1. University of Wisconsin

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    1. Mentioned In 116 Articles

    2. Retinal specialist versus artificial intelligence detection of retinal fluid from optical coherence tomography: AREDS2 10-year Follow-On

      Retinal specialist versus artificial intelligence detection of retinal fluid from optical coherence tomography: AREDS2 10-year Follow-On
      Purpose To evaluate the performance of retinal specialists in detecting retinal fluid presence in spectral domain optical coherence tomography (SD-OCT) macular volume scans from eyes with age-related macular degeneration (AMD), and to compare performance with the artificial intelligence (AI)-based Notal OCT Analyzer (NOA). Design Prospective comparison of retinal fluid grades from human retinal specialists and the NOA on SD-OCT scans from two commonly used devices (Cirrus and Spectralis). Participants ...
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    3. Double diversity optical coherence tomography

      Double diversity optical coherence tomography
      This article provides theoretical analysis for a new generation of optical coherence tomography (OCT) scanners to overcome some main limitations of the technology. In the new design, exposure and detection are not limited to plane-waves that enter or reflect back from the sample exclusively orthogonally. Instead, the sample is scanned by more complex radiation patterns such as spherical or partially spherical light waves. Images that are generated based on this ...
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    4. Imaging of Macrophage-Like Cells in Living Human Retina Using Clinical OCT

      Imaging of Macrophage-Like Cells in Living Human Retina Using Clinical OCT
      Purpose : To image retinal macrophages at the vitreoretinal interface in the living human retina using a clinical optical coherence tomography (OCT) device. Methods : Eighteen healthy controls and three patients with retinopathies were imaged using a clinical spectral-domain OCT. In controls, 10 sequential scans were collected at three different locations: (1) 9 degrees temporal to the fovea, (2) the macula, and (3) the optic nerve head (ONH). Intervisit repeatability was evaluated ...
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    5. Noise reduction in supercontinuum sources for OCT by single-pulse spectral normalization

      Noise reduction in supercontinuum sources for OCT by single-pulse spectral normalization
      Supercontinuum (SC) sources offer high illumination power from a single-mode fiber with large spectral bandwidth including the visible spectrum, which is a growing application area for optical coherence tomography (OCT). However, SC spectra suffer from pulse-to-pulse variations, increasing noise in the resulting images. By simultaneously collecting a normalization spectrum, OCT image noise can be reduced by more than half (7 dB) for single pulses without any pulse averaging using only ...
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    6. Standard 6 mm Compared to Wide Field 16.5 mm Optical Coherence Tomography for Staging of Posterior Vitreous Detachment

      Standard 6 mm Compared to Wide Field 16.5 mm Optical Coherence Tomography for Staging of Posterior Vitreous Detachment
      Objective To assess whether 6 mm optical coherence tomography (OCT) scans, which image the macula, can distinguish complete from partial posterior vitreous detachment (PVD) in comparison to 16.5 mm OCT scans, which image the macula, optic nerve, and midperiphery. Design Retrospective cross-sectional study. Subjects We compared 6 mm and 16.5 mm scans in 157 eyes of 157 retina clinic patients (mean age 50 years; range 1064) with diabetic ...
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    7. A semi-automated machine-learning based workflow for ellipsoid zone analysis in eyes with macular edema: SCORE2 pilot study

      A semi-automated machine-learning based workflow for ellipsoid zone analysis in eyes with macular edema: SCORE2 pilot study
      ...he EZ was performed by expert graders at the SCORE2 central reading center (Fundus Photograph Reading Center, University of Wisconsin). The EZ was qualitatively deemed ungradable when the RPE was not visible due to signa...
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    8. Platform for quantitative multiscale imaging of tissue composition

      Platform for quantitative multiscale imaging of tissue composition
      Changes in the multi-level physical structure of biological features going from cellular to tissue level composition is a key factor in many major diseases. However, we are only beginning to understand the role of these structural changes because there are few dedicated multiscale imaging platforms with sensitivity at both the cellular and macrostructural spatial scale. A single platform reduces bias and complications from multiple sample preparation methods and can ease ...
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    9. Effect of partial posterior vitreous detachment on spectral-domain optical coherence tomography retinal nerve fibre layer thickness measurements

      Effect of partial posterior vitreous detachment on spectral-domain optical coherence tomography retinal nerve fibre layer thickness measurements
      Background/aims To assess the effect of partial posterior vitreous detachment (pPVD) on spectral-domain optical coherence tomography (OCT) peripapillary retinal nerve fibre layer thickness (RNFL) measurements. Methods Spectral-domain OCT RNFL thickness measurements were obtained from 684 consecutive patients who were seen in the Massachusetts Eye and Ear Glaucoma Service. Of these patients, we compared RNFL thickness measurements between 101 eyes of 101 glaucoma suspects who met inclusion criteria (55 eyes ...
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    10. Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies

      Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies
      Importance Individual differences in axial length affect the lateral magnification of in vivo retinal images and as a result can affect the accuracy of quantitative measurements made from these images. As measurements from optical coherence tomography angiography (OCTA) images are becoming increasingly used in the diagnosis and monitoring of a wide range of diseases, evaluating which studies use correctly scaled images is crucial to their interpretation. Objective To perform a ...
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    11. Comprehensive Clinical, Diagnostic, and Advanced Imaging Characterization of the Ocular Surface in Spontaneous Aqueous Deficient Dry Eye Disease in Dogs

      Comprehensive Clinical, Diagnostic, and Advanced Imaging Characterization of the Ocular Surface in Spontaneous Aqueous Deficient Dry Eye Disease in Dogs
      Purpose: To perform a comprehensive clinical, diagnostic, and imaging characterization of the ocular surface in West Highland White Terriers (WHWTs) diagnosed with aqueous deficient dry eye (ADDE) disease. Methods: Six ADDE-affected and 13 ADDE-unaffected WHWT dogs were enrolled and underwent clinical assessment and disease scoring, tear osmolarity, phenol red thread test, Schirmer tear test, tear film breakup time, fluorescein staining, Rose bengal and lissamine green vital dye staining, meibometry, corneal ...
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    12. Accuracy of Spectral Domain Optical Coherence Tomography of the Macula for Detection of Complete Posterior Vitreous Detachment

      Accuracy of Spectral Domain Optical Coherence Tomography of the Macula for Detection of Complete Posterior Vitreous Detachment
      Purpose To assess the accuracy of macular spectral domain optical coherence tomography (OCT) in detecting complete posterior vitreous detachment (PVD). Design Evaluation of diagnostic test or technology using a retrospective comparative study. Subjects 175 eyes in 175 patients (111 female, 64 male; mean age = 65 years) with pre-operative OCT within 90 days of vitrectomy. Methods PVD status on preoperative macular OCT was compared to PVD determination during vitrectomy. Attached vitreous ...
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    13. State-of-the-art in retinal optical coherence tomography image analysis

      State-of-the-art in retinal optical coherence tomography image analysis
      Optical coherence tomography (OCT) is an emerging imaging modality that has been widely used in the field of biomedical imaging. In the recent past, it has found uses as a diagnostic tool in dermatology, cardiology, and ophthalmology. In this paper we focus on its applications in the field of ophthalmology and retinal imaging. OCT is able to non-invasively produce cross-sectional volumetric images of the tissues which can be used for ...
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  2. About University of Wisconsin

    University of Wisconsin

    University of Wisconsin System has established itself as one of the world's premier public university systems. The UW educates more than 173,000 students on 26 campuses, and serves more than one million citizens through statewide extension programs. The UW System's campuses in Madison and Milwaukee offer both undergraduate and graduate degree programs, including doctoral and professional programs. Eleven comprehensive campuses provide students both undergraduate and master's degree programs in smaller, more individualized academic settings. The UW System's 13 UW Colleges deliver freshman-sophomore courses for students seeking a foundation for a bachelor's degree.