1. University of Washington

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    1. Mentioned In 397 Articles

    2. Correcting intra-volume distortion for AO-OCT using 3D correlation based registration

      Correcting intra-volume distortion for AO-OCT using 3D correlation based registration
      Adaptive optics (AO) based ophthalmic imagers, such as scanning laser ophthalmoscopes (SLO) and optical coherence tomography (OCT), are used to evaluate the structure and function of the retina with high contrast and resolution. Fixational eye movements during a raster-scanned image acquisition lead to intra-frame and intra-volume distortion, resulting in an inaccurate reproduction of the underlying retinal structure. For three-dimensional (3D) AO-OCT, segmentation-based and 3D correlation based registration methods have been ...
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    3. Correlations Between Choriocapillaris and Choroidal Measurements and the Growth of Geographic Atrophy using Swept Source OCT Imaging

      Correlations Between Choriocapillaris and Choroidal Measurements and the Growth of Geographic Atrophy using Swept Source OCT Imaging
      Purpose The correlations between enlargement rates (ERs) of geographic atrophy (GA) and choriocapillaris (CC) flow deficits (FDs), mean choroidal thickness (MCT), and choroidal vascularity index (CVI) were investigated using swept source optical coherence tomography (SS-OCT) in age-related macular degeneration (AMD). Design Retrospective review of prospective, observational case series. Methods Eyes with GA from AMD were imaged with SS-OCT (PLEX Elite 9000; Carl Zeiss Meditec, Inc, Dublin, CA) using 6x6 mm ...
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    4. Reduced Pulsatile Trabecular Meshwork Motion in Eyes With Primary Open Angle Glaucoma Using Phase-Sensitive Optical Coherence Tomography

      Reduced Pulsatile Trabecular Meshwork Motion in Eyes With Primary Open Angle Glaucoma Using Phase-Sensitive Optical Coherence Tomography
      Purpose: The purpose of this study was to investigate the difference in pulsatile trabecular meshwork (TM) motion between normal and eyes with POAG using phase-sensitive optical coherence tomography (PhS-OCT). Methods: In this cross-sectional study, eight healthy subjects (16 eyes) and nine patients with POAG (18 eyes) were enrolled. A laboratory-based prototype PhS-OCT system was used to measure pulsatile TM motion. PhS-OCT images were analyzed to obtain parameters of pulsatile TM ...
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    5. Optical Coherence Tomography for the Investigation of Skin Adaptation in Lower-Limb Prosthesis Users

      Optical Coherence Tomography for the Investigation of Skin Adaptation in Lower-Limb Prosthesis Users
      Introduction Mechanically induced skin breakdown is a significant problem for many lower-limb prosthesis users. It is known that skin can adapt to the mechanical stresses of prosthesis use thereby reducing the risk of breakdown, yet little is understood about the biology behind skin adaptation . This is a proof-of-concept study for the use of novel, noninvasive optical coherence tomography (OCT) imaging techniques to investigate skin adaptation . Methods Two OCT imaging-based tests ...
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    6. OCT-Based Angiography and Surface Topography in Burn-Damaged Skin

      OCT-Based Angiography and Surface Topography in Burn-Damaged Skin
      Background and objectives: There is a clinical need for an accurate, non-invasive imaging tool that can provide the objective assessment of burn wounds. The aims of this study are to demonstrate the potential of optical coherence tomography (OCT) in evaluating burn wound healing, as well as exploring the physiological basis of human wound healing. Study design/materials and methods: This was a retrospective study. Seven patients with severe burn wounds ...
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    7. Quantitative assessment of choriocapillaris flow deficits in diabetic retinopathy: A swept-source optical coherence tomography angiography study

      Quantitative assessment of choriocapillaris flow deficits in diabetic retinopathy: A swept-source optical coherence tomography angiography study
      ... Portability and Accountability Act. The protocol was approved by the Institutional Review Board (IRB) of the University of Washington. Signed IRB-approved consent was obtained from each subject before SS-OCTA imaging. A...
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    8. Stable fiber-based polarization-sensitive optical coherence tomography using polarization maintaining common-path interferometer

      Stable fiber-based polarization-sensitive optical coherence tomography using polarization maintaining common-path interferometer
      Significance: Our work advances the development of fiber-based polarization-sensitive optical coherence tomography (PS-OCT) by stabilizing the output polarization state of the light beam when the system is under environmental disturbance. While the fiber-based PS-OCT has been demonstrated previously, it remains a challenge for the traditional fiber-based PS-OCT to obtain a stable measurement when the optic fibers are disturbed by the environment. This important issue is addressed, paving the path for ...
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    9. Polarization state tracing method to map local birefringent properties in samples using polarization sensitive optical coherence tomography

      Polarization state tracing method to map local birefringent properties in samples using polarization sensitive optical coherence tomography
      We propose a method that utilizes the trajectory of output polarization states on the Poincar sphere to derive depth-resolved birefringent information within samples using a fiber-based polarization sensitive optical coherence tomography. The apparent (or intermediate) optic axis and the local phase retardation are first obtained by fitting a plane to the adjacent output polarization states along depths in the Poincare sphere. A sequence of 3D rotation operation determined by the ...
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    10. Relative retinal flow velocity detection using optical coherence tomography angiography imaging

      Relative retinal flow velocity detection using optical coherence tomography angiography imaging
      Optical coherence tomography angiography (OCTA) imaging is a valuable tool for the visualization of retinal vasculature at an unprecedented level of details. However, due to relatively long time-interval between repeated scans in the conventional OCTA scanning protocol, the OCTA flow signal suffers from low dynamic range and loss of velocity-intensity correlation. The ability to distinguish fast and slow flow in the retina may provide a powerful tool for the assessment ...
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    11. Diagnosis of Occlusal Tooth Wear Using 3D Imaging of Optical Coherence Tomography Ex Vivo

      Diagnosis of Occlusal Tooth Wear Using 3D Imaging of Optical Coherence Tomography Ex Vivo
      The aim of this study was to assess the utility of 3D imaging of optical coherence tomography (OCT) for the diagnosis of occlusal tooth wear ex vivo. Sixty-three extracted human molars with or without visible tooth wear were collected to take digital intraoral radiography and 3D OCT images. The degree of tooth wear was evaluated by 12 examiners and scored using 4-rank scale: 1slight enamel wear; 2distinct enamel wear; 3tooth ...
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    12. Polarization sensitive optical coherence tomography for imaging microvascular information within living tissue without polarization-induced artifacts

      Polarization sensitive optical coherence tomography for imaging microvascular information within living tissue without polarization-induced artifacts
      When imaging birefringent samples using optical coherence tomography angiography (OCTA), the phase retardation may appear opposite to the phase change due to the blood flow in the orthogonal signals, for which a cancellation effect can occur when deriving OCTA signals. This effect can diminish the ability of OCTA to detect vascular information, leading to an erroneous interpretation of the final OCTA images. To mitigate this issue, we demonstrate polarization-sensitive optical ...
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    13. Handheld swept-source optical coherence tomography guided by smartphone-enabled wide-field autofluorescence photography for imaging facial sebaceous glands

      Handheld swept-source optical coherence tomography guided by smartphone-enabled wide-field autofluorescence photography for imaging facial sebaceous glands
      We report a method to image facial sebaceous glands (SGs) using smartphone-enabled wide-field autofluorescence photography (AFP) and handheld swept-source optical coherence tomography (SS-OCT). Smartphone-enabled AFP provides a 2D wide-field fluorescence image that is used both as a functional mapping of the sebum and a positioning guidance for OCT imaging of the SG. Following the guidance, handheld SS-OCT conducts the volume scan to investigate depth-resolved conditions of the SG in the ...
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    14. Matching Misaligned Spectralis OCTs to a Reference Scan in Pediatric Glaucoma with Poor Fixation and Nystagmus

      Matching Misaligned Spectralis OCTs to a Reference Scan in Pediatric Glaucoma with Poor Fixation and Nystagmus
      Purpose : Poor fixation or nystagmus in children causes misalignment errors when measuring circumpapillary retinal nerve fiber layer (cpRNFL) thickness by simultaneous scanning laser ophthalmoscope imaging/optical coherence tomography (SLO/OCT). We investigated a method to assess cpRNFL from misaligned SLO/OCT scans. Methods : Heidelberg Spectralis SLO/OCT scans from a single clinical examination were retrospectively analyzed when automated eye tracking was unreliable. Retinal layer thickness was measured at overlapping match ...
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    15. 3D imaging of proximal caries in posterior teeth using optical coherence tomography

      3D imaging of proximal caries in posterior teeth using optical coherence tomography
      Optical coherence tomography (OCT) can create cross-sectional images of tooth without X-ray exposure. This study aimed to investigate the diagnostic accuracy of 3D imaging of OCT for proximal caries in posterior teeth. Thirty-six human molar teeth with 51 proximal surfaces visibly 6 intact, 16 slightly demineralized, and 29 distinct carious changes were mounted to take digital radiographs and 3D OCT images. The sensitivity, specificity and area under the receiver operating ...
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    16. Optical microangiography reveals temporal and depth-resolved hemodynamic change in mouse barrel cortex during whisker stimulation

      Optical microangiography reveals temporal and depth-resolved hemodynamic change in mouse barrel cortex during whisker stimulation
      Significance: Cerebral blood flow (CBF) regulation at neurovascular coupling (NVC) plays an important role in normal brain functioning to support oxygen delivery to activating neurons. Therefore, studying the mechanisms of CBF adjustment is crucial for the improved understanding of brain activity. Aim: We investigated the temporal profile of hemodynamic signal change in mouse cortex caused by neural activation and its variation over cortical depth. Approach: Following the cranial window surgery ...
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    17. 1-15 of 397 1 2 3 4 ... 25 26 27 »
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  2. About University of Washington

    University of Washington

    The University of Washington, founded in 1861, is a public research university in Seattle, Washington, United States. It is the largest university in the Northwestern United States and the oldest public university in Washington. The UW maintains three locations, with its flagship campus in Seattle's University District and branch campuses in Tacoma and Bothell. Its operating budget for fiscal year 2005 was $3.1 billion. The university is known as a Public Ivy, an American term for state-funded institutions of higher learning that "provide[s] an Ivy League collegiate experience at a public school price."