1. University of Tsukuba

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    1. Mentioned In 179 Articles

    2. Non-destructive characterization of adult zebrafish models using Jones matrix optical coherence tomography

      Non-destructive characterization of adult zebrafish models using Jones matrix optical coherence tomography
      The zebrafish is a valuable vertebrate animal model in pre-clinical cancer research. A Jones matrix optical coherence tomography (JM-OCT) prototype operating at 1310 nm and an intensity-based spectral-domain OCT setup at 840 nm were utilized to investigate adult wildtype and a tumor-developing zebrafish model. Various anatomical features were characterized based on their inherent scattering and polarization signature. A motorized translation stage in combination with the JM-OCT prototype enabled large field-of-view ...
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    3. Evaluation of choroidal melanin-containing tissue in healthy Japanese subjects by polarization-sensitive optical coherence tomography

      Evaluation of choroidal melanin-containing tissue in healthy Japanese subjects by polarization-sensitive optical coherence tomography
      In this study, the choroidal melanin content in healthy eyes was evaluated with polarization-sensitive optical coherence tomography (PS-OCT). We evaluated 105 healthy eyes of 105 Japanese subjects. The mean thickness of melanin-containing tissue in the choroid (thickness of MeCh) and the choroidal melanin occupancy rate within a 5-mm circular region from the foveal center were calculated using the degree of polarization uniformity obtained by PS-OCT and compared with the choroidal ...
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    4. Objective evaluation of choroidal melanin loss in patients with Vogt–Koyanagi–Harada disease using polarization-sensitive optical coherence tomography

      Objective evaluation of choroidal melanin loss in patients with Vogt–Koyanagi–Harada disease using polarization-sensitive optical coherence tomography
      In this study, sunset glow fundus was evaluated in patients with Vogt-Koyanagi-Harada (VKH) disease using polarization-sensitive optical coherence tomography (PS-OCT). We evaluated 40 VKH eyes (20 patients) and 59 healthy eyes (59 age-matched controls). VKH eyes were divided into three groups according to color fundus images: sunset (17 eyes), potential sunset (13 eyes), and non-sunset (10 eyes). Choroidal melanin thickness (ChMeT) and the choroidal melanin thickness ratio (ChMeTratio) were calculated ...
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    5. Multicontrast investigation of in vivo wildtype zebrafish in three development stages using polarization-sensitive optical coherence tomography

      Multicontrast investigation of in vivo wildtype zebrafish in three development stages using polarization-sensitive optical coherence tomography
      Significance: The scattering and polarization characteristics of various organs of in vivo wildtype zebrafish in three development stages were investigated using a non-destructive and label-free approach. The presented results showed a promising first step for the usability of Jones-matrix optical coherence tomography (JM-OCT) in zebrafish-based research. Aim: We aim to visualize and quantify the scatter and polarization signatures of various zebrafish organs for larvae, juvenile, and young adult animals in ...
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    6. Visualization of Anterior Chamber Angle Structures With Scattering- and Polarization-Sensitive Anterior Segment Optical Coherence Tomography

      Visualization of Anterior Chamber Angle Structures With Scattering- and Polarization-Sensitive Anterior Segment Optical Coherence Tomography
      Purpose: The purpose of this study was to compare three optical coherence tomography (OCT) modalities in the observation of anterior chamber angle structures; trabecular meshwork (TM), Schlemm's canal (SC), and band of extracanalicular limbal lamina (BELL). Methods: Three OCT modalities were used: (1) 2 2 Jones-matrix scattering OCT (S-OCT) representing conventional intensity OCT, (2) polarization-diverse S-OCT that was calculated as summation of all elements of the Jones-matrix to eliminate ...
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    7. Deep convolutional neural network-based scatterer density and resolution estimators in optical coherence tomography

      Deep convolutional neural network-based scatterer density and resolution estimators in optical coherence tomography
      We present deep convolutional neural network (DCNN)-based estimators of the tissue scatterer density (SD), lateral and axial resolutions, signal-to-noise ratio (SNR), and effective number of scatterers (ENS, the number of scatterers within a resolution volume). The estimators analyze the speckle pattern of an optical coherence tomography (OCT) image in estimating these parameters. The DCNN is trained by a large number (1,280,000) of image patches that are fully ...
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    8. Three-dimensional dynamics optical coherence tomography for tumor spheroid evaluation

      Three-dimensional dynamics optical coherence tomography for tumor spheroid evaluation
      We present a completely label-free three-dimensional (3D) optical coherence tomography (OCT)-based tissue dynamics imaging method for visualization and quantification of the metabolic and necrotic activities of tumor spheroid. Our method is based on a custom 3D scanning protocol that is designed to capture volumetric tissue dynamics tomography images only in a few tens of seconds. The method was applied to the evaluation of a tumor spheroid. The time-course viability ...
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    9. Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography

      Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography
      We demonstrate label-free imaging of the functional and structural properties of microvascular complex in mice liver. The imaging was performed by a custom-built Jones-matrix based polarization sensitive optical coherence tomography (JM-OCT), which is capable of measuring tissue's attenuation coefficient, birefringence, and tiny tissue dynamics. Two longitudinal studies comprising a healthy liver and an early fibrotic liver model were performed. In the healthy liver, we observed distinctive high dynamics beneath ...
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    10. Computational multi-directional optical coherence tomography for visualizing the microstructural directionality of the tissue

      Computational multi-directional optical coherence tomography for visualizing the microstructural directionality of the tissue
      We demonstrate computational multi-directional optical coherence tomography (OCT) to assess the directional property of tissue microstructure. This method is the combination of phase-sensitive volumetric OCT imaging and post-signal processing. The latter comprises of two steps. The first step is an intensity-directional analysis, which determines the dominant en face fiber orientations. The second step is the phase-directional imaging, which reveals the sub-resolution depth-orientation of the microstructure. The feasibility of the method ...
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    11. Effect of A-scan rate and interscan interval on optical coherence angiography

      Effect of A-scan rate and interscan interval on optical coherence angiography
      Optical coherence tomography angiography (OCTA) can provide rapid, volumetric, and noninvasive imaging of tissue microvasculature without the requirement of exogenous contrast agents. To investigate how A-scan rate and interscan time affected the contrast and dynamic range of OCTA, we developed a 1.06-m swept-source OCT system enabling 100-kHz or 200-kHz OCT using two light sources. After system settings were carefully adjusted, almost the same detection sensitivity was achieved between the ...
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    12. Accurately motion-corrected Lissajous OCT with multi-type image registration

      Accurately motion-corrected Lissajous OCT with multi-type image registration
      Passive motion correction methods for optical coherence tomography (OCT) use image registration to estimate eye movements. To improve motion correction, a multi-image cross-correlation that employs spatial features in different image types is introduced. Lateral motion correction using en face OCT and OCT-A projections on Lissajous-scanned OCT data is applied. Motion correction using OCT-A projection of whole depth and OCT amplitude, OCT logarithmic intensity, and OCT maximum intensity projections were evaluated ...
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    13. Optical coherence tomography angiography and Humphrey field analyser for macular capillary non-perfusion evaluation in branch retinal vein occlusion

      Optical coherence tomography angiography and Humphrey field analyser for macular capillary non-perfusion evaluation in branch retinal vein occlusion
      We non-invasively evaluated macular non-perfused areas (m-NPAs) of branch retinal vein occlusion (BRVO) using optical coherence tomography (OCT) angiography and the Humphrey visual field analyser 10-2 programme (HFA 10-2). We enrolled 30 patients (30 eyes) with macular oedema secondary to BRVO. OCT angiography was used to photograph the macula at 6 6-mm; sizes of m-NPAs in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were measured in four ...
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    14. In vivo evaluation of coronary arteritis by serial optical coherence tomography in large vessel vasculitis

      In vivo evaluation of coronary arteritis by serial optical coherence tomography in large vessel vasculitis
      A 74-year-old man with acute coronary syndrome underwent emergency percutaneous coronary intervention with the implantation of everolimus-eluting stents for severe stenosis in proximal left ascending coronary artery (LAD) ( Panel A , red arrows). Coronary angiography (CAG) revealed mild stenosis in proximal right coronary artery (RCA) and severe stenosis in distal LAD ( Panel A , yellow arrows, Supplementary material online, Video S1 ). Optical coherence tomography (OCT) showed diffusely thickened homogenous intima in mid-LAD ...
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  2. About University of Tsukuba

    University of Tsukuba

    University of Tsukuba is located in the city of Tsukuba. The university is ranked one of the top Asian universities in the "Academic Ranking of World Universities" and is ranked 102-150 in the world. The University of Tsukuba has had several Nobel Prize winners so far, namely Leo Esaki, Hideki Shirakawa and Sin-Itiro Tomonaga, which is extremely rare among universities in Asia, where there have been fewer Nobel laureates than in European and American universities. 

    The Computational Optics Group (COG)  at the University of Tsukuba formed in 1999 as a division of applied optics laboratory, institute of applied physics, university of Tsukuba. On that moment we were not COG but spatio-temporal optics group, and our main research subject was spatio-temporal optical computing.   In 2000, we started a optical measurement project using spatio-temporal optical computing technologies, and in 2002, we changed our direction to more computationally.   Since 2002, our main research interest is computer assisted optical measurment. We are trying to introduce computational technologies into optical measurement.  Since 2007, we are an independent research group and no longer a part of Applied Optics Laboratory of University of Tsukuba.