Purpose: To compare the vascular response after paclitaxel-coated nitinol drug-eluting stent (Zilver PTX) implantation for superficial femoral artery lesions after 6 and 12 months using optical coherence tomography (OCT). Methods: Serial OCT examinations were performed in 5 patients (4 men; mean age 78.4±6.8 years) with 9 Zilver PTX stents at 6- and 12-month follow-up. Variables evaluated included neointimal thickness and apposition on each strut, the incidence of extrastent lumen (ESL), peristrut low-intensity area (PLIA), and neovascularization at 1-mm intervals. Results: A total of 249 matched cross-section images were evaluated and included 4788 and 4826 struts at 6 ...

From OCT measurement data, image data for only the choroid vascular plexus present in the choroid layer is selectively extracted and the size of the choroid blood vessels and thickness of the choroid vascular plexus are obtained accurately from the image data, making quantitative evaluation of the choroid vascular plexus possible. The optical coherence tomography apparatus is provided with an optical coherence tomograph and a computer for performing image-processing on the three-dimensional OCT tomographic image obtained on the basis of the OCT measurement data acquired by the optical coherence tomogrph. The computer functions as a means for selectively isolating only ...

The scanning speed of a sample in Doppler OCT, etc., is increased to enable quick measurement of blood flow rate, blood flow volume, etc. Wideband light from a light source 2 is linearly polarized by a polarization controller 3 and this linearly polarized beam is split into vertically polarized light and horizontally polarized light using a Wollaston prism 14 at a sample arm, which are then irradiated simultaneously onto two different locations of the sample in the scanning direction using a galvanometer mirror 18, and reference light from a reference arm 5 and object light from a sample arm 6 ...

We report on a new articular cartilage imaging technique with potential for clinical arthroscopic use, by supplementing the variable-incidence-angle polarization-sensitive optical coherence tomography method (VIA-PS-OCT) previously developed by us with a conical beam scan protocol. In the protocol, the beam is scanned such that the k-vector sweeps out a conical surface whose apex is chosen, for convenience, to lie at the tissue surface. In the implementation reported here we achieve this by mounting the sample on a motorized rotation stage with the sample surface roughly parallel to the stage rotating plane (i.e. normal to the stage rotation axis). The ...

A 71-year-old man underwent endovascular therapy (EVT) with a paclitaxel-eluting stent in superficial femoral artery (SFA). Optical coherence tomography (OCT) of SFA at 2 months after EVT revealed that several struts were not covered with neointima. Moreover, some mural thrombi were detected within the stent. Although OCT revealed that the frequency of stent strut coverage was improved at the 4-month follow-up, uncovered stent strut still remained and some mural thrombi were observed within the stent even at 4 months after EVT. This is the first report to demonstrate the vascular response after paclitaxel-eluting stent placement for the lesion using serial ...

Optical coherence tomography has been proven in the last two decades its clinical value by providing 3D non-invasive in vivo biopsy of the biological samples. In addition to structural information given by the backscattered intensity, the optical absorption will also provide another powerful contrast. Optical absorbers in biological tissues exhibits important role such as hemoglobin and melanin. However, current methods of absorption contrast take long time and not suitable for in vivo imaging. Toward in vivo absorption contrast imaging, we developed photothermal OCT system by combining swept-source OCT system and excitation laser. A swept-source OCT system is used with a ...

There are several applications of quantitative micro-displacement measurement of a biological specimen, including characterization of mechanical property and monitoring a laser-induced photothermal expansion. In this study, we proposed a quantitative micro-displacement measurement method using optical coherence tomography (OCT). Specifically, the axial displacement is measured by Doppler OCT and magnitude of displacement is measured by correlation coefficient. By using this method, we measured the local and microdisplacement of the chicken muscles during laser irradiation. The proposed method successfully visualizes thermal changes of chicken muscle due to the laser irradiation. The measured displacement and deformation are useful information for the further understanding ...