1. University of Toronto

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    1. Mentioned In 235 Articles

    2. Single-capture ultra-widefield guided swept-source optical coherence tomography in the management of rhegmatogenous retinal detachment and associated peripheral vitreoretinal patholog

      Single-capture ultra-widefield guided swept-source optical coherence tomography in the management of rhegmatogenous retinal detachment and associated peripheral vitreoretinal patholog
      Background/Aim To assess the utility of single-capture ultra-widefield confocal scanning laser ophthalmoscope with integrated swept-source optical coherence tomography (UWF-SS-OCT) in the management of rhegmatogenous retinal detachment (RRD) and associated peripheral pathology. Methods 138 eyes of 101 consecutive patients with RRD and/or associated peripheral pathology at a vitreoretinal practice in Toronto, Canada between December 2020 and February 2021 that had UWF-SS-OCT with interpretable scans were included. A 200 degree ...
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    3. Longitudinal in-vivo quantification of tumour microvasculature heterogeneity via optical coherence tomography (OCT) angiography in a pre-clinical model of radiation therapy

      Longitudinal in-vivo quantification of tumour microvasculature heterogeneity via optical coherence tomography (OCT) angiography in a pre-clinical model of radiation therapy
      Stereotactic body radiotherapy (SBRT) is an emerging cancer treatment due to its logistical and potential therapeutic benefits as compared to conventional radiotherapy. However, its mechanism of action is yet to be fully understood, likely involving the ablation of tumour microvasculature by higher doses per fraction used in SBRT. In this study, we hypothesized that longitudinal imaging and quantification of the vascular architecture may elucidate the relationship between the microvasculature and ...
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    4. Differentiation of semi-transparent tissue phantom inclusions using optical coherence tomography towards label-free neurography and lymphography

      Differentiation of semi-transparent tissue phantom inclusions using optical coherence tomography towards label-free neurography and lymphography
      Significance: Lymphatic and peripheral nervous system imaging is of prime importance for monitoring various important pathologic processes including cancer development, metastasis, and response to therapy. Aim: Optical coherence tomography (OCT) is a promising approach for this imaging task but is challenged by the near-transparent nature of these structures. Our aim is to detect and differentiate semi-transparent materials using OCT texture analysis, towards label-free neurography and lymphography. Approach: We have recently ...
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    5. Time interval optimized optical coherence tomographic angiography for bulk motion suppression on human skin

      Time interval optimized optical coherence tomographic angiography for bulk motion suppression on human skin
      Bulk motions occurred during in vivo scanning could modulate the backscattered light signals with the same mechanism of moving scatterers (such as red blood cells), so bulk motion suppression plays a key role for optical coherence tomographic angiography (OCTA) applications. One classic method to overcome this issue is to compensate the bulk motions with image registration algorithms before calculating vascular signals, which is however computationally intensive and makes real-time screening ...
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    6. Bridging the macro to micro resolution gap with angiographic optical coherence tomography and dynamic contrast enhanced MRI

      Bridging the macro to micro resolution gap with angiographic optical coherence tomography and dynamic contrast enhanced MRI
      Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is emerging as a valuable tool for non-invasive volumetric monitoring of the tumor vascular status and its therapeutic response. However, clinical utility of DCE-MRI is challenged by uncertainty in its ability to quantify the tumor microvasculature (
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    7. Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts

      Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts
      Purpose: To develop a consensus nomenclature for reporting optical coherence tomography angiography (OCTA) findings in retinal vascular disease (e.g., diabetic retinopathy, retinal vein occlusion) by international experts. Design: Delphi-based survey SUBJECTS, PARTICIPANTS AND/OR CONTROLS: Twenty-five retinal vascular disease and OCTA imaging experts METHODS, INTERVENTION, OR TESTING: A Delphi method of consensus development was used, comprising two rounds of online questionnaires, followed by a face-to-face meeting conducted virtually. Twenty-five ...
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    8. Quantification metrics for telangiectasia using optical coherence tomography

      Quantification metrics for telangiectasia using optical coherence tomography
      Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder that causes vascular malformations throughout the body. The most prevalent and accessible of these lesions are found throughout the skin and mucosa, and often rupture causing bleeding and anemia. A recent increase in potential HHT treatments have created a demand for quantitative metrics that can objectively measure the efficacy of new and developing treatments. We employ optical coherence tomography (OCT)-a ...
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    9. Physiology of retinal reattachment in humans: Swept source optical coherence tomography imaging data supporting a novel staging system

      Physiology of retinal reattachment in humans: Swept source optical coherence tomography imaging data supporting a novel staging system
      This article presents high-resolution swept source optical coherence tomography (SS-OCT) imaging data used to describe the physiology of retinal reattachment in humans. SS-OCT imaging was performed at baseline and every 2 h for the first 6 h and at frequent intervals thereafter up to 6 weeks following the injection of intravitreal gas in eyes undergoing pneumatic retinopexy for rhegmatogenous retinal detachment. Imaging data presented in this article is related to ...
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    10. First in‐human evaluation of a novel intravascular ultrasound and optical coherence tomography system for intracoronary imaging

      First in‐human evaluation of a novel intravascular ultrasound and optical coherence tomography system for intracoronary imaging
      Aims We evaluated the first in-human performance of a novel hybrid imaging catheter that permits simultaneous and co-registered acquisition of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) images. Methods and Results A total of 17 patients undergoing planned percutaneous coronary intervention (PCI) were imaged between August 2018 and August 2019. Eleven patients with both pre- and post-PCI IVUS and OCT images were included in the offline image analysis. IVUS ...
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    11. Enface vitreous OCT ‘worm holes’: A novel finding in a patient with diffuse unilateral subacute neuroretinitis (DUSN

      Enface vitreous OCT ‘worm holes’: A novel finding in a patient with diffuse unilateral subacute neuroretinitis (DUSN
      Purpose: To describe a case of diffuse unilateral subacute neuroretinitis (DUSN), a rare condition that causes progressive vision loss following infection by a nematode using enface vitreous imaging. Observations: We present the clinical findings of a 37-year-old female, clinically diagnosed with DUSN after a non-invasive multimodal imaging approach that included MultiColor scanning laser imaging and enface vitreous OCT, which revealed the nematode body and lacunae created by worm migration, respectively ...
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    12. Minimally invasive intrathecal spinal cord imaging with optical coherence tomography

      Minimally invasive intrathecal spinal cord imaging with optical coherence tomography
      ignificance: Imaging of the spinal cord is challenging due to the surrounding bony anatomy, physiologic motion, and the small diameter of the spinal cord. This precludes the use of non-invasive imaging techniques in assessing structural changes related to trauma and evaluating residual function. Aim: The purpose of our research was to apply endovascular technology and techniques and construct a preclinical animal model of intrathecal spinal cord imaging using optical coherence ...
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    13. Effects of the PCSK9 Antibody Alirocumab on Coronary Atherosclerosis in Patients with Acute Myocardial Infarction: A Serial, Multivessel, Intravascular Ultrasound, Near-Infrared Spectroscopy and Optical Coherence Tomography Imaging Study Rationale and Des

      Effects of the PCSK9 Antibody Alirocumab on Coronary Atherosclerosis in Patients with Acute Myocardial Infarction: A Serial, Multivessel, Intravascular Ultrasound, Near-Infrared Spectroscopy and Optical Coherence Tomography Imaging Study Rationale and Des
      Background: The risk for cardiovascular adverse events after acute myocardial infarction (AMI) remains high despite potent medical treatment including low-density lipoprotein cholesterol (LDL-C) lowering with statins. Proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies substantially reduce LDL-C when added to statin. Alirocumab, a momoclonal antibody to PCSK9, reduces major adverse cardiovascular events after AMI. The effects of alirocumab on coronary atherosclerosis including plaque burden, plaque composition and fibrous cap thickness ...
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    14. The APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies

      The APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies
      Objective: To update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising the previously published Advised Protocol for OCT Study Terminology and Elements (APOSTEL) recommendations. Methods: To identify studies reporting quantitative OCT results, we performed a PubMed search for the terms "quantitative" and "optical coherence tomography" from 2015 to 2017. Corresponding authors of the identified publications were invited to provide feedback on the initial ...
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    15. Volumetric tumor delineation and assessment of its early response to radiotherapy with optical coherence tomography

      Volumetric tumor delineation and assessment of its early response to radiotherapy with optical coherence tomography
      Texture analyses of optical coherence tomography (OCT) images have shown initial promise for differentiation of normal and tumor tissues. This work develops a fully automatic volumetric tumor delineation technique employing quantitative OCT image speckle analysis based on Gamma distribution fits. We test its performance in-vivo using immunodeficient mice with dorsal skin window chambers and subcutaneously grown tumor models. Tumor boundaries detection is confirmed using epi-fluorescence microscopy, combined photoacoustic-ultrasound imaging, and ...
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    16. 1-15 of 235 1 2 3 4 ... 14 15 16 »
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  2. About University of Toronto

    University of Toronto

    The University of Toronto (U of T) is a public research university in Toronto, Ontario, Canada. The university's main campus, St. George, is located in Downtown Toronto surrounding Queen's Park and the Ontario Legislature. Its two other campuses, the University of Toronto Scarborough (UTSC) and the University of Toronto at Mississauga (UTM, also informally referred to as "Erindale Campus"), are located in the eastern and western ends, respectively, of the Greater Toronto Area.   The institution was founded as King's College by John Strachan, and was granted its Royal Charter in 1827. Its name was changed to the University of Toronto in 1849, after it ended ties with the Church of England to become a secular institution. University College was created as a constituent college in 1853, and over time, the formerly independent Trinity College, Victoria University and St. Michael's College became federated with the university.  A 2006 university ranking by Newsweek International ranks the University of Toronto 1st in Canada, 18th worldwide, and 5th outside of the United States. Similar academic rankings consistently place the university among the world's best. Research at the University of Toronto has been responsible for the world's first electronic heart pacemaker, artificial larynx, single-lung transplant, nerve transplant, artificial pancreas, chemical laser, G-suit, the first practical electron microscope, the first cloning of T-cells, and the extraction of insulin."