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2. Platform for quantitative multiscale imaging of tissue composition
  
  Explore OSA | OSA Publishing Mar 17 2020
  
  Changes in the multi-level physical structure of biological features going from cellular to tissue level composition is a key factor in many major diseases. However, we are only beginning to understand the role of these structural changes because there are few dedicated multiscale imaging platforms with sensitivity at both the cellular and macrostructural spatial scale. A single platform reduces bias and complications from multiple sample preparation methods and can ease ...
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  Mentions: University of Wisconsin
3. Effect of partial posterior vitreous detachment on spectral-domain optical coherence tomography retinal nerve fibre layer thickness measurements
  
  Explore BJO Online Feb 18 2020 Ophthalmology
  
  Background/aims To assess the effect of partial posterior vitreous detachment (pPVD) on spectral-domain optical coherence tomography (OCT) peripapillary retinal nerve fibre layer thickness (RNFL) measurements. Methods Spectral-domain OCT RNFL thickness measurements were obtained from 684 consecutive patients who were seen in the Massachusetts Eye and Ear Glaucoma Service. Of these patients, we compared RNFL thickness measurements between 101 eyes of 101 glaucoma suspects who met inclusion criteria (55 eyes ...
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  Mentions: University of Wisconsin Harvard University Massachusetts Eye and Ear Infirmary
4. Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies
  
  Explore The JAMA Network Dec 3 2019 Ophthalmology
  
  Importance Individual differences in axial length affect the lateral magnification of in vivo retinal images and as a result can affect the accuracy of quantitative measurements made from these images. As measurements from optical coherence tomography angiography (OCTA) images are becoming increasingly used in the diagnosis and monitoring of a wide range of diseases, evaluating which studies use correctly scaled images is crucial to their interpretation. Objective To perform a ...
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  Mentions: University of Wisconsin Joseph Carroll Fred K. Chen
5. Comprehensive Clinical, Diagnostic, and Advanced Imaging Characterization of the Ocular Surface in Spontaneous Aqueous Deficient Dry Eye Disease in Dogs
  
  Explore LWW Online Nov 6 2019 Ophthalmology
  
  Purpose: To perform a comprehensive clinical, diagnostic, and imaging characterization of the ocular surface in West Highland White Terriers (WHWTs) diagnosed with aqueous deficient dry eye (ADDE) disease. Methods: Six ADDE-affected and 13 ADDE-unaffected WHWT dogs were enrolled and underwent clinical assessment and disease scoring, tear osmolarity, phenol red thread test, Schirmer tear test, tear film breakup time, fluorescein staining, Rose bengal and lissamine green vital dye staining, meibometry, corneal ...
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  Mentions: University of Wisconsin UC Davis
6. Accuracy of Spectral Domain Optical Coherence Tomography of the Macula for Detection of Complete Posterior Vitreous Detachment
  
  Explore Ophthalmology Retina Nov 5 2019 Ophthalmology
  
  Purpose To assess the accuracy of macular spectral domain optical coherence tomography (OCT) in detecting complete posterior vitreous detachment (PVD). Design Evaluation of diagnostic test or technology using a retrospective comparative study. Subjects 175 eyes in 175 patients (111 female, 64 male; mean age = 65 years) with pre-operative OCT within 90 days of vitrectomy. Methods PVD status on preoperative macular OCT was compared to PVD determination during vitrectomy. Attached vitreous ...
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  Mentions: University of Wisconsin UCLA
7. State-of-the-art in retinal optical coherence tomography image analysis
  
  Explore Home Oct 4 2019
  
  Optical coherence tomography (OCT) is an emerging imaging modality that has been widely used in the field of biomedical imaging. In the recent past, it has found uses as a diagnostic tool in dermatology, cardiology, and ophthalmology. In this paper we focus on its applications in the field of ophthalmology and retinal imaging. OCT is able to non-invasively produce cross-sectional volumetric images of the tissues which can be used for ...
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  Mentions: University of Wisconsin
8. Researchers See Around Corners To Detect Object Shapes
  
  Explore Homepage Jun 19 2019
  
  ...researchers are part of a larger collaborative team, which includes researchers from Stanford University, the University of Wisconsin Madison, the University of Zaragosa, Politecnico di Milano and the French-German Resea...
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  Mentions: University of Wisconsin University of Toronto University College London
9. University of Wisconsin-Madison Receives NIH Grant for The Interaction Between Vocal Fold Hydration and Vibratory Biomechanics
  
  Explore Optical Coherence Tomography News Jun 4 2019 Otolaryngology , Funding
  
  ...he change in stress distribution of the tissue with changes in fluid content.
  University of Wisconsin-Madison Receives a 2019 NIH Grant for $400,600 for The Interaction Between Vocal Fold ...
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  Mentions: University of Wisconsin National Institutes of Health
10. Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents
  
  Explore TVST Journal May 23 2019 Ophthalmology
  
  Purpose : Optical coherence tomography (OCT) is widely used for ocular imaging in clinical and research settings. OCT natively provides structural information based on the reflectivity of the tissues it images. We demonstrate the utility of photothermal OCT (PTOCT) imaging of gold nanorods (GNR) in the mouse retina in vivo in the laser-induced choroidal neovascularization (LCNV) model to provide additional image contrast within the lesion. Methods : Wild-type C57BL/6 mice were ...
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  Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala
11. Comparative Intraoperative Anterior Segment Optical Coherence Tomography Findings in Pediatric Patients with and without Glaucoma
  
  Explore ophthalmologyglaucoma.org May 11 2019 Ophthalmology
  
  Purpose To compare the angle structures intraoperatively using anterior segment optical coherence tomography (AS OCT) in children with and without glaucoma. Design Prospective comparative study, with single masked grader evaluating AS OCT images. Participants This study included a total of 44 eyes of 8 children with glaucoma and 14 children without glaucoma undergoing ophthalmic surgery under general anesthesia. The median age for the glaucoma group was 6 months (range 0 ...
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  Mentions: University of Wisconsin University of São Paulo
12. Assessing Retinal Structure in Patients with Parkinson Disease
  
  Explore OMICS Group May 9 2019 Neurology , Ophthalmology
  
  Objective : The retina is an extension of the central nervous system (CNS), and ocular symptoms can precede manifestations of CNS disorders. Given that several neurodegenerative conditions that affect the brain exhibit ocular symptoms, the retina may be an accessible biomarker to monitor disease progression. Dopamine, the key neurotransmitter related to Parkinsons disease (PD), is contained in amacrine and interplexiform cells, which reside in specific retinal layers. Understanding how loss of ...
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  Mentions: University of Wisconsin Joseph Carroll Pooja Godara
13. Redox imaging and optical coherence tomography of the respiratory ciliated epithelium
  
  Explore SPIE Digital Library Feb 3 2019 Pulmonology
  
  Optical coherence tomography (OCT) is an emerging technology for in vivo airway and lung imaging. However, OCT lacks sensitivity to the metabolic changes caused by inflammation, which drives chronic respiratory diseases such as asthma and chronic obstructive pulmonary disorder. Redox imaging (RI) is a label-free technique that uses the autofluorescence of the metabolic coenzymes NAD(P)H and flavin adenine dinucleotide (FAD) to probe cellular metabolism and could provide complimentary ...
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  Mentions: University of Wisconsin Thorlabs Yale University
14. Earliest Evidence of Preclinical Diabetic Retinopathy Revealed using OCT Angiography (OCTA) Perfused Capillary Density
  
  Explore American Journal of Ophthalmology Jan 25 2019 Ophthalmology
  
  Purpose To compare perfused capillary density (PCD) in diabetic patients and healthy controls using optical coherence tomography angiography (OCTA). Methods Forty controls, 36 diabetics without clinical retinopathy (NoDR), 38 with nonproliferative retinopathy (NPDR), and 38 with proliferative retinopathy (PDR) were imaged using SD-OCT. A 3x3 mm full-thickness parafoveal OCTA scan was obtained from each participant. Following manual delineation of the foveal avascular zone (FAZ), FAZ area, perimeter, and acircularity index ...
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  Mentions: University of Wisconsin New York Eye and Ear Infirmary Richard B. Rosen
15. Variability of Foveal Avascular Zone Metrics Derived From Optical Coherence Tomography Angiography Images
  
  Explore TVST Journal Oct 6 2018 Ophthalmology
  
  Purpose : To characterize sources of inter- and intrasubject variability in quantitative foveal avascular zone (FAZ) metrics. Methods : Two 33-mm optical coherence tomography angiography scans (centered on the fovea) were acquired in both eyes of 175 subjects. An image of the superficial plexus was extracted from each scan and segmented twice by a single observer. Four quantitative FAZ morphology metrics (area, axis ratio, acircularity, major horizontal axis angle) were calculated, and ...
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  Mentions: University of Wisconsin Joseph Carroll
16. Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography
  
  Explore TVST Journal Sep 8 2018 Developmental Biology , Ophthalmology
  
  Purpose : To demonstrate and validate that photothermal optical coherence tomography (PT-OCT) can image melanin in the retinal pigment epithelium (RPE) and can observe light-driven melanosome translocation in the zebrafish retina. Methods : A commercial spectral domain OCT system was modified to perform both OCT and PT-OCT. Four adult tyrosinase-mosaic zebrafish with varying levels of melanin expression across their retinas were imaged, and the PT-OCT signal for pigmented and nonpigmented regions were ...
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  Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala
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