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2. Spatially confined quantification of bilirubin concentrations by spectroscopic visible-light optical coherence tomography
  
  Explore OSA | OSA Publishing Jul 10 2018 Dermatology
  
  Spatially confined measurements of bilirubin in tissue can be of great value for noninvasive bilirubin estimations during neonatal jaundice, as well as our understanding of the physiology behind bilirubin extravasation. This work shows the potential of spectroscopic visible-light optical coherence tomography (sOCT) for this purpose. At the bilirubin absorption peak around 460 nm, sOCT suffers from a strong signal decay with depth, which we overcome by optimizing our system sensitivity ...
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  Mentions: University of Twente Nienke Bosschaart
3. Chip based common-path optical coherence tomography system with an on-chip microlens and multi-reference suppression algorithm
  
  Explore OSA | OSA Publishing Jun 7 2016
  
  We demonstrate an integrated optical probe including an on-chip microlens for a common-path swept-source optical coherence tomography system. This common-path design uses the end facet of the silicon oxynitride waveguide as the reference plane, thus eliminating the need of a space-consuming and dispersive on-chip loop reference arm, thereby obviating the need for dispersion compensation. The on-chip micro-ball lens eliminates the need of external optical elements for coupling the light between ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen
4. Validation of quantitative attenuation and backscattering coefficient measurements by optical coherence tomography in the concentration-dependent and multiple scattering regime
  
  Explore SPIE | Journal Jan 1 2016
  
  Optical coherence tomography (OCT) has the potential to quantitatively measure optical properties of tissue such as the attenuation coefficient and backscattering coefficient. However, to obtain reliable values for strong scattering tissues, accurate consideration of the effects of multiple scattering and the nonlinear relation between the scattering coefficient and scatterer concentration (concentration-dependent scattering) is required. We present a comprehensive model for the OCT signal in which we quantitatively account for both ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam Dirk J. Faber
5. Learning curve and interobserver variance in quantification of the optical coherence tomography attenuation coefficient
  
  Explore SPIE | Journal Dec 15 2015
  
  The learning curve and interobserver variance of attenuation coefficient ( OCT ) determination from optical coherence tomography (OCT) images were quantified. The OCT of normal and diseased vulvar tissues was determined at five time points by three novice students and three OCT experts who reached consensus for reference. Students received feedback between time points. Eventually, variance in OCT was smaller in images of diseased tissue than in images of normal vulvar tissue ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam Dirk J. Faber
6. Integrated Photonics helps Optical Coherence Tomography to Set New Non-Invasive Standard
  
  Explore healthtechevent.com Sep 29 2015
  
  Optical Coherence Tomography (OCT) is a relatively new method of examining living tissue, which uses light instead of needles and incisions. Current OCT systems are rather cumbersome and involve a trolley laden with equipment being pushed through the hospital. This is expensive, unwieldy and unsuitable for a family doctor to carry out a quick check. The Academic Medical Centre of the University of Amsterdam (AMC), among others, is keen to ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam
7. Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study
  
  Explore Urology Annals Aug 13 2015
  
  Introduction: Currently, (multiple) biopsies are taken to obtain histopathological diagnosis of suspicious lesions of the penile skin. Optical coherence tomography (OCT) provides noninvasive in vivo images from which epidermal layer thickness and attenuation coefficient (m oct ) can be quantified. We hypothesize that qualitative (image assessment) and quantitative (epidermal layer thickness and attenuation coefficient, m oct ) analysis of penile skin with OCT is possible and may differentiate benign penile tissue from ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam Dirk J. Faber
8. Clinical experiences with optical coherence tomography in epithelial (pre)malignancies (Thesis)
  
  Explore Repository home May 30 2015 Student Theses
  
  More than 80% of all cancers originate from the epithelium. Epithelium lines organs and cavities inside the body and forms the skin on the outside. Epithelium regenerates constantly and the tissue is prone to the development of cancer. In this thesis we concentrate on cancers arising in the epithelial lining of the male and female genital area and of the skin. The thesis describes the potential of optical coherence tomography ...
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  Mentions: University of Twente
9. Short-term effects of Nano+™ polymer-free sirolimus-eluting stents on native coronary vessels: an optical coherence tomography imaging study
  
  Explore Orient Medical Supplies May 16 2015 Cardiology
  
  Aims: Newly developed drug-eluting stents (DES) aim to promote early endothelialisation and prevent stent thrombosis. We sought to evaluate the extent of neointima growth by optical coherence tomography (OCT) three months after implantation of a polymer-free stent with a nano-sized-pore surface eluting sirolimus. Methods and results: In this prospective, multicentre, open-label study, patients were enrolled with documented stable angina or silent ischaemia and planned intervention for up to two de ...
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  Mentions: Imperial College London University of Twente Patrick W. Serruys
10. Functional optical coherence tomography of pigmented lesions
  
  Explore Wiley Online Library Mar 30 2015 Dermatology
  
  Background Cutaneous melanomas are diagnosed worldwide in 231 130 patients per year. The sensitivity and specificity of melanoma diagnosis expresses the need for an additional diagnostic method. Optical coherence tomography (OCT) has shown that it allows morphological (qualitative) description of image features and quantitative analysis of pathology related light scattering by means of the attenuation coefficient ( oct ). Objective We hypothesize that OCT images of nevi will differ qualitatively and quantitatively ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam Dirk J. Faber
11. Hydrogel-coated feed spacers in two-phase flow cleaning in spiral wound membrane elements: A novel platform for eco-friendly biofouling mitigation
  
  Explore ScienceDirect Jan 24 2015 NDE/NDT
  
  Biofouling is still a major challenge in the application of nanofiltration and reverse osmosis membranes. Here we present a platform approach for environmentally friendly biofouling control using a combination of a hydrogel-coated feed spacer and two-phase flow cleaning. Neutral (polyHEMA-co-PEG 10 MA), cationic (polyDMAEMA) and anionic (polySPMA) hydrogels have been successfully grafted onto polypropylene (PP) feed spacers via plasma-mediated UV-polymerization. These coatings maintained their chemical stability after 7 days incubation ...
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  Mentions: University of Twente
12. Functional optical coherence tomography of pigmented lesions
  
  Explore Wiley Online Library Sep 2 2014 Dermatology
  
  Background Cutaneous melanomas are diagnosed worldwide in 231 130 patients per year. The sensitivity and specificity of melanoma diagnosis expresses the need for an additional diagnostic method. Optical coherence tomography (OCT) has shown that it allows morphological (qualitative) description of image features and quantitative analysis of pathology related light scattering by means of the attenuation coefficient ( oct ). Objective We hypothesize that OCT images of nevi will differ qualitatively and quantitatively ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam Dirk J. Faber
13. Miniature spectrometer and beam splitter for an optical coherence tomography on a silicon chip
  
  Explore opticsinfobase.org Jul 9 2013
  
  Optical coherence tomography (OCT) has enabled clinical applications that revolutionized in vivo medical diagnostics. Nevertheless, its current limitations owing to cost, size, complexity, and the need for accurate alignment must be overcome by radically novel approaches. Exploiting integrated optics, we assemble the central components of a spectral-domain OCT system on a silicon chip. The spectrometer comprises an arrayed-waveguide grating with 136-nm free spectral range and 0.21-nm wavelength resolution. The ...
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  Mentions: Wolfgang Drexler Medical University of Vienna University of Twente
14. Advanced integrated spectrometer designs for miniaturized optical coherence tomography systems
  
  Explore Conference Proceedings Jun 23 2013
  
  Optical coherence tomography (OCT) has enabled clinical applications that revolutionized in vivo medical diagnostics. Nevertheless, its current limitations owing to cost, size, complexity, and the need for accurate alignment must be overcome by radically novel approaches. Exploiting integrated optics, the central components of a spectral-domain OCT (SD-OCT) system can be integrated on a chip. Arrayed-waveguide grating (AWG) spectrometers with their high spectral resolution and compactness are excellent candidates for on-chip ...
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  Mentions: Wolfgang Drexler Medical University of Vienna University of Twente
15. Optical biopsy of epithelial cancers by optical coherence tomography (OCT)
  
  Explore Home - Springer Mar 20 2013 Oncology
  
  Optical coherence tomography (OCT) is an optical technique that measures the backscattering of near-infrared light by tissue. OCT yields in 2D and 3D images at micrometer-scale resolution, thus providing optical biopsies, approaching the resolution of histopathological imaging. The technique has shown to allow in vivo differentiation between benign and malignant epithelial tissue, through qualitative assessment of OCT images, as well as by quantitative evaluation, e.g., functional OCT. This study ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam Dirk J. Faber
16. Optical coherence tomography in vulvar intraepithelial neoplasia
  
  Explore SPIE | Journal Nov 13 2012 Gynecology
  
  Vulvar squamous cell carcinoma (VSCC) is a gynecological cancer with an incidence of two to three per 100,000 women. VSCC arises from vulvar intraepithelial neoplasia (VIN), which is diagnosed through painful punch biopsy. In this study, optical coherence tomography (OCT) is used to differentiate between normal and VIN tissue. We hypothesize that (a) epidermal layer thickness measured in OCT images is different in normal tissue and VIN, and (b ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam Dirk J. Faber
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