1. University of Washington

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    1. Mentioned In 326 Articles

    2. Multifunctional imaging of human retina and choroid with 1050-nm spectral domain optical coherence tomography at 92-kHz line scan rate

      Multifunctional imaging of human retina and choroid with 1050-nm spectral domain optical coherence tomography at 92-kHz line scan rate
      ...uman eye, delivering the volumetric imaging of microstructure and microvasculature within retina and choroid. University of Washington, Department of Bioengineering, Seattle, Washington 98195 The light source at ∼1-μm wa...
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    3. Measurement of strain and strain rate in embryonic chick heart in vivo using spectral domain optical coherence tomography

      Measurement of strain and strain rate in embryonic chick heart in vivo using spectral domain optical coherence tomography
      ..., P.;   Yin, X.;   Shi, L.;   Liu, A.;   Rugonyi, S.;   Wang, R.; P. Li is with Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. This paper appears in: Biomedical Engineering, IEEE Transact...
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    4. Elastic properties of soft tissue-mimicking phantoms assessed by combined use of laser ultrasonics and low coherence interferometry

      Elastic properties of soft tissue-mimicking phantoms assessed by combined use of laser ultrasonics and low coherence interferometry
      Advances in the field of laser ultrasonics have opened up new possibilities in medical applications. This paper evaluates this technique as a method that would allow for rapid characterization of the elastic properties of soft biological tissue. In doing so, we propose a novel approach that utilizes a low coherence interferometer to detect the laser-induced surface acoustic waves (SAW) from the tissue-mimicking phantoms. A Nd:YAG focused laser line-source is ...
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    5. Feature Of The Week 4/24/11: In vivo 3D imaging of intra-cochlear microstructures and microvascular perfusion in mice with ultra-high sensitive optical micro-angiography (UHS-OMAG)

      Feature Of The Week 4/24/11: In vivo 3D imaging of intra-cochlear microstructures and microvascular perfusion in mice with ultra-high sensitive optical micro-angiography (UHS-OMAG)
      Feature Of The Week 4/24/11: Researchers from the Biophotonics and Imaging Laboratory (BAIL) at Oregon Health & Science University (OHSU) have recently pioneered a novel ultra-high sensitive volumetric perfusion imaging modality based on optical micro-angiography (OMAG), which is a spectral-domain functional optical coherence tomographic imaging modality capable of imaging blood perfusion with very high flow sensitivity of 4microns/sec down to capillary level resolution. The imaging contrast of blood perfusion in OMAG is based on endogenous light scattering from moving blood cells; thus, no exogenous contrast agents are necessary for imaging. In traditional OMAG imaging, in order to separate the moving scatters from static one, a constant modulation frequency was introduced into the spectral interferogram along the B-scan direction. This modulation frequency can be introduced either by using a moving reference arm mirror mounted ...
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    6. Highly sensitive imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiography

      Highly sensitive imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiography
      Studying renal microcirculation and its dynamics is of great importance for understanding the renal function and further aiding the diagnosis, prevention and treatment of renal pathologies. In this paper, we present a potentially useful method to provide high-sensitive volumetric imaging of renal microcirculations using ultrahigh-sensitive optical microangiography (UHS-OMAG). The UHS-OMAG image system used here is based on spectral domain optical coherence tomography, which uses a broadband light source centered at ...
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    7. Volumetric and quantitative imaging of retinal blood flow in rats with optical microangiography

      Volumetric and quantitative imaging of retinal blood flow in rats with optical microangiography
      In this paper, we present methods for 3D visualization and quantitative measurements of retinal blood flow in rats by the use of optical microangiography imaging technique (OMAG). We use ultrahigh sensitive OMAG to provide high-quality 3D RBF perfusion maps in the rat eye, from which the Doppler angle, as well as the diameters of blood vessels, are evaluated. Estimation of flow velocity (i.e. axial flow velocity) is achieved by ...
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    8. High sensitive volumetric imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiography

      High sensitive volumetric imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiography
      We present a non-invasive, label-free imaging technique called Ultrahigh Sensitive Optical Microangiography (UHSOMAG) for high sensitive volumetric imaging of renal microcirculation. The UHS-OMAG imaging system is based on spectral domain optical coherence tomography (SD-OCT), which uses a 47000 A-line scan rate CCD camera to perform an imaging speed of 150 frames per second that takes only ~7 seconds to acquire a 3D image. The technique, capable of measuring slow blood ...
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    9. Label-free in vivo optical micro-angiography imaging of cerebral capillary blood flow within meninges and cortex in mice with the skull left intact

      Label-free in vivo optical micro-angiography imaging of cerebral capillary blood flow within meninges and cortex in mice with the skull left intact
      Abnormal microcirculation within meninges is common in many neurological diseases. There is a need for an imaging method that is capable of visualizing functional meningeal microcirculations alone, preferably decoupled from the cortical blood flow. Optical microangiography (OMAG) is a recently developed label-free imaging method capable of producing 3D images of dynamic blood perfusion within micro-circulatory tissue beds at an imaging depth up to ~2 mm, with an unprecedented imaging sensitivity ...
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    10. Volumetric In Vivo Imaging of Microvascular Perfusion Within the Intact Cochlea in Mice Using Ultra-High Sensitive Optical Microangiography

      Volumetric In Vivo Imaging of Microvascular Perfusion Within the Intact Cochlea in Mice Using Ultra-High Sensitive Optical Microangiography
      Studying the inner ear microvascular dynamics is extremely important to understand the cochlear function and to further advance the diagnosis, prevention, and treatment of many otologic disorders. However, there is currently no effective imaging tool available that is able to access the blood flow within the intact cochlea. In this paper, we report the use of an ultrahigh sensitive optical micro-angiography (UHS-OMAG) imaging system to image 3-D microvascular perfusion within ...
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    11. Noninvasive optical coherence tomography monitoring of structure and hydration changes of human corneas in different preservation media

      Noninvasive optical coherence tomography monitoring of structure and hydration changes of human corneas in different preservation media
      The influence of different tissue preservation (a test solution under development and a standard storage solution) on human cornea morphology, refractive index and hydration was assessed noninvasively by ultrahigh-resolution optical coherence tomography (OCT) over time. For 28 days’ or 15 days’ storage in the preservation media, corneas in the two media exhibited different structural changes with different onset times including epithelial desquamation, edema-induced cornea thickening and change in tissue refractive ...
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    12. Available Postdoctoral Positions in Biomedical Optics and Optical Coherence Tomography at the University of Washington

      Available Postdoctoral Positions in Biomedical Optics and Optical Coherence Tomography at the University of Washington
      ...me and names of 3 references to:   Ruikang Wang, PhD Professor, Bioengineering, University of Washington wangrk@u.washington.edu Bioengineering Dept, Box 355061 University of Washington Seattle, WA 98195...
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    13. Autocorrelation optical coherence tomography for mapping transverse particle-flow velocity

      Autocorrelation optical coherence tomography for mapping transverse particle-flow velocity
      We present an autocorrelation method to quantitatively map transverse particle-flow velocity with a Fourier-domain optical coherence tomography system. This method is derived from the intensity fluctuation of the backscattered light modulated by flowing particles. When passing through the probe beam, moving particles encode a transit time into the backscattered light. The slope of the normalized autocorrelation function of the backscattered light is proportional to the transverse velocity. The proposed method ...
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    14. Robust High-Resolution Fine OCT Needle for Side-Viewing Interstitial Tissue Imaging

      Robust High-Resolution Fine OCT Needle for Side-Viewing Interstitial Tissue Imaging
      Fine optical coherence tomography (OCT) imaging needles that can be integrated with a standard biopsy needle have been developed with a new optics design to improve the optical quality and mechanical robustness, where a fiber-optic lens (that is spliced to a single-mode fiber) and a microreflector are encased within a microglass tube. The design also minimizes the cylindrical lens effect induced by the glass tube and eases the needle assembly ...
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    15. Multimodality Cardiovascular Molecular Imaging Technology

      Multimodality Cardiovascular Molecular Imaging Technology
      Cardiovascular molecular imaging is a new discipline that integrates scientific advances in both functional imaging and molecular probes to improve our understanding of the molecular basis of the cardiovascular system. These advances are driven by in vivo imaging of molecular processes in animals, usually small animals, and are rapidly moving toward clinical applications. Molecular imaging has the potential to revolutionize the diagnosis and treatment of cardiovascular disease. The 2 key ...
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  2. About University of Washington

    University of Washington

    The University of Washington, founded in 1861, is a public research university in Seattle, Washington, United States. It is the largest university in the Northwestern United States and the oldest public university in Washington. The UW maintains three locations, with its flagship campus in Seattle's University District and branch campuses in Tacoma and Bothell. Its operating budget for fiscal year 2005 was $3.1 billion. The university is known as a Public Ivy, an American term for state-funded institutions of higher learning that "provide[s] an Ivy League collegiate experience at a public school price."