1. University of Tsukuba

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    1. Mentioned In 166 Articles

    2. In vivo evaluation of coronary arteritis by serial optical coherence tomography in large vessel vasculitis

      In vivo evaluation of coronary arteritis by serial optical coherence tomography in large vessel vasculitis
      A 74-year-old man with acute coronary syndrome underwent emergency percutaneous coronary intervention with the implantation of everolimus-eluting stents for severe stenosis in proximal left ascending coronary artery (LAD) ( Panel A , red arrows). Coronary angiography (CAG) revealed mild stenosis in proximal right coronary artery (RCA) and severe stenosis in distal LAD ( Panel A , yellow arrows, Supplementary material online, Video S1 ). Optical coherence tomography (OCT) showed diffusely thickened homogenous intima in mid-LAD ...
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    3. Optical coherence tomography-based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroids

      Optical coherence tomography-based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroids
      We present optical coherence tomography (OCT)-based tissue dynamics imaging method to visualize and quantify tissue dynamics such as subcellular motion based on statistical analysis of rapid-time-sequence OCT signals at the same location. The analyses include logarithmic intensity variance (LIV) method and two types of OCT correlation decay speed analysis (OCDS). LIV is sensitive to the magnitude of the signal fluctuations, while OCDSs including early- and late-OCDS (OCDS e and ...
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    4. Quantitative multi-contrast in vivo mouse imaging with polarization diversity optical coherence tomography and angiography

      Quantitative multi-contrast in vivo mouse imaging with polarization diversity optical coherence tomography and angiography
      Retinal microvasculature and the retinal pigment epithelium (RPE) play vital roles in maintaining the health and metabolic activity of the eye. Visualization of these retina structures is essential for pre-clinical studies of vision-robbing diseases, such as age-related macular degeneration (AMD). We have developed a quantitative multi-contrast polarization diversity OCT and angiography (QMC-PD-OCTA) system for imaging and visualizing pigment in the RPE using degree of polarization uniformity (DOPU), along with flow ...
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    5. Clinical utility of morphofunctional correlation of microperimetry and optical coherence tomography

      Clinical utility of morphofunctional correlation of microperimetry and optical coherence tomography
      Purpose: To demonstrate the clinical and research value of a simplified technique enabling alignment of functional microperimetry data with retinal structure imaged by eye-tracked optical coherence tomography (OCT) in eyes with macular disease. Methods: Normal and diseased eyes underwent sequential Spectralis OCT macular raster scans and Macular Integrity Assessment (MAIA) microperimetry using both standard central 10 analysis and custom scan patterns. The microperimetry data were imported into Spectralis research software ...
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    6. Depth‐resolved investigation of multiple optical properties and wrinkle morphology in eye‐corner areas with multi‐contrast Jones matrix optical coherence tomography

      Depth‐resolved investigation of multiple optical properties and wrinkle morphology in eye‐corner areas with multi‐contrast Jones matrix optical coherence tomography
      Background Multi‐contrast Jones matrix optical coherence tomography (JM‐OCT) can provide quantitative depth‐resolved local optical properties by improving the measurement algorithm. Materials and methods We examined the relationship between depth‐resolved local optical properties of eye‐corner skin measured by JM‐OCT and corresponding wrinkle morphology of aged women (n = 21; age range, 71.7 1.7 years). Wrinkle morphology was analyzed by measuring the surface topography of ...
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    7. In Vivo Evaluation of Tissue Protrusion by Using Optical Coherence Tomography and Coronary Angioscopy Immediately After Stent Implantation

      In Vivo Evaluation of Tissue Protrusion by Using Optical Coherence Tomography and Coronary Angioscopy Immediately After Stent Implantation
      Background: The relationship between the characteristics of tissue protrusion detected by using optical coherence tomography (OCT) and the findings of coronary angioscopy (CAS) immediately after stent implantation were evaluated. Methods and Results: A total of 186 patients (192 stents) underwent OCT before and after stenting and were observed by using CAS immediately after stenting and at the chronic phase. Patients were assigned to irregular protrusion, smooth protrusion, and disrupted fibrous ...
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    8. Bulk-phase-error correction for phase-sensitive signal processing of optical coherence tomography

      Bulk-phase-error correction for phase-sensitive signal processing of optical coherence tomography
      We present a numerical phase stabilization method for phase-sensitive signal processing of optical coherence tomography (OCT). This method removes the bulk phase error caused by the axial bulk motion of the sample and the environmental perturbation during volumetric acquisition. In this method, the partial derivatives of the phase error are computed along both fast and slow scanning directions, so that the vectorial gradient field of the phase error is given ...
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    9. Optical coherence tomography interpreted by diffractive optics: A-scan image formation with wavelength-scale diffraction gratings as samples

      Optical coherence tomography interpreted by diffractive optics: A-scan image formation with wavelength-scale diffraction gratings as samples
      Seeking a detailed investigation of polarization sensitive optical coherence tomography, electromagnetic numerical simulation of optical coherence tomography is carried out assuming deep diffraction gratings, some of which are in the resonance domain, as a sample to be measured. This is an approach from diffractive optics, and its simplification of the problem makes analysis more focused on its fundamental nature. The combination of the two disciplines provides previously unnoticed issues such ...
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    10. Jones matrix OCT system and program for carrying out image processing on measured data obtained by said OCT

      Jones matrix OCT system and program for carrying out image processing on measured data obtained by said OCT
      A Jones matrix OCT offers improved image stability, image quality, and depth range of image, wherein light from a wavelength-scanning light source is split into two optical paths, and a reference arm is provided along one optical path, while a probe arm that irradiates and reflects light onto the measuring target to generate object light is provided along the other optical path. The probe arm has a polarization delay unit ...
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    11. Polarization-sensitive optical coherence elastography

      Polarization-sensitive optical coherence elastography
      Polarization-sensitive optical coherence elastography (PS-OCE) is developed for improved tissue discrimination. It integrates Jones matrix-based PS-optical coherence tomography (PS-OCT) with compression OCE. The method simultaneously measures the OCT intensity, attenuation coefficient, birefringence, and microstructural deformation (MSD) induced by tissue compression. Ex vivo porcine aorta and esophagus tissues were investigated by PS-OCE and histological imaging. The tissue properties measured by PS-OCE are shown as cross-sectional images and a three-dimensional (3-D) depth-trajectory ...
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    12. Evaluation of Retinal Pigment Epithelium Layer Change in Vogt-Koyanagi-Harada Disease With Multicontrast Optical Coherence Tomography

      Evaluation of Retinal Pigment Epithelium Layer Change in Vogt-Koyanagi-Harada Disease With Multicontrast Optical Coherence Tomography
      Purpose : Clinical evaluation of retinal pigment epithelium (RPE) change is important for the therapeutic management of chronic Vogt-Koyanagi-Harada (VKH) disease. We evaluated long-term change in the RPE layer in VKH disease, using near-infrared (NIR; 817 nm) images and autofluorescence images at 488 nm (short-wavelength [SW]-AF) and 785 nm (NIR-AF), and compared those images with images from multicontrast optical coherence tomography (MC-OCT). MC-OCT is capable of simultaneous measurement of OCT ...
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    13. Multi-scale and -contrast sensorless adaptive optics optical coherence tomography

      Multi-scale and -contrast sensorless adaptive optics optical coherence tomography
      Background: The roles of the retinal microvasculature and the retinal pigment epithelium (RPE) in maintaining the health and metabolic activity of the retina lend great clinical value to their high-resolution visualization. Methods: By integrating polarization diversity detection (PDD) into multi-scale and -contrast sensorless adaptive optics optical coherence tomography (MSC-SAO-OCT), we have developed a novel multi-contrast SAO OCT system for imaging pigment in the RPE as well as flow in the ...
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    14. 1-15 of 166 1 2 3 4 ... 9 10 11 »
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  2. About University of Tsukuba

    University of Tsukuba

    University of Tsukuba is located in the city of Tsukuba. The university is ranked one of the top Asian universities in the "Academic Ranking of World Universities" and is ranked 102-150 in the world. The University of Tsukuba has had several Nobel Prize winners so far, namely Leo Esaki, Hideki Shirakawa and Sin-Itiro Tomonaga, which is extremely rare among universities in Asia, where there have been fewer Nobel laureates than in European and American universities. 

    The Computational Optics Group (COG)  at the University of Tsukuba formed in 1999 as a division of applied optics laboratory, institute of applied physics, university of Tsukuba. On that moment we were not COG but spatio-temporal optics group, and our main research subject was spatio-temporal optical computing.   In 2000, we started a optical measurement project using spatio-temporal optical computing technologies, and in 2002, we changed our direction to more computationally.   Since 2002, our main research interest is computer assisted optical measurment. We are trying to introduce computational technologies into optical measurement.  Since 2007, we are an independent research group and no longer a part of Applied Optics Laboratory of University of Tsukuba.