1. University of Washington

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    1. Mentioned In 137 Articles

    2. In vivo imaging of functional microvasculature within tissue beds of oral and nasal cavities by swept-source optical coherence tomography with a forward/side-viewing probe

      In vivo imaging of functional microvasculature within tissue beds of oral and nasal cavities by swept-source optical coherence tomography with a forward/side-viewing probe
      ...ikang K. Wang »View Author Affiliations Woo June Choi and Ruikang K. Wang^* ^Department of Bioengineering, University of Washington, 3720 15th NE, Seattle, WA 98195, USA ^*Corresponding author: wangrk@uw.edu Biome...
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    3. Optical coherence tomography microangiography for monitoring the response of vascular perfusion to external pressure on human skin tissue

      Optical coherence tomography microangiography for monitoring the response of vascular perfusion to external pressure on human skin tissue
      ... great potential for quantitatively assessing tissue microcirculation in the locally pressed tissue in vivo . University of Washington, Department of Bioengineering, Seattle, Washington 98195 Abstract.  Characterizatio...
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    4. Laser induced surface acoustic wave combined with phase sensitive optical coherence tomography for superficial tissue characterization: a solution for practical application

      Laser induced surface acoustic wave combined with phase sensitive optical coherence tomography for superficial tissue characterization: a solution for practical application
      ...Physics and Mathematics, University of Dundee, Dundee DD1 4HN, Scotland, UK ^3Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA 98195, USA ^*Corresponding author: z.y.huang@dundee....
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    5. Shear wave elastography using phase sensitive optical coherence tomography

      Shear wave elastography using phase sensitive optical coherence tomography

      Optical coherence tomography (OCT) provides high spatial resolution and sensitivity that are ideal for imaging the cornea and lens. Quantifying the biomechanical properties of these tissues could add clinically valuable information. Thus, we propose a dynamic elastography method combining OCT detection and a mechanical actuator to map the shear modulus of soft tissues. We used a piezoelectric actuator driven in the kHz range and we used phase-sensitive OCT (PhS-OCT) to track the resulting shear waves at an equivalent frame rate of 47 kHz. We mapped the shear wave speed of anesthetized mice cornea using monochromatic excitations. We found a significant ...

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    6. Improved microcirculation imaging of human skin in vivo using optical microangiography with a correlation mapping mask

      Improved microcirculation imaging of human skin in vivo using optical microangiography with a correlation mapping mask

      Optical microangiography based on optical coherence tomography (OCT) is prone to noise that arises from a static tissue region. Here, we propose a method that can significantly reduce this noise. The method is developed based on an approach that uses the magnitude information of OCT signals to produce tissue microangiograms, especially suitable for the case where a swept-source OCT system is deployed. By combined use of two existing OCT microangiography methods—ultrahigh-sensitive optical microangiography (UHS-OMAG) and correlation mapping OCT (cmOCT)—the final tissue microangiogram is generated by masking UHS-OMAG image using the binary representation of cmOCT image. We find that ...

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    7. Visualization of ultrasonically-induced shear wave propagation using phase sensitive optical coherence tomography

      Visualization of ultrasonically-induced shear wave propagation using phase sensitive optical coherence tomography

      Shear wave elastography measures the stiffness of soft tissues from the speed of propagating shear waves induced in tissue. Optical coherence tomography (OCT) is a promising detection modality given its high sensitivity and spatial resolution, making it suitable for elastic characterization of skin, peripheral vasculature or ocular tissues. For clinical applications, it would be valuable to use a non-contact shear source. Thus, we propose acoustic radiation force as a remote shear source combined with OCT for visualization. A single-element focused transducer (central frequency 7.5 MHz) was used to apply a maximal pressure of ~3 MPa for 100 μs in ...

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    8. Automated choroidal segmentation method in human eye with 1050nm optical coherence tomography

      Automated choroidal segmentation method in human eye with 1050nm optical coherence tomography

      Choroidal thickness (ChT), defined as the distance between the retinal pigment epithelium (RPE) and the choroid-sclera interface (CSI), is highly correlated with various ocular disorders like high myopia, diabetic retinopathy, and central serous chorioretinopathy. Long wavelength Optical Coherence Tomography (OCT) has the ability to penetrate deep to the CSI, making the measurement of the ChT possible. The ability to accurately segment the CSI and RPE is important in extracting clinical information. However, automated CSI segmentation is challenging due to the weak boundary in the lower choroid and inconsistent texture with varied blood vessels. We propose a K-means clustering based automated ...

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    9. University of Washington Receives NIH Grant for Studying Non-Invasive Real-Time Label-Free 3D Imaging of Retinal Microcircuation

      University of Washington Receives NIH Grant for Studying Non-Invasive Real-Time Label-Free 3D Imaging of Retinal Microcircuation
      ...r structure and function. This study will serve as the foundation for interpretation of rOMAG data in future. University of Washington Received a 2-14 NIH Grant for $465,750 for Studying Non-Invasive Real-Time Label-Free...
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    10. Noninvasive Imaging of Retinal Morphology and Microvasculature in Obese Mice using Optical Coherence Tomography and Optical Microangiography

      Noninvasive Imaging of Retinal Morphology and Microvasculature in Obese Mice using Optical Coherence Tomography and Optical Microangiography
      ...versity of Washington, 3720 NE 15th Avenue, Seattle, Washington, 98195, United States 1. ↵* Bioengineering, University of Washington, 3720 NE 15th Avenue, Seattle, Washington, 98195, United States wangrk{at}uw.edu Ab...
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    11. Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography

      Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography

      Assessing the biomechanical properties of soft tissue provides clinically valuable information to supplement conventional structural imaging. In the previous studies, we introduced a dynamic elastography technique based on phase-sensitive optical coherence tomography (PhS-OCT) to characterize submillimetric structures such as skin layers or ocular tissues. Here, we propose to implement a pulse compression technique for shear wave elastography. We performed shear wave pulse compression in tissue-mimicking phantoms. Using a mechanical actuator to generate broadband frequency-modulated vibrations (1 to 5 kHz), induced displacements were detected at an equivalent frame rate of 47 kHz using a PhS-OCT. The recorded signal was digitally compressed ...

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    12. 1-15 of 137 1 2 3 4 5 6 7 8 9 »
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  2. About University of Washington

    University of Washington

    The University of Washington, founded in 1861, is a public research university in Seattle, Washington, United States. It is the largest university in the Northwestern United States and the oldest public university in Washington. The UW maintains three locations, with its flagship campus in Seattle's University District and branch campuses in Tacoma and Bothell. Its operating budget for fiscal year 2005 was $3.1 billion. The university is known as a Public Ivy, an American term for state-funded institutions of higher learning that "provide[s] an Ivy League collegiate experience at a public school price."