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2. Optical density based quantification of total haemoglobin concentrations with spectroscopic optical coherence tomography
  
  Explore Nature Publishing Group Apr 24 2021
  
  Spectroscopic optical coherence tomography (sOCT) has emerged as a new possibility for non-invasive quantification of total haemoglobin concentrations [tHb]. Recently, we demonstrated that [tHb] measured in ex-vivo human whole-blood with a conventional sOCT system achieves a precision of 9.10 g/dL with a bias of 1.50 g/dL. This precision improved by acquiring data with a combination of focus tracking and zero-delay acquisition (FZA) that compensated for experimental ...
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  Mentions: University of Twente
3. Novel imaging techniques for intraoperative margin assessment in surgical oncology: a systematic review
  
  Explore Wiley Online Library Mar 21 2021
  
  Inadequate margins continue to occur frequently in patients who undergo surgical resection of a tumor, suggesting that current intraoperative methods are not sufficiently reliable in determining the margin status. This clinical demand has inspired the development of many novel imaging techniques that could help surgeons with intraoperative margin assessment. This systematic review provides an overview of novel imaging techniques for intraoperative margin assessment in surgical oncology, and reports on their ...
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4. Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant read-outs for tissue permeability and vascular structure
  
  Explore RSC Publishing Home Dec 15 2020 NDE/NDT
  
  The outer bloodretinal barrier (oBRB) tightly controls the transport processes between the neural tissue of the retina and the underlying blood vessel network. The barrier is formed by the retinal pigment epithelium (RPE), its basal membrane and the underlying choroidal capillary bed. Realistic three-dimensional cell culture based models of the oBRB are needed to study mechanisms and potential treatments of visual disorders such as age-related macular degeneration that result from ...
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5. Visible light spectroscopic optical coherence tomography for applications in neonatal healthcare (Thesis)
  
  Explore research.utwente.nl Jun 29 2020 Student Theses
  
  In this thesis, we explored the opportunities of spatially resolved optical spectroscopy for neonatal healthcare. Hereto, we developed a setup that makes use of spectroscopic optical coherence tomography (sOCT). This technique allows for spectroscopic measurement of the attenuation of light within a confined measurement volume, without being influenced by surrounding tissues. Throughout this thesis, we explored the possibilities of sOCT for estimating tissue properties which are relevant to newborns. In ...
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6. Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomography
  
  Explore Nature Publishing Group Nov 4 2019
  
  The non-invasive quantification of total haemoglobin concentrations [tHb] is highly desired for the assessment of haematologic disorders in vulnerable patient groups, but invasive blood sampling is still the gold standard in current clinical practice. This work demonstrates the potential of visible-light spectroscopic optical coherence tomography (sOCT) for quantifying the [tHb] in human whole blood. To accurately quantify the [tHb] from the substantial optical attenuation by blood in the visible wavelength ...
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7. Optical properties of human milk
  
  Explore OSA | OSA Publishing Jul 23 2019 NDE/NDT , Other Non-Medical
  
  With human milk being the most important source of infant nutrition, the protection and support of breastfeeding are essential from a global health perspective. Nevertheless, relatively few objective methods are available to investigate human milk composition and lactation physiology when a mother experiences breastfeeding problems. We argue that optics and photonics offer promising opportunities for this purpose. Any research activity within this new application field starts with a thorough understanding ...
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8. Optos, Bühler, Lumishore among latest Queen's Award winners
  
  Explore optics.org Apr 24 2019 Ophthalmology
  
  ...rior imaging which had been demonstrated in over 600 clinical studies to aid the enhancement of patient care. University of Twente develops method to inject âsmart tattoosâ for potential health monitoring options. El...
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  Mentions: University of Twente Optos
9. PhD student – Organs-On-Chip monitoring with optical coherence tomography
  
  Explore Universiteit Twente in Enschede Nov 6 2018 Jobs & Studentships
  
  ...es we do particularly support women to apply. Within the TNW Faculty (Faculty of Science & Technology) of the University of Twente some 700 staff members and 2000 students are involved in training and research on the int...
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10. Spatially confined quantification of bilirubin concentrations by spectroscopic visible-light optical coherence tomography
  
  Explore OSA | OSA Publishing Jul 10 2018 Dermatology
  
  Spatially confined measurements of bilirubin in tissue can be of great value for noninvasive bilirubin estimations during neonatal jaundice, as well as our understanding of the physiology behind bilirubin extravasation. This work shows the potential of spectroscopic visible-light optical coherence tomography (sOCT) for this purpose. At the bilirubin absorption peak around 460 nm, sOCT suffers from a strong signal decay with depth, which we overcome by optimizing our system sensitivity ...
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11. Chip based common-path optical coherence tomography system with an on-chip microlens and multi-reference suppression algorithm
  
  Explore OSA | OSA Publishing Jun 7 2016
  
  We demonstrate an integrated optical probe including an on-chip microlens for a common-path swept-source optical coherence tomography system. This common-path design uses the end facet of the silicon oxynitride waveguide as the reference plane, thus eliminating the need of a space-consuming and dispersive on-chip loop reference arm, thereby obviating the need for dispersion compensation. The on-chip micro-ball lens eliminates the need of external optical elements for coupling the light between ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam
12. Validation of quantitative attenuation and backscattering coefficient measurements by optical coherence tomography in the concentration-dependent and multiple scattering regime
  
  Explore SPIE | Journal Jan 1 2016
  
  Optical coherence tomography (OCT) has the potential to quantitatively measure optical properties of tissue such as the attenuation coefficient and backscattering coefficient. However, to obtain reliable values for strong scattering tissues, accurate consideration of the effects of multiple scattering and the nonlinear relation between the scattering coefficient and scatterer concentration (concentration-dependent scattering) is required. We present a comprehensive model for the OCT signal in which we quantitatively account for both ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam
13. Learning curve and interobserver variance in quantification of the optical coherence tomography attenuation coefficient
  
  Explore SPIE | Journal Dec 15 2015
  
  The learning curve and interobserver variance of attenuation coefficient ( OCT ) determination from optical coherence tomography (OCT) images were quantified. The OCT of normal and diseased vulvar tissues was determined at five time points by three novice students and three OCT experts who reached consensus for reference. Students received feedback between time points. Eventually, variance in OCT was smaller in images of diseased tissue than in images of normal vulvar tissue ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam
14. Integrated Photonics helps Optical Coherence Tomography to Set New Non-Invasive Standard
  
  Explore healthtechevent.com Sep 29 2015
  
  Optical Coherence Tomography (OCT) is a relatively new method of examining living tissue, which uses light instead of needles and incisions. Current OCT systems are rather cumbersome and involve a trolley laden with equipment being pushed through the hospital. This is expensive, unwieldy and unsuitable for a family doctor to carry out a quick check. The Academic Medical Centre of the University of Amsterdam (AMC), among others, is keen to ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam
15. Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study
  
  Explore Urology Annals Aug 13 2015
  
  Introduction: Currently, (multiple) biopsies are taken to obtain histopathological diagnosis of suspicious lesions of the penile skin. Optical coherence tomography (OCT) provides noninvasive in vivo images from which epidermal layer thickness and attenuation coefficient (m oct ) can be quantified. We hypothesize that qualitative (image assessment) and quantitative (epidermal layer thickness and attenuation coefficient, m oct ) analysis of penile skin with OCT is possible and may differentiate benign penile tissue from ...
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  Mentions: University of Twente Academic Medical Center at the University of Amsterdam
16. Clinical experiences with optical coherence tomography in epithelial (pre)malignancies (Thesis)
  
  Explore Repository home May 30 2015 Student Theses
  
  More than 80% of all cancers originate from the epithelium. Epithelium lines organs and cavities inside the body and forms the skin on the outside. Epithelium regenerates constantly and the tissue is prone to the development of cancer. In this thesis we concentrate on cancers arising in the epithelial lining of the male and female genital area and of the skin. The thesis describes the potential of optical coherence tomography ...
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