Real-time observation of coronary artery perforation by intravascular ultrasound and optical coherence tomography
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University of Tsukuba
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University of Tsukuba
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Mentioned In 170 Articles
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Effect of A-scan rate and interscan interval on optical coherence angiography
Optical coherence tomography angiography (OCTA) can provide rapid, volumetric, and noninvasive imaging of tissue microvasculature without the requirement of exogenous contrast agents. To investigate how A-scan rate and interscan time affected the contrast and dynamic range of OCTA, we developed a 1.06-m swept-source OCT system enabling 100-kHz or 200-kHz OCT using two light sources. After system settings were carefully adjusted, almost the same detection sensitivity was achieved between the ...Read Full Article -
Accurately motion-corrected Lissajous OCT with multi-type image registration
Passive motion correction methods for optical coherence tomography (OCT) use image registration to estimate eye movements. To improve motion correction, a multi-image cross-correlation that employs spatial features in different image types is introduced. Lateral motion correction using en face OCT and OCT-A projections on Lissajous-scanned OCT data is applied. Motion correction using OCT-A projection of whole depth and OCT amplitude, OCT logarithmic intensity, and OCT maximum intensity projections were evaluated ...Read Full ArticleMentions: University of Tsukuba -
Optical coherence tomography angiography and Humphrey field analyser for macular capillary non-perfusion evaluation in branch retinal vein occlusion
We non-invasively evaluated macular non-perfused areas (m-NPAs) of branch retinal vein occlusion (BRVO) using optical coherence tomography (OCT) angiography and the Humphrey visual field analyser 10-2 programme (HFA 10-2). We enrolled 30 patients (30 eyes) with macular oedema secondary to BRVO. OCT angiography was used to photograph the macula at 6 6-mm; sizes of m-NPAs in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were measured in four ...Read Full ArticleMentions: University of Tsukuba -
Kao research opens door for better understanding of wrinkle formation
...atory and Skin Care Products Research Laboratory in collaboration with the Computational Optics Group at the University of Tsukuba used a technique called Jones matrix-optical coherence tomography (JM-OCT) to unravel t...Read Full ArticleMentions: University of Tsukuba -
In vivo evaluation of coronary arteritis by serial optical coherence tomography in large vessel vasculitis
A 74-year-old man with acute coronary syndrome underwent emergency percutaneous coronary intervention with the implantation of everolimus-eluting stents for severe stenosis in proximal left ascending coronary artery (LAD) ( Panel A , red arrows). Coronary angiography (CAG) revealed mild stenosis in proximal right coronary artery (RCA) and severe stenosis in distal LAD ( Panel A , yellow arrows, Supplementary material online, Video S1 ). Optical coherence tomography (OCT) showed diffusely thickened homogenous intima in mid-LAD ...Read Full ArticleMentions: University of Tsukuba -
Optical coherence tomography-based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroids
We present optical coherence tomography (OCT)-based tissue dynamics imaging method to visualize and quantify tissue dynamics such as subcellular motion based on statistical analysis of rapid-time-sequence OCT signals at the same location. The analyses include logarithmic intensity variance (LIV) method and two types of OCT correlation decay speed analysis (OCDS). LIV is sensitive to the magnitude of the signal fluctuations, while OCDSs including early- and late-OCDS (OCDS e and ...Read Full ArticleMentions: University of Tsukuba -
Quantitative multi-contrast in vivo mouse imaging with polarization diversity optical coherence tomography and angiography
Retinal microvasculature and the retinal pigment epithelium (RPE) play vital roles in maintaining the health and metabolic activity of the eye. Visualization of these retina structures is essential for pre-clinical studies of vision-robbing diseases, such as age-related macular degeneration (AMD). We have developed a quantitative multi-contrast polarization diversity OCT and angiography (QMC-PD-OCTA) system for imaging and visualizing pigment in the RPE using degree of polarization uniformity (DOPU), along with flow ...Read Full Article -
Clinical utility of morphofunctional correlation of microperimetry and optical coherence tomography
Purpose: To demonstrate the clinical and research value of a simplified technique enabling alignment of functional microperimetry data with retinal structure imaged by eye-tracked optical coherence tomography (OCT) in eyes with macular disease. Methods: Normal and diseased eyes underwent sequential Spectralis OCT macular raster scans and Macular Integrity Assessment (MAIA) microperimetry using both standard central 10 analysis and custom scan patterns. The microperimetry data were imported into Spectralis research software ...Read Full Article -
Depth‐resolved investigation of multiple optical properties and wrinkle morphology in eye‐corner areas with multi‐contrast Jones matrix optical coherence tomography
Background Multi‐contrast Jones matrix optical coherence tomography (JM‐OCT) can provide quantitative depth‐resolved local optical properties by improving the measurement algorithm. Materials and methods We examined the relationship between depth‐resolved local optical properties of eye‐corner skin measured by JM‐OCT and corresponding wrinkle morphology of aged women (n = 21; age range, 71.7 1.7 years). Wrinkle morphology was analyzed by measuring the surface topography of ...Read Full ArticleMentions: University of Tsukuba -
In Vivo Evaluation of Tissue Protrusion by Using Optical Coherence Tomography and Coronary Angioscopy Immediately After Stent Implantation
Background: The relationship between the characteristics of tissue protrusion detected by using optical coherence tomography (OCT) and the findings of coronary angioscopy (CAS) immediately after stent implantation were evaluated. Methods and Results: A total of 186 patients (192 stents) underwent OCT before and after stenting and were observed by using CAS immediately after stenting and at the chronic phase. Patients were assigned to irregular protrusion, smooth protrusion, and disrupted fibrous ...Read Full ArticleMentions: University of Tsukuba -
Bulk-phase-error correction for phase-sensitive signal processing of optical coherence tomography
We present a numerical phase stabilization method for phase-sensitive signal processing of optical coherence tomography (OCT). This method removes the bulk phase error caused by the axial bulk motion of the sample and the environmental perturbation during volumetric acquisition. In this method, the partial derivatives of the phase error are computed along both fast and slow scanning directions, so that the vectorial gradient field of the phase error is given ...Read Full ArticleMentions: University of Tsukuba -
Optical coherence tomography interpreted by diffractive optics: A-scan image formation with wavelength-scale diffraction gratings as samples
Seeking a detailed investigation of polarization sensitive optical coherence tomography, electromagnetic numerical simulation of optical coherence tomography is carried out assuming deep diffraction gratings, some of which are in the resonance domain, as a sample to be measured. This is an approach from diffractive optics, and its simplification of the problem makes analysis more focused on its fundamental nature. The combination of the two disciplines provides previously unnoticed issues such ...Read Full ArticleMentions: University of Tsukuba -
Jones matrix OCT system and program for carrying out image processing on measured data obtained by said OCT
A Jones matrix OCT offers improved image stability, image quality, and depth range of image, wherein light from a wavelength-scanning light source is split into two optical paths, and a reference arm is provided along one optical path, while a probe arm that irradiates and reflects light onto the measuring target to generate object light is provided along the other optical path. The probe arm has a polarization delay unit ...Read Full ArticleMentions: University of Tsukuba -
Polarization-sensitive optical coherence elastography
Polarization-sensitive optical coherence elastography (PS-OCE) is developed for improved tissue discrimination. It integrates Jones matrix-based PS-optical coherence tomography (PS-OCT) with compression OCE. The method simultaneously measures the OCT intensity, attenuation coefficient, birefringence, and microstructural deformation (MSD) induced by tissue compression. Ex vivo porcine aorta and esophagus tissues were investigated by PS-OCE and histological imaging. The tissue properties measured by PS-OCE are shown as cross-sectional images and a three-dimensional (3-D) depth-trajectory ...Read Full ArticleMentions: University of Tsukuba
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About University of Tsukuba
University of Tsukuba is located in the city of Tsukuba. The university is ranked one of the top Asian universities in the "Academic Ranking of World Universities" and is ranked 102-150 in the world. The University of Tsukuba has had several Nobel Prize winners so far, namely Leo Esaki, Hideki Shirakawa and Sin-Itiro Tomonaga, which is extremely rare among universities in Asia, where there have been fewer Nobel laureates than in European and American universities.
The Computational Optics Group (COG) at the University of Tsukuba formed in 1999 as a division of applied optics laboratory, institute of applied physics, university of Tsukuba. On that moment we were not COG but spatio-temporal optics group, and our main research subject was spatio-temporal optical computing. In 2000, we started a optical measurement project using spatio-temporal optical computing technologies, and in 2002, we changed our direction to more computationally. Since 2002, our main research interest is computer assisted optical measurment. We are trying to introduce computational technologies into optical measurement. Since 2007, we are an independent research group and no longer a part of Applied Optics Laboratory of University of Tsukuba.