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    1. Mentioned In 95 Articles

    2. Line-scanning SD-OCT for in-vivo, non-contact, volumetric, cellular resolution imaging of the human cornea and limbus

      Line-scanning SD-OCT for in-vivo, non-contact, volumetric, cellular resolution imaging of the human cornea and limbus
      In-vivo , non-contact, volumetric imaging of the cellular and sub-cellular structure of the human cornea and limbus with optical coherence tomography (OCT) is challenging due to involuntary eye motion that introduces both motion artifacts and blur in the OCT images. Here we present the design of a line-scanning (LS) spectral-domain (SD) optical coherence tomography system that combines 2 3 1.7 m (x, y, z) resolution in biological tissue with an ...
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    3. 2 Postdoctoral Positions Available at the Biomedical Optics Research Group at the University of Waterloo

      2 Postdoctoral Positions Available at the Biomedical Optics Research Group at the University of Waterloo
      ...zheva@uwaterloo.ca Two postdoctoral positions in the field of biomedical optical imaging are available at the University of Waterloo, Canada in the Biomedical Optics Research Group of Prof. Kostadinka Bizheva. The positi...
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    4. Volumetric quantification of choroid and Haller's sublayer using OCT scans: An accurate and unified approach based on stratified smoothing

      Volumetric quantification of choroid and Haller's sublayer using OCT scans: An accurate and unified approach based on stratified smoothing
      Background and objective: The choroid, a dense vascular structure in the posterior segment of the eye, maintains the health of the retina by supplying oxygen and nutrients, and assumes clinical significance in screening ocular diseases including age-related macular degeneration (AMD) and central serous chorioretinopathy (CSCR). As a technological assist, algorithmic estimation of choroidal biomarkers has been suggested based on sectional (B-scan) optical coherence tomography (OCT) images. However, most such 2D ...
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    5. Regression patterns of central serous chorioretinopathy using en face optical coherence tomography

      Regression patterns of central serous chorioretinopathy using en face optical coherence tomography
      Purpose To study the regression patterns of subretinal fluid (SRF) in central serous chorioretinopathy (CSCR) on sequential en face optical coherence tomography (OCT) and its relationship to leak locations. Methods Retrospective study on patients with acute CSCR. Inclusion criteria were (i) availability of data, sequential OCT and OCT angiography (B scan and en face OCT) every 2 weeks until resolution of SRF or 6 months, whichever is earlier; (ii) single ...
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    6. 400 kHz Spectral Domain Optical Coherence Tomography for Corneal Imaging

      400 kHz Spectral Domain Optical Coherence Tomography for Corneal Imaging
      The cornea is the transparent, outermost layer of the human eye that contributes approximately 70% of the refractive power of the eye in air. It is composed of five major tissue layers: the epithelium, the Bowmans membrane, the stroma, the Descemets membrane, and the endothelium. Corneal diseases such as Keratoconus and Fuchs dystrophy can change the morphology of some or all of the corneal layers, which can lead to vision ...
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    7. Wide-field optical coherence tomography imaging in diabetic retinopathy

      Wide-field optical coherence tomography imaging in diabetic retinopathy
      Purpose: To report the individual retinal layer thicknesses up to mid-equator in patients with diabetic retinopathy (DR) using Spectralis (Heidelberg Engineering, Heidelberg, Germany) wide-field optical coherence tomography (OCT). Methods: Retinal layers were segmented using a custom designed semi-automated algorithm, where reference points were marked by the examiner to enable software to automatically compute the thickness values of each retinal sublayer at an interval of 1 mm from reference points. The ...
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    8. ODTiD: Optic Nerve Head SD-OCT Image Dataset

      ODTiD: Optic Nerve Head SD-OCT Image Dataset
      Introduction: Optic disc tilt (ODT) or tilted optic disc is a common finding in the general population. It is due to anomalous development caused by the malclosure of the embryonic optic fissure. ODT is commonly associated with high myopia as well as other conditions. In recent days, the common method to image the optic disc (OD) is by optical coherence tomography (OCT). To the best of our knowledge, there are ...
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    9. Three-dimensional virtual histology in unprocessed resected tissues with photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT)

      Three-dimensional virtual histology in unprocessed resected tissues with photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT)
      Histological images are critical in the diagnosis and treatment of cancers. Unfortunately, current methods for capturing these microscopy images require resource intensive tissue preparation that may delay diagnosis for days or weeks. To streamline this process, clinicians are limited to assessing small macroscopically representative subsets of tissues. Here, a combined photoacoustic remote sensing (PARS) microscope and swept source optical coherence tomography system designed to circumvent these diagnostic limitations is presented ...
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    10. Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography

      Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography
      Early diagnosis of ocular diseases improves the understanding of pathophysiology and aids in accurate monitoring and effective treatment. Advanced, multimodal ocular imaging platforms play a crucial role in visualization of ocular components and provide clinicians with a valuable tool for evaluating various eye diseases. Here, for the first time we present a non-contact, multiwavelength photoacoustic remote sensing (PARS) microscopy and swept-source optical coherence tomography (SS-OCT) for in-vivo functional and structural ...
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    11. Validation of Optical Coherence Tomography Retinal Segmentation in Neurodegenerative Disease

      Validation of Optical Coherence Tomography Retinal Segmentation in Neurodegenerative Disease
      Purpose : This study assessed agreement between an automated spectral-domain optical coherence tomography (SD-OCT) retinal segmentation software and manually corrected segmentation to validate its use in a prospective clinical study of neurodegenerative diseases (NDD). Methods : The sample comprised 30 subjects with NDD, including vascular cognitive impairment, frontotemporal dementia, Parkinson's disease, and Alzheimer's disease. Macular SD-OCT scans were acquired and segmented using Heidelberg Spectralis. For the central foveal B scan ...
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    12. OCTID: Optical Coherence Tomography Image Database

      OCTID: Optical Coherence Tomography Image Database
      Optical coherence tomography (OCT) is a non-invasive imaging modality which is widely used in clinical ophthalmology. OCT images are capable of visualizing deep retinal layers which is crucial for the early diagnosis of retinal diseases. In this paper, we describe a comprehensive open-access database containing more than 500 high-resolution images categorized into different pathological conditions. The image classes include Normal (NO), Macular Hole (MH), Age-related Macular Degeneration (AMD), Central Serous ...
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    13. 250 kHz, 1.5 µm resolution SD-OCT for in-vivo cellular imaging of the human cornea

      250 kHz, 1.5 µm resolution SD-OCT for in-vivo cellular imaging of the human cornea
      We present the first spectral domain optical coherence tomography (SD-OCT) system that combines an isotropic imaging resolution of ~1.5 m in biological tissue with a 250 kHz image acquisition rate, for in vivo non-contact, volumetric imaging of the cellular structure of the human cornea. OCT images of the healthy human cornea acquired with this system reveal the cellular structure of the corneal epithelium, cellular debris and mucin clusters in ...
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    14. Lid-parallel conjunctival fold (LIPCOF) morphology imaged by optical coherence tomography and its relationship to LIPCOF grade

      Lid-parallel conjunctival fold (LIPCOF) morphology imaged by optical coherence tomography and its relationship to LIPCOF grade
      Purpose Lid-parallel conjunctival folds (LIPCOF) are a well-accepted clinical sign in dry eye diagnosis. Commonly, LIPCOF is classified by grading the number of folds observed by slit-lamp microscope. This study investigated the relationship between subjective grading scale and LIPCOF morphology imaged by optical coherence tomography (OCT). Methods Temporal and nasal LIPCOF of 42 subjects (mean age 27.38.4 (SD) years; 13M, 29F) were observed and classified by an experienced ...
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    15. Visualisation of the visual system

      Visualisation of the visual system
      In vivo imaging techniques have had a major impact on vision science research, not least because they provide access to the entire human visual pathway from the anterior eye to higher‐level processing areas within the brain. A special issue of Ophthalmic Physiological Optics titled Imaging the visual system: from the eye to the brain 1 highlighted the breadth of imaging‐related research in vision science by including papers that ...
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    16. Comparative Study of Optical Coherence Tomography Angiography and Phase-Resolved Doppler Optical Coherence Tomography for Measurement of Retinal Blood Vessels Caliber

      Comparative Study of Optical Coherence Tomography Angiography and Phase-Resolved Doppler Optical Coherence Tomography for Measurement of Retinal Blood Vessels Caliber
      Purpose : To compare the accuracy of Doppler optical coherence tomography (DOCT) and OCT angiography (OCTA) for measuring retinal blood vessel caliber at different flow rates. Methods : A research-grade 1060-nm OCT system with 3.5-m axial resolution in retinal tissue and 92,000 A scan/s image acquisition rate was used in this study. DOCT and OCTA measurements were acquired both from a flow phantom and in vivo from retinal blood ...
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  2. About University of Waterloo

    University of Waterloo

    University of Waterloo has long been recognized as the most innovative university in Canada. We are committed to advancing learning and knowledge through teaching, research, and scholarship in our faculties, colleges, and schools.