1. University of Western Australia

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    1. Mentioned In 222 Articles

    2. Use of the Retinal Vascular Histology to Validate an Optical Coherence Tomography Angiography Technique

      Explore TVST Journal Ophthalmology
      Use of the Retinal Vascular Histology to Validate an Optical Coherence Tomography Angiography Technique
      Purpose: To determine the fidelity of optical coherence tomography angiography (OCTA) techniques by direct comparison of the retinal capillary network images obtained from the same region as imaged by OCTA and high-resolution confocal microscope. Method: Ten porcine eyes were perfused with red blood cells for OCTA image acquisition from the area centralis and then perfusion-fixed, and the vessels were labeled for confocal imaging. Two approaches involving post-processing of two-dimensional projection ...
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      Mentions: University of Western Australia Marinko V. Sarunic Simon Fraser University

    3. The Thorlabs OCT team is proud to present a webinar given by Dr. Brendan Kennedy from the University of Western Australia - January 20, 2021

      Explore Optical Coherence Tomography News
      The Thorlabs OCT team is proud to present a webinar given by Dr. Brendan Kennedy from the University of Western Australia - January 20, 2021
      ...hanical properties. The Thorlabs OCT team is proud to present a webinar given by Dr. Brendan Kennedy from the University of Western Australia. This live event will take place on January 20 at 3pm GMT and include a Q&A ...
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      Mentions: Thorlabs University of Western Australia Brendan F. Kennedy

    4. Evaluation of Transthoracic Echocardiography in the Assessment of Atherosclerosis of the Left Main Coronary Artery: Comparison with Optical Frequency Domain Imaging (a Pilot Study)

      Explore MDPI Open Access Journals Platform Cardiology
      Evaluation of Transthoracic Echocardiography in the Assessment of Atherosclerosis of the Left Main Coronary Artery: Comparison with Optical Frequency Domain Imaging (a Pilot Study)
      Background: Risk stratification using non-invasive imaging of the coronary vessels is emerging as an optimal standard of care for patients with dyslipidemias. Of particular interest is the evaluation of the left main coronary artery (LMCA), where calcium deposition appears to be a predictor of cardiovascular events. Methods: In coronary patients, we evaluated wall thickness and internal diameter of the LMCA examined by transthoracic echocardiography (TTE) and compared these with findings ...
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      Mentions: University of Western Australia

    5. Coronary 18F-sodium fluoride PET detects high-risk plaque features on optical coherence tomography and CT-angiography in patients with acute coronary syndrome

      Explore atherosclerosis-journal.com Cardiology
      Coronary 18F-sodium fluoride PET detects high-risk plaque features on optical coherence tomography and CT-angiography in patients with acute coronary syndrome
      Background and aims 18 F-Sodium Fluoride Positron Emission Tomography ( 18 F-NaF PET) non-invasively detects micro-calcification activity, the earliest stage of atherosclerotic arterial calcification. We studied the association between coronary 18 F-NaF uptake and high-risk plaque features on intra-coronary optical coherence tomography (OCT) and CT-angiography (CTCA) and the potential application to patient-level risk stratification. Methods Sixty-two prospectively recruited patients with acute coronary syndrome (ACS) underwent multi-vessel OCT, 18 F-NaF PET and ...
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      Mentions: University of Western Australia

    6. Retinal layer thicknesses retrieved with different segmentation algorithms from optical coherence tomography scans acquired under different signal-to-noise ratio conditions

      Explore OSA | OSA Publishing Ophthalmology
      Retinal layer thicknesses retrieved with different segmentation algorithms from optical coherence tomography scans acquired under different signal-to-noise ratio conditions
      Glaucomatous damage can be quantified by measuring the thickness of different retinal layers. However, poor image quality may hamper the accuracy of the layer thickness measurement. We determined the effect of poor image quality (low signal-to-noise ratio) on the different layer thicknesses and compared different segmentation algorithms regarding their robustness against this degrading effect. For this purpose, we performed OCT measurements in the macular area of healthy subjects and degraded ...
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      Mentions: University of Western Australia Barry Cense Yonsei University

    7. Retinal Boundary Segmentation in Stargardt Disease Optical Coherence Tomography Images Using Automated

      Explore TVST Journal Ophthalmology
      Retinal Boundary Segmentation in Stargardt Disease Optical Coherence Tomography Images Using Automated
      Purpose : To use a deep learning model to develop a fully automated method (fully semantic network and graph search [FS-GS]) of retinal segmentation for optical coherence tomography (OCT) images from patients with Stargardt disease. Methods : Eighty-seven manually segmented (ground truth) OCT volume scan sets (5171 B-scans) from 22 patients with Stargardt disease were used for training, validation and testing of a novel retinal boundary detection approach (FS-GS) that combines a ...
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      Mentions: University of Queensland University of Western Australia Fred K. Chen

    8. Camera-based optical palpation

      Explore Nature Publishing Group
      Camera-based optical palpation
      Optical elastography is undergoing extensive development as an imaging tool to map mechanical contrast in tissue. Here, we present a new platform for optical elastography by generating sub-millimetre-scale mechanical contrast from a simple digital camera. This cost-effective, compact and easy-to-implement approach opens the possibility to greatly expand applications of optical elastography both within and beyond the field of medical imaging. Camera-based optical palpation (CBOP) utilises a digital camera to acquire ...
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      Mentions: University of Western Australia Andrea Curatolo Brendan F. Kennedy

    9. Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography

      Explore SPIE Digital Library Dermatology
      Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography
      Significance: Pulsatility is a vital characteristic of the cardiovascular system. Characterization of the pulsatility pattern locally in the peripheral microvasculature is currently not readily available and would provide an additional source of information, which may prove important in understanding the pathophysiology of arterial stiffening, vascular ageing, and their linkage with cardiovascular disease development. Aim: We aim to confirm the suitability of speckle decorrelation optical coherence tomography angiography (OCTA) under various ...
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      Mentions: David D. Sampson University of Western Australia Qiang Wang

    10. Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples

      Explore SPIE Digital Library Dentistry
      Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples
      Significance: To advance our understanding of the contrast observed when imaging with polarization-sensitive optical coherence tomography (PS-OCT) and its correlation with oral cancerous pathologies, a detailed comparison with histology provided via ex vivo fixed tissue is required. The effects of tissue fixation, however, on such polarization-based contrast have not yet been investigated. Aim: A study was performed to assess the impact of tissue fixation on depth-resolved (i.e., local) birefringence ...
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      Mentions: Massachusetts General Hospital Harvard University David D. Sampson

    11. In vivo imaging of the depth-resolved optic axis of birefringence in human skin

      Explore OSA | OSA Publishing
      In vivo imaging of the depth-resolved optic axis of birefringence in human skin
      Recent progress has enabled the reconstruction of the local (i.e., depth-resolved) optic axis (OAx) of biological tissue from measurements made with polarization-sensitive optical coherence tomography (PS-OCT). Here we demonstrate local OAx imaging in healthy human skin in vivo . The images reveal dense, weaving patterns that are imperceptible in OCT intensity tomograms or conventional PS-OCT metrics and that suggest a mesh-like tissue organization, consistent with the morphology of dermal collagen ...
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      Mentions: Massachusetts General Hospital Harvard University David D. Sampson

    12. Optical coherence tomography: a novel imaging approach to visualize and quantify cutaneous microvascular structure and function in patients with diabetes.

      Explore BMJ Open Diabetes Research & Care Dermatology
      Optical coherence tomography: a novel imaging approach to visualize and quantify cutaneous microvascular structure and function in patients with diabetes.
      Introduction The pathophysiology of microvascular disease is poorly understood, partly due to the lack of tools to directly image microvessels in vivo. Research design and methods In this study, we deployed a novel optical coherence tomography (OCT) technique during local skin heating to assess microvascular structure and function in diabetics with (DFU group, n=13) and without (DNU group, n=10) foot ulceration, and healthy controls (CON group, n=13 ...
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      Mentions: University of Western Australia

    13. Contrast-free optical coherence tomography: Systematic evaluation of non-contrast media for intravascular assessment

      Explore Journals | PLOS Cardiology
      Contrast-free optical coherence tomography: Systematic evaluation of non-contrast media for intravascular assessment
      Background Coronary revascularization using imaging guidance is rapidly becoming the standard of care. Intravascular optical coherence tomography uses near-infrared light to obtain high resolution intravascular images. Standard optical coherence tomography imaging technique employs iodinated contrast dye to achieve the required blood clearance during acquisition. We sought to systematically evaluate the technical performance of saline as an alternative to iodinated contrast for intravascular optical coherence tomography assessment. Methods and results We ...
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      Mentions: University of Western Australia University of Calgary University of Ottawa

    14. Strain and elasticity imaging in compression optical coherence elastography: the two‐decade perspective and recent advances

      Explore Wiley Online Library
      Strain and elasticity imaging in compression optical coherence elastography: the two‐decade perspective and recent advances
      Quantitative mapping of deformation and elasticity in optical coherence tomography has attracted much attention of researchers during the last two decades. However, despite intense effort it took ~15years to demonstrate optical coherence elastography (OCE) as a practically useful technique. Similarly to medical ultrasound, where elastography was first realized using the quasi‐static compression principle and later shear‐wave‐based systems were developed, in OCE these two approaches also developed in ...
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      Mentions: University of Western Australia Institute of Applied Physics Brendan F. Kennedy

    16. Investigating Local Polarisation Contrast With Fibre-Based Polarisation-Sensitive Optical Coherence Tomography and Microscopy (Thesis)

      Explore Pure API Student Theses
      Investigating Local Polarisation Contrast With Fibre-Based Polarisation-Sensitive Optical Coherence Tomography and Microscopy (Thesis)
      This thesis makes several important contributions to polarisation-sensitive optical coherence tomography (PS-OCT) through developing no el methods to effectively extract local contrast from birefringence and the orientation of the associated optic axis, at conventional and ultra-high resolution.
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      Mentions: University of Western Australia
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  4. About University of Western Australia

    University of Western Australia

    University of Western Australia  is a leading Australian research university and has an international reputation for excellence, innovation and enterprise. A member of the Australian 'Group of Eight' research universities, it is also among Australia's leading research universities.

    The Optical and Biomedical Engineering Laboratory is in the School of Electrical, Electronic and Computer Engineering at the University of Western Australia in Perth, Western Australia.  OBEL's research is in the fields of biomedical optics, biophotonics, and optical microscopy. It is conducted at the interfaces of the disciplines of optics, biomedical engineering, biology and clinical medicine.

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