1. University of Washington

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    1. Mentioned In 175 Articles

    2. Feature Of The Week 03/29/15: University of Washington Demonstrates In vivo Microvascular Imaging of Human Oral and Nasal Cavities using SS-OCT

      Feature Of The Week 03/29/15: University of Washington Demonstrates In vivo Microvascular Imaging of Human Oral and Nasal Cavities using SS-OCT
      ...pan>University of Washington.

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    3. Imaging patients with glaucoma using spectral-domain optical coherence tomography and optical microangiography

      Imaging patients with glaucoma using spectral-domain optical coherence tomography and optical microangiography

      In ophthalmology, a reliable means of diagnosing glaucoma in its early stages is still an open issue. Past efforts, including forays into fluorescent angiography (FA) and early optical coherence tomography (OCT) systems, to develop a potential biomarker for the disease have been explored. However, this development has been hindered by the inability of the current techniques to provide useful depth and microvasculature information of the optic nerve head (ONH), which have been debated as possible hallmarks of glaucoma progression. We reasoned that a system incorporating a spectral-domain OCT (SD-OCT) based Optical Microangiography (OMAG) system, could allow an effective, non-invasive methodology ...

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    4. Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic radiation force impulses (ARFI) induced by phase array transducer

      Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic radiation force impulses (ARFI) induced by phase array transducer

      Shear Wave Optical Coherence Elastography (SW-OCE) uses the speed of propagating shear waves to provide a quantitative measurement of localized shear modulus, making it a valuable technique for the elasticity characterization of tissues such as skin and ocular tissue. One of the main challenges in shear wave elastography is to induce a reliable source of shear wave; most of nowadays techniques use external vibrators which have several drawbacks such as limited wave propagation range and/or difficulties in non-invasive scans requiring precisions, accuracy. Thus, we propose linear phase array ultrasound transducer as a remote wave source, combined with the high-speed ...

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    5. Characterization of rat model of acute anterior uveitis using optical coherence tomography angiography

      Characterization of rat model of acute anterior uveitis using optical coherence tomography angiography

      Uveitis, or ocular inflammation, is a cause of severe visual impairment. Rodent models of uveitis are powerful tools used to investigate the pathological mechanisms of ocular inflammation and to study the efficacy of new therapies prior to human testing. In this paper, we report the utility of spectral-domain optical coherence tomography (SD-OCT) angiography in characterizing the inflammatory changes induced in the anterior segment of a rat model of uveitis. Acute anterior uveitis (AAU) was induced in two rats by intravitreal injection of a killed mycobacterial extract. One of them received a concurrent periocular injection of steroids to model a treatment ...

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    6. Amplitude-modulated ultrasound radiation force combined with phase-sensitive optical coherence tomography for shear wave elastography

      Amplitude-modulated ultrasound radiation force combined with phase-sensitive optical coherence tomography for shear wave elastography

      Tissue stiffness can be measured from the propagation speed of shear waves. Acoustic radiation force (ARF) can generate shear waves by focusing ultrasound in tissue for ~100 μs. Safety considerations and electronics abilities limit ultrasound pressures. We previously presented shear wave elastography combining ARF and phase-sensitive optical coherence tomography (PhS-OCT) [1]. Here, we use amplitude-modulated ARF to enhance shear wave signal-to-noise ratio (SNR) at low pressures. Experiments were performed on tissue-mimicking phantoms. ARF was applied using a single-element transducer, driven by a 7.5 MHz, 3-ms, sine wave modulated in amplitude by a linear-swept frequency (1 to 7 kHz). Pressures ...

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    7. In vivo microvascular imaging of human oral and nasal cavities using swept-source optical coherence tomography with a single forward/side viewing probe

      In vivo microvascular imaging of human oral and nasal cavities using swept-source optical coherence tomography with a single forward/side viewing probe

      We report three-dimensional (3D) imaging of microcirculation within human cavity tissues in vivo using a high-speed swept-source optical coherence tomography (SS-OCT) at 1.3 μm with a modified probe interface. Volumetric structural OCT images of the inner tissues of oral and nasal cavities are acquired with a field of view of 2 mm x 2 mm. Two types of disposable and detachable probe attachments are devised and applied to the port of the imaging probe of OCT system, enabling forward and side imaging scans for selective and easy access to specific cavity tissue sites. Blood perfusion is mapped with OCT-based ...

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    8. High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography

      High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography
      ... of Bioengineering, University of Washington, Seattle, Washington 2. 2 Department of Electrical Engineering, University of Washington, Seattle, Washington 3. 3 Department of Dermatology, Yildırım Beyazıt University, Ank...
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    9. Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography

      Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography

      In this study, we measure the in vivo apical-turn vibrations of the guinea pig organ of Corti in both axial and radial directions using phase-sensitive Fourier domain optical coherence tomography. The apical turn in guinea pig cochlea has best frequencies around 100 – 500 Hz which are relevant for human speech. Prior measurements of vibrations in the guinea pig apex involved opening the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here this limitation is overcome by measuring the vibrations through bone without opening the otic capsule. Furthermore, we have significantly reduced the ...

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    10. Assessment of natural enamel lesions with optical coherence tomography in comparison with microfocus x-ray computed tomography

      Assessment of natural enamel lesions with optical coherence tomography in comparison with microfocus x-ray computed tomography

      A technology to characterize early enamel lesions is needed in dentistry. Optical coherence tomography (OCT) is a noninvasive method that provides high-resolution cross-sectional images. The aim of this study is to compare OCT with microfocus x-ray computed tomography ( μ CT ) for assessment of natural enamel lesions in vitro . Ten human teeth with visible white spot-like changes on the enamel smooth surface and no cavitation (ICDAS code 2) were subjected to imaging by μCT (SMX-100CT, Shimadzu) and 1300-nm swept-source OCT (Dental SS-OCT, Panasonic Health Care). In μ CT , the lesions appeared as radiolucent dark areas, while in SS-OCT, they appeared as areas of ...

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    11. University of Washington Receives NIH Grant to Study Non-invasive Real-Time Label-Free 3D Imaging of Retinal Microcirculation.

      University of Washington Receives NIH Grant to Study Non-invasive Real-Time Label-Free 3D Imaging of Retinal Microcirculation.
      ...r structure and function. This study will serve as the foundation for interpretation of rOMAG data in future. University of Washington Received a 2015 NIH Grant to Study Non-invasive real-time label-free 3D imaging of re...
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      2. About University of Washington

        University of Washington

        The University of Washington, founded in 1861, is a public research university in Seattle, Washington, United States. It is the largest university in the Northwestern United States and the oldest public university in Washington. The UW maintains three locations, with its flagship campus in Seattle's University District and branch campuses in Tacoma and Bothell. Its operating budget for fiscal year 2005 was $3.1 billion. The university is known as a Public Ivy, an American term for state-funded institutions of higher learning that "provide[s] an Ivy League collegiate experience at a public school price."