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1. Mentioned In 353 Articles
2. Measurement and visualization of stimulus-evoked tissue dynamics in mouse barrel cortex using phase-sensitive optical coherence tomography
  
  Explore OSA | OSA Publishing Jan 10 2020 Neurology
  
  We describe a method to measure tissue dynamics in mouse barrel cortex during functional activation via phase-sensitive optical coherence tomography (PhS-OCT). The method measures the phase changes in OCT signals, which are induced by the tissue volume change, upon which to localize the activated tissue region. Phase unwrapping, compensation and normalization are applied to increase the dynamic range of the OCT phase detection. To guide the OCT scanning, intrinsic optical ...
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  Mentions: James G. Fujimoto Wolfgang Drexler University of Washington
3. Ultra-Widefield Protocol Enhances Automated Classification of Diabetic Retinopathy Severity with Optical Coherence Tomography Angiography
  
  Explore ScienceDirect Nov 12 2019 Ophthalmology
  
  Purpose To assess the diagnostic utility of retinal nonperfusion to classify eyes based on diabetic retinopathy (DR) severity on optical coherence tomography angiography (OCTA). To determine whether wider field of view (FOV) OCTA protocols enhance the diagnostic utility of retinal nonperfusion in the classification of DR severity. Design Retrospective cross-sectional study Subjects Diabetic patients undergoing ultra-widefield OCTA imaging at one academic retina practice Methods Ultra-widefield OCTA images with 100 degree ...
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  Mentions: University of Washington Ruikang K. Wang
4. Does lining class-II cavities with flowable composite improve the interfacial adaptation?
  
  Explore Taylor & Francis Online Oct 28 2019 Dentistry
  
  The objective of this study was to assess in-vitro interfacial cavity adaptation of different adhesive/composites systems in class-II restoration using SS-OCT and to confirm the findings with a confocal laser scanning microscope (CLSM). Standardized rectangular-shaped class-II cavities were prepared on 24 extracted human molar teeth, bonded with adhesive and lined with flowable composite. Cavities were further restored by bulk filling using packable composite. Specimens were divided into four groups ...
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  Mentions: University of Washington Alireza Sadr Junji Tagami
5. Application of functional optical coherence tomography angiography in neurovascular research (Thesis)
  
  Explore digital.lib.washington.edu Oct 24 2019 Neurology , Ophthalmology , Student Theses
  
  Optical coherence tomography (OCT) is a revolutionary non-invasive imaging technique that can perform high-resolution, cross-sectional tomographic imaging of the internal microstructure in biological tissues by measuring backscattered or backreflected light. Its functional extension, OCT angiography (OCTA), analyzes the intrinsic scattering property of the heterogenous tissue bed to extract dynamic blood flow signals to the capillary level without a need of contrast agents. Aside from the commonly known application of OCTA ...
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  Mentions: University of Washington
6. Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice
  
  Explore OSA | OSA Publishing Oct 15 2019
  
  We report the use of an electrically tunable lens (ETL) in a 1.3 m spectral-domain optical coherence tomography (SD-OCT) system to overcome the depth of focus (DOF) limitation in conventional OCT systems for OCT angiography (OCTA) in a mouse cerebral cortex. The ETL provides fast and dynamic control of the axial focus of the probe beam along the entire range of the mouse cortex, upon which we performed cerebral ...
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  Mentions: University of Washington Ruikang K. Wang
7. Handheld swept-source optical coherence tomography with angiography in awake premature neonates
  
  Explore Home Oct 1 2019 Ophthalmology
  
  Background: Retinopathy of prematurity (ROP) can lead to retinal detachment and severe vision loss and is a common cause of childhood blindness. Optical coherence tomography angiography (OCTA) is a non-invasive imaging modality that can be used to detect potential abnormalities in the microvasculature in this population. The objective of this study is to assess the feasibility of a newly developed handheld swept source OCT (SS-OCT) device to successfully acquire structural ...
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  Mentions: University of Washington Ruikang K. Wang
8. Correlations between Different Choriocapillaris Flow Deficit Parameters in Normal Eyes using Swept Source OCT Angiography
  
  Explore American Journal of Ophthalmology Sep 25 2019 Ophthalmology
  
  Purpose Choriocapillaris (CC) imaging of normal eyes with swept-source optical coherence tomography SS-OCTA was performed, and the percentage of CC flow deficits (FD%) and the average area of CC flow deficits (FDa) were compared within given macular regions. Design A prospective, cross-sectional study. Methods Subjects with normal eyes ranging in age from their 20s through their 80s were imaged with SS-OCTA (PLEX Elite 9000, Carl Zeiss Meditec, Dublin, CA) using ...
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  Mentions: Giovanni Gregori Philip J. Rosenfeld University of Washington
9. Spatial resolution in dynamic optical coherence elastography
  
  Explore SPIE Digital Library Sep 24 2019
  
  Dynamic optical coherence elastography (OCE) tracks elastic wave propagation speed within tissue, enabling quantitative three-dimensional imaging of the elastic modulus. We show that propagating mechanical waves are mode converted at interfaces, creating a finite region on the order of an acoustic wavelength where there is not a simple one-to-one correspondence between wave speed and elastic modulus. Depending on the details of a boundarys geometry and elasticity contrast, highly complex propagating ...
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  Mentions: University of Washington Ruikang K. Wang Chunhui Li
10. Two-Year Risk of Exudation in Eyes with Nonexudative Age-Related Macular Degeneration and Subclinical Neovascularization Detected with Swept Source Optical Coherence Tomography Angiography
  
  Explore American Journal of Ophthalmology Sep 22 2019 Ophthalmology
  
  Purpose Swept source optical coherence tomography angiography (SS-OCTA) was used to study the prevalence, incidence, and natural history of subclinical macular neovascularization (MNV) in eyes with unilateral nonexudative age-related macular degeneration. Design Prospective cohort study. Methods Patients were imaged using 3- 3-mm and 6- 6-mm SS-OCTA scan patterns. MNV was detected using the outer retina to choriocapillaris en face slab. Prevalence and incidence of subclinical MNV, KaplanMeier cumulative estimates for ...
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  Mentions: Giovanni Gregori Philip J. Rosenfeld University of Washington
11. Systems and methods for in vivo visualization of lymphatic vessels with optical coherence tomography
  
  Explore uspto.gov Sep 10 2019 Patents
  
  The present technology relates generally to systems and methods for in vivo visualization of lymphatic vessels. A system includes an optical coherence tomography (OCT) device and a computing device coupled to the OCT device configured to cause the OCT device to perform an OCT scan, generate image data in response to the OCT scan, and apply an eigendecomposition filter to the image data to produce processed image data. Alternatively or ...
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  Mentions: University of Washington Ruikang K. Wang
12. Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography
  
  Explore Medical Journals Publisher Aug 26 2019 Ophthalmology
  
  ...Department of Ophthalmology, University of California, San Francisco, CA, USA; 2Department of Bioengineering, University of Washington, Seattle, WA, USA; 3Francis I. Proctor Foundation, University of California, San Fran...
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  Mentions: University of Washington Ruikang K. Wang UCSF
13. Quantification of choriocapillaris with OCTA: a comparison study
  
  Explore American Journal of Ophthalmology Jul 16 2019 Ophthalmology
  
  Purpose To demonstrate the variation in quantitative choriocapillaris (CC) metrics with various binarization approaches using optical coherence tomography angiography (OCTA). Design Retrospective, observational, cross-sectional case series. Methods 3x3 mm and 6x6 mm macular OCTA scans were obtained from normal eyes and from eyes with drusen secondary to AMD. The CC slab was extracted and the CC flow deficits (FDs) were segmented with two previously published algorithms: fuzzy C-means approach (FCM ...
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  Mentions: Giovanni Gregori Philip J. Rosenfeld University of Washington
14. Systems and methods for quantitative assessment of microvasculature using optical coherence tomography angiography
  
  Explore uspto.gov Jul 16 2019 Patents
  
  A five-index quantitative analysis of OCT angiograms is disclosed. One method of analyzing an anatomical region of interest of a subject includes acquiring vascular image data from the region of interest and generating a binary vasculature map from the vascular image data. A vessel skeleton map and vessel perimeter map are generated from the binary vasculature map. Based on the three generated maps, a vessel area density, vessel skeleton density ...
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  Mentions: University of Washington Ruikang K. Wang
15. University of Washington Receives NIH Grant for Ultra-Wide Field Optical Coherence Tomography Based Angiography for Imaging Diabetic Retinopathy
  
  Explore Optical Coherence Tomography News Jul 2 2019 Ophthalmology , Funding
  
  ...neration of OCT angiography and for interpretation of UW-OMAG data in future.
  University of Washington Receives a 2019 NIH Grant for $364,428 for Ultra-Wide Field Optical Coherence Tomogra...
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  Mentions: National Institutes of Health University of Washington Ruikang K. Wang
16. Impaired Retinal Vascular Reactivity in Diabetic Retinopathy as Assessed by Optical Coherence Tomography Angiography
  
  Explore IOVS Journal Jun 25 2019 Ophthalmology
  
  Purpose : To assess retinal vascular reactivity in healthy controls and subjects with diabetic retinopathy (DR). Methods : A total of 22 healthy control eyes and 16 eyes with DR were enrolled. Images were acquired using a commercially available swept-source optical coherence tomography angiography (SS-OCTA) system. Three conditions were tested for each patient (hyperoxia, hypercapnia, and room-air) by employing a non-rebreathing apparatus that delivered appropriate gas mixtures (100% O 2 , 5% CO ...
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  Mentions: University of Southern California University of Washington Ruikang K. Wang
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