In 80 Articles

    2. Imaging the adult zebrafish cone mosaic using optical coherence tomography

      Imaging the adult zebrafish cone mosaic using optical coherence tomography
      Zebrafish ( Danio rerio ) provide many advantages as a model organism for studying ocular disease and development, and there is great interest in the ability to non-invasively assess their photoreceptor mosaic. Despite recent applications of scanning light ophthalmoscopy, fundus photography, and gonioscopy to in vivo imaging of the adult zebrafish eye, current techniques either lack accurate scaling information (limiting quantitative analyses) or require euthanizing the fish (precluding longitudinal analyses). Here we ...
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    3. Directional optical coherence tomography systems and methods

      Directional optical coherence tomography systems and methods
      An optical coherence tomography system that includes an optical device having an adjustable optical element configured to displace a pupil entry point of light is provided. Optical coherence tomography methods using the optical coherence tomography system are also provided. The subject optical coherence tomography systems and methods find use in a variety of different applications, including imaging applications.
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    4. Variability in Spectral-Domain Optical Coherence Tomography over 4 Weeks by Age

      Variability in Spectral-Domain Optical Coherence Tomography over 4 Weeks by Age
      Purpose: To quantify variation in spectral-domain optical coherence tomography (SD-OCT) measures of total retinal thickness (top of inner limiting membrane to top of retinal pigment epithelium, RPE) and RPE thickness measures over a 4-week period and by age. Methods: A total of 76 volunteers aged 4085 years were seen at three visits over 4 weeks. Two Topcon SD-OCT scans were taken at each visit. Following grid re-centration, total retinal and ...
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    5. Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics

      Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics
      We analyzed heart wall motion and blood flow dynamics in chicken embryos using in vivo optical coherence tomography (OCT) imaging and computational fluid dynamics (CFD) embryo-specific modeling. We focused on the heart outflow tract (OFT) region of day 3 embryos, and compared normal (control) conditions to conditions after performing an OFT banding intervention, which alters hemodynamics in the embryonic heart and vasculature. We found that hemodynamics and cardiac wall motion ...
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    6. Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography

      Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography
      Angle-resolved low coherence interferometry (a/LCI) is an optical technique used to measure nuclear morphology in situ . However, a/LCI is not an imaging modality and can produce ambiguous results when the measurements are not properly oriented to the tissue architecture. Here we present a 2D a/LCI system which incorporates optical coherence tomography imaging to guide the measurements. System design and characterization are presented, along with example cases which ...
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    7. State-of-the-art in retinal optical coherence tomography image analysis

      State-of-the-art in retinal optical coherence tomography image analysis
      Optical coherence tomography (OCT) is an emerging imaging modality that has been widely used in the field of biomedical imaging. In the recent past, it has found uses as a diagnostic tool in dermatology, cardiology, and ophthalmology. In this paper we focus on its applications in the field of ophthalmology and retinal imaging. OCT is able to non-invasively produce cross-sectional volumetric images of the tissues which can be used for ...
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    8. Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation

      Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation
      The lack of capability to quantify oxygen metabolism noninvasively impedes both fundamental investigation and clinical diagnosis of a wide spectrum of diseases including all the major blinding diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Using visible light optical coherence tomography (vis-OCT), we demonstrated accurate and robust measurement of retinal oxygen metabolic rate (rMRO 2 ) noninvasively in rat eyes. We continuously monitored the regulatory response of oxygen consumption ...
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    9. En Face Optical Coherence Tomography of Outer Retinal Discontinuity and Fan-Shaped Serous Macular Detachment in Diabetic Macular Edema

      En Face Optical Coherence Tomography of Outer Retinal Discontinuity and Fan-Shaped Serous Macular Detachment in Diabetic Macular Edema
      This case report describes en face optical coherence tomographic imaging of serous macular detachment secondary to retinal microangiopathy in a patient with diabetic retinopathy and macular edema. We report en face optical coherence tomographic (OCT) imaging of serous macular detachment secondary to retinal microangiopathy in a patient with diabetic retinopathy and macular edema. The en face OCT clearly delineated a fan shape of the detachment. Our findings implicate an outer ...
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    10. Medical College of Wisconsin Receives NIH Grant to study Inhibition of Reflux-Induced Esophageal Adenocarinoma by Proanthocyanidins.

      Medical College of Wisconsin Receives NIH Grant  to study Inhibition of Reflux-Induced Esophageal Adenocarinoma by Proanthocyanidins.
      Medical College of Wisconsin Received a 2015 NIH Grant for $317,475 to study Inhibition of Reflux-Induced Esophageal Adenocarinoma by Proanthocyanidins. The prinipal investigator is Laura Kreesty. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. Esophageal adenocarcinoma (EAC) rates have increased 500% over the last three decades resulting in EAC being identified as the fastest increasing of all cancer types in ...
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    11. In vivo evaluation of the cornea and conjunctiva of the normal laboratory beagle using time- and Fourier-domain optical coherence tomography and ultrasound pachymetry

      In vivo evaluation of the cornea and conjunctiva of the normal laboratory beagle using time- and Fourier-domain optical coherence tomography and ultrasound pachymetry
      ...rshall Court Suite 200, USA 5. 5 Comparative Ophthalmic Research Laboratories, School of Veterinary Medicine, University of Wisconsin, Madison, 2828 Marshall Court Suite 200, USA 6. 6 Covance Laboratories, Inc., Madison,...
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    12. Monitoring Cerebral Hemodynamics Following Optogenetic Stimulation via Optical Coherence Tomography

      Monitoring Cerebral Hemodynamics Following Optogenetic Stimulation via Optical Coherence Tomography
      In this article, spectral domain optical coherence tomography is used to measure the hemodynamic response induced by optogenetic stimulation in the somatosensory cortex of transgenic mice. By analyzing the 3-D angiograms and Doppler measurements produced by coherence tomography, we observed significant increase in blood flow as a result of increased vessel diameter and blood velocity following optical stimulation of cortical neurons. Such distinct responses were not observed in control experiments ...
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  2. About University of Wisconsin

    University of Wisconsin

    University of Wisconsin System has established itself as one of the world's premier public university systems. The UW educates more than 173,000 students on 26 campuses, and serves more than one million citizens through statewide extension programs. The UW System's campuses in Madison and Milwaukee offer both undergraduate and graduate degree programs, including doctoral and professional programs. Eleven comprehensive campuses provide students both undergraduate and master's degree programs in smaller, more individualized academic settings. The UW System's 13 UW Colleges deliver freshman-sophomore courses for students seeking a foundation for a bachelor's degree.