1. University of Washington

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    1. Mentioned In 149 Articles

    2. Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography

      Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography

      The aqueous outflow system (AOS) is responsible for maintaining normal intraocular pressure (IOP) in the eye. Structures of the AOS have an active role in regulating IOP in healthy eyes and these structures become abnormal in the eyes with glaucoma. We describe a newly developed system platform to obtain high-resolution images of the AOS structures. By incorporating spectral domain optical coherence tomography (SD-OCT), the platform allows us to systematically control, image, and quantitate the responses of AOS tissue to pressure with a millisecond resolution of pulsed flow. We use SD-OCT to image radial limbal segments from the surface of the ...

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    3. Shear wave elastography method combining phase-sensitive optical coherence tomography and coded acoustic radiation force

      Shear wave elastography method combining phase-sensitive optical coherence tomography and coded acoustic radiation force

      We combined phase-sensitive optical coherence tomography (PhS-OCT) and acoustic radiation force (ARF) to develop a shear wave elastography (SWE) method that could be used for ophthalmic applications. SWE measures tissue stiffness from the speed of shear waves propagating through tissue. Assessing the elastic properties of the cornea and the intraocular lens can, for example, help the management of refractive surgeries (myopia or presbyopia correction). OCT is a non-contact imaging method easily applicable in vivo that provides micron-scale resolution particularly suitable for characterizing ocular tissues. ARF is commonly used to remotely induce shear waves in tissue by emitting short (∼100 µs ...

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    4. Shear wave elastography of ex vivo human corneas using phase-sensitive optical coherence tomography

      Shear wave elastography of ex vivo human corneas using phase-sensitive optical coherence tomography

      Assessing the biomechanical properties of the cornea can provide clinically valuable information in addition to structural images for better management of pathologies (e.g. glaucoma) or refractive surgeries. OCT provides a micron scale and high sensitivity that are ideal for ophthalmic applications. We propose a shear wave elastography (SWE) method for the cornea based on phase-sensitive optical coherence tomography (PhS-OCT). SWE consists in launching a propagating shear wave in tissues and retrieving tissue elasticity from the shear wave speed. We used a piezo-electric actuator in contact with the cornea to induce shear waves that were then tracked using a PhSOCT ...

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    5. Segmentation and quantification of blood vessels for OCT-based micro-angiograms using hybrid shape/intensity compounding

      Segmentation and quantification of blood vessels for OCT-based micro-angiograms using hybrid shape/intensity compounding

      Optical coherence tomography (OCT) based microangiography is capable of visualizing 3D functional blood vessel networks within microcirculatory tissue beds in vivo. To provide the quantitative information of vasculature from the microangiograms such as vessel diameter and morphology, it is necessary to develop efficient vessel segmentation algorithms. In this paper, we propose to develop a hybrid Hessian/intensity based method to segment and quantify shape and diameter of the blood vessels innervating capillary beds that are imaged by functional OCT in vivo. The proposed method utilizes multi-scale Hessian filters to segment tubular structures such as blood vessels, but compounded by the ...

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    6. User-guided segmentation for volumetric retinal optical coherence tomography images

      User-guided segmentation for volumetric retinal optical coherence tomography images

      Despite the existence of automatic segmentation techniques, trained graders still rely on manual segmentation to provide retinal layers and features from clinical optical coherence tomography (OCT) images for accurate measurements. To bridge the gap between this time-consuming need of manual segmentation and currently available automatic segmentation techniques, this paper proposes a user-guided segmentation method to perform the segmentation of retinal layers and features in OCT images. With this method, by interactively navigating three-dimensional (3-D) OCT images, the user first manually defines user-defined (or sketched) lines at regions where the retinal layers appear very irregular for which the automatic segmentation method ...

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    7. In vivo imaging of functional microvasculature within tissue beds of oral and nasal cavities by swept-source optical coherence tomography with a forward/side-viewing probe

      In vivo imaging of functional microvasculature within tissue beds of oral and nasal cavities by swept-source optical coherence tomography with a forward/side-viewing probe
      ...ikang K. Wang »View Author Affiliations Woo June Choi and Ruikang K. Wang^* ^Department of Bioengineering, University of Washington, 3720 15th NE, Seattle, WA 98195, USA ^*Corresponding author: wangrk@uw.edu Biome...
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    8. Optical coherence tomography microangiography for monitoring the response of vascular perfusion to external pressure on human skin tissue

      Optical coherence tomography microangiography for monitoring the response of vascular perfusion to external pressure on human skin tissue
      ... great potential for quantitatively assessing tissue microcirculation in the locally pressed tissue in vivo . University of Washington, Department of Bioengineering, Seattle, Washington 98195 Abstract.  Characterizatio...
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    9. Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm

      Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm

      We demonstrate an extended-imaging-range anterior-segment optical coherence tomography (eAS-OCT) system for the biometric assessment of full AS in human eye. This newly developed eAS-OCT operating at 1340-nm wavelength band is simultaneously capable of an imaging speed of 120 kHz A-line scan rate, an axial resolution of 7.2 μ m, and an extended imaging range of up to 16 mm in air. Imaging results from three healthy subjects and one subject with a narrow-angle demonstrate the instrument’s utility. With this system, it can provide anatomical dimensions of AS, including central corneal thickness, anterior chamber width, anterior chamber depth, crystalline lens ...

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  2. About University of Washington

    University of Washington

    The University of Washington, founded in 1861, is a public research university in Seattle, Washington, United States. It is the largest university in the Northwestern United States and the oldest public university in Washington. The UW maintains three locations, with its flagship campus in Seattle's University District and branch campuses in Tacoma and Bothell. Its operating budget for fiscal year 2005 was $3.1 billion. The university is known as a Public Ivy, an American term for state-funded institutions of higher learning that "provide[s] an Ivy League collegiate experience at a public school price."