1. University of Wisconsin

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    1. Mentioned In 109 Articles

    2. Platform for quantitative multiscale imaging of tissue composition

      Platform for quantitative multiscale imaging of tissue composition
      Changes in the multi-level physical structure of biological features going from cellular to tissue level composition is a key factor in many major diseases. However, we are only beginning to understand the role of these structural changes because there are few dedicated multiscale imaging platforms with sensitivity at both the cellular and macrostructural spatial scale. A single platform reduces bias and complications from multiple sample preparation methods and can ease ...
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    3. Effect of partial posterior vitreous detachment on spectral-domain optical coherence tomography retinal nerve fibre layer thickness measurements

      Effect of partial posterior vitreous detachment on spectral-domain optical coherence tomography retinal nerve fibre layer thickness measurements
      Background/aims To assess the effect of partial posterior vitreous detachment (pPVD) on spectral-domain optical coherence tomography (OCT) peripapillary retinal nerve fibre layer thickness (RNFL) measurements. Methods Spectral-domain OCT RNFL thickness measurements were obtained from 684 consecutive patients who were seen in the Massachusetts Eye and Ear Glaucoma Service. Of these patients, we compared RNFL thickness measurements between 101 eyes of 101 glaucoma suspects who met inclusion criteria (55 eyes ...
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    4. Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies

      Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies
      Importance Individual differences in axial length affect the lateral magnification of in vivo retinal images and as a result can affect the accuracy of quantitative measurements made from these images. As measurements from optical coherence tomography angiography (OCTA) images are becoming increasingly used in the diagnosis and monitoring of a wide range of diseases, evaluating which studies use correctly scaled images is crucial to their interpretation. Objective To perform a ...
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    5. Comprehensive Clinical, Diagnostic, and Advanced Imaging Characterization of the Ocular Surface in Spontaneous Aqueous Deficient Dry Eye Disease in Dogs

      Comprehensive Clinical, Diagnostic, and Advanced Imaging Characterization of the Ocular Surface in Spontaneous Aqueous Deficient Dry Eye Disease in Dogs
      Purpose: To perform a comprehensive clinical, diagnostic, and imaging characterization of the ocular surface in West Highland White Terriers (WHWTs) diagnosed with aqueous deficient dry eye (ADDE) disease. Methods: Six ADDE-affected and 13 ADDE-unaffected WHWT dogs were enrolled and underwent clinical assessment and disease scoring, tear osmolarity, phenol red thread test, Schirmer tear test, tear film breakup time, fluorescein staining, Rose bengal and lissamine green vital dye staining, meibometry, corneal ...
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    6. Accuracy of Spectral Domain Optical Coherence Tomography of the Macula for Detection of Complete Posterior Vitreous Detachment

      Accuracy of Spectral Domain Optical Coherence Tomography of the Macula for Detection of Complete Posterior Vitreous Detachment
      Purpose To assess the accuracy of macular spectral domain optical coherence tomography (OCT) in detecting complete posterior vitreous detachment (PVD). Design Evaluation of diagnostic test or technology using a retrospective comparative study. Subjects 175 eyes in 175 patients (111 female, 64 male; mean age = 65 years) with pre-operative OCT within 90 days of vitrectomy. Methods PVD status on preoperative macular OCT was compared to PVD determination during vitrectomy. Attached vitreous ...
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    7. State-of-the-art in retinal optical coherence tomography image analysis

      State-of-the-art in retinal optical coherence tomography image analysis
      Optical coherence tomography (OCT) is an emerging imaging modality that has been widely used in the field of biomedical imaging. In the recent past, it has found uses as a diagnostic tool in dermatology, cardiology, and ophthalmology. In this paper we focus on its applications in the field of ophthalmology and retinal imaging. OCT is able to non-invasively produce cross-sectional volumetric images of the tissues which can be used for ...
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    8. Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents

      Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents
      Purpose : Optical coherence tomography (OCT) is widely used for ocular imaging in clinical and research settings. OCT natively provides structural information based on the reflectivity of the tissues it images. We demonstrate the utility of photothermal OCT (PTOCT) imaging of gold nanorods (GNR) in the mouse retina in vivo in the laser-induced choroidal neovascularization (LCNV) model to provide additional image contrast within the lesion. Methods : Wild-type C57BL/6 mice were ...
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    9. Comparative Intraoperative Anterior Segment Optical Coherence Tomography Findings in Pediatric Patients with and without Glaucoma

      Comparative Intraoperative Anterior Segment Optical Coherence Tomography Findings in Pediatric Patients with and without Glaucoma
      Purpose To compare the angle structures intraoperatively using anterior segment optical coherence tomography (AS OCT) in children with and without glaucoma. Design Prospective comparative study, with single masked grader evaluating AS OCT images. Participants This study included a total of 44 eyes of 8 children with glaucoma and 14 children without glaucoma undergoing ophthalmic surgery under general anesthesia. The median age for the glaucoma group was 6 months (range 0 ...
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    10. Assessing Retinal Structure in Patients with Parkinson Disease

      Assessing Retinal Structure in Patients with Parkinson Disease
      Objective : The retina is an extension of the central nervous system (CNS), and ocular symptoms can precede manifestations of CNS disorders. Given that several neurodegenerative conditions that affect the brain exhibit ocular symptoms, the retina may be an accessible biomarker to monitor disease progression. Dopamine, the key neurotransmitter related to Parkinsons disease (PD), is contained in amacrine and interplexiform cells, which reside in specific retinal layers. Understanding how loss of ...
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    11. Redox imaging and optical coherence tomography of the respiratory ciliated epithelium

      Redox imaging and optical coherence tomography of the respiratory ciliated epithelium
      Optical coherence tomography (OCT) is an emerging technology for in vivo airway and lung imaging. However, OCT lacks sensitivity to the metabolic changes caused by inflammation, which drives chronic respiratory diseases such as asthma and chronic obstructive pulmonary disorder. Redox imaging (RI) is a label-free technique that uses the autofluorescence of the metabolic coenzymes NAD(P)H and flavin adenine dinucleotide (FAD) to probe cellular metabolism and could provide complimentary ...
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    12. Earliest Evidence of Preclinical Diabetic Retinopathy Revealed using OCT Angiography (OCTA) Perfused Capillary Density

      Earliest Evidence of Preclinical Diabetic Retinopathy Revealed using OCT Angiography (OCTA) Perfused Capillary Density
      Purpose To compare perfused capillary density (PCD) in diabetic patients and healthy controls using optical coherence tomography angiography (OCTA). Methods Forty controls, 36 diabetics without clinical retinopathy (NoDR), 38 with nonproliferative retinopathy (NPDR), and 38 with proliferative retinopathy (PDR) were imaged using SD-OCT. A 3x3 mm full-thickness parafoveal OCTA scan was obtained from each participant. Following manual delineation of the foveal avascular zone (FAZ), FAZ area, perimeter, and acircularity index ...
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    13. Variability of Foveal Avascular Zone Metrics Derived From Optical Coherence Tomography Angiography Images

      Variability of Foveal Avascular Zone Metrics Derived From Optical Coherence Tomography Angiography Images
      Purpose : To characterize sources of inter- and intrasubject variability in quantitative foveal avascular zone (FAZ) metrics. Methods : Two 33-mm optical coherence tomography angiography scans (centered on the fovea) were acquired in both eyes of 175 subjects. An image of the superficial plexus was extracted from each scan and segmented twice by a single observer. Four quantitative FAZ morphology metrics (area, axis ratio, acircularity, major horizontal axis angle) were calculated, and ...
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    14. Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography

      Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography
      Purpose : To demonstrate and validate that photothermal optical coherence tomography (PT-OCT) can image melanin in the retinal pigment epithelium (RPE) and can observe light-driven melanosome translocation in the zebrafish retina. Methods : A commercial spectral domain OCT system was modified to perform both OCT and PT-OCT. Four adult tyrosinase-mosaic zebrafish with varying levels of melanin expression across their retinas were imaged, and the PT-OCT signal for pigmented and nonpigmented regions were ...
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  2. About University of Wisconsin

    University of Wisconsin

    University of Wisconsin System has established itself as one of the world's premier public university systems. The UW educates more than 173,000 students on 26 campuses, and serves more than one million citizens through statewide extension programs. The UW System's campuses in Madison and Milwaukee offer both undergraduate and graduate degree programs, including doctoral and professional programs. Eleven comprehensive campuses provide students both undergraduate and master's degree programs in smaller, more individualized academic settings. The UW System's 13 UW Colleges deliver freshman-sophomore courses for students seeking a foundation for a bachelor's degree.