1. University of Tsukuba

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    1. Mentioned In 115 Articles

    2. Doppler Optical Coherence Tomography Imaging of Feeder Vessels in Exudative Macular Disease

      Doppler Optical Coherence Tomography Imaging of Feeder Vessels in Exudative Macular Disease

      We evaluated the three-dimensional vascular architecture of feeder vessels in exudative macular disease. A case of polypoidal choroidal vasculopathy with choroidal neovascularization was examined with Doppler optical coherence tomography (OCT), and the three-dimensional architecture of the feeder vessels could be clearly visualized in the Doppler OCT angiography image, showing the site of growth of the feeder vessels passing through Bruch’s membrane. Together, the results demonstrated in this case report that Doppler OCT was useful for the noninvasive assessment of feeder vessels in exudative macular disease.

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    3. Depth-Resolved Dynamics of Aceto-Whitening in Rabbit Cornea Studied by 1300 nm Optical Coherence Tomography

      Depth-Resolved Dynamics of Aceto-Whitening in Rabbit Cornea Studied by 1300 nm Optical Coherence Tomography

      In many developing parts of the world, colposcopy supplemented by aceto-whitening remains the most widespread means of reliably diagnosing cervical dysplasia, potentially leading to cervical cancer. The use of aceto-whitening to enhance detection rates for Barrett’s esophagus is also emerging in recent years. Here we quantitatively study the aceto-whitening phenomenon using 1300 nm optical coherence tomography. By exposing a simple epithelial tissue model (excised rabbit cornea) to 0.5 M acetic acid we report for the first time to our knowledge the direct measurement of the time over which the cellular brightening effect propagates down through the epithelial layer ...

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    4. STEREOPSIS AND OPTICAL COHERENCE TOMOGRAPHY FINDINGS AFTER EPIRETINAL MEMBRANE SURGERY

      STEREOPSIS AND OPTICAL COHERENCE TOMOGRAPHY FINDINGS AFTER EPIRETINAL MEMBRANE SURGERY

      Purpose: To evaluate stereopsis in patients undergoing vitrectomy for epiretinal membrane and to investigate the relationship between stereopsis and foveal microstructures. Methods: This study included 55 eyes of 55 patients who underwent vitrectomy for unilateral epiretinal membrane and 27 age-matched normal subjects. We examined stereopsis using the Titmus Stereo Test, TNO stereotest, and, optical coherence tomography before surgery and 6 months after surgery. Central foveal thickness, central retinal thickness at the parafovea (CRT-3 mm), macular volume, and retinal layer thickness were measured with the optical coherence tomography software and an image-processing program. Results: Epiretinal membrane surgery significantly improved stereopsis in ...

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    5. Vascular Response After Zilver PTX Stent Implantation for Superficial Femoral Artery Lesions Serial Optical Coherence Tomography Findings at 6 and 12 Months

      Vascular Response After Zilver PTX Stent Implantation for Superficial Femoral Artery Lesions Serial Optical Coherence Tomography Findings at 6 and 12 Months

      Purpose: To compare the vascular response after paclitaxel-coated nitinol drug-eluting stent (Zilver PTX) implantation for superficial femoral artery lesions after 6 and 12 months using optical coherence tomography (OCT). Methods: Serial OCT examinations were performed in 5 patients (4 men; mean age 78.4±6.8 years) with 9 Zilver PTX stents at 6- and 12-month follow-up. Variables evaluated included neointimal thickness and apposition on each strut, the incidence of extrastent lumen (ESL), peristrut low-intensity area (PLIA), and neovascularization at 1-mm intervals. Results: A total of 249 matched cross-section images were evaluated and included 4788 and 4826 struts at 6 ...

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    6. In Vivo Evaluation of Fibrous Cap Thickness by Optical Coherence Tomography for Positive Remodeling and Low-attenuation Plaques Assessed by Computed Tomography Angiography

      In Vivo Evaluation of Fibrous Cap Thickness by Optical Coherence Tomography for Positive Remodeling and Low-attenuation Plaques Assessed by Computed Tomography Angiography
      ...es by this author Correspondence * Corresponding author at: Cardiovascular Division, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan. correspondence x Akira Sato Search for artic...
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    7. Optical Coherence Tomography Apparatus For Selectively Visualizing And Analyzing Choroid Vascular Plexus, And IMAGE-PROCESSING Program And IMAGE-PROCESSING Method Therefor

      Optical Coherence Tomography Apparatus For Selectively Visualizing And Analyzing Choroid Vascular Plexus, And IMAGE-PROCESSING Program And IMAGE-PROCESSING Method Therefor

      From OCT measurement data, image data for only the choroid vascular plexus present in the choroid layer is selectively extracted and the size of the choroid blood vessels and thickness of the choroid vascular plexus are obtained accurately from the image data, making quantitative evaluation of the choroid vascular plexus possible. The optical coherence tomography apparatus is provided with an optical coherence tomograph and a computer for performing image-processing on the three-dimensional OCT tomographic image obtained on the basis of the OCT measurement data acquired by the optical coherence tomogrph. The computer functions as a means for selectively isolating only ...

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    8. Two beams formed by Wollaston prism in sample arm in an optical coherence tomography apparatus

      Two beams formed by Wollaston prism in sample arm in an optical coherence tomography apparatus

      The scanning speed of a sample in Doppler OCT, etc., is increased to enable quick measurement of blood flow rate, blood flow volume, etc. Wideband light from a light source 2 is linearly polarized by a polarization controller 3 and this linearly polarized beam is split into vertically polarized light and horizontally polarized light using a Wollaston prism 14 at a sample arm, which are then irradiated simultaneously onto two different locations of the sample in the scanning direction using a galvanometer mirror 18, and reference light from a reference arm 5 and object light from a sample arm 6 ...

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    9. Noninvasive Evaluation of Phase Retardation in Blebs after Glaucoma Surgery Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography

      Noninvasive Evaluation of Phase Retardation in Blebs after Glaucoma Surgery Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography
      ... 3. ^3Computational Optics Group, University of Tsukuba, Tsukuba, 305-8575, Japan 4. ^4Ophthalmology, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan 5. ^5Ophthalmology, University o...
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    10. Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography
      ...University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8573, Japan 5. ^5Computational Optics Group, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8571, Japan 1. ↵* Computational Optics Grou...
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  2. About University of Tsukuba

    University of Tsukuba

    University of Tsukuba is located in the city of Tsukuba. The university is ranked one of the top Asian universities in the "Academic Ranking of World Universities" and is ranked 102-150 in the world. The University of Tsukuba has had several Nobel Prize winners so far, namely Leo Esaki, Hideki Shirakawa and Sin-Itiro Tomonaga, which is extremely rare among universities in Asia, where there have been fewer Nobel laureates than in European and American universities. 

    The Computational Optics Group (COG)  at the University of Tsukuba formed in 1999 as a division of applied optics laboratory, institute of applied physics, university of Tsukuba. On that moment we were not COG but spatio-temporal optics group, and our main research subject was spatio-temporal optical computing.   In 2000, we started a optical measurement project using spatio-temporal optical computing technologies, and in 2002, we changed our direction to more computationally.   Since 2002, our main research interest is computer assisted optical measurment. We are trying to introduce computational technologies into optical measurement.  Since 2007, we are an independent research group and no longer a part of Applied Optics Laboratory of University of Tsukuba.