1. University of Tsukuba

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    1. Mentioned In 173 Articles

    2. Three-dimensional dynamics optical coherence tomography for tumor spheroid evaluation

      Three-dimensional dynamics optical coherence tomography for tumor spheroid evaluation
      We present a completely label-free three-dimensional (3D) optical coherence tomography (OCT)-based tissue dynamics imaging method for visualization and quantification of the metabolic and necrotic activities of tumor spheroid. Our method is based on a custom 3D scanning protocol that is designed to capture volumetric tissue dynamics tomography images only in a few tens of seconds. The method was applied to the evaluation of a tumor spheroid. The time-course viability ...
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    3. Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography

      Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography
      We demonstrate label-free imaging of the functional and structural properties of microvascular complex in mice liver. The imaging was performed by a custom-built Jones-matrix based polarization sensitive optical coherence tomography (JM-OCT), which is capable of measuring tissue's attenuation coefficient, birefringence, and tiny tissue dynamics. Two longitudinal studies comprising a healthy liver and an early fibrotic liver model were performed. In the healthy liver, we observed distinctive high dynamics beneath ...
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    4. Computational multi-directional optical coherence tomography for visualizing the microstructural directionality of the tissue

      Computational multi-directional optical coherence tomography for visualizing the microstructural directionality of the tissue
      We demonstrate computational multi-directional optical coherence tomography (OCT) to assess the directional property of tissue microstructure. This method is the combination of phase-sensitive volumetric OCT imaging and post-signal processing. The latter comprises of two steps. The first step is an intensity-directional analysis, which determines the dominant en face fiber orientations. The second step is the phase-directional imaging, which reveals the sub-resolution depth-orientation of the microstructure. The feasibility of the method ...
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    5. Effect of A-scan rate and interscan interval on optical coherence angiography

      Effect of A-scan rate and interscan interval on optical coherence angiography
      Optical coherence tomography angiography (OCTA) can provide rapid, volumetric, and noninvasive imaging of tissue microvasculature without the requirement of exogenous contrast agents. To investigate how A-scan rate and interscan time affected the contrast and dynamic range of OCTA, we developed a 1.06-m swept-source OCT system enabling 100-kHz or 200-kHz OCT using two light sources. After system settings were carefully adjusted, almost the same detection sensitivity was achieved between the ...
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    6. Accurately motion-corrected Lissajous OCT with multi-type image registration

      Accurately motion-corrected Lissajous OCT with multi-type image registration
      Passive motion correction methods for optical coherence tomography (OCT) use image registration to estimate eye movements. To improve motion correction, a multi-image cross-correlation that employs spatial features in different image types is introduced. Lateral motion correction using en face OCT and OCT-A projections on Lissajous-scanned OCT data is applied. Motion correction using OCT-A projection of whole depth and OCT amplitude, OCT logarithmic intensity, and OCT maximum intensity projections were evaluated ...
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    7. Optical coherence tomography angiography and Humphrey field analyser for macular capillary non-perfusion evaluation in branch retinal vein occlusion

      Optical coherence tomography angiography and Humphrey field analyser for macular capillary non-perfusion evaluation in branch retinal vein occlusion
      We non-invasively evaluated macular non-perfused areas (m-NPAs) of branch retinal vein occlusion (BRVO) using optical coherence tomography (OCT) angiography and the Humphrey visual field analyser 10-2 programme (HFA 10-2). We enrolled 30 patients (30 eyes) with macular oedema secondary to BRVO. OCT angiography was used to photograph the macula at 6 6-mm; sizes of m-NPAs in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were measured in four ...
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    8. In vivo evaluation of coronary arteritis by serial optical coherence tomography in large vessel vasculitis

      In vivo evaluation of coronary arteritis by serial optical coherence tomography in large vessel vasculitis
      A 74-year-old man with acute coronary syndrome underwent emergency percutaneous coronary intervention with the implantation of everolimus-eluting stents for severe stenosis in proximal left ascending coronary artery (LAD) ( Panel A , red arrows). Coronary angiography (CAG) revealed mild stenosis in proximal right coronary artery (RCA) and severe stenosis in distal LAD ( Panel A , yellow arrows, Supplementary material online, Video S1 ). Optical coherence tomography (OCT) showed diffusely thickened homogenous intima in mid-LAD ...
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    9. Optical coherence tomography-based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroids

      Optical coherence tomography-based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroids
      We present optical coherence tomography (OCT)-based tissue dynamics imaging method to visualize and quantify tissue dynamics such as subcellular motion based on statistical analysis of rapid-time-sequence OCT signals at the same location. The analyses include logarithmic intensity variance (LIV) method and two types of OCT correlation decay speed analysis (OCDS). LIV is sensitive to the magnitude of the signal fluctuations, while OCDSs including early- and late-OCDS (OCDS e and ...
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    10. Quantitative multi-contrast in vivo mouse imaging with polarization diversity optical coherence tomography and angiography

      Quantitative multi-contrast in vivo mouse imaging with polarization diversity optical coherence tomography and angiography
      Retinal microvasculature and the retinal pigment epithelium (RPE) play vital roles in maintaining the health and metabolic activity of the eye. Visualization of these retina structures is essential for pre-clinical studies of vision-robbing diseases, such as age-related macular degeneration (AMD). We have developed a quantitative multi-contrast polarization diversity OCT and angiography (QMC-PD-OCTA) system for imaging and visualizing pigment in the RPE using degree of polarization uniformity (DOPU), along with flow ...
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    11. Clinical utility of morphofunctional correlation of microperimetry and optical coherence tomography

      Clinical utility of morphofunctional correlation of microperimetry and optical coherence tomography
      Purpose: To demonstrate the clinical and research value of a simplified technique enabling alignment of functional microperimetry data with retinal structure imaged by eye-tracked optical coherence tomography (OCT) in eyes with macular disease. Methods: Normal and diseased eyes underwent sequential Spectralis OCT macular raster scans and Macular Integrity Assessment (MAIA) microperimetry using both standard central 10 analysis and custom scan patterns. The microperimetry data were imported into Spectralis research software ...
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    12. Depth‐resolved investigation of multiple optical properties and wrinkle morphology in eye‐corner areas with multi‐contrast Jones matrix optical coherence tomography

      Depth‐resolved investigation of multiple optical properties and wrinkle morphology in eye‐corner areas with multi‐contrast Jones matrix optical coherence tomography
      Background Multi‐contrast Jones matrix optical coherence tomography (JM‐OCT) can provide quantitative depth‐resolved local optical properties by improving the measurement algorithm. Materials and methods We examined the relationship between depth‐resolved local optical properties of eye‐corner skin measured by JM‐OCT and corresponding wrinkle morphology of aged women (n = 21; age range, 71.7 1.7 years). Wrinkle morphology was analyzed by measuring the surface topography of ...
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    13. In Vivo Evaluation of Tissue Protrusion by Using Optical Coherence Tomography and Coronary Angioscopy Immediately After Stent Implantation

      In Vivo Evaluation of Tissue Protrusion by Using Optical Coherence Tomography and Coronary Angioscopy Immediately After Stent Implantation
      Background: The relationship between the characteristics of tissue protrusion detected by using optical coherence tomography (OCT) and the findings of coronary angioscopy (CAS) immediately after stent implantation were evaluated. Methods and Results: A total of 186 patients (192 stents) underwent OCT before and after stenting and were observed by using CAS immediately after stenting and at the chronic phase. Patients were assigned to irregular protrusion, smooth protrusion, and disrupted fibrous ...
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    14. Bulk-phase-error correction for phase-sensitive signal processing of optical coherence tomography

      Bulk-phase-error correction for phase-sensitive signal processing of optical coherence tomography
      We present a numerical phase stabilization method for phase-sensitive signal processing of optical coherence tomography (OCT). This method removes the bulk phase error caused by the axial bulk motion of the sample and the environmental perturbation during volumetric acquisition. In this method, the partial derivatives of the phase error are computed along both fast and slow scanning directions, so that the vectorial gradient field of the phase error is given ...
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    15. 1-15 of 173 1 2 3 4 ... 10 11 12 »
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  2. About University of Tsukuba

    University of Tsukuba

    University of Tsukuba is located in the city of Tsukuba. The university is ranked one of the top Asian universities in the "Academic Ranking of World Universities" and is ranked 102-150 in the world. The University of Tsukuba has had several Nobel Prize winners so far, namely Leo Esaki, Hideki Shirakawa and Sin-Itiro Tomonaga, which is extremely rare among universities in Asia, where there have been fewer Nobel laureates than in European and American universities. 

    The Computational Optics Group (COG)  at the University of Tsukuba formed in 1999 as a division of applied optics laboratory, institute of applied physics, university of Tsukuba. On that moment we were not COG but spatio-temporal optics group, and our main research subject was spatio-temporal optical computing.   In 2000, we started a optical measurement project using spatio-temporal optical computing technologies, and in 2002, we changed our direction to more computationally.   Since 2002, our main research interest is computer assisted optical measurment. We are trying to introduce computational technologies into optical measurement.  Since 2007, we are an independent research group and no longer a part of Applied Optics Laboratory of University of Tsukuba.