1. University of Twente

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    1. Mentioned In 63 Articles

    2. Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT–FFR trial

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      Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT–FFR trial
      Aims The aim of this study was to understand the impact of optical coherence tomography (OCT)-detected thin-cap fibroatheroma (TCFA) on clinical outcomes of diabetes mellitus (DM) patients with fractional flow reserve (FFR)-negative lesions. Methods and results COMBINE OCT-FFR study was a prospective, double-blind, international, natural history study. After FFR assessment, and revascularization of FFR-positive lesions, patients with 1 FFR-negative lesions (target lesions) were classified in two groups based ...
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      Mentions: University of Twente San Carlos University Hospital Erasmus University

    3. Optical density based quantification of total haemoglobin concentrations with spectroscopic optical coherence tomography

      Explore Nature Publishing Group
      Optical density based quantification of total haemoglobin concentrations with spectroscopic optical coherence tomography
      Spectroscopic optical coherence tomography (sOCT) has emerged as a new possibility for non-invasive quantification of total haemoglobin concentrations [tHb]. Recently, we demonstrated that [tHb] measured in ex-vivo human whole-blood with a conventional sOCT system achieves a precision of 9.10 g/dL with a bias of 1.50 g/dL. This precision improved by acquiring data with a combination of focus tracking and zero-delay acquisition (FZA) that compensated for experimental ...
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      Mentions: University of Twente

    4. Novel imaging techniques for intraoperative margin assessment in surgical oncology: a systematic review

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      Novel imaging techniques for intraoperative margin assessment in surgical oncology: a systematic review
      Inadequate margins continue to occur frequently in patients who undergo surgical resection of a tumor, suggesting that current intraoperative methods are not sufficiently reliable in determining the margin status. This clinical demand has inspired the development of many novel imaging techniques that could help surgeons with intraoperative margin assessment. This systematic review provides an overview of novel imaging techniques for intraoperative margin assessment in surgical oncology, and reports on their ...
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      Mentions: University of Twente

    5. Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant read-outs for tissue permeability and vascular structure

      Explore RSC Publishing Home NDE/NDT
      Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant read-outs for tissue permeability and vascular structure
      The outer bloodretinal barrier (oBRB) tightly controls the transport processes between the neural tissue of the retina and the underlying blood vessel network. The barrier is formed by the retinal pigment epithelium (RPE), its basal membrane and the underlying choroidal capillary bed. Realistic three-dimensional cell culture based models of the oBRB are needed to study mechanisms and potential treatments of visual disorders such as age-related macular degeneration that result from ...
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      Mentions: University of Twente

    6. Visible light spectroscopic optical coherence tomography for applications in neonatal healthcare (Thesis)

      Explore research.utwente.nl Student Theses
      Visible light spectroscopic optical coherence tomography for applications in neonatal healthcare (Thesis)
      In this thesis, we explored the opportunities of spatially resolved optical spectroscopy for neonatal healthcare. Hereto, we developed a setup that makes use of spectroscopic optical coherence tomography (sOCT). This technique allows for spectroscopic measurement of the attenuation of light within a confined measurement volume, without being influenced by surrounding tissues. Throughout this thesis, we explored the possibilities of sOCT for estimating tissue properties which are relevant to newborns. In ...
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      Mentions: University of Twente

    7. Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomography

      Explore Nature Publishing Group
      Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomography
      The non-invasive quantification of total haemoglobin concentrations [tHb] is highly desired for the assessment of haematologic disorders in vulnerable patient groups, but invasive blood sampling is still the gold standard in current clinical practice. This work demonstrates the potential of visible-light spectroscopic optical coherence tomography (sOCT) for quantifying the [tHb] in human whole blood. To accurately quantify the [tHb] from the substantial optical attenuation by blood in the visible wavelength ...
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      Mentions: University of Twente

    8. Optical properties of human milk

      Explore OSA | OSA Publishing NDE/NDT , Other Non-Medical
      Optical properties of human milk
      With human milk being the most important source of infant nutrition, the protection and support of breastfeeding are essential from a global health perspective. Nevertheless, relatively few objective methods are available to investigate human milk composition and lactation physiology when a mother experiences breastfeeding problems. We argue that optics and photonics offer promising opportunities for this purpose. Any research activity within this new application field starts with a thorough understanding ...
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      Mentions: University of Twente

    11. Spatially confined quantification of bilirubin concentrations by spectroscopic visible-light optical coherence tomography

      Explore OSA | OSA Publishing Dermatology
      Spatially confined quantification of bilirubin concentrations by spectroscopic visible-light optical coherence tomography
      Spatially confined measurements of bilirubin in tissue can be of great value for noninvasive bilirubin estimations during neonatal jaundice, as well as our understanding of the physiology behind bilirubin extravasation. This work shows the potential of spectroscopic visible-light optical coherence tomography (sOCT) for this purpose. At the bilirubin absorption peak around 460 nm, sOCT suffers from a strong signal decay with depth, which we overcome by optimizing our system sensitivity ...
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      Mentions: University of Twente

    12. Chip based common-path optical coherence tomography system with an on-chip microlens and multi-reference suppression algorithm

      Explore OSA | OSA Publishing
      Chip based common-path optical coherence tomography system with an on-chip microlens and multi-reference suppression algorithm
      We demonstrate an integrated optical probe including an on-chip microlens for a common-path swept-source optical coherence tomography system. This common-path design uses the end facet of the silicon oxynitride waveguide as the reference plane, thus eliminating the need of a space-consuming and dispersive on-chip loop reference arm, thereby obviating the need for dispersion compensation. The on-chip micro-ball lens eliminates the need of external optical elements for coupling the light between ...
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      Mentions: University of Twente Academic Medical Center at the University of Amsterdam

    13. Validation of quantitative attenuation and backscattering coefficient measurements by optical coherence tomography in the concentration-dependent and multiple scattering regime

      Explore SPIE | Journal
      Validation of quantitative attenuation and backscattering coefficient measurements by optical coherence tomography in the concentration-dependent and multiple scattering regime
      Optical coherence tomography (OCT) has the potential to quantitatively measure optical properties of tissue such as the attenuation coefficient and backscattering coefficient. However, to obtain reliable values for strong scattering tissues, accurate consideration of the effects of multiple scattering and the nonlinear relation between the scattering coefficient and scatterer concentration (concentration-dependent scattering) is required. We present a comprehensive model for the OCT signal in which we quantitatively account for both ...
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      Mentions: University of Twente Academic Medical Center at the University of Amsterdam

    14. Learning curve and interobserver variance in quantification of the optical coherence tomography attenuation coefficient

      Explore SPIE | Journal
      Learning curve and interobserver variance in quantification of the optical coherence tomography attenuation coefficient
      The learning curve and interobserver variance of attenuation coefficient ( OCT ) determination from optical coherence tomography (OCT) images were quantified. The OCT of normal and diseased vulvar tissues was determined at five time points by three novice students and three OCT experts who reached consensus for reference. Students received feedback between time points. Eventually, variance in OCT was smaller in images of diseased tissue than in images of normal vulvar tissue ...
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      Mentions: University of Twente Academic Medical Center at the University of Amsterdam

    15. Integrated Photonics helps Optical Coherence Tomography to Set New Non-Invasive Standard

      Explore healthtechevent.com
      Integrated Photonics helps Optical Coherence Tomography to Set New Non-Invasive Standard
      Optical Coherence Tomography (OCT) is a relatively new method of examining living tissue, which uses light instead of needles and incisions. Current OCT systems are rather cumbersome and involve a trolley laden with equipment being pushed through the hospital. This is expensive, unwieldy and unsuitable for a family doctor to carry out a quick check. The Academic Medical Centre of the University of Amsterdam (AMC), among others, is keen to ...
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      Mentions: University of Twente Academic Medical Center at the University of Amsterdam

    16. Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study

      Explore Urology Annals
      Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study
      Introduction: Currently, (multiple) biopsies are taken to obtain histopathological diagnosis of suspicious lesions of the penile skin. Optical coherence tomography (OCT) provides noninvasive in vivo images from which epidermal layer thickness and attenuation coefficient (m oct ) can be quantified. We hypothesize that qualitative (image assessment) and quantitative (epidermal layer thickness and attenuation coefficient, m oct ) analysis of penile skin with OCT is possible and may differentiate benign penile tissue from ...
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      Mentions: University of Twente Academic Medical Center at the University of Amsterdam
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  4. About University of Twente

    University of Twente

    The Universityof Twente is a university located in Enschede, Netherlands. The emphasis is mainly on technical subjects combined with sociocultural aspects.  The faculties of the University of Twente are primarily responsible for teaching and personnel, whereas the institutes are primarily responsible for research.   Memphis Project.   (Merging Electronics and Micro & nano-PHotonics in Integrated Systems)  project aims at miniaturizing and standardizing optical technology and integrating this with electronics. This opens the way to major new applications for the use of light, in medical diagnostics, healthcare, entertainment, telecommunications, tracking, and positioning. Within this framework the Academic Medical Center, together with the University of Twente, focuses on the development of a miniature Optical Coherence Tomography (OCT) device.

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