1. University of Washington

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    1. Mentioned In 288 Articles

    2. Methods and systems for integrated imaging using optical coherence tomography and photoacoustic imaging

      Methods and systems for integrated imaging using optical coherence tomography and photoacoustic imaging
      Systems and methods for photoacoustic imaging are provided. Photoacoustic signals are excited from a body and the excited photoacoustic signals are detected with a low coherence interferometer system serving as a photoacoustic detector. Cross-sectional images of the body are then reconstructed by the system from the detected photoacoustic signals.
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    3. Long ranging swept-source optical coherence tomography-based angiography outperforms its spectral-domain counterpart in imaging human skin microcirculations

      Long ranging swept-source optical coherence tomography-based angiography outperforms its spectral-domain counterpart in imaging human skin microcirculations
      There is an increasing demand for imaging tools in clinical dermatology that can perform in vivo wide-field morphological and functional examination from surface to deep tissue regions at various skin sites of the human body. The conventional spectral-domain optical coherence tomography-based angiography (SD-OCTA) system is difficult to meet these requirements due to its fundamental limitations of the sensitivity roll-off, imaging range as well as imaging speed. To mitigate these issues ...
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    4. Multifunctional in vivo imaging for monitoring wound healing using swept-source polarization-sensitive optical coherence tomography

      Multifunctional in vivo imaging for monitoring wound healing using swept-source polarization-sensitive optical coherence tomography
      Background and Objective Wound healing involves a complex and dynamic biological process in response to tissue injury. Monitoring of the cascade of cellular events is useful for wound management and treatment. The aim of this study is to demonstrate the potential of multifunctional polarization-sensitive optical coherence tomography (PS-OCT) to longitudinally monitor the self-healing process in a murine cutaneous wound model. Materials and Methods A multi-functional PS-OCT system based on swept ...
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    5. Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid

      Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid
      The choriocapillaris (CC) plays an essential role in maintaining the normal functions of the human eye. There is increasing interest in the community to develop an imaging technique for visualizing the CC, yet this remains underexplored due to technical limitations. We propose an approach for the visualization of the CC in humans via a complex signal-based optical microangiography (OMAG) algorithm, based on commercially available spectral domain optical coherence tomography (SD-OCT ...
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    6. A benchmark study of automated intra-retinal cyst segmentation algorithms using optical coherence tomography B-scan

      A benchmark study of automated intra-retinal cyst segmentation algorithms using optical coherence tomography B-scan
      Retinal cysts are formed by accumulation of fluid in the retina caused by leakages from inflammation or vitreous fractures. Analysis of the retinal cystic spaces holds significance in detection and treatment of several ocular diseases like age-related macular degeneration, diabetic macular edema etc. Thus, segmentation of intra-retinal cysts and quantification of cystic spaces are vital for retinal pathology and severity detection. In the recent years, automated segmentation of intra-retinal cysts ...
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    7. Optical coherence tomography angiography as an imaging modality for evaluation of diabetic macular edema

      Optical coherence tomography angiography as an imaging modality for evaluation of diabetic macular edema
      iabetic retinopathy remains a leading cause of blindness worldwide in patients aged 2064 years. [1] Diabetic macular edema (DME) threating or involving the fovea is a common etiology for vision loss. Traditionally, treatment methods have been guided by contact and non-contact slit lamp biomicroscopy, fluorescein angiography and fundus stereo photography. [1] Fluorescein angiography (FA) is a dynamic, invasive imaging technique first described in 1961 and more thoroughly invested and popularized ...
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    8. Utility of optical coherence tomography angiography in detecting glaucomatous damage in a uveitic patient with disc congestion: A case report

      Utility of optical coherence tomography angiography in detecting glaucomatous damage in a uveitic patient with disc congestion: A case report
      Purpose To report a case of uveitic glaucoma with congested optic disc where optical coherence tomography angiography (OCT-A) provided diagnostic utility in assessing glaucomatous damage but optical coherence tomography (OCT) alone had limited utility. Observations We report a case of a 33-year-old Caucasian female referred to the USC Roski Eye Institute for uncontrolled intraocular pressure (IOP) in the left eye. She was managed by an outside provider for 6 months ...
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    9. Flexible wide-field optical micro-angiography based on Fourier-domain multiplexed dual-beam swept source optical coherence tomography

      Flexible wide-field optical micro-angiography based on Fourier-domain multiplexed dual-beam swept source optical coherence tomography
      Wide-field optical coherence tomography angiography (OCTA) is gaining interest in clinical imaging applications. In this pursuit, it is challenging to maintain the imaging resolution and sensitivity throughout the wide field of view (FoV). Here, we propose a novel method/system of dual-beam arrangement and Fourier domain multiplexing to achieve wide field OCTA when imaging the uneven surface samples. The proposed system provides two separate FoVs, with flexibility that the imaging ...
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    10. Methods of reducing motion artifacts for optical coherence tomography angiography

      Methods of reducing motion artifacts for optical coherence tomography angiography
      A method for reducing motion artifacts in optical coherence tomography (OCT) angiography images is disclosed. The method is applied to the intensity or complex OCT data prior to applying the motion contrast analysis and involves determining sub-pixel level shifts between at least two B-scans repeated approximately at the same location and applying the sub-pixel level shifts to the B-scans to be able to correct for motion and accurately determine motion ...
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    11. Eckhaus Instability in the Fourier-Domain Mode Locked Fiber Laser Cavity

      Eckhaus Instability in the Fourier-Domain Mode Locked Fiber Laser Cavity
      High frequency fluctuation in the optical signal generated in Fourier-Domain Mode Locked fiber laser (FDML-FL), which is the major problem and degrades the laser performance, is not yet fully analyzed or studied. The basic theory which is causing this high frequency fluctuation is required to clearly understand its dynamics and to control it for various applications. In this letter, by analyzing the signal and system dynamics of FDML-FL, we theoretically ...
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    12. Optical coherence tomography imaging of cranial meninges post brain injury in vivo

      Optical coherence tomography imaging of cranial meninges post brain injury in vivo
      We report a new application of optical coherence tomography (OCT) to investigate the cranial meninges in an animal model of brain injury in vivo. The injury is induced in a mouse due to skull thinning, in which the repeated and excessive drilling exerts mechanical stress on the mouse brain through the skull, resulting in acute and mild brain injury. Transcranial OCT imaging reveals an interesting virtual space between the cranial ...
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    13. The effect of age on the response of retinal capillary filling to changes in intraocular pressure measured by optical coherence tomography angiography

      The effect of age on the response of retinal capillary filling to changes in intraocular pressure measured by optical coherence tomography angiography
      Purpose To compare the effect of elevated intraocular pressure (IOP) on retinal capillary filling in elderly vs adult rats using optical coherence tomography angiography (OCTA). Methods The IOP of elderly (24-month-old, N = 12) and adult (68 month-old, N = 10) Brown Norway rats was elevated in 10 mmHg increments from 10 to 100 mmHg. At each IOP level, 3D OCT data were captured using an optical microangiography (OMAG) scanning protocol and ...
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    14. Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

      Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications
      OCT has revolutionized the practice of ophthalmology over the past 1020 years. Advances in OCT technology have allowed for the creation of novel OCT-based methods. OCT-Angiography (OCTA) is one such method that has rapidly gained clinical acceptance since it was approved by the FDA in late 2016. OCTA images are based on the variable backscattering of light from the vascular and neurosensory tissue in the retina. Since the intensity and ...
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    15. Deep-learning based, automated segmentation of macular edema in optical coherence tomography

      Deep-learning based, automated segmentation of macular edema in optical coherence tomography
      Evaluation of clinical images is essential for diagnosis in many specialties. Therefore the development of computer vision algorithms to help analyze biomedical images will be important. In ophthalmology, optical coherence tomography (OCT) is critical for managing retinal conditions. We developed a convolutional neural network (CNN) that detects intraretinal fluid (IRF) on OCT in a manner indistinguishable from clinicians. Using 1,289 OCT images, the CNN segmented images with a 0 ...
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  2. About University of Washington

    University of Washington

    The University of Washington, founded in 1861, is a public research university in Seattle, Washington, United States. It is the largest university in the Northwestern United States and the oldest public university in Washington. The UW maintains three locations, with its flagship campus in Seattle's University District and branch campuses in Tacoma and Bothell. Its operating budget for fiscal year 2005 was $3.1 billion. The university is known as a Public Ivy, an American term for state-funded institutions of higher learning that "provide[s] an Ivy League collegiate experience at a public school price."