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    1. Mentioned In 103 Articles

    4. Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents

      Explore TVST Journal Ophthalmology
      Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents
      Purpose : Optical coherence tomography (OCT) is widely used for ocular imaging in clinical and research settings. OCT natively provides structural information based on the reflectivity of the tissues it images. We demonstrate the utility of photothermal OCT (PTOCT) imaging of gold nanorods (GNR) in the mouse retina in vivo in the laser-induced choroidal neovascularization (LCNV) model to provide additional image contrast within the lesion. Methods : Wild-type C57BL/6 mice were ...
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      Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala

    5. Comparative Intraoperative Anterior Segment Optical Coherence Tomography Findings in Pediatric Patients with and without Glaucoma

      Explore ophthalmologyglaucoma.org Ophthalmology
      Comparative Intraoperative Anterior Segment Optical Coherence Tomography Findings in Pediatric Patients with and without Glaucoma
      Purpose To compare the angle structures intraoperatively using anterior segment optical coherence tomography (AS OCT) in children with and without glaucoma. Design Prospective comparative study, with single masked grader evaluating AS OCT images. Participants This study included a total of 44 eyes of 8 children with glaucoma and 14 children without glaucoma undergoing ophthalmic surgery under general anesthesia. The median age for the glaucoma group was 6 months (range 0 ...
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      Mentions: University of Wisconsin University of São Paulo

    6. Assessing Retinal Structure in Patients with Parkinson Disease

      Explore OMICS Group Neurology , Ophthalmology
      Assessing Retinal Structure in Patients with Parkinson Disease
      Objective : The retina is an extension of the central nervous system (CNS), and ocular symptoms can precede manifestations of CNS disorders. Given that several neurodegenerative conditions that affect the brain exhibit ocular symptoms, the retina may be an accessible biomarker to monitor disease progression. Dopamine, the key neurotransmitter related to Parkinsons disease (PD), is contained in amacrine and interplexiform cells, which reside in specific retinal layers. Understanding how loss of ...
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      Mentions: University of Wisconsin Joseph Carroll Pooja Godara

    7. Redox imaging and optical coherence tomography of the respiratory ciliated epithelium

      Explore SPIE Digital Library Pulmonology
      Redox imaging and optical coherence tomography of the respiratory ciliated epithelium
      Optical coherence tomography (OCT) is an emerging technology for in vivo airway and lung imaging. However, OCT lacks sensitivity to the metabolic changes caused by inflammation, which drives chronic respiratory diseases such as asthma and chronic obstructive pulmonary disorder. Redox imaging (RI) is a label-free technique that uses the autofluorescence of the metabolic coenzymes NAD(P)H and flavin adenine dinucleotide (FAD) to probe cellular metabolism and could provide complimentary ...
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      Mentions: University of Wisconsin Thorlabs Yale University

    8. Earliest Evidence of Preclinical Diabetic Retinopathy Revealed using OCT Angiography (OCTA) Perfused Capillary Density

      Explore American Journal of Ophthalmology Ophthalmology
      Earliest Evidence of Preclinical Diabetic Retinopathy Revealed using OCT Angiography (OCTA) Perfused Capillary Density
      Purpose To compare perfused capillary density (PCD) in diabetic patients and healthy controls using optical coherence tomography angiography (OCTA). Methods Forty controls, 36 diabetics without clinical retinopathy (NoDR), 38 with nonproliferative retinopathy (NPDR), and 38 with proliferative retinopathy (PDR) were imaged using SD-OCT. A 3x3 mm full-thickness parafoveal OCTA scan was obtained from each participant. Following manual delineation of the foveal avascular zone (FAZ), FAZ area, perimeter, and acircularity index ...
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      Mentions: University of Wisconsin New York Eye and Ear Infirmary Richard B. Rosen

    9. Variability of Foveal Avascular Zone Metrics Derived From Optical Coherence Tomography Angiography Images

      Explore TVST Journal Ophthalmology
      Variability of Foveal Avascular Zone Metrics Derived From Optical Coherence Tomography Angiography Images
      Purpose : To characterize sources of inter- and intrasubject variability in quantitative foveal avascular zone (FAZ) metrics. Methods : Two 33-mm optical coherence tomography angiography scans (centered on the fovea) were acquired in both eyes of 175 subjects. An image of the superficial plexus was extracted from each scan and segmented twice by a single observer. Four quantitative FAZ morphology metrics (area, axis ratio, acircularity, major horizontal axis angle) were calculated, and ...
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      Mentions: University of Wisconsin Joseph Carroll

    10. Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography

      Explore TVST Journal Developmental Biology , Ophthalmology
      Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography
      Purpose : To demonstrate and validate that photothermal optical coherence tomography (PT-OCT) can image melanin in the retinal pigment epithelium (RPE) and can observe light-driven melanosome translocation in the zebrafish retina. Methods : A commercial spectral domain OCT system was modified to perform both OCT and PT-OCT. Four adult tyrosinase-mosaic zebrafish with varying levels of melanin expression across their retinas were imaged, and the PT-OCT signal for pigmented and nonpigmented regions were ...
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      Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala

    11. Photothermal optical coherence tomography of indocyanine green in ex vivo eyes

      Explore OSA | OSA Publishing Ophthalmology
      Photothermal optical coherence tomography of indocyanine green in ex vivo eyes
      Indocyanine green (ICG) is routinely used during surgery to stain the inner limiting membrane (ILM) and provide contrast on white light surgical microscopy. While translation of optical coherence tomography (OCT) for intraoperative imaging during ophthalmic surgery has enhanced visualization, the ILM remains difficult to distinguish from underlying retinal structures and ICG does not provide additional OCT contrast. We present photothermal OCT (PT-OCT) for high-specificity detection of ICG on retinal OCT ...
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      Mentions: University of Wisconsin Vanderbilt University Melissa C. Skala

    12. Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina

      Explore Home - Springer Developmental Biology , Ophthalmology
      Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina
      Zebrafish ( Danio rerio ) are widely used as an experimental model for a wide range of retinal diseases. Previously, optical coherence tomography (OCT) was introduced for quantitative analysis of the zebrafish cone photoreceptor cell mosaic; however no data exists on the intersession reproducibility or intrasession repeatability of such measurements. We imaged 14 wild-type (WT) fish three times each, with 48 h between each time point. En face images of the UV ...
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      Mentions: University of Wisconsin Joseph Carroll

    14. Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones

      Explore OSA | OSA Publishing Gastroenterology
      Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones
      Microwave ablation is a minimally invasive image guided thermal therapy for cancer that can be adapted to endoscope use in the gastrointestinal (GI) tract. Microwave ablation in the GI tract requires precise control over the ablation zone that could be guided by high resolution imaging with quantitative contrast. Optical coherence tomography (OCT) provides ideal imaging resolution and allows for the quantification of tissue scattering properties to characterize ablated tissue. Visible ...
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      Mentions: University of Wisconsin Melissa C. Skala

    15. Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

      Explore Hindawi Publishing Corporation
      Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner
      In the past decades, spectral-domain optical coherence tomography (SD-OCT) has transformed into a widely popular imaging technology which is used in many research and clinical applications. Despite such fast growth in the field, the technology has not been readily accessible to many research laboratories either due to the cost or inflexibility of the commercially available systems or due to the lack of essential knowledge in the field of optics to ...
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      Mentions: University of Wisconsin

    16. Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Medical College of Wisconsin Receives NIH Grant for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae
      Medical College of Wisconsin Receives a 2017 NIH Grant for $545,415 for Assessing Photoreceptor Structure and Function in Normal and Diseased Retinae. The principal investigator is Josepth Carroll. The program began in 2008 and ends in 2021. Below is a summary of the proposed work. Inherited retinal degenerations affect approximately 1 in 1,500 individuals in the US, and given the extreme genotypic and phenotypic heterogeneity, the prospect of ...
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      Mentions: University of Wisconsin National Institutes of Health Joseph Carroll
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  4. About University of Wisconsin

    University of Wisconsin

    University of Wisconsin System has established itself as one of the world's premier public university systems. The UW educates more than 173,000 students on 26 campuses, and serves more than one million citizens through statewide extension programs. The UW System's campuses in Madison and Milwaukee offer both undergraduate and graduate degree programs, including doctoral and professional programs. Eleven comprehensive campuses provide students both undergraduate and master's degree programs in smaller, more individualized academic settings. The UW System's 13 UW Colleges deliver freshman-sophomore courses for students seeking a foundation for a bachelor's degree.

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