1. University of Twente

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    1. Mentioned In 54 Articles

    2. Spatially confined quantification of bilirubin concentrations by spectroscopic visible-light optical coherence tomography

      Spatially confined quantification of bilirubin concentrations by spectroscopic visible-light optical coherence tomography
      Spatially confined measurements of bilirubin in tissue can be of great value for noninvasive bilirubin estimations during neonatal jaundice, as well as our understanding of the physiology behind bilirubin extravasation. This work shows the potential of spectroscopic visible-light optical coherence tomography (sOCT) for this purpose. At the bilirubin absorption peak around 460 nm, sOCT suffers from a strong signal decay with depth, which we overcome by optimizing our system sensitivity ...
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    3. Chip based common-path optical coherence tomography system with an on-chip microlens and multi-reference suppression algorithm

      Chip based common-path optical coherence tomography system with an on-chip microlens and multi-reference suppression algorithm
      We demonstrate an integrated optical probe including an on-chip microlens for a common-path swept-source optical coherence tomography system. This common-path design uses the end facet of the silicon oxynitride waveguide as the reference plane, thus eliminating the need of a space-consuming and dispersive on-chip loop reference arm, thereby obviating the need for dispersion compensation. The on-chip micro-ball lens eliminates the need of external optical elements for coupling the light between ...
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    4. Validation of quantitative attenuation and backscattering coefficient measurements by optical coherence tomography in the concentration-dependent and multiple scattering regime

      Validation of quantitative attenuation and backscattering coefficient measurements by optical coherence tomography in the concentration-dependent and multiple scattering regime
      Optical coherence tomography (OCT) has the potential to quantitatively measure optical properties of tissue such as the attenuation coefficient and backscattering coefficient. However, to obtain reliable values for strong scattering tissues, accurate consideration of the effects of multiple scattering and the nonlinear relation between the scattering coefficient and scatterer concentration (concentration-dependent scattering) is required. We present a comprehensive model for the OCT signal in which we quantitatively account for both ...
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    5. Learning curve and interobserver variance in quantification of the optical coherence tomography attenuation coefficient

      Learning curve and interobserver variance in quantification of the optical coherence tomography attenuation coefficient
      The learning curve and interobserver variance of attenuation coefficient ( OCT ) determination from optical coherence tomography (OCT) images were quantified. The OCT of normal and diseased vulvar tissues was determined at five time points by three novice students and three OCT experts who reached consensus for reference. Students received feedback between time points. Eventually, variance in OCT was smaller in images of diseased tissue than in images of normal vulvar tissue ...
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    6. Integrated Photonics helps Optical Coherence Tomography to Set New Non-Invasive Standard

      Integrated Photonics helps Optical Coherence Tomography to Set New Non-Invasive Standard
      Optical Coherence Tomography (OCT) is a relatively new method of examining living tissue, which uses light instead of needles and incisions. Current OCT systems are rather cumbersome and involve a trolley laden with equipment being pushed through the hospital. This is expensive, unwieldy and unsuitable for a family doctor to carry out a quick check. The Academic Medical Centre of the University of Amsterdam (AMC), among others, is keen to ...
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    7. Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study

      Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study
      Introduction: Currently, (multiple) biopsies are taken to obtain histopathological diagnosis of suspicious lesions of the penile skin. Optical coherence tomography (OCT) provides noninvasive in vivo images from which epidermal layer thickness and attenuation coefficient (m oct ) can be quantified. We hypothesize that qualitative (image assessment) and quantitative (epidermal layer thickness and attenuation coefficient, m oct ) analysis of penile skin with OCT is possible and may differentiate benign penile tissue from ...
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    8. Clinical experiences with optical coherence tomography in epithelial (pre)malignancies (Thesis)

      Clinical experiences with optical coherence tomography in epithelial (pre)malignancies (Thesis)
      More than 80% of all cancers originate from the epithelium. Epithelium lines organs and cavities inside the body and forms the skin on the outside. Epithelium regenerates constantly and the tissue is prone to the development of cancer. In this thesis we concentrate on cancers arising in the epithelial lining of the male and female genital area and of the skin. The thesis describes the potential of optical coherence tomography ...
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    9. Short-term effects of Nano+™ polymer-free sirolimus-eluting stents on native coronary vessels: an optical coherence tomography imaging study

      Short-term effects of Nano+™ polymer-free sirolimus-eluting stents on native coronary vessels: an optical coherence tomography imaging study
      Aims: Newly developed drug-eluting stents (DES) aim to promote early endothelialisation and prevent stent thrombosis. We sought to evaluate the extent of neointima growth by optical coherence tomography (OCT) three months after implantation of a polymer-free stent with a nano-sized-pore surface eluting sirolimus. Methods and results: In this prospective, multicentre, open-label study, patients were enrolled with documented stable angina or silent ischaemia and planned intervention for up to two de ...
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    10. Functional optical coherence tomography of pigmented lesions

      Functional optical coherence tomography of pigmented lesions
      Background Cutaneous melanomas are diagnosed worldwide in 231 130 patients per year. The sensitivity and specificity of melanoma diagnosis expresses the need for an additional diagnostic method. Optical coherence tomography (OCT) has shown that it allows morphological (qualitative) description of image features and quantitative analysis of pathology related light scattering by means of the attenuation coefficient ( oct ). Objective We hypothesize that OCT images of nevi will differ qualitatively and quantitatively ...
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    11. Hydrogel-coated feed spacers in two-phase flow cleaning in spiral wound membrane elements: A novel platform for eco-friendly biofouling mitigation

      Hydrogel-coated feed spacers in two-phase flow cleaning in spiral wound membrane elements: A novel platform for eco-friendly biofouling mitigation
      Biofouling is still a major challenge in the application of nanofiltration and reverse osmosis membranes. Here we present a platform approach for environmentally friendly biofouling control using a combination of a hydrogel-coated feed spacer and two-phase flow cleaning. Neutral (polyHEMA-co-PEG 10 MA), cationic (polyDMAEMA) and anionic (polySPMA) hydrogels have been successfully grafted onto polypropylene (PP) feed spacers via plasma-mediated UV-polymerization. These coatings maintained their chemical stability after 7 days incubation ...
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    12. Functional optical coherence tomography of pigmented lesions

      Functional optical coherence tomography of pigmented lesions
      Background Cutaneous melanomas are diagnosed worldwide in 231 130 patients per year. The sensitivity and specificity of melanoma diagnosis expresses the need for an additional diagnostic method. Optical coherence tomography (OCT) has shown that it allows morphological (qualitative) description of image features and quantitative analysis of pathology related light scattering by means of the attenuation coefficient ( oct ). Objective We hypothesize that OCT images of nevi will differ qualitatively and quantitatively ...
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    13. Miniature spectrometer and beam splitter for an optical coherence tomography on a silicon chip

      Miniature spectrometer and beam splitter for an optical coherence tomography on a silicon chip
      Optical coherence tomography (OCT) has enabled clinical applications that revolutionized in vivo medical diagnostics. Nevertheless, its current limitations owing to cost, size, complexity, and the need for accurate alignment must be overcome by radically novel approaches. Exploiting integrated optics, we assemble the central components of a spectral-domain OCT system on a silicon chip. The spectrometer comprises an arrayed-waveguide grating with 136-nm free spectral range and 0.21-nm wavelength resolution. The ...
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    14. Advanced integrated spectrometer designs for miniaturized optical coherence tomography systems

      Advanced integrated spectrometer designs for miniaturized optical coherence tomography systems
      Optical coherence tomography (OCT) has enabled clinical applications that revolutionized in vivo medical diagnostics. Nevertheless, its current limitations owing to cost, size, complexity, and the need for accurate alignment must be overcome by radically novel approaches. Exploiting integrated optics, the central components of a spectral-domain OCT (SD-OCT) system can be integrated on a chip. Arrayed-waveguide grating (AWG) spectrometers with their high spectral resolution and compactness are excellent candidates for on-chip ...
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    15. Optical biopsy of epithelial cancers by optical coherence tomography (OCT)

      Optical biopsy of epithelial cancers by optical coherence tomography (OCT)
      Optical coherence tomography (OCT) is an optical technique that measures the backscattering of near-infrared light by tissue. OCT yields in 2D and 3D images at micrometer-scale resolution, thus providing optical biopsies, approaching the resolution of histopathological imaging. The technique has shown to allow in vivo differentiation between benign and malignant epithelial tissue, through qualitative assessment of OCT images, as well as by quantitative evaluation, e.g., functional OCT. This study ...
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    16. Optical coherence tomography in vulvar intraepithelial neoplasia

      Optical coherence tomography in vulvar intraepithelial neoplasia
      Vulvar squamous cell carcinoma (VSCC) is a gynecological cancer with an incidence of two to three per 100,000 women. VSCC arises from vulvar intraepithelial neoplasia (VIN), which is diagnosed through painful punch biopsy. In this study, optical coherence tomography (OCT) is used to differentiate between normal and VIN tissue. We hypothesize that (a) epidermal layer thickness measured in OCT images is different in normal tissue and VIN, and (b ...
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  2. About University of Twente

    University of Twente

    The Universityof Twente is a university located in Enschede, Netherlands. The emphasis is mainly on technical subjects combined with sociocultural aspects.  The faculties of the University of Twente are primarily responsible for teaching and personnel, whereas the institutes are primarily responsible for research.   Memphis Project.   (Merging Electronics and Micro & nano-PHotonics in Integrated Systems)  project aims at miniaturizing and standardizing optical technology and integrating this with electronics. This opens the way to major new applications for the use of light, in medical diagnostics, healthcare, entertainment, telecommunications, tracking, and positioning. Within this framework the Academic Medical Center, together with the University of Twente, focuses on the development of a miniature Optical Coherence Tomography (OCT) device.