1. University of Western Australia

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    1. Mentioned In 156 Articles

    2. Axial Length Variation Impacts on Superficial Retinal Vessel Density and Foveal Avascular Zone Area Measurements Using Optical Coherence Tomography Angiography

      Axial Length Variation Impacts on Superficial Retinal Vessel Density and Foveal Avascular Zone Area Measurements Using Optical Coherence Tomography Angiography
      Purpose : To evaluate the impact of image magnification correction on superficial retinal vessel density (SRVD) and foveal avascular zone area (FAZA) measurements using optical coherence tomography angiography (OCTA). Methods : Participants with healthy retinas were recruited for ocular biometry, refraction, and RTVue XR Avanti OCTA imaging with the 3 3-mm protocol. The foveal and parafoveal SRVD and FAZA were quantified with custom software before and after correction for magnification error using ...
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    3. OncoRes Medical backed by MRCF to develop innovative imaging technology for breast cancer surgery

      OncoRes Medical backed by MRCF to develop innovative imaging technology for breast cancer surgery
      ...Kennedy and Professor David Sampson from the School of Electrical, Electronic and Computer Engineering at The University of Western Australia, in collaboration with leading breast surgeon Professor Christobel Saunders an...
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    4. Microscale imaging of breast tumor margins using optical coherence elastography

      Microscale imaging of breast tumor margins using optical coherence elastography
      A variant of optical coherence elastography offers a promising method of distinguishing between tumor and breast tissue in lumpectomy specimens in an intraoperative time frame. 1 May 2017, SPIE Newsroom. DOI: 10.1117/2.1201702.006873 Breast-conserving surgery is the most common surgical procedure used in the treatment of early-stage breast cancer. 1 The aim of this surgery is to remove all malignant tissue such that the surgical margin is ...
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    5. Perth Researchers Developed the World's Smallest Microscope

      Perth Researchers Developed the World's Smallest Microscope
      One in four women who have a lump removed from their breast needs more surgery to remove remaining cancer cells. Thats a pretty scary statistic for patients. And its one Professor David Sampson believes could be better. One of the main reasons [breast cancer patients need extra surgery] is because all of the tumour is not being identified. Because it cant all be seen. Because you dont have the resolution ...
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    6. The emergence of optical elastography in biomedicine

      The emergence of optical elastography in biomedicine
      Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load. Such measurements may be used to form an image of a mechanical property, often elastic modulus, with the resulting mechanical contrast complementary to the more familiar optical contrast. Optical elastography is experiencing new impetus in response to developments in the closely related fields ...
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    7. Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces

      Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces
      Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the ...
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    8. Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

      Optical coherence elastography – OCT at work in tissue biomechanics [Invited]
      Optical coherence elastography (OCE), as the use of OCT to perform elastography has come to be known, began in 1998, around ten years after the rest of the field of elastography the use of imaging to deduce mechanical properties of tissues. After a slow start, the maturation of OCT technology in the early to mid 2000s has underpinned a recent acceleration in the field. With more than 20 papers published ...
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    9. Enhanced Visualization of Subtle Outer Retinal Pathology by En Face Optical Coherence Tomography and Correlation with Multi-Modal Imaging

      Enhanced Visualization of Subtle Outer Retinal Pathology by En Face Optical Coherence Tomography and Correlation with Multi-Modal Imaging
      ...microperimetry and adaptive optics flood-illumination ophthalmoscopy (AO-FIO). This study was approved by The University of Western Australia Human Ethics Research Office (RA/4/1/7916) and written informed consent was ob...
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    10. Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes

      Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes
      Background Evaluation of lymph node involvement is an important factor in detecting metastasis and deciding whether to perform axillary lymph node dissection (ALND) in breast cancer surgery. As ALND is associated with potentially severe long term morbidity, the accuracy of lymph node assessment is imperative in avoiding unnecessary ALND. The mechanical properties of malignant lymph nodes are often distinct from those of normal nodes. A method to image the micro-scale ...
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    11. In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography

      In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography
      We present an automated, label-free method for lymphangiography of cutaneous lymphatic vessels in humans in vivo using optical coherence tomography (OCT). This method corrects for the variation in OCT signal due to the confocal function and sensitivity fall-off of a spectral-domain OCT system and utilizes a single-scattering model to compensate for A-scan signal attenuation to enable reliable thresholding of lymphatic vessels. A segment-joining algorithm is then incorporated into the method ...
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    12. Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

      Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins
      Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a ...
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    13. Promising New Imaging Tool Allows Surgeons to Detect Malignant Tissue During Breast-Conserving Surgery for Breast Cancer

      Promising New Imaging Tool Allows Surgeons to Detect Malignant Tissue During Breast-Conserving Surgery for Breast Cancer
      ...nd David Sampson, professors of electronic engineering and Christobel Saunders, a professor of surgery at the University of Western Australia, Allen has developed a new tool that allows surgeons to detect malignant tissu...
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    14. Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress

      Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress
      There are limited imaging technologies available that can accurately assess or provide surrogate markers of the in vivo cutaneous microvessel network in humans. In this study, we establish the use of optical coherence tomography (OCT) as a novel imaging technique to assess acute changes in cutaneous microvessel area density and diameter in humans. OCT speckle decorrelation images of the skin on the ventral side of the forearm up to a ...
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    15. Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography

      Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography
      Surgical treatment of breast cancer aims to identify and remove all malignant tissue. Intraoperative assessment of tumor margins is, however, not exact; thus, re-excision is frequently needed, or excess normal tissue is removed. Imaging methods applicable intraoperatively could help to reduce re-excision rates whilst minimizing removal of excess healthy tissue. Optical coherence elastography (OCE) has been proposed for use in breast-conserving surgery; however, intraoperative interpretation of complex OCE images may ...
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    16. 1-15 of 156 1 2 3 4 ... 9 10 11 »
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  2. About University of Western Australia

    University of Western Australia

    University of Western Australia  is a leading Australian research university and has an international reputation for excellence, innovation and enterprise. A member of the Australian 'Group of Eight' research universities, it is also among Australia's leading research universities.

    The Optical and Biomedical Engineering Laboratory is in the School of Electrical, Electronic and Computer Engineering at the University of Western Australia in Perth, Western Australia.  OBEL's research is in the fields of biomedical optics, biophotonics, and optical microscopy. It is conducted at the interfaces of the disciplines of optics, biomedical engineering, biology and clinical medicine.