1. University of Washington

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    1. Mentioned In 328 Articles

    2. Evaluating elastic properties of heterogeneous soft tissue by surface acoustic waves detected by phase-sensitive optical coherence tomography

      Evaluating elastic properties of heterogeneous soft tissue by surface acoustic waves detected by phase-sensitive optical coherence tomography
      The combined use of surface acoustic wave (SAW) and phase-sensitive optical coherence tomography (PhS-OCT) is useful to evaluate the elasticity of layered biological tissues, such as normal skin. However, the pathological tissue is often originated locally, leading to the alternation of mechanical properties along both axial and lateral directions. We present a feasibility study on whether the SAW technique is sensitive to detect the alternation of mechanical property along the ...
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    3. Automated segmentation of intramacular layers in Fourier domain optical coherence tomography structural images from normal subjects

      Automated segmentation of intramacular layers in Fourier domain optical coherence tomography structural images from normal subjects
      Segmentation of optical coherence tomography (OCT) cross-sectional structural images is important for assisting ophthalmologists in clinical decision making in terms of both diagnosis and treatment. We present an automatic approach for segmenting intramacular layers in Fourier domain optical coherence tomography (FD-OCT) images using a searching strategy based on locally weighted gradient extrema, coupled with an error-removing technique based on statistical error estimation. A two-step denoising preprocess in different directions is ...
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    4. Multifunctional nanoprobe to enhance the utility of optical based imaging techniques

      Multifunctional nanoprobe to enhance the utility of optical based imaging techniques
      Several imaging modalities such as optical coherence tomography, photothermal, photoacoustic and magnetic resonance imaging, are sensitive to different physical properties (i.e. scattering, absorption and magnetic) that can provide contrast within biological tissues. Usually exogenous agents are designed with specific properties to provide contrast for these imaging methods. In nano-biotechnology there is a need to combine several of these properties into a single contrast agent. This multifunctional contrast agent can ...
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    5. Simultaneous depth-resolved imaging of sub-nanometer scale ossicular vibrations and morphological features of the human-cadaver middle ear with spectral-domain phase-sensitive optical coherence tomography

      Simultaneous depth-resolved imaging of sub-nanometer scale ossicular vibrations and morphological features of the human-cadaver middle ear with spectral-domain phase-sensitive optical coherence tomography
      We describe a novel method for the detection of the tiny motions of the middle ear (ME) ossicles and their morphological features with a spectral-domain phase sensitive optical coherence tomography (PS-OCT). Laser Doppler Vibrometry (LDV) and its variations are the most extensively used methods for studding the vibrational modes of the ME. However, most techniques are limited to single point analysis methods, and do not have the ability to provide ...
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    6. Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography

      Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography
      Direct measurement of absolute vibration parameters from different locations within the mammalian organ of Corti is crucial for understanding the hearing mechanics such as how sound propagates through the cochlea and how sound stimulates the vibration of various structures of the cochlea, namely, basilar membrane (BM), recticular lamina, outer hair cells and tectorial membrane (TM). In this study we demonstrate the feasibility a modified phase-sensitive spectral domain optical coherence tomography ...
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    7. Label-free 3D imaging of microstructure, blood, and lymphatic vessels within tissue beds in vivo

      Label-free 3D imaging of microstructure, blood, and lymphatic vessels within tissue beds in vivo
      This Letter reports the use of an ultrahigh resolution optical microangiography (OMAG) system for simultaneous 3D imaging of microstructure and lymphatic and blood vessels without the use of an exogenous contrast agent. An automatic algorithm is developed to segment the lymphatic vessels from the microstructural images based on the fact that the lymph fluid is optically transparent. An OMAG system is developed that utilizes a broadband supercontinuum light source, providing ...
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    8. Quantitative elastography provided by surface acoustic waves measured by phase-sensitive optical coherence tomography

      Quantitative elastography provided by surface acoustic waves measured by phase-sensitive optical coherence tomography
      We report on a quantitative elastography technique achieved by combining phase-sensitive optical coherence tomography (PhS-OCT) with the surface acoustic wave (SAW) method. Different from traditional optical coherence elastography, the elastography is achieved by impulse-stimulated SAW, rather than by shear waves. PhS-OCT serves not only as a detector to measure SAW signals but also as a means to provide a cross-sectional image of the sample. The experimental results indicate that the ...
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    9. Depth profile absorber concentration reconstruction using photothermal optical coherence tomography

      Depth profile absorber concentration reconstruction using photothermal optical coherence tomography
      The concentration of photothermal (light-to-heat converters) compounds as a function of depth is determined in solid agar gel phantoms. The system contains an 808nm pump laser, which excites the photothermal compound, and a phase sensitive spectral domain optical coherence tomography system, which detects the changes in the optical pathlength of the sample induced by the temperature increase. The derivation of the model is described, and its parameters are empirically determined ...
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    10. Depth profiling of photothermal compound concentrations using phase sensitive optical coherence tomography

      Depth profiling of photothermal compound concentrations using phase sensitive optical coherence tomography
      A model that describes the concentration of photothermal (light-to-heat converters) compounds as a function of depth in a turbid medium is developed. The system consists of a pump laser (808 nm modulated at 400 Hz), which heats a photothermal compound, and a phase sensitive spectral domain optical coherence tomography system, which detects the changes in the optical path length of the sample induced by the temperature increase. The model is ...
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    11. Imaging in Developmental Biology: A Laboratory Manual (Book)

      Imaging in Developmental Biology: A Laboratory Manual (Book)
      New imaging technologies have revolutionized the study of developmental biology. Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visualize the dynamic form and function of molecules, cells, tissues, and whole embryos throughout the entire developmental process. Imaging in Developmental Biology: A Laboratory Manual, a new volume in Cold Spring Harbor Laboratory Press’ Imaging series, presents a comprehensive set of essential visualization ...
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    12. Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography

      Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography
      ...g Guan1,2, 3. Roberto Reif1, 4. Zhihong Huang2,* and 5. Ruikang K. Wang1,* 1. ^1Department of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, WA 98195, USA 2. ^2Division of Mechanical Engineering ...
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    13. Using ultrahigh sensitive optical microangiography to achieve comprehensive depth resolved microvasculature mapping for human retina

      Using ultrahigh sensitive optical microangiography to achieve comprehensive depth resolved microvasculature mapping for human retina
      Lin An, Tueng T. Shen, and Ruikang K. Wang This paper presents comprehensive and depth-resolved retinal microvasculature images within human retina achieved by a newly developed ultrahigh sensitive optical microangiography (UHS-OMAG) system. Due to its high flow sensitivity, UHS-OMAG is much more sensitive to tissue motion due to the involun ... [J. Biomed. Opt. 16, 106013 (2011)] published Mon Oct 24, 2011.
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    14. Assessment of strain and strain rate in embryonic chick heart in vivo using tissue Doppler optical coherence tomography

      Assessment of strain and strain rate in embryonic chick heart in vivo using tissue Doppler optical coherence tomography
      ...heart in vivo using tissue Doppler optical coherence tomography wangrk@uw.edu 1 Department of Bioengineering, University of Washington, Seattle, WA 98195, USA 2 Department of Biomedical Engineering, Oregon Health and Sci...
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    15. In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography

      In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography
      The corneo-scleral limbus contains several biological components, which are important constituents for understanding, diagnosing and managing several ocular pathologies, such as glaucoma and corneal abnormalities. An anterior segment optical coherence tomography (AS-OCT) system integrated with optical microangiography (OMAG) is used in this study to non-invasively visualize the three-dimensional microstructural and microvascular properties of the limbal region. Advantages include first the ability to correct optical distortion of microstructural images enabling quantification ...
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  2. About University of Washington

    University of Washington

    The University of Washington, founded in 1861, is a public research university in Seattle, Washington, United States. It is the largest university in the Northwestern United States and the oldest public university in Washington. The UW maintains three locations, with its flagship campus in Seattle's University District and branch campuses in Tacoma and Bothell. Its operating budget for fiscal year 2005 was $3.1 billion. The university is known as a Public Ivy, an American term for state-funded institutions of higher learning that "provide[s] an Ivy League collegiate experience at a public school price."