1. University of Washington

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    1. Mentioned In 335 Articles

    2. Biomechanics of the Chick Embryonic Heart Outflow Tract at HH18 Using 4D Optical Coherence Tomography Imaging and Computational Modeling

      Biomechanics of the Chick Embryonic Heart Outflow Tract at HH18 Using 4D Optical Coherence Tomography Imaging and Computational Modeling
      During developmental stages, biomechanical stimuli on cardiac cells modulate genetic programs, and deviations from normal stimuli can lead to cardiac defects. Therefore, it is important to characterize normal cardiac biomechanical stimuli during early developmental stages. Using the chicken embryo model of cardiac development, we focused on characterizing biomechanical stimuli on the HamburgerHamilton (HH) 18 chick cardiac outflow tract (OFT), the distal portion of the heart from which a large portion ...
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    3. Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement in ex vivo nonhuman primate eyes

      Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement in ex vivo nonhuman primate eyes
      Glaucoma is a blinding disease for which intraocular pressure (IOP) is the only treatable risk factor. The mean IOP is regulated through the aqueous outflow system, which contains the trabecular meshwork (TM). Considerable evidence indicates that trabecular tissue movement regulates the aqueous outflow and becomes abnormal during glaucoma; however, such motion has thus far escaped detection. The purpose of this study is to describe anovel use of a phase-sensitive optical ...
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    4. Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System

      Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System
      The blood vessel morphology is known to correlate with several diseases, such as cancer, and is important for describing several tissue physiological processes, like angiogenesis. Therefore, a quantitative method for characterizing the angiography obtained from medical images would have several clinical applications. Optical microangiography (OMAG) is a method for obtaining three-dimensional images of blood vessels within a volume of tissue. In this study we propose to quantify OMAG images obtained ...
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    5. Feature Of The Week 6/17/12: Middle Ear Vibrometry of Human Cadaver Temporal Bone with Spectral Domain Phase-Sensitive Optical Coherence Tomography

      Feature Of The Week 6/17/12: Middle Ear Vibrometry of Human Cadaver Temporal Bone with Spectral Domain Phase-Sensitive Optical Coherence Tomography
      Hearing loss is the most frequent sensory deficit in the human population, affecting more than 250 million people in the world. The National Center for Health Statistics estimates that 37 million adults (17%) in the United States have hearing difficulty. Analysis of a large database of audiometric records from the University of Minnesota reveals that 39% of patients diagnosed with hearing loss have conductive hearing loss (CHL) either alone (15 ...
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    6. Feasibility of spectral-domain phase-sensitive optical coherence tomography for middle ear vibrometry

      Feasibility of spectral-domain phase-sensitive optical coherence tomography for middle ear vibrometry
      We describe a novel application of spectral-domain phase-sensitive optical coherence tomography (SD PS-OCT) to detect the tiny motions of the middle ear structures, such as the tympanic membrane and ossicular chain, and their morphological features for differential diagnosis of CHL. This technique has the potential to provide meaningful vibration of ossicles with a vibration sensitivity of ∼ 0.5  nm at 1 kHz of acoustic stimulation. To the best of our ...
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    7. Feature Of The Week 5/27/11: Researchers Utilize Optical Coherence Tomography to Perform in vivo Investigation into the Process of Hearing

      Feature Of The Week 5/27/11: Researchers Utilize Optical Coherence Tomography to Perform in vivo Investigation into the Process of Hearing
      A multidisciplinary research groups spanning several countries (USA, China, Sweden) are using optical coherence tomography (OCT) to investigate minute changes in hair cells within the cochlea - the auditory portion of the inner ear. Below is a summary of their work. Mammalian hearing is refined by amplification of the sound-evoked vibration of the cochlear partition. This amplification is at least partly due to forces produced by protein motors residing in the ...
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    8. Noncontact all-optical measurement of corneal elasticity

      Noncontact all-optical measurement of corneal elasticity
      We report on a noninvasive and noncontact all-optical method to measure the elasticity of the cornea. We use a pulsed laser to excite surface acoustic waves (SAW) that propagate on the corneal surface, then use a phase-sensitive optical coherence tomography system to remotely record the SAWs from which the corneal elasticity is estimated. In addition, the system is able to provide real-time tomographic images of the cornea being examined, an ...
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    9. Evaluating elastic properties of heterogeneous soft tissue by surface acoustic waves detected by phase-sensitive optical coherence tomography

      Evaluating elastic properties of heterogeneous soft tissue by surface acoustic waves detected by phase-sensitive optical coherence tomography
      The combined use of surface acoustic wave (SAW) and phase-sensitive optical coherence tomography (PhS-OCT) is useful to evaluate the elasticity of layered biological tissues, such as normal skin. However, the pathological tissue is often originated locally, leading to the alternation of mechanical properties along both axial and lateral directions. We present a feasibility study on whether the SAW technique is sensitive to detect the alternation of mechanical property along the ...
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    10. Automated segmentation of intramacular layers in Fourier domain optical coherence tomography structural images from normal subjects

      Automated segmentation of intramacular layers in Fourier domain optical coherence tomography structural images from normal subjects
      Segmentation of optical coherence tomography (OCT) cross-sectional structural images is important for assisting ophthalmologists in clinical decision making in terms of both diagnosis and treatment. We present an automatic approach for segmenting intramacular layers in Fourier domain optical coherence tomography (FD-OCT) images using a searching strategy based on locally weighted gradient extrema, coupled with an error-removing technique based on statistical error estimation. A two-step denoising preprocess in different directions is ...
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    11. Multifunctional nanoprobe to enhance the utility of optical based imaging techniques

      Multifunctional nanoprobe to enhance the utility of optical based imaging techniques
      Several imaging modalities such as optical coherence tomography, photothermal, photoacoustic and magnetic resonance imaging, are sensitive to different physical properties (i.e. scattering, absorption and magnetic) that can provide contrast within biological tissues. Usually exogenous agents are designed with specific properties to provide contrast for these imaging methods. In nano-biotechnology there is a need to combine several of these properties into a single contrast agent. This multifunctional contrast agent can ...
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    12. Simultaneous depth-resolved imaging of sub-nanometer scale ossicular vibrations and morphological features of the human-cadaver middle ear with spectral-domain phase-sensitive optical coherence tomography

      Simultaneous depth-resolved imaging of sub-nanometer scale ossicular vibrations and morphological features of the human-cadaver middle ear with spectral-domain phase-sensitive optical coherence tomography
      We describe a novel method for the detection of the tiny motions of the middle ear (ME) ossicles and their morphological features with a spectral-domain phase sensitive optical coherence tomography (PS-OCT). Laser Doppler Vibrometry (LDV) and its variations are the most extensively used methods for studding the vibrational modes of the ME. However, most techniques are limited to single point analysis methods, and do not have the ability to provide ...
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    13. Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography

      Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography
      Direct measurement of absolute vibration parameters from different locations within the mammalian organ of Corti is crucial for understanding the hearing mechanics such as how sound propagates through the cochlea and how sound stimulates the vibration of various structures of the cochlea, namely, basilar membrane (BM), recticular lamina, outer hair cells and tectorial membrane (TM). In this study we demonstrate the feasibility a modified phase-sensitive spectral domain optical coherence tomography ...
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    14. Label-free 3D imaging of microstructure, blood, and lymphatic vessels within tissue beds in vivo

      Label-free 3D imaging of microstructure, blood, and lymphatic vessels within tissue beds in vivo
      This Letter reports the use of an ultrahigh resolution optical microangiography (OMAG) system for simultaneous 3D imaging of microstructure and lymphatic and blood vessels without the use of an exogenous contrast agent. An automatic algorithm is developed to segment the lymphatic vessels from the microstructural images based on the fact that the lymph fluid is optically transparent. An OMAG system is developed that utilizes a broadband supercontinuum light source, providing ...
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    15. Quantitative elastography provided by surface acoustic waves measured by phase-sensitive optical coherence tomography

      Quantitative elastography provided by surface acoustic waves measured by phase-sensitive optical coherence tomography
      We report on a quantitative elastography technique achieved by combining phase-sensitive optical coherence tomography (PhS-OCT) with the surface acoustic wave (SAW) method. Different from traditional optical coherence elastography, the elastography is achieved by impulse-stimulated SAW, rather than by shear waves. PhS-OCT serves not only as a detector to measure SAW signals but also as a means to provide a cross-sectional image of the sample. The experimental results indicate that the ...
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  2. About University of Washington

    University of Washington

    The University of Washington, founded in 1861, is a public research university in Seattle, Washington, United States. It is the largest university in the Northwestern United States and the oldest public university in Washington. The UW maintains three locations, with its flagship campus in Seattle's University District and branch campuses in Tacoma and Bothell. Its operating budget for fiscal year 2005 was $3.1 billion. The university is known as a Public Ivy, an American term for state-funded institutions of higher learning that "provide[s] an Ivy League collegiate experience at a public school price."