1. University of Toronto

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    1. Mentioned In 187 Articles

    2. Optical Coherence Tomography as an Adjunct During Carotid Artery Stenting for Carotid Atherosclerotic Disease

      Optical Coherence Tomography as an Adjunct During Carotid Artery Stenting for Carotid Atherosclerotic Disease
      Purpose Carotid artery stenting (CAS) has been proven to decrease the risk of stroke in symptomatic patients with moderate/high-grade carotid stenosis; however, there is an increased periprocedural risk of stroke with CAS compared to carotid endarterectomy. The goal of this article is to report the utilization of endovascular optical coherence tomography (OCT) during CAS to aid in the identification of stent malapposition, plaque prolapse, and adjacent residual thrombus that ...
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    3. 2D MEMS-based high-speed beam-shifting technique for speckle noise reduction and flow rate measurement in optical coherence tomography

      2D MEMS-based high-speed beam-shifting technique for speckle noise reduction and flow rate measurement in optical coherence tomography
      In this manuscript, a two-dimensional (2D) micro-electro-mechanical system (MEMS)-based, high-speed beam-shifting spectral domain optical coherence tomography (MHB-SDOCT) is proposed for speckle noise reduction and absolute flow rate measurement. By combining a zigzag scanning protocol, the frame rates of 45.2 Hz for speckle reduction and 25.6 Hz for flow rate measurement are achieved for in-vivo tissue imaging. Phantom experimental results have shown that by setting the incident beam ...
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    4. Beam-shifting technique for speckle reduction and flow rate measurement in optical coherence tomography

      Beam-shifting technique for speckle reduction and flow rate measurement in optical coherence tomography
      In this Letter, we propose a beam-shifting optical coherence tomography scheme for speckle reduction and blood flow rate calculation, where variations of the speckle pattern and Doppler angle were generated by parallel shifting of the sample beam incident on the objective lens. The resultant optical coherent tomography images could then be averaged for speckle noise reduction and simultaneously analyzed for flow rate measurement. The performance of the proposed technique was ...
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    5. Buffer-averaging super-continuum source based spectral domain optical coherence tomography for high speed imaging

      Buffer-averaging super-continuum source based spectral domain optical coherence tomography for high speed imaging
      In super-continuum (SC) source based spectral domain optical coherence tomography (SC-SDOCT), the stability of the power spectral density (PSD) has a significant impact on OCT system sensitivity and image signal to noise ratio (SNR). High speed imaging decreases the camera's exposure time, thus each A-scan contained fewer laser pulse excited SC wideband emissions, resulting in a decrease of SNR. In this manuscript, we present a buffer-averaging SC-SDOCT (BASC-SDOCT) to ...
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    6. Investigating the reliability and clinical utility of minimally invasive portable electroretinography and optical coherence tomography techniques in children undergoing vigabatrin therapy (Thesis)

      Investigating the reliability and clinical utility of minimally invasive portable electroretinography and optical coherence tomography techniques in children undergoing vigabatrin therapy (Thesis)
      The antiepileptic drug for Infantile Spasms vigabatrin, has been associated with retinal toxicity in over one third of children treated. Young and non-verbal children cannot cooperate with conventional adult-oriented monitoring devices, therefore a safe and reliable technique to monitor for vigabatrin retinal toxicity is missing. This study evaluated the tolerability, reliability and clinical feasibility of two alternative, handheld systems for assessment of retinal function: the RETeval ERG and Envisu OCT ...
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    7. Preclinical quantitative in-vivo assessment of skin tissue vascularity in radiation-induced fibrosis with optical coherence tomography

      Preclinical quantitative in-vivo assessment of skin tissue vascularity in radiation-induced fibrosis with optical coherence tomography
      Radiation therapy (RT) is widely and effectively used for cancer treatment but can also cause deleterious side effects, such as a late-toxicity complication called radiation-induced fibrosis (RIF). Accurate diagnosis of RIF requires analysis of histological sections to assess extracellular matrix infiltration. This is invasive, prone to sampling limitations, and thus rarely used; instead, current practice relies on subjective clinical surrogates, including visual observation, palpation, and patient symptomatology questionnaires. This preclinical ...
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    8. Vision and visual potential for perifoveal retinoblastoma after optical coherence tomographic-guided sequential laser photocoagulation

      Vision and visual potential for perifoveal retinoblastoma after optical coherence tomographic-guided sequential laser photocoagulation
      Background/aims To assess tumour control, vision and anatomical visual potential in eyes with perifoveal retinoblastoma treated by sequential photocoagulation from the antifoveal tumour edge inwards, avoiding treatment near the fovea. Patients were monitored for tumour control, foveal and perifoveal anatomy at each treatment session by optical coherence tomography (OCT) and treated for amblyopia when the other eye had better vision. Methods Eyes with perifoveal retinoblastoma treated between 1 January ...
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    9. Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use

      Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use
      This work is dedicated to the development of the OCT system with angiography for everyday clinical use. Two major problems were solved during the development: compensation of specific natural tissue displacements, induced by contact scanning mode and physiological motion of patients (eg, respiratory and cardiac motions) and online visualization of vessel cross‐sections to provide feedback for the system operator.
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    10. Cross-Polarization Optical Coherence Tomography with Active Maintenance of the Circular Polarization of a Sounding Wave in a Common Path System

      Cross-Polarization Optical Coherence Tomography with Active Maintenance of the Circular Polarization of a Sounding Wave in a Common Path System
      We consider a cross-polarization optical coherence tomography system with a common path for the sounding and reference waves and active maintenance of the circular polarization of a sounding wave. The system is based on the formation of birefringent characteristics of the total optical path, which are equivalent to a quarter-wave plate with a 45 orientation of its optical axes with respect to the linearly polarized reference wave. Conditions under which ...
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    11. Alternative Contrast Mechanism in Optical Coherence Tomography: Temporal Speckle Synchronization Effects

      Alternative Contrast Mechanism in Optical Coherence Tomography: Temporal Speckle Synchronization Effects
      We propose an alternative optical coherence tomography (OCT) contrast mechanism based on analysis of speckle temporal synchronization using B-mode OCT structural images. We show that the changes in synchronized speckle intensities with time may be used to distinguish between different tissue types, thus providing a novel and potentially useful contrast for OCT imaging. The developed methodology is tested in scattering flow phantoms, and in vivo on cervical cancer tumour grown ...
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    12. Quantitative Cross-Polarization Optical Coherence Tomography Detection of Infiltrative Tumor Margin in a Rat Glioma Model: a Pilot Study

      Quantitative Cross-Polarization Optical Coherence Tomography Detection of Infiltrative Tumor Margin in a Rat Glioma Model: a Pilot Study
      Determining boundaries of infiltrative glial tumors remains a challenging problem in neurooncology. Optical coherence tomography (OCT) with cross-polarization (CP) visualization is a promising technique as a surgical guidance tool. However, the outcome of the procedures performed under OCT guidance strongly depends on the surgeons qualification. Thus, a quantitative method for assessing resection margins with OCT is required. The aim of this study was to develop a robust quantitative approach for ...
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    13. Ultrasound and Infrared-Based Imaging Modalities for Diagnosis and Management of Cutaneous Diseases

      Ultrasound and Infrared-Based Imaging Modalities for Diagnosis and Management of Cutaneous Diseases
      Non-invasive bedside imaging tools are becoming more prevalent for assessing cutaneous lesions. Ultrasound used at specific frequencies allows us to assess margins of lesions to minimize the extent of the biopsy that is performed and improve cosmetic outcomes. Vascularity, seen on Doppler ultrasound and contrast-enhanced ultrasound, and stiffness, assessed on tissue elastography, can help differentiate between benign and malignant lesions for clinicians to be more judicious in deciding whether to ...
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    14. Preclinical longitudinal imaging of tumor microvascular radiobiological response with functional optical coherence tomography

      Preclinical longitudinal imaging of tumor microvascular radiobiological response with functional optical coherence tomography
      Radiation therapy (RT) is widely used for cancer treatment, alone or in combination with other therapies. Recent RT advances have revived interest in delivering higher dose in fewer fractions, which may invoke both cellular and microvascular damage mechanisms. Microvasculature may thus be a potentially sensitive functional biomarker of RT early response, especially for such emerging RT treatments. However it is difficult to measure directly and non-invasively, and its time course ...
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    15. In-vivo longitudinal imaging of microvascular changes in irradiated oral mucosa of radiotherapy cancer patients using optical coherence tomography

      In-vivo longitudinal imaging of microvascular changes in irradiated oral mucosa of radiotherapy cancer patients using optical coherence tomography
      Mucositis is the limiting toxicity of radio(chemo)therapy of head and neck cancer. Diagnostics, prophylaxis and correction of this condition demand new accurate and objective approaches. Here we report on an in vivo longitudinal monitoring of the oral mucosa dynamics in 25 patients during the course of radiotherapy of oropharyngeal and nasopharyngeal cancer using multifunctional optical coherence tomography (OCT). A spectral domain OCT system with a specially-designed oral imaging ...
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    16. 1-15 of 187 1 2 3 4 ... 11 12 13 »
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  2. About University of Toronto

    University of Toronto

    The University of Toronto (U of T) is a public research university in Toronto, Ontario, Canada. The university's main campus, St. George, is located in Downtown Toronto surrounding Queen's Park and the Ontario Legislature. Its two other campuses, the University of Toronto Scarborough (UTSC) and the University of Toronto at Mississauga (UTM, also informally referred to as "Erindale Campus"), are located in the eastern and western ends, respectively, of the Greater Toronto Area.   The institution was founded as King's College by John Strachan, and was granted its Royal Charter in 1827. Its name was changed to the University of Toronto in 1849, after it ended ties with the Church of England to become a secular institution. University College was created as a constituent college in 1853, and over time, the formerly independent Trinity College, Victoria University and St. Michael's College became federated with the university.  A 2006 university ranking by Newsweek International ranks the University of Toronto 1st in Canada, 18th worldwide, and 5th outside of the United States. Similar academic rankings consistently place the university among the world's best. Research at the University of Toronto has been responsible for the world's first electronic heart pacemaker, artificial larynx, single-lung transplant, nerve transplant, artificial pancreas, chemical laser, G-suit, the first practical electron microscope, the first cloning of T-cells, and the extraction of insulin."