1. University of Waterloo

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    1. Mentioned In 84 Articles

    2. 250 kHz, 1.5 µm resolution SD-OCT for in-vivo cellular imaging of the human cornea

      250 kHz, 1.5 µm resolution SD-OCT for in-vivo cellular imaging of the human cornea
      We present the first spectral domain optical coherence tomography (SD-OCT) system that combines an isotropic imaging resolution of ~1.5 m in biological tissue with a 250 kHz image acquisition rate, for in vivo non-contact, volumetric imaging of the cellular structure of the human cornea. OCT images of the healthy human cornea acquired with this system reveal the cellular structure of the corneal epithelium, cellular debris and mucin clusters in ...
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    3. Lid-parallel conjunctival fold (LIPCOF) morphology imaged by optical coherence tomography and its relationship to LIPCOF grade

      Lid-parallel conjunctival fold (LIPCOF) morphology imaged by optical coherence tomography and its relationship to LIPCOF grade
      Purpose Lid-parallel conjunctival folds (LIPCOF) are a well-accepted clinical sign in dry eye diagnosis. Commonly, LIPCOF is classified by grading the number of folds observed by slit-lamp microscope. This study investigated the relationship between subjective grading scale and LIPCOF morphology imaged by optical coherence tomography (OCT). Methods Temporal and nasal LIPCOF of 42 subjects (mean age 27.38.4 (SD) years; 13M, 29F) were observed and classified by an experienced ...
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    4. Visualisation of the visual system

      Visualisation of the visual system
      In vivo imaging techniques have had a major impact on vision science research, not least because they provide access to the entire human visual pathway from the anterior eye to higher‐level processing areas within the brain. A special issue of Ophthalmic Physiological Optics titled Imaging the visual system: from the eye to the brain 1 highlighted the breadth of imaging‐related research in vision science by including papers that ...
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    5. Comparative Study of Optical Coherence Tomography Angiography and Phase-Resolved Doppler Optical Coherence Tomography for Measurement of Retinal Blood Vessels Caliber

      Comparative Study of Optical Coherence Tomography Angiography and Phase-Resolved Doppler Optical Coherence Tomography for Measurement of Retinal Blood Vessels Caliber
      Purpose : To compare the accuracy of Doppler optical coherence tomography (DOCT) and OCT angiography (OCTA) for measuring retinal blood vessel caliber at different flow rates. Methods : A research-grade 1060-nm OCT system with 3.5-m axial resolution in retinal tissue and 92,000 A scan/s image acquisition rate was used in this study. DOCT and OCTA measurements were acquired both from a flow phantom and in vivo from retinal blood ...
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    6. Automated Segmentation of Retinal Optical Coherence Tomography Images (Thesis)

      Automated Segmentation of Retinal Optical Coherence Tomography Images (Thesis)
      Aim Optical Coherence Tomography (OCT) is a fast and non-invasive medical imaging technique which helps in the investigation of each individual retinal layer structure. For early detection of retinal diseases and the study of their progression, segmentation of the OCT images into the distinct layers of the retina plays a crucial role. However, segmentation done by the clinicians manually is extremely tedious, time-consuming and variable with respect to the expertise ...
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    7. Developing algorithms for the analysis of retinal Optical Coherence Tomography images (Thesis)

      Developing algorithms for the analysis of retinal Optical Coherence Tomography images (Thesis)
      Vision loss, with a prevalence loss greater than 42 million in the United States is one of the major challenges of today's health-care industry and medical science. Early detection of different retinal-related diseases will dramatically reduce the risk of vision loss. Optical Coherence Tomography (OCT) is a relatively new imaging technique which is of great importance in the identification of ocular and especially retinal diseases. Thus, the efficient analysis ...
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    8. Classification of optical coherence tomography images for diagnosing different ocular diseases

      Classification of optical coherence tomography images for diagnosing different ocular diseases
      Optical Coherence tomography (OCT) images provide several indicators, e.g., the shape and the thickness of different retinal layers, which can be used for various clinical and non-clinical purposes. We propose an automated classification method to identify different ocular diseases, based on the local binary pattern features. The database consists of normal and diseased human eye SD-OCT images. We use a multiphase approach for building our classifier, including preprocessing, Meta ...
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    9. Intra-retinal segmentation of optical coherence tomography images using active contours with a dynamic programming initialization and an adaptive weighting strategy

      Intra-retinal segmentation of optical coherence tomography images using active contours with a dynamic programming initialization and an adaptive weighting strategy
      Retinal layer shape and thickness are one of the main indicators in the diagnosis of ocular diseases. We present an active contour approach to localize intra-retinal boundaries of eight retinal layers from OCT images. The initial locations of the active contour curves are determined using a Viterbi dynamic programming method. The main energy function is a Chan-Vese active contour model without edges. A boundary term is added to the energy ...
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    10. Scleral Lens Clearance Assessment with Biomicroscopy and Anterior Segment Optical Coherence Tomography

      Scleral Lens Clearance Assessment with Biomicroscopy and Anterior Segment Optical Coherence Tomography
      SIGNIFICANCE It is important to be able to accurately estimate the central corneal clearance when fitting scleral contact lenses. Tools available have intrinsic biases due to the angle of viewing, and therefore an idea of the amount of error in estimation will benefit the fitter. PURPOSE To compare the accuracy of observers' ability to estimate scleral contact lens central corneal clearance (CCC) with biomicroscopy to measurements using slit-lamp imaging and ...
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    11. Dense concentric circle scanning protocol for measuring pulsatile retinal blood flow in rats with Doppler optical coherence tomography

      Dense concentric circle scanning protocol for measuring pulsatile retinal blood flow in rats with Doppler optical coherence tomography
      The variability in the spatial orientation of retinal blood vessels near the optic nerve head (ONH) results in imprecision of the measured Doppler angle and therefore the pulsatile blood flow (BF), when those parameters are evaluated using Doppler OCT imaging protocols based on dual-concentric circular scans. Here, we utilized a dense concentric circle scanning protocol and evaluated its precision for measuring pulsatile retinal BF in rats for different numbers of ...
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    12. Evaluation and Correlation of Morphological, Blood Flow and Physiological Retinal Changes in a Rat Model of Glaucoma with a Combined Optical Coherence Tomography and Electroretinography System (Thesis)

      Evaluation and Correlation of Morphological, Blood Flow and Physiological Retinal Changes in a Rat Model of Glaucoma with a Combined Optical Coherence Tomography and Electroretinography System (Thesis)
      Glaucoma is a chronic disease associated with progressive dysfunction of the retinal ganglion cells (RGC), reduction of the retinal blood flow, thinning of the retinal nerve fiber layer (RNFL) and deformation of the optical nerve head (ONH). It is the second leading cause of blindness worldwide, with an estimate of 64.3 million people between the ages of 40 to 80 years affected in 2013, 76.7 million by 2020 ...
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    13. In-vivo imaging of the palisades of Vogt and the limbal crypts with sub-micrometer axial resolution optical coherence tomography

      In-vivo imaging of the palisades of Vogt and the limbal crypts with sub-micrometer axial resolution optical coherence tomography
      A research-grade OCT system was used to image in-vivo and without contact with the tissue, the cellular structure and microvasculature of the healthy human corneo-scleral limbus. The OCT system provided 0.95 m axial and 4 m (2 m) lateral resolution in biological tissue depending on the magnification of the imaging objective. Cross-sectional OCT images acquired tangentially from the inferior limbus showed reflective, loop-like features that correspond to the fibrous ...
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    14. Relationship between vessel diameter and depth measurements within the limbus using ultra-high resolution optical coherence tomography

      Relationship between vessel diameter and depth measurements within the limbus using ultra-high resolution optical coherence tomography
      To establish a relationship between the diameter and depth position of vessels in the superior and inferior corneo-scleral limbus using ultra-high resolution optical coherence tomography (UHR-OCT). Methods Volumetric OCT images of the superior and inferior limbus were acquired from 14 healthy subjects with a research-grade UHR-OCT system. Differences in vessel diameter and depth between superior and inferior limbus were analyzed using repeated measured ANOVA in SPSS and R. Results The ...
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  2. About University of Waterloo

    University of Waterloo

    University of Waterloo has long been recognized as the most innovative university in Canada. We are committed to advancing learning and knowledge through teaching, research, and scholarship in our faculties, colleges, and schools.