1. University of Washington

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    1. Mentioned In 342 Articles

    2. High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A‑lines per second

      High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A‑lines per second
      We present a new development of ultrahigh speed spectral domain optical coherence tomography (SDOCT) for human retinal imaging at 850 nm central wavelength by employing two high-speed line scan CMOS cameras, each running at 250 kHz. Through precisely controlling the recording and reading time periods of the two cameras, the SDOCT system realizes an imaging speed at 500,000 A-lines per second, while maintaining both high axial resolution (~8 m ...
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    3. Optical microangiography provides an ability to monitor responses of cerebral microcirculation to hypoxia and hyperoxia in mice

      Optical microangiography provides an ability to monitor responses of cerebral microcirculation to hypoxia and hyperoxia in mice
      In vivo imaging of microcirculation can improve our fundamental understanding of cerebral microhemodynamics under various physiological challenges, such as hypoxia and hyperoxia. However, existing techniques often involve the use of invasive procedures or exogenous contrast agents, which would inevitably perturb the intrinsic physiologic responses of microcirculation being investigated. We report ultrahigh sensitive optical microangiography (OMAG) for label-free monitoring of microcirculation responses challenged by oxygen inhalation. For the first time, we ...
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    4. Automatic estimation of point-spread-function for deconvoluting out-of-focus optical coherence tomographic images using information entropy-based approach

      Automatic estimation of point-spread-function for deconvoluting out-of-focus optical coherence tomographic images using information entropy-based approach
      This paper proposes an automatic point spread function (PSF) estimation method to de-blur out-of-focus optical coherence tomography (OCT) images. The method utilizes Richardson-Lucy deconvolution algorithm to deconvolve noisy defocused images with a family of Gaussian PSFs with different beam spot sizes. Then, the best beam spot size is automatically estimated based on the discontinuity of information entropy of recovered images. Therefore, it is not required a prior knowledge of the ...
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    5. A tomography system for imaging deep tissues

      A tomography system for imaging deep tissues
      An innovative fast optical coherence tomography system obtains high-resolution 3D images of deep retinal tissue structures and their vascularization. The number of people with major eye disease, such as glaucoma, age-related macular degeneration (ARMD), and diabetic retinopathy, is set to increase and to become a major public health problem.1 Several methods are used to diagnose and monitor the progression of such diseases. Optical coherence tomography (OCT) is a noninvasive ...
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    6. Supercontinuum light source enables in vivooptical microangiography of capillary vessels within tissue beds

      Supercontinuum light source enables in vivooptical microangiography of capillary vessels within tissue beds
      This Letter reports on the use of a supercontinuum light source to achieve ultrahigh resolution and ultrahigh sensitive optical microangiography (OMAG) imaging of microcirculations within tissue beds in vivo. After passing through a specially designed optical filter with a passband of 120 nm centered on 800 nm, the light source is coupled into an optic-fiber-based OMAG system that provides a measured axial resolution of ∼3 μm over a ranging distance ...
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    7. University of Washington Wins NIH Grant for Volumetric Imaging of Blood Perfusion and Tissue Morphology in the Cochlea

      University of Washington Wins NIH Grant for Volumetric Imaging of Blood Perfusion and Tissue Morphology in the Cochlea
      ...ove the understanding, diagnosis and treatment of sudden sensorineural hearing loss and Meniere's disease   University of Washington Received a $371,186 NIH Grant for Volumetric Imaging of Blood Perfusion and Tissue Mo...
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    8. Washington University Wins NIH Grant to Study Mechanics of Early Brain and Eye Development Using OCT

      Washington University Wins NIH Grant to Study Mechanics of Early Brain and Eye Development Using OCT
      Washington University won an NIH grant for $325,850 to study mechanics of early brain and eye development using OCT and other imaging technology.  The principal investigator is Larry Taber and a short summary of the work is given below.  In human embryos, the primary subdivisions of the brain (forebrain, midbrain, and hindbrain) are formed by the fourth week of gestation. During this time, the primitive eyes (optic vesicles) emerge ...
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    9. Ultrahigh sensitive optical microangiography reveals depth-resolved microcirculation and its longitudinal response to prolonged ischemic event within skeletal muscles in mice

      Ultrahigh sensitive optical microangiography reveals depth-resolved microcirculation and its longitudinal response to prolonged ischemic event within skeletal muscles in mice
      The primary pathophysiology of peripheral arterial disease is associated with impaired perfusion to the muscle tissue in the lower extremities. The lack of effective pharmacologic treatments that stimulate vessel collateralization emphasizes the need for an imaging method that can be used to dynamically visualize depth-resolved microcirculation within muscle tissues. Optical microangiography (OMAG) is a recently developed label-free imaging method capable of producing three-dimensional images of dynamic blood perfusion within microcirculatory ...
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    10. Three-Dimensional High-Resolution Imaging of Gold Nanorods Uptake in Sentinel Lymph Nodes

      Three-Dimensional High-Resolution Imaging of Gold Nanorods Uptake in Sentinel Lymph Nodes
      n this paper, we demonstrate an application of a noninvasive imaging modality, photothermal optical coherence tomography (PT-OCT), for imaging gold nanorods (GNRs) uptake in sentinel lymph node (SLN) of mice in situ. This application enables us to obtain higher quality images of SLN structures due to the photothermal contrast properties of the GNRs. It is also demonstrated that GNRs accumulate differently within several SLN structures, and this uptake is time ...
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    11. High resolution optical coherence tomography based imaging for intraluminal and interstitial use implemented with a reduced form factor

      High resolution optical coherence tomography based imaging for intraluminal and interstitial use implemented with a reduced form factor
      Mechanically robust minimal form factor OCT probes suitable for medical applications such as needle biopsy, intraluminal and intravascular imaging are achieved in part by employing compound lenses with some or all of the optical elements, including an optical fiber, to be thermally fused in tandem. To achieve a desired working distance without increasing a diameter of the optics assembly, a spacer can be disposed between the optical fiber and focusing ...
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    12. Introduction: feature issue on In Vivo Microcirculation Imaging

      Introduction: feature issue on In Vivo Microcirculation Imaging
      The editors introduce the Biomedical Optics Express feature issue, “In Vivo Microcirculation Imaging,” which includes 14 contributions from the biomedical optics community, covering such imaging techniques as optical coherence tomography, photoacoustic microscopy, laser Doppler /speckle imaging, and near infrared spectroscopy and fluorescence imaging.
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    13. 286-300 of 342 « 1 2 ... 17 18 19 20 21 22 23 »
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  2. About University of Washington

    University of Washington

    The University of Washington, founded in 1861, is a public research university in Seattle, Washington, United States. It is the largest university in the Northwestern United States and the oldest public university in Washington. The UW maintains three locations, with its flagship campus in Seattle's University District and branch campuses in Tacoma and Bothell. Its operating budget for fiscal year 2005 was $3.1 billion. The university is known as a Public Ivy, an American term for state-funded institutions of higher learning that "provide[s] an Ivy League collegiate experience at a public school price."