1. University of Washington

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    1. Mentioned In 222 Articles

    2. Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow

      Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow
      We demonstrate in vivo volumetric optical microangiography at 200 volumes / s 200volumes/s by the use of 1.6 MHz Fourier domain mode-locking swept source optical coherence tomography and an effective 36 kHz microelectromechanical system (MEMS) scanner. We propose an intervolume analysis strategy to contrast the dynamic blood flow signal from the static tissue background. The proposed system is demonstrated by imaging cerebral blood flow in mice in vivo . For ...
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    3. Video-rate volumetric optical coherence tomography-based microangiography

      Video-rate volumetric optical coherence tomography-based microangiography
      Video-rate volumetric optical coherence tomography (vOCT) is relatively young in the field of OCT imaging but has great potential in biomedical applications. Due to the recent development of the MHz range swept laser sources, vOCT has started to gain attention in the community. Here, we report the first in vivo video-rate volumetric OCT-based microangiography (vOMAG) system by integrating an 18-kHz resonant microelectromechanical system (MEMS) mirror with a 1.6-MHz FDML ...
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    4. Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics

      Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics
      We analyzed heart wall motion and blood flow dynamics in chicken embryos using in vivo optical coherence tomography (OCT) imaging and computational fluid dynamics (CFD) embryo-specific modeling. We focused on the heart outflow tract (OFT) region of day 3 embryos, and compared normal (control) conditions to conditions after performing an OFT banding intervention, which alters hemodynamics in the embryonic heart and vasculature. We found that hemodynamics and cardiac wall motion ...
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    5. Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications

      Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications
      Recent advances in optical coherence tomography (OCT)-based angiography have demonstrated a variety of biomedical applications in the diagnosis and therapeutic monitoring of diseases with vascular involvement. While promising, its imaging field of view (FOV) is however still limited (typically less than 9 mm 2 ), which somehow slows down its clinical acceptance. In this paper, we report a high-speed spectral-domain OCT operating at 1310 nm to enable wide FOV up ...
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    6. Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography

      Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography
      Background: To investigate the differences of perfusion in the optic nerve head (ONH) between normal and glaucomatous eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. Methods: One eye from each subject was scanned with a 68 kHz Cirrus 5000 HD-OCT-based OMAG prototype system centered at the ONH (Carl Zeiss Meditec Inc, Dublin, CA, USA). Microvascular images were generated from the OMAG dataset by detecting the differences ...
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    7. Blood flow changes after unilateral carotid artery ligation monitored by optical coherence tomography

      Blood flow changes after unilateral carotid artery ligation monitored by optical coherence tomography
      Unilateral carotid artery ligation which could induce adaptive improvement is a classic model that has been widely used to study pathology of ischemic disease. In those studies, blood flow is an important parameter to characterize the ischemia. Optical coherence tomography (OCT) is a powerful imaging modality which can provide depth resolved images in biological tissue with high spatial and temporal resolution. SPF rats was anesthetized with isoflurane and divided into ...
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    8. Application of optical coherence tomography based microangiography for cerebral imaging

      Application of optical coherence tomography based microangiography for cerebral imaging
      Requirements of in vivo rodent brain imaging are hard to satisfy using traditional technologies such as magnetic resonance imaging and two-photon microscopy. Optical coherence tomography (OCT) is an emerging tool that can easily reach at high speeds and provide high resolution volumetric images with a relatively large field of view for rodent brain imaging. Here, we provide the overview of recent developments of functional OCT based imaging techniques for neuroscience ...
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    9. Automated detection of inflammatory cells in whole anterior chamber of a uveitis mouse from swept-source optical coherence tomography images

      Automated detection of inflammatory cells in whole anterior chamber of a uveitis mouse from swept-source optical coherence tomography images
      Cell grading in a rodent anterior chamber is essential for anterior inflammation evaluation in preclinical vision research. This paper describes a computerized method for detection and counting of the anterior chamber cells from swept-source optical coherence tomography (SS-OCT) images of a experimental rodent model of uveitis. The volumetric anterior segment OCT data is obtained from 100 kHz SS-OCT imaging of mouse eye in vivo. For the OCT cross-sections, each OCT ...
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    10. Assessment of cervical demineralization induced by Streptococcus mutans using swept-source optical coherence tomography

      Assessment of cervical demineralization induced by Streptococcus mutans using swept-source optical coherence tomography
      Exposed root surfaces due to gingival recession are subject to biofilm stagnation that can result in caries formation. Cervical enamel and dentin demineralization induced by a cariogenic biofilm was evaluated using swept-source optical coherence tomography (SS-OCT). The cementoenamel junction (CEJ) sections of extracted human teeth were subjected to demineralization for 1, 2, or 3 weeks. A suspension of Streptococcus mutans was applied to form a cariogenic biofilm using an oral ...
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    11. Measurement of strain and strain rate in embryonic chick heart using spectral domain optical coherence tomography

      Measurement of strain and strain rate in embryonic chick heart using spectral domain optical coherence tomography
      It is important to measure embryonic heart myocardial wall strain and strain rate for understanding the mechanisms of embryonic heart development. Optical coherence tomography (OCT) can provide depth resolved images with high spatial and temporal resolution, which makes it have the potential to reveal the complex myocardial activity in the early stage embryonic heart. We develop a novel method to measure strain in embryonic chick heart based on spectral domain ...
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    12. Elasticity imaging of speckle-free tissue regions with moving acoustic radiation force and phase-sensitive optical coherence tomography

      Elasticity imaging of speckle-free tissue regions with moving acoustic radiation force and phase-sensitive optical coherence tomography
      Phase-sensitive optical coherence tomography (PhS-OCT) can be utilized for quantitative shear-wave elastography using speckle tracking. However, current approaches cannot directly reconstruct elastic properties in speckle-less or speckle-free regions, for example within the crystalline lens in ophthalmology. Investigating the elasticity of the crystalline lens could improve understanding and help manage presbyopia-related pathologies that change biomechanical properties. We propose to reconstruct the elastic properties in speckle-less regions by sequentially launching shear waves ...
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    13. Wide-field optical coherence tomography based microangiography for retinal imaging

      Wide-field optical coherence tomography based microangiography for retinal imaging
      Optical coherence tomography angiography (OCTA) allows for the evaluation of functional retinal vascular networks without a need for contrast dyes. For sophisticated monitoring and diagnosis of retinal diseases, OCTA capable of providing wide-field and high definition images of retinal vasculature in a single image is desirable. We report OCTA with motion tracking through an auxiliary real-time line scan ophthalmoscope that is clinically feasible to image functional retinal vasculature in patients ...
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    14. OCT-based label-free in vivo lymphangiography within human skin and areola

      OCT-based label-free in vivo lymphangiography within human skin and areola
      Due to the limitations of current imaging techniques, visualization of lymphatic capillaries within tissue in vivo has been challenging. Here, we present a label-free high resolution optical coherence tomography (OCT) based lymphangiography (OLAG) within human skin in vivo . OLAG enables rapid (~seconds) mapping of lymphatic networks, along with blood vessel networks, over 8mm x 8mm of human skin and 5mm x 5mm of human areola. Moreover, lymphatic systems response to ...
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    15. Optical coherence tomography based microangiography findings in hydroxychloroquine toxicity

      Optical coherence tomography based microangiography findings in hydroxychloroquine toxicity
      Optical coherence tomography based microangiography (OMAG) is a new, non-invasive imaging modality capable of providing three dimentional (3D) retinal and choroidal microvascular maps without a need for exogenous dye. In this study, we evaluated the retinal and choroidal microvascular architecture of the macula in a patient with hydroxychloroquine (HCQ) toxicity using OMAG. Detailed microvascular information of the retina and the underlying choroid showed loss of parafoveal outer retinal vasculature with ...
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    16. Optical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration

      Optical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration
      Purpose To determine whether angiography with swept-source (SS) optical coherence tomography (OCT) identifies subclinical type 1 neovascularization in asymptomatic eyes with intermediate age-related macular degeneration (iAMD). Design Prospective, observational, consecutive case series. Participants Patients with asymptomatic iAMD in one eye and neovascular age-related macular degeneration (AMD) in their fellow eye. Methods The patients underwent SS OCT angiography (OCTA), fluorescein angiography (FA), and indocyanine green angiography (ICGA), and the images from ...
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  2. About University of Washington

    University of Washington

    The University of Washington, founded in 1861, is a public research university in Seattle, Washington, United States. It is the largest university in the Northwestern United States and the oldest public university in Washington. The UW maintains three locations, with its flagship campus in Seattle's University District and branch campuses in Tacoma and Bothell. Its operating budget for fiscal year 2005 was $3.1 billion. The university is known as a Public Ivy, an American term for state-funded institutions of higher learning that "provide[s] an Ivy League collegiate experience at a public school price."