1. University of Wisconsin

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    1. Mentioned In 94 Articles

    2. Photothermal optical coherence tomography of indocyanine green in ex vivo eyes

      Photothermal optical coherence tomography of indocyanine green in ex vivo eyes
      Indocyanine green (ICG) is routinely used during surgery to stain the inner limiting membrane (ILM) and provide contrast on white light surgical microscopy. While translation of optical coherence tomography (OCT) for intraoperative imaging during ophthalmic surgery has enhanced visualization, the ILM remains difficult to distinguish from underlying retinal structures and ICG does not provide additional OCT contrast. We present photothermal OCT (PT-OCT) for high-specificity detection of ICG on retinal OCT ...
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    3. Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina

      Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina
      Zebrafish ( Danio rerio ) are widely used as an experimental model for a wide range of retinal diseases. Previously, optical coherence tomography (OCT) was introduced for quantitative analysis of the zebrafish cone photoreceptor cell mosaic; however no data exists on the intersession reproducibility or intrasession repeatability of such measurements. We imaged 14 wild-type (WT) fish three times each, with 48 h between each time point. En face images of the UV ...
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    4. Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones

      Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones
      Microwave ablation is a minimally invasive image guided thermal therapy for cancer that can be adapted to endoscope use in the gastrointestinal (GI) tract. Microwave ablation in the GI tract requires precise control over the ablation zone that could be guided by high resolution imaging with quantitative contrast. Optical coherence tomography (OCT) provides ideal imaging resolution and allows for the quantification of tissue scattering properties to characterize ablated tissue. Visible ...
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    5. Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

      Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner
      In the past decades, spectral-domain optical coherence tomography (SD-OCT) has transformed into a widely popular imaging technology which is used in many research and clinical applications. Despite such fast growth in the field, the technology has not been readily accessible to many research laboratories either due to the cost or inflexibility of the commercially available systems or due to the lack of essential knowledge in the field of optics to ...
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    6. Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae
      Medical College of Wisconsin Receives a 2017 NIH Grant for $545,415 for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae. The principal investigator is Josepth Carroll. The program began in 2008 and ends in 2021. Below is a summary of the proposed work. Inherited retinal degenerations affect approximately 1 in 1,500 individuals in the US, and given the extreme genotypic and phenotypic heterogeneity, the prospect of ...
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    7. INTRAOPERATIVE IMAGING OF RETAINED PERFLUOROCARBON LIQUID USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      INTRAOPERATIVE IMAGING OF RETAINED PERFLUOROCARBON LIQUID USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY
      Purpose: To report images of retained perfluorocarbon liquid (PFCL) on the surface of the retina obtained during an intraoperative use of hand-held spectral domain optical coherence tomography. Methods: A 54-year-old man underwent pars plana vitrectomy with injection of PFCL to repair retinal detachment. Postoperatively, visually significant PFCL droplets were found to be retained in the eye. During the surgical removal of PFCL, a hand-held spectral domain optical coherence tomography was ...
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    8. Assessing the Accuracy of Foveal Avascular Zone Measurements Using Optical Coherence Tomography Angiography: Segmentation and Scaling

      Assessing the Accuracy of Foveal Avascular Zone Measurements Using Optical Coherence Tomography Angiography: Segmentation and Scaling
      Purpose : The foveal avascular zone (FAZ) is altered in numerous diseases. We assessed factors (axial length, segmentation method, age, sex) impacting FAZ measurements from optical coherence tomography (OCT) angiography images. Methods : We recruited 116 Caucasian subjects without ocular disease, and acquired two 3 3 mm AngioVue scans per each right eye (232 total scans). In images of the superficial plexus, the FAZ was segmented using the AngioVue semiautomatic nonflow measurement ...
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    9. Blood capillaries and vessels segmentation in optical coherence tomography angiogram using fuzzy C-means and Curvelet transform

      Blood capillaries and vessels segmentation in optical coherence tomography angiogram using fuzzy C-means and Curvelet transform
      Blood capillaries density and vessels structure in vivo brain provide information about diseases and hemodynamic in the brain network. Capillary density in animal brain is one of the indexes that determines if it has diabetes. Capillary density in the animal brain subjected to diabetes diminishes over time. Variation in physical structure and diameter of the vessels as a function of time gives us information about hemodynamic in the brain network ...
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    10. Simultaneous Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Correlate Retinal Thickness Changes to Vascular Abnormalities in an In Vivo Mouse Model of Retinopathy of Prematurity

      Simultaneous Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Correlate Retinal Thickness Changes to Vascular Abnormalities in an In Vivo Mouse Model of Retinopathy of Prematurity
      Background . Retinopathy of prematurity (ROP) is a condition of abnormal retinal vascular development (RVD) in premature infants. Fluorescein angiography (FA) has depicted phases (early, mid, late, and mature) of RVD in oxygen-induced retinopathy (OIR) mice. We sought to establish the relationship between retinal structural and vascular changes using simultaneous FA and spectral domain optical coherence tomography (SD-OCT). Method . 63 mice were exposed to 77% oxygen at postnatal day 7 (P7 ...
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    11. The University of Wisconsin-Madison Receives Grant for Epidemiology of Age-Related Macular Degeneration and Other Retinal Diseases

      The University of Wisconsin-Madison Receives  Grant for  Epidemiology of Age-Related Macular Degeneration and Other Retinal Diseases
      ...of AMD independent of age, smoking status, and high-risk genetic markers.

      The University of Wisconsin-Madison Receives a 2017 NIH Grant for $768,348 for Epidemiology of Age-Related Macular...

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    12. University of Wisconsin-Madison Receives NIH Grant for Epidemiology of Age-Related Macular Degeneration and Other retinal diseases -Enrollment Center

      University of Wisconsin-Madison Receives NIH Grant  for Epidemiology of Age-Related Macular Degeneration and Other retinal diseases -Enrollment Center
      ...sis of AMD independent of age, smoking status, and high-risk genetic markers.

      University of Wisconsin-Madison Receives a 2017 NIH Grant for $149,848 for Epidemiology of Age-Related Macular...

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    13. The Effect of Retinal Melanin on Optical Coherence Tomography Images

      The Effect of Retinal Melanin on Optical Coherence Tomography Images
      Purpose : We assessed the effect of melanin on the appearance of hyperreflective outer retinal bands in optical coherence tomography (OCT) images. Methods : A total of 23 normal subjects and 51 patients with albinism were imaged using the Bioptigen high-resolution spectral-domain OCT. In addition, three wild type, three albino ( slc45a2 b4/b4 ), and eight tyrosinase mosaic zebrafish were imaged with the hand-held Bioptigen Envisu R2200 OCT. To identify pigmented versus nonpigmented ...
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    14. Involuntary Eye Motion Correction in Retinal Optical Coherence Tomography: Hardware or Software Solution?

      Involuntary Eye Motion Correction in Retinal Optical Coherence Tomography: Hardware or Software Solution?
      In this paper, we review state-of-the-art techniques to correct eye motion artifacts in Optical Coherence Tomography (OCT) imaging. The methods for eye motion artifact reduction can be categorized into two major classes: 1) hardware-based techniques and 2) software-based techniques. In the first class, additional hardware is mounted onto the OCT scanner to gather information about the eye motion patterns during OCT data acquisition. This information is later processed and applied ...
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    15. Imaging the adult zebrafish cone mosaic using optical coherence tomography

      Imaging the adult zebrafish cone mosaic using optical coherence tomography
      Zebrafish ( Danio rerio ) provide many advantages as a model organism for studying ocular disease and development, and there is great interest in the ability to non-invasively assess their photoreceptor mosaic. Despite recent applications of scanning light ophthalmoscopy, fundus photography, and gonioscopy to in vivo imaging of the adult zebrafish eye, current techniques either lack accurate scaling information (limiting quantitative analyses) or require euthanizing the fish (precluding longitudinal analyses). Here we ...
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  2. About University of Wisconsin

    University of Wisconsin

    University of Wisconsin System has established itself as one of the world's premier public university systems. The UW educates more than 173,000 students on 26 campuses, and serves more than one million citizens through statewide extension programs. The UW System's campuses in Madison and Milwaukee offer both undergraduate and graduate degree programs, including doctoral and professional programs. Eleven comprehensive campuses provide students both undergraduate and master's degree programs in smaller, more individualized academic settings. The UW System's 13 UW Colleges deliver freshman-sophomore courses for students seeking a foundation for a bachelor's degree.