1. University of Toronto

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    1. Mentioned In 199 Articles

    2. Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study

      Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study
      Microvascular networks of human basal cell carcinomas (BCC) and surrounding skin were assessed with optical coherence angiography (OCA) in conjunction with photodynamic therapy (PDT). OCA images were collected and analyzed in 31 lesions pre-treatment, and immediately/24hours/312 months post-treatment. Pre-treatment OCA enabled differentiation between prevalent subtypes of BCC (nodular and superficial) and nodular-with-necrotic-core BCC subtypes with a diagnostic accuracy of 78%; this can facilitate more accurate biopsy reducing sampling ...
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    3. Gabor optical coherence tomographic angiography (GOCTA) (Part II): theoretical basis of sensitivity improvement and optimization for processing speed

      Gabor optical coherence tomographic angiography (GOCTA) (Part II): theoretical basis of sensitivity improvement and optimization for processing speed
      We previously proposed a Gabor optical coherence tomography angiography (GOCTA) algorithm for spectral domain optical coherence tomography (SDOCT) to extract microvascular signals from spectral fringes directly, with speed improvement of 4 to 20 times over existing methods. In this manuscript, we explored the theoretical basis of GOCTA with comparison of experimental data using solid and liquid displacement sample targets, demonstrating that the majority of the GOCTA sensitivity advantage over speckle ...
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    4. Full‐field swept‐source optical coherence tomography and neural tissue classification for deep brain imagingv

      Full‐field swept‐source optical coherence tomography and neural tissue classification for deep brain imagingv
      Optical coherence tomography can differentiate brain regions with intrinsic contrast and at a micron scale resolution. Such a device can be particularly useful as a realtime neurosurgical guidance tool. We present, to our knowledge, the first full‐field swept‐source optical coherence tomography system operating near a wavelength of 1310 nm. The proof‐of‐concept system was integrated with an endoscopic probe tip, that is compatible with deep brain stimulation ...
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    5. VASCULAR PERFUSION DENSITY MAPPING USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY COMPARING NORMAL AND OPTIC DISK PIT EYES

      VASCULAR PERFUSION DENSITY MAPPING USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY COMPARING NORMAL AND OPTIC DISK PIT EYES
      Purpose: Optic disk pits (ODPs) are typically detected incidentally as small, gray, unilateral, oval-shaped excavation in the temporal optic disk on routine fundus examination. In this cross-sectional retrospective case series, we report optical coherence tomography angiography findings in patients with unilateral ODPs and describe changes in vessel perfusion associated with ODP. Methods: A total of eight eyes (four with ODP and four normal contralateral) were included in this study. Patients ...
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    6. Impact of velocity gradient in Poiseuille flow on the statistics of coherent radiation scattered by flowing Brownian particles in optical coherence tomography

      Impact of velocity gradient in Poiseuille flow on the statistics of coherent radiation scattered by flowing Brownian particles in optical coherence tomography
      A closed-form expression is obtained for the temporal correlation function of the scattered radiation detected in optical coherence tomography (OCT), taking into account the flow velocity gradient across the OCT detection volume in the suspension of flowing Brownian particles. The analytical approach we use includes both the laser beam and wavefront curvature radii changing over the depth. Also, we compare our results with a previously obtained theoretical model, partially an ...
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    7. Optical coherence tomography–guided flow diversion for aneurysmal treatment

      Optical coherence tomography–guided flow diversion for aneurysmal treatment
      A 28-year-old man presenting with right third nerve palsy was diagnosed with a giant unruptured aneurysm supplied by the right posterior communicating and cerebral arteries (figure 1, A and B). The aneurysm was treated with flow-diverting stent-assisted coiling. Two months later, he presented with new-onset left-sided weakness, and MRI showed increased edema in the thalamus (figure 1C) and increased aneurysm size and no filling. There was no evidence of stent ...
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    8. Validation of Optical Coherence Tomography Retinal Segmentation in Neurodegenerative Disease

      Validation of Optical Coherence Tomography Retinal Segmentation in Neurodegenerative Disease
      Purpose : This study assessed agreement between an automated spectral-domain optical coherence tomography (SD-OCT) retinal segmentation software and manually corrected segmentation to validate its use in a prospective clinical study of neurodegenerative diseases (NDD). Methods : The sample comprised 30 subjects with NDD, including vascular cognitive impairment, frontotemporal dementia, Parkinson's disease, and Alzheimer's disease. Macular SD-OCT scans were acquired and segmented using Heidelberg Spectralis. For the central foveal B scan ...
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    9. Optical coherence tomography imaging after endovascular thrombectomy for basilar artery occlusion: report of 3 cases

      Optical coherence tomography imaging after endovascular thrombectomy for basilar artery occlusion: report of 3 cases
      Studies evaluating individuals for endothelial injury after endovascular thrombectomy (EVT) have been done by means of retrieved human thrombus, MR vessel-wall imaging, and animal histopathological studies. These techniques have limitations, because MR imaging has insufficient spatial resolution to directly visualize endothelium, and histopathological examinations are performed ex vivo and are unable to provide real-time patterns of injury. The purpose of the current study was to obtain in vivo intraluminal imaging ...
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    10. Does Projection Artifact Removal Improve Visualization of Images in Optical Coherence Tomography Angiography?

      Does Projection Artifact Removal Improve Visualization of Images in Optical Coherence Tomography Angiography?
      Purpose: This study assesses the frequency of projection artifacts in optical coherence tomography angiography (OCTA) en face images and compares images before and after applying a 3-dimensional projection artifact removal (3D-PAR) algorithm. Methods: This is a single-center, retrospective study that included consecutive patients with any underlying diagnosis who had OCTA obtained from January to March 2017. Patients with various retinal diseases and also healthy eyes were included. All participants underwent ...
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    11. Chronic chiasmal compression and persistent visual field defect without detectable changes in optical coherence tomography of the macular ganglion cell complex

      Chronic chiasmal compression and persistent visual field defect without detectable changes in optical coherence tomography of the macular ganglion cell complex
      Purpose Optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) are important in the ophthalmological evaluation of patients with sellar masses. Changes in OCT of the RNFL and macular GCC often precede visual field changes in patients with chronic chiasmal compression. OCT of the macular GCC has been shown to have better correlation with visual function and allow for even earlier detection ...
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    12. Analysis of low-scattering regions in optical coherence tomography: applications to neurography and lymphangiography

      Analysis of low-scattering regions in optical coherence tomography: applications to neurography and lymphangiography
      Analysis of semi-transparent low scattering biological structures in optical coherence tomography (OCT) has been actively pursued in the context of lymphatic imaging, with most approaches relying on the relative absence of signal as a means of detection. Here we present an alternate methodology based on spatial speckle statistics, utilizing the similarity of a distribution of given voxel intensities to the power distribution function of pure noise, to visualize the low-scattering ...
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    13. Analysis of low-scattering regions in optical coherence tomography

      Analysis of low-scattering regions in optical coherence tomography
      Analysis of semi-transparent low scattering biological structures in optical coherence tomography (OCT) has been actively pursued in the context of lymphatic imaging, with most approaches relying on the relative absence of signal as a means of detection. Here we present an alternate methodology based on spatial speckle statistics, utilizing the similarity of a distribution of given voxel intensities to the power distribution function of pure noise, to visualize the low-scattering ...
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    14. Optical Coherence Tomography as an Adjunct During Carotid Artery Stenting for Carotid Atherosclerotic Disease

      Optical Coherence Tomography as an Adjunct During Carotid Artery Stenting for Carotid Atherosclerotic Disease
      Purpose Carotid artery stenting (CAS) has been proven to decrease the risk of stroke in symptomatic patients with moderate/high-grade carotid stenosis; however, there is an increased periprocedural risk of stroke with CAS compared to carotid endarterectomy. The goal of this article is to report the utilization of endovascular optical coherence tomography (OCT) during CAS to aid in the identification of stent malapposition, plaque prolapse, and adjacent residual thrombus that ...
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    15. 2D MEMS-based high-speed beam-shifting technique for speckle noise reduction and flow rate measurement in optical coherence tomography

      2D MEMS-based high-speed beam-shifting technique for speckle noise reduction and flow rate measurement in optical coherence tomography
      In this manuscript, a two-dimensional (2D) micro-electro-mechanical system (MEMS)-based, high-speed beam-shifting spectral domain optical coherence tomography (MHB-SDOCT) is proposed for speckle noise reduction and absolute flow rate measurement. By combining a zigzag scanning protocol, the frame rates of 45.2 Hz for speckle reduction and 25.6 Hz for flow rate measurement are achieved for in-vivo tissue imaging. Phantom experimental results have shown that by setting the incident beam ...
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    16. 1-15 of 199 1 2 3 4 ... 12 13 14 »
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  2. About University of Toronto

    University of Toronto

    The University of Toronto (U of T) is a public research university in Toronto, Ontario, Canada. The university's main campus, St. George, is located in Downtown Toronto surrounding Queen's Park and the Ontario Legislature. Its two other campuses, the University of Toronto Scarborough (UTSC) and the University of Toronto at Mississauga (UTM, also informally referred to as "Erindale Campus"), are located in the eastern and western ends, respectively, of the Greater Toronto Area.   The institution was founded as King's College by John Strachan, and was granted its Royal Charter in 1827. Its name was changed to the University of Toronto in 1849, after it ended ties with the Church of England to become a secular institution. University College was created as a constituent college in 1853, and over time, the formerly independent Trinity College, Victoria University and St. Michael's College became federated with the university.  A 2006 university ranking by Newsweek International ranks the University of Toronto 1st in Canada, 18th worldwide, and 5th outside of the United States. Similar academic rankings consistently place the university among the world's best. Research at the University of Toronto has been responsible for the world's first electronic heart pacemaker, artificial larynx, single-lung transplant, nerve transplant, artificial pancreas, chemical laser, G-suit, the first practical electron microscope, the first cloning of T-cells, and the extraction of insulin."