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2. Non‐invasive multimodal imaging by integrating optical coherence tomography with autofluorescence imaging for dental applications
  
  Explore Wiley Online Library Mar 24 2020 Dentistry
  
  We report the development of an integrated multi‐functional imaging system capable of providing anatomical (optical coherence tomography, OCT), functional (OCT angiography, OCTA) and molecular imaging (light‐induced autofluorescence, LIAF) for in vivo dental applications. Blue excitation light (405nm) was used for LIAF imaging, while the OCT was powered by a 1310nm swept laser source. A red‐green‐blue (RGB) digital camera, with a 450nm cut‐on broad‐band optical ...
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  Mentions: University of Washington Ruikang K. Wang Hrebesh M. Subhash
3. Diagnosis of Occlusal Caries with Dynamic Slicing of 3D Optical Coherence Tomography Images
  
  Explore MDPI Open Access Journals Platform Mar 22 2020 Dentistry
  
  Detecting the extent of occlusal caries is a clinically important but challenging task required for treatment decision making. The aim of this study was to assess the diagnostic power of 3D swept-source optical coherence tomography (OCT) for evaluation of occlusal caries in comparison with X-ray radiography. Extracted human molars not exhibiting American Dental Association (ADA) criteria advanced caries were mounted in a silicone block and digital dental radiographs were captured ...
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  Mentions: University of Washington Tokyo Medical & Dental University Alireza Sadr
4. Long-term in vivo Monitoring of Gliotic Sheathing of Ultrathin Entropic Coated Brain Microprobes with Fiber-based Optical Coherence Tomography
  
  Explore bioRxiv.org Mar 4 2020 Neurology
  
  Microfabricated neuroprosthetic devices have made possible important observations on neuron activity; however, long-term high-fidelity recording performance of these devices has yet to be realized. Tissue-device interactions appear to be a primary source of lost recording performance. The current state of the art for visualizing the tissue response surrounding brain implants in animals is Immunohistochemistry + Confocal Microscopy, which is mainly performed after sacrificing the animal. Monitoring the tissue response as it ...
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  Mentions: University of Washington
5. Effect of Light Irradiation Condition on Gap Formation Under Polymeric Dental Restoration; OCT study
  
  Explore ScienceDirect Mar 1 2020 Dentistry
  
  Objective To investigate the effect of two light-curing systems; quartz tungsten-halogen (QTH) and light-emitting diode (LED), and irradiation time on interfacial gap formation of dental composite resin restorations bonded with an adhesive resin using optical coherence tomography (OCT). Materials and Methods Forty cavities were prepared in extracted human molar teeth and divided into four groups (n = 10) based on the type of light curing system QTH (LITEX 680A) and LED ...
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  Mentions: Santec University of Washington Tokyo Medical & Dental University
6. Biophotonics and Imaging Graduate Summer School to be held on August 2020 at National University of Ireland, Galway
  
  Explore Optical Coherence Tomography News Feb 25 2020
  
  Dates: August 25th - 29th 2020 This is our eight Biophotonics and Imaging Graduate Summer School. It is an important opportunity for graduate students in 2020 to access the kind of close contact with leading professors that only this kind of environment facilitates. Tutors for BIGSS 2020 will include: Martin Booth (Oxford): Advanced Microscopy Steve Jacques (Washington): Tissue Optics Caroline Boudoux (Montreal): Endoscopy David Sampson (Surrey): OCT Sarah Bohndiek (Cambridge): Photoacoustics ...
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  Mentions: University of Toronto David D. Sampson University of Washington
7. Methodological Challenges of Deep Learning in Optical Coherence Tomography for Retinal Diseases: A Review
  
  Explore TVST Journal Feb 22 2020 Ophthalmology
  
  Artificial intelligence (AI)-based automated classification and segmentation of optical coherence tomography (OCT) features have become increasingly popular. However, its 3-dimensional volumetric nature has made developing an algorithm that generalizes across all patient populations and OCT devices challenging. Several recent studies have reported high diagnostic performances of AI models; however, significant methodological challenges still exist in applying these models in real-world clinical practice. Lack of large-image datasets from multiple OCT ...
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  Mentions: University of Washington National University of Singapore
8. Measurement and visualization of stimulus-evoked tissue dynamics in mouse barrel cortex using phase-sensitive optical coherence tomography
  
  Explore OSA | OSA Publishing Jan 10 2020 Neurology
  
  We describe a method to measure tissue dynamics in mouse barrel cortex during functional activation via phase-sensitive optical coherence tomography (PhS-OCT). The method measures the phase changes in OCT signals, which are induced by the tissue volume change, upon which to localize the activated tissue region. Phase unwrapping, compensation and normalization are applied to increase the dynamic range of the OCT phase detection. To guide the OCT scanning, intrinsic optical ...
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  Mentions: James G. Fujimoto Wolfgang Drexler University of Washington
9. Ultra-Widefield Protocol Enhances Automated Classification of Diabetic Retinopathy Severity with Optical Coherence Tomography Angiography
  
  Explore ScienceDirect Nov 12 2019 Ophthalmology
  
  Purpose To assess the diagnostic utility of retinal nonperfusion to classify eyes based on diabetic retinopathy (DR) severity on optical coherence tomography angiography (OCTA). To determine whether wider field of view (FOV) OCTA protocols enhance the diagnostic utility of retinal nonperfusion in the classification of DR severity. Design Retrospective cross-sectional study Subjects Diabetic patients undergoing ultra-widefield OCTA imaging at one academic retina practice Methods Ultra-widefield OCTA images with 100 degree ...
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  Mentions: University of Washington Ruikang K. Wang
10. Does lining class-II cavities with flowable composite improve the interfacial adaptation?
  
  Explore Taylor & Francis Online Oct 28 2019 Dentistry
  
  The objective of this study was to assess in-vitro interfacial cavity adaptation of different adhesive/composites systems in class-II restoration using SS-OCT and to confirm the findings with a confocal laser scanning microscope (CLSM). Standardized rectangular-shaped class-II cavities were prepared on 24 extracted human molar teeth, bonded with adhesive and lined with flowable composite. Cavities were further restored by bulk filling using packable composite. Specimens were divided into four groups ...
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  Mentions: University of Washington Alireza Sadr Junji Tagami
11. Application of functional optical coherence tomography angiography in neurovascular research (Thesis)
  
  Explore digital.lib.washington.edu Oct 24 2019 Neurology , Ophthalmology , Student Theses
  
  Optical coherence tomography (OCT) is a revolutionary non-invasive imaging technique that can perform high-resolution, cross-sectional tomographic imaging of the internal microstructure in biological tissues by measuring backscattered or backreflected light. Its functional extension, OCT angiography (OCTA), analyzes the intrinsic scattering property of the heterogenous tissue bed to extract dynamic blood flow signals to the capillary level without a need of contrast agents. Aside from the commonly known application of OCTA ...
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  Mentions: University of Washington
12. Electrically tunable lens integrated with optical coherence tomography angiography for cerebral blood flow imaging in deep cortical layers in mice
  
  Explore OSA | OSA Publishing Oct 15 2019
  
  We report the use of an electrically tunable lens (ETL) in a 1.3 m spectral-domain optical coherence tomography (SD-OCT) system to overcome the depth of focus (DOF) limitation in conventional OCT systems for OCT angiography (OCTA) in a mouse cerebral cortex. The ETL provides fast and dynamic control of the axial focus of the probe beam along the entire range of the mouse cortex, upon which we performed cerebral ...
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  Mentions: University of Washington Ruikang K. Wang
13. Handheld swept-source optical coherence tomography with angiography in awake premature neonates
  
  Explore Home Oct 1 2019 Ophthalmology
  
  Background: Retinopathy of prematurity (ROP) can lead to retinal detachment and severe vision loss and is a common cause of childhood blindness. Optical coherence tomography angiography (OCTA) is a non-invasive imaging modality that can be used to detect potential abnormalities in the microvasculature in this population. The objective of this study is to assess the feasibility of a newly developed handheld swept source OCT (SS-OCT) device to successfully acquire structural ...
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  Mentions: University of Washington Ruikang K. Wang
14. Correlations between Different Choriocapillaris Flow Deficit Parameters in Normal Eyes using Swept Source OCT Angiography
  
  Explore American Journal of Ophthalmology Sep 25 2019 Ophthalmology
  
  Purpose Choriocapillaris (CC) imaging of normal eyes with swept-source optical coherence tomography SS-OCTA was performed, and the percentage of CC flow deficits (FD%) and the average area of CC flow deficits (FDa) were compared within given macular regions. Design A prospective, cross-sectional study. Methods Subjects with normal eyes ranging in age from their 20s through their 80s were imaged with SS-OCTA (PLEX Elite 9000, Carl Zeiss Meditec, Dublin, CA) using ...
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  Mentions: Giovanni Gregori Philip J. Rosenfeld University of Washington
15. Spatial resolution in dynamic optical coherence elastography
  
  Explore SPIE Digital Library Sep 24 2019
  
  Dynamic optical coherence elastography (OCE) tracks elastic wave propagation speed within tissue, enabling quantitative three-dimensional imaging of the elastic modulus. We show that propagating mechanical waves are mode converted at interfaces, creating a finite region on the order of an acoustic wavelength where there is not a simple one-to-one correspondence between wave speed and elastic modulus. Depending on the details of a boundarys geometry and elasticity contrast, highly complex propagating ...
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  Mentions: University of Washington Ruikang K. Wang Chunhui Li
16. Two-Year Risk of Exudation in Eyes with Nonexudative Age-Related Macular Degeneration and Subclinical Neovascularization Detected with Swept Source Optical Coherence Tomography Angiography
  
  Explore American Journal of Ophthalmology Sep 22 2019 Ophthalmology
  
  Purpose Swept source optical coherence tomography angiography (SS-OCTA) was used to study the prevalence, incidence, and natural history of subclinical macular neovascularization (MNV) in eyes with unilateral nonexudative age-related macular degeneration. Design Prospective cohort study. Methods Patients were imaged using 3- 3-mm and 6- 6-mm SS-OCTA scan patterns. MNV was detected using the outer retina to choriocapillaris en face slab. Prevalence and incidence of subclinical MNV, KaplanMeier cumulative estimates for ...
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  Mentions: Giovanni Gregori Philip J. Rosenfeld University of Washington
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