1. University of Washington

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    1. Mentioned In 412 Articles

    2. Long-term in vivo monitoring of gliotic sheathing of ultrathin entropic coated brain microprobes with fiber-based optical coherence tomography

      Long-term in vivo monitoring of gliotic sheathing of ultrathin entropic coated brain microprobes with fiber-based optical coherence tomography
      Microfabricated neuroprosthetic devices have made possible important observations on neuron activity; however, long-term high-fidelity recording performance of these devices has yet to be realized. Tissue-device interactions appear to be a primary source of lost recording performance. The current state of the art for visualizing the tissue response surrounding brain implants in animals is Immunohistochemistry + Confocal Microscopy, which is mainly performed after sacrificing the animal. Monitoring the tissue response as it ...
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    3. Quantitative research on the interaction between cerebral edema and peripheral cerebral blood perfusion using swept-source optical coherence tomography

      Quantitative research on the interaction between cerebral edema and peripheral cerebral blood perfusion using swept-source optical coherence tomography
      Background: Ischemic cerebral edema (CE) is a major leading cause of death in patients with ischemic stroke. The CE progression is closely related to the local cerebral blood perfusion (LCBP) level surrounding the edema area. Quantitative studying the interaction between the CE and peripheral LCBP may provide new inspiration for control and even treatment of CE. Methods: Photothrombosis ischemia mouse model was established and observed for 9 hours using swept-source ...
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    4. Optical coherence tomography angiography measures blood pulsatile waveforms at variable tissue depths

      Optical coherence tomography angiography measures blood pulsatile waveforms at variable tissue depths
      Background: Photoplethysmography (PPG) is routinely used to detect the blood pulse signal from skin tissue beds in clinics. However, the origin of the PPG signal remains controversial. The purpose of this study is to explore optical coherence tomography angiography (OCTA) to indicate pulsatile waveforms in the papillary plexus and dermal plexus separately under different hand elevations. Method: Optical microangiography (OMAG) algorithm was used to obtain a 3D OCTA signals, from ...
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    5. Optical coherence tomography angiography distortion correction in widefield montage images

      Optical coherence tomography angiography distortion correction in widefield montage images
      Background: Optical coherence tomography (OCT) imaging is inherently susceptible to distortion artifacts due to the natural curvature of the eye. This study proposes a novel model for widefield OCT angiography (OCTA) distortion correction and analyzes the effects of this correction on quantification metrics. Methods: Widefield OCTA images were obtained on normal subjects at five fixation spatial positions. Radial and field distortion correction were applied and images stitched together to form ...
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    6. Choroidal Thickness by Handheld Swept-Source Optical Coherence Tomography in Term Newborns

      Choroidal Thickness by Handheld Swept-Source Optical Coherence Tomography in Term Newborns
      Purpose : To describe normative values for choroidal thickness in newborns and characterize their relationship to vitreoretinal features. Methods : Term newborns underwent awake, handheld swept-source optical coherence tomography (SS-OCT) in this prospective cohort study. An automated segmentation algorithm followed by manual adjustments measured choroidal thickness at the fovea and five perifoveal locations. Two masked, trained graders, with a third mediating disagreements, analyzed scans for vitreoretinal findings. OCT vitreoretinal findings, including dome-shaped ...
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    7. Robust three-dimensional registration on optical coherence tomography angiography for speckle reduction and visualization

      Robust three-dimensional registration on optical coherence tomography angiography for speckle reduction and visualization
      Background: In the clinical applications of optical coherence tomography angiography (OCTA), the repeated scanning and averaging method can provide better contrast with reduced speckle noises in the final results, which are useful for visualizing and quantifying vascular components with high accuracy, reproducibility, and reliability. However, the inevitable patient motion presents a challenge to this method. The objective of this study is to meet this challenge by introducing a 3D registration ...
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    8. Differences in cerebral blood vasculature and flow in awake and anesthetized mouse cortex revealed by quantitative optical coherence tomography angiography

      Differences in cerebral blood vasculature and flow in awake and anesthetized mouse cortex revealed by quantitative optical coherence tomography angiography
      Background Most of the in vivo neurovascular imaging studies are performed in anesthetized animals. However, anesthesia significantly affects cerebral hemodynamics. New method We applied optical coherence tomography (OCT) methods such as optical microangiography (OMAG) and Doppler optical microangiography (DOMAG) to quantitatively evaluate the effect of anesthesia in cerebral vasculature and blood flow in mouse brain. Results The OMAG results indicated the increase of large vessel diameter and capillary density induced ...
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    9. Unraveling the deep learning gearbox in optical coherence tomography image segmentation towards explainable artificial intelligence

      Unraveling the deep learning gearbox in optical coherence tomography image segmentation towards explainable artificial intelligence
      Machine learning has greatly facilitated the analysis of medical data, while the internal operations usually remain intransparent. To better comprehend these opaque procedures, a convolutional neural network for optical coherence tomography image segmentation was enhanced with a Traceable Relevance Explainability (T-REX) technique. The proposed application was based on three components: ground truth generation by multiple graders, calculation of Hamming distances among graders and the machine learning algorithm, as well as ...
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    10. Imaging human skin autograft integration with optical coherence tomography

      Imaging human skin autograft integration with optical coherence tomography
      Background: Skin autografting is a common clinical procedure for reconstructive surgery. Despite its widespread use, very few studies have been conducted to non-invasively evaluate and monitor the vascular and structural features of skin grafts. This study, therefore, aims to demonstrate the potential of optical coherence tomography (OCT) alongside OCT-based angiography (OCTA) to non-invasively image and monitor human skin graft health and integration over time. Methods: An in-house-built clinical prototype OCT ...
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    11. Swept source OCTA reveals a link between choriocapillaris blood flow and vision loss in a case of tubercular serpiginous-like choroiditis

      Swept source OCTA reveals a link between choriocapillaris blood flow and vision loss in a case of tubercular serpiginous-like choroiditis
      Optical coherence tomography angiography (OCTA) is a non-invasive technique that is useful in the diagnosis and management of patients with posterior uveitis. Here we report the use of swept source OCTA (SS-OCTA) in a patient with tuberculosis (TB) associated serpiginous like choroiditis (TB-SLC) that made a full visual recovery following treatment with ATT, local and systemic corticosteroids, and systemic immune modulation. By comparing en face images of choriocapillaris (CC) blood ...
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    12. Evaluation of microleakage in class-II bulk-fill composite restorations

      Evaluation of microleakage in class-II bulk-fill composite restorations
      Background/purpose Despite the clinical appeal of restoring deep class II cavities in single increment using bulk-fill resin composite, sealing of bulk-filled composite restorations is a concern. This study evaluated interfacial adaptation of bulk-fill composite restoration to axial wall and gingival floor of class II cavities using cross-polarization optical coherence tomography (CP-OCT). Materials and methods Box-shaped class II cavities were prepared in extracted molars and divided into three groups ( n ...
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    13. SenEvaluation of Internal Fit and Marginal Adaptation of Provisional Crowns Fabricated with Three Different Techniques

      SenEvaluation of Internal Fit and Marginal Adaptation of Provisional Crowns Fabricated with Three Different Techniques
      Different techniques have been used to construct provisional crowns to protect prepared teeth. The purpose of this in vitro study was to assess the internal fit and marginal discrepancy of provisional crowns made by different methods. A total of 48 provisional crowns were constructed and divided into three groups ( n = 16) according to the fabrication methods: fabricated manually-group MAN; computer-aided design/computer aided manufacturing technology-group CAM; and 3-dimensional (3D)-printed ...
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    14. Detection and analysis of early degradation at resin-dentin interface by optical coherence tomography (OCT) and confocal laser scanning microscope (CLSM)

      Detection and analysis of early degradation at resin-dentin interface by optical coherence tomography (OCT) and confocal laser scanning microscope (CLSM)
      Objective To evaluate early degradation at resin-dentin interface using non-invasive swept-source optical coherence tomography (SS-OCT) and confocal laser scanning microscope (CLSM). Methods Self-etch adhesives and resin-composites containing bisphenol-glycidyl-dimethacrylate (Bis-GMA), which is one of the most widely used monomers in restorative materials, were investigated in this study. Forty cervical cavities were prepared in bovine incisors and applied by the adhesive with/without Bis-GMA (AdhesiveBG/Adhesive), filled by the resin with/without ...
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    15. Correcting intra-volume distortion for AO-OCT using 3D correlation based registration

      Correcting intra-volume distortion for AO-OCT using 3D correlation based registration
      Adaptive optics (AO) based ophthalmic imagers, such as scanning laser ophthalmoscopes (SLO) and optical coherence tomography (OCT), are used to evaluate the structure and function of the retina with high contrast and resolution. Fixational eye movements during a raster-scanned image acquisition lead to intra-frame and intra-volume distortion, resulting in an inaccurate reproduction of the underlying retinal structure. For three-dimensional (3D) AO-OCT, segmentation-based and 3D correlation based registration methods have been ...
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    16. 1-15 of 412 1 2 3 4 ... 26 27 28 »
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  2. About University of Washington

    University of Washington

    The University of Washington, founded in 1861, is a public research university in Seattle, Washington, United States. It is the largest university in the Northwestern United States and the oldest public university in Washington. The UW maintains three locations, with its flagship campus in Seattle's University District and branch campuses in Tacoma and Bothell. Its operating budget for fiscal year 2005 was $3.1 billion. The university is known as a Public Ivy, an American term for state-funded institutions of higher learning that "provide[s] an Ivy League collegiate experience at a public school price."