1. University of Western Australia

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    1. Mentioned In 251 Articles

    2. An optically-guided cochlear implant sheath for real-time monitoring of electrode insertion into the human cochlea

      An optically-guided cochlear implant sheath for real-time monitoring of electrode insertion into the human cochlea
      In cochlear implant surgery, insertion of perimodiolar electrode arrays into the scala tympani can be complicated by trauma or even accidental translocation of the electrode array within the cochlea. In patients with partial hearing loss, cochlear trauma can not only negatively affect implant performance, but also reduce residual hearing function. These events have been related to suboptimal positioning of the cochlear implant electrode array with respect to critical cochlear walls ...
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    3. Quantitative Micro-Elastography Enables In Vivo Detection of Residual Cancer in the Surgical Cavity during Breast-Conserving Surgery

      Quantitative Micro-Elastography Enables In Vivo Detection of Residual Cancer in the Surgical Cavity during Breast-Conserving Surgery
      Breast-conserving surgery (BCS) is commonly used for the treatment of early-stage breast cancer. Following BCS, approximately 20% to 30% of patients require reexcision because postoperative histopathology identifies cancer in the surgical margins of the excised specimen. Quantitative micro-elastography (QME) is an imaging technique that maps microscale tissue stiffness and has demonstrated a high diagnostic accuracy (96%) in detecting cancer in specimens excised during surgery. However, current QME methods, in common ...
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    4. How to improve microendoscopes? New probe design brings promises to improve biomedical imaging

      How to improve microendoscopes? New probe design brings promises to improve biomedical imaging
      ...ki of ICTER, Dr. Gavrielle Untracht of the Technical University of Denmark (DTU), Dr. Michael Hackmann of the University of Western Australia (UWA), Onur Cetinkaya of ICTER and Prof. David Sampson of the University of Su...
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    5. Superior Imaging Performance of All-Fiber, Two-Focusing-Element Microendoscopes

      Superior Imaging Performance of All-Fiber, Two-Focusing-Element Microendoscopes
      All-fiber-optic imaging microendoscopes are emerging as an important tool in bioimaging studies, including those conducted with optical coherence tomography, but physical limitations constrain the achievable beam characteristics of designs using a single focusing element. These constraints are especially relevant for applications that require a long working distance, high resolution, and/or minimal probe diameter. Through detailed analysis based on ABCD matrix modelling, we show that side-viewing probes combining a graded-index ...
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    6. Cocoa flavanol consumption improves lower extremity endothelial function in healthy individuals and people with type 2 diabetes

      Cocoa flavanol consumption improves lower extremity endothelial function in healthy individuals and people with type 2 diabetes
      Background : diabetes and age are major risk factors for the development of lower extremity peripheral artery disease (PAD). Cocoa flavanol (CF) consumption is associated with lower risk for PAD and improves brachial artery (BA) endothelial function. Objectives : to assess if femoral artery (FA) endothelial function and dermal microcirculation are impaired in individuals with type 2 diabetes mellitus (T2DM) and evaluate the acute effect of CF consumption on FA endothelial function ...
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    7. Correcting magnification error in foveal avascular zone area measurements of optical coherence tomography angiography images with estimated axial length

      Correcting magnification error in foveal avascular zone area measurements of optical coherence tomography angiography images with estimated axial length
      Background: To generate and validate a method to estimate axial length estimated (AL est ) from spherical equivalent (SE) and corneal curvature [keratometry (K)], and to determine if this AL est can replace actual axial length (AL act ) for correcting transverse magnification error in optical coherence tomography angiography (OCTA) images using the Littmann-Bennett formula. Methods: Data from 1301 participants of the Raine Study Gen2-20 year follow-up were divided into two datasets ...
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    8. Visualising and quantifying microvascular structure and function in patients with heart failure using optical coherence tomography

      Visualising and quantifying microvascular structure and function in patients with heart failure using optical coherence tomography
      Heart failure (HF) is characterised by abnormal conduit and resistance artery function in humans. Microvascular function in HF is less well characterised, due in part to the lack of tools to image these vessels in vivo . The skin microvasculature is a surrogate for systemic microvascular function and health and plays a key role in thermoregulation, which is dysfunctional in HF. We deployed a novel optical coherence tomography (OCT) technique to ...
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    9. Multimodal imaging needle combining optical coherence tomography and fluorescence for imaging of live breast cancer cells labeled with a fluorescent analog of tamoxifen

      Multimodal imaging needle combining optical coherence tomography and fluorescence for imaging of live breast cancer cells labeled with a fluorescent analog of tamoxifen
      Significance: Imaging needles consist of highly miniaturized focusing optics encased within a hypodermic needle. The needles may be inserted tens of millimeters into tissue and have the potential to visualize diseased cells well beyond the penetration depth of optical techniques applied externally. Multimodal imaging needles acquire multiple types of optical signals to differentiate cell types. However, their use has not previously been demonstrated with live cells. Aim: We demonstrate the ...
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    10. Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography

      Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography
      Purpose: To characterize macular blood flow connectivity in vivo using high-resolution optical coherence tomography (HighRes OCT). Methods: Cross-sectional, observational study. Dense (6-m interscan distance) perifoveal HighRes OCT raster scans were performed on healthy participants. To mitigate the limitations of projection-resolved OCT-angiography, flow and structural data were used to observe the vascular structures of the superficial vascular complex (SVC) and the deep vascular complex. Vascular segmentation and rendering were performed using ...
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    11. Multi-class classification of breast tissue using optical coherence tomography and attenuation imaging combined via deep learning

      Multi-class classification of breast tissue using optical coherence tomography and attenuation imaging combined via deep learning
      ...n Microscopy & Microanalysis Research Facility at the Centre for Microscopy, Characterisation & Analysis, The University of Western Australia, a facility funded by the University, State and Commonwealth Governments. The ...
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    12. Correlation of Optical Coherence Tomography Angiography of Type 3 Macular Neovascularization With Corresponding Histology

      Correlation of Optical Coherence Tomography Angiography of Type 3 Macular Neovascularization With Corresponding Histology
      Importance By validating optical coherence tomography angiography (OCTA) in the analysis of type 3 macular neovascularization secondary to age-related macular degeneration, the overall value of clinical OCTA for disease observation, diagnosis, and staging is increased. Objective To assess the association of in vivo OCTA of type 3 macular neovascularization secondary to age-related macular degeneration with corresponding ex vivo histology. Design, Setting, and Participants This study included clinical imaging, laboratory microscopy ...
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    13. In vivo PS-OCT needle probe scan of human skeletal muscle

      In vivo PS-OCT needle probe scan of human skeletal muscle
      Polarization-sensitive optical coherence tomography (PS-OCT) derived birefringence values effectively identify skeletal muscle structural disruption due to muscular dystrophy and exercise-related muscle damage in animal models in ex vivo tissue. The purpose of this investigation was to determine if a PS-OCT needle probe inserted into the leg of a human subject could accurately identify various anatomical structures with implications for use as a diagnostic tool for the determination of skeletal muscle ...
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    14. Towards standardizing retinal optical coherence tomography angiography: a review

      Towards standardizing retinal optical coherence tomography angiography: a review
      The visualization and assessment of retinal microvasculature are important in the study, diagnosis, monitoring, and guidance of treatment of ocular and systemic diseases. With the introduction of optical coherence tomography angiography (OCTA), it has become possible to visualize the retinal microvasculature volumetrically and without a contrast agent. Many lab-based and commercial clinical instruments, imaging protocols and data analysis methods and metrics, have been applied, often inconsistently, resulting in a confusing ...
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    15. Requirements and limitations of imaging airway smooth muscle throughout the lung in vivo

      Requirements and limitations of imaging airway smooth muscle throughout the lung in vivo
      Clinical visualization and quantification of the amount and distribution of airway smooth muscle (ASM) in the lungs of individuals with asthma has major implications for our understanding of airway wall remodeling as well as treatments targeted at the ASM. This paper theoretically investigates the feasibility of quantifying airway wall thickness (focusing on the ASM) throughout the lung in vivo by means of bronchoscopic polarisation-sensitive optical coherence tomography (PS-OCT). Using extensive ...
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    16. 1-15 of 251 1 2 3 4 ... 15 16 17 »
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  2. About University of Western Australia

    University of Western Australia

    University of Western Australia  is a leading Australian research university and has an international reputation for excellence, innovation and enterprise. A member of the Australian 'Group of Eight' research universities, it is also among Australia's leading research universities.

    The Optical and Biomedical Engineering Laboratory is in the School of Electrical, Electronic and Computer Engineering at the University of Western Australia in Perth, Western Australia.  OBEL's research is in the fields of biomedical optics, biophotonics, and optical microscopy. It is conducted at the interfaces of the disciplines of optics, biomedical engineering, biology and clinical medicine.