1. University of Toronto

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    1. Mentioned In 243 Articles

    2. The Use of Optical Coherence Tomography for Gross Examination and Sampling of Fixed Breast Specimens: A Pilot Study

      The Use of Optical Coherence Tomography for Gross Examination and Sampling of Fixed Breast Specimens: A Pilot Study
      Abstract Thorough gross examination of breast cancer specimens is critical in order to sample relevant portions for subsequent microscopic examination. This task would benefit from an imaging tool which permits targeted and accurate block selection. Optical coherence tomography (OCT) is a non-destructive imaging technique that visualizes tissue architecture and has the potential to be an adjunct at the gross bench. Our objectives were: (1) to familiarize pathologists with the appearance ...
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    3. Optical Coherence Tomography Features in Idiopathic Non-Infectious Intermediate, Posterior, or Panuveitis

      Optical Coherence Tomography Features in Idiopathic Non-Infectious Intermediate, Posterior, or Panuveitis
      Purpose: To characterize optical coherence tomography (OCT) features in patients with idiopathic intermediate, posterior, or panuveitis. Methods: This is a retrospective case series of all consecutive cases of idiopathic intermediate, posterior, or panuveitis at four tertiary care centres between 2010 and 2021. Results: A total of 94 eyes (55 patients) were followed for an average duration of 29.8 (SD 21) months. The median central macular thickness (CMT) was 284m ...
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    4. The use of optical coherence tomography in neurology: a review

      The use of optical coherence tomography in neurology: a review
      Optical coherence tomography (OCT) is a non-invasive, cost-efficient technique that provides high-resolution in vivo imaging of retinal tissue. The peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell complex (mGCC) are surrogate markers of neuroaxonal integrity in not only the eye, but also the central nervous system. Retinal atrophy may occur in tandem with central nervous system pathologies as a result of injury to ganglion cells, direct degeneration of ...
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    5. Baseline Microperimetry and OCT in the RUSH2A Study: Structure-Function Association and Correlation with Disease Severity

      Baseline Microperimetry and OCT in the RUSH2A Study: Structure-Function Association and Correlation with Disease Severity
      Purpose: To investigate baseline mesopic microperimetry (MP) and spectral domain optical coherence tomography (OCT) in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study. Design: Natural history study SETTING: 16 clinical sites in Europe and North America STUDY POPULATION: Participants with Usher syndrome type 2 (USH2) (N=80) or autosomal recessive nonsyndromic RP (ARRP) (N=47) associated with biallelic disease-causing sequence variants in USH2A. Observation procedures: General linear models ...
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    6. Binary dose level classification of tumour microvascular response to radiotherapy using artificial intelligence analysis of optical coherence tomography images

      Binary dose level classification of tumour microvascular response to radiotherapy using artificial intelligence analysis of optical coherence tomography images
      The dominant consequence of irradiating biological systems is cellular damage, yet microvascular damage begins to assume an increasingly important role as the radiation dose levels increase. This is currently becoming more relevant in radiation medicine with its pivot towards higher-dose-per-fraction/fewer fractions treatment paradigm (e.g., stereotactic body radiotherapy (SBRT)). We have thus developed a 3D preclinical imaging platform based on speckle-variance optical coherence tomography (svOCT) for longitudinal monitoring of ...
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    7. Persistent subfoveal fluid in pneumatic retinopexy versus pars plana vitrectomy for rhegmatogenous retinal detachment: posthoc analysis of the PIVOT randomised trial

      Persistent subfoveal fluid in pneumatic retinopexy versus pars plana vitrectomy for rhegmatogenous retinal detachment: posthoc analysis of the PIVOT randomised trial
      Purpose To assess the incidence of persistent subfoveal fluid (PSFF) in pneumatic retinopexy (PnR) versus pars plana vitrectomy (PPV) following rhegmatogenous retinal detachment (RRD) repair and to determine its association with functional outcomes. Methods Posthoc analysis of the PIVOT randomised trial. Eyes with gradable en face and cross-sectional spectral-domain optical coherence tomography (SD-OCT) scans at 12 months postoperatively were included. Primary outcome was the proportion of patients with PSFF following ...
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    8. Machine learning classification of multiple sclerosis in children using optical coherence tomography

      Machine learning classification of multiple sclerosis in children using optical coherence tomography
      Background: In children, multiple sclerosis (MS) is the ultimate diagnosis in only 1/5 to 1/3 of cases after a first episode of central nervous system (CNS) demyelination. As the visual pathway is frequently affected in MS and other CNS demyelinating disorders (DDs), structural retinal imaging such as optical coherence tomography (OCT) can be used to differentiate MS. Objective: This study aimed to investigate the utility of machine learning ...
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    9. 2 Postdoctoral Positions Available at the Biomedical Optics Research Group at the University of Waterloo

      2 Postdoctoral Positions Available at the Biomedical Optics Research Group at the University of Waterloo
      ...UW School of Pharmacy. The group also has long-standing collaborations with the Dept. of Ophthalmology at the University of Toronto and the Ophthalmology Departments at multiple Toronto-based hospitals though the Univers...
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    10. Single-capture ultra-widefield guided swept-source optical coherence tomography in the management of rhegmatogenous retinal detachment and associated peripheral vitreoretinal patholog

      Single-capture ultra-widefield guided swept-source optical coherence tomography in the management of rhegmatogenous retinal detachment and associated peripheral vitreoretinal patholog
      Background/Aim To assess the utility of single-capture ultra-widefield confocal scanning laser ophthalmoscope with integrated swept-source optical coherence tomography (UWF-SS-OCT) in the management of rhegmatogenous retinal detachment (RRD) and associated peripheral pathology. Methods 138 eyes of 101 consecutive patients with RRD and/or associated peripheral pathology at a vitreoretinal practice in Toronto, Canada between December 2020 and February 2021 that had UWF-SS-OCT with interpretable scans were included. A 200 degree ...
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    11. Longitudinal in-vivo quantification of tumour microvasculature heterogeneity via optical coherence tomography (OCT) angiography in a pre-clinical model of radiation therapy

      Longitudinal in-vivo quantification of tumour microvasculature heterogeneity via optical coherence tomography (OCT) angiography in a pre-clinical model of radiation therapy
      Stereotactic body radiotherapy (SBRT) is an emerging cancer treatment due to its logistical and potential therapeutic benefits as compared to conventional radiotherapy. However, its mechanism of action is yet to be fully understood, likely involving the ablation of tumour microvasculature by higher doses per fraction used in SBRT. In this study, we hypothesized that longitudinal imaging and quantification of the vascular architecture may elucidate the relationship between the microvasculature and ...
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    12. Differentiation of semi-transparent tissue phantom inclusions using optical coherence tomography towards label-free neurography and lymphography

      Differentiation of semi-transparent tissue phantom inclusions using optical coherence tomography towards label-free neurography and lymphography
      Significance: Lymphatic and peripheral nervous system imaging is of prime importance for monitoring various important pathologic processes including cancer development, metastasis, and response to therapy. Aim: Optical coherence tomography (OCT) is a promising approach for this imaging task but is challenged by the near-transparent nature of these structures. Our aim is to detect and differentiate semi-transparent materials using OCT texture analysis, towards label-free neurography and lymphography. Approach: We have recently ...
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    13. Time interval optimized optical coherence tomographic angiography for bulk motion suppression on human skin

      Time interval optimized optical coherence tomographic angiography for bulk motion suppression on human skin
      Bulk motions occurred during in vivo scanning could modulate the backscattered light signals with the same mechanism of moving scatterers (such as red blood cells), so bulk motion suppression plays a key role for optical coherence tomographic angiography (OCTA) applications. One classic method to overcome this issue is to compensate the bulk motions with image registration algorithms before calculating vascular signals, which is however computationally intensive and makes real-time screening ...
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    14. Bridging the macro to micro resolution gap with angiographic optical coherence tomography and dynamic contrast enhanced MRI

      Bridging the macro to micro resolution gap with angiographic optical coherence tomography and dynamic contrast enhanced MRI
      Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is emerging as a valuable tool for non-invasive volumetric monitoring of the tumor vascular status and its therapeutic response. However, clinical utility of DCE-MRI is challenged by uncertainty in its ability to quantify the tumor microvasculature (
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    15. Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts

      Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts
      Purpose: To develop a consensus nomenclature for reporting optical coherence tomography angiography (OCTA) findings in retinal vascular disease (e.g., diabetic retinopathy, retinal vein occlusion) by international experts. Design: Delphi-based survey SUBJECTS, PARTICIPANTS AND/OR CONTROLS: Twenty-five retinal vascular disease and OCTA imaging experts METHODS, INTERVENTION, OR TESTING: A Delphi method of consensus development was used, comprising two rounds of online questionnaires, followed by a face-to-face meeting conducted virtually. Twenty-five ...
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  2. About University of Toronto

    University of Toronto

    The University of Toronto (U of T) is a public research university in Toronto, Ontario, Canada. The university's main campus, St. George, is located in Downtown Toronto surrounding Queen's Park and the Ontario Legislature. Its two other campuses, the University of Toronto Scarborough (UTSC) and the University of Toronto at Mississauga (UTM, also informally referred to as "Erindale Campus"), are located in the eastern and western ends, respectively, of the Greater Toronto Area.   The institution was founded as King's College by John Strachan, and was granted its Royal Charter in 1827. Its name was changed to the University of Toronto in 1849, after it ended ties with the Church of England to become a secular institution. University College was created as a constituent college in 1853, and over time, the formerly independent Trinity College, Victoria University and St. Michael's College became federated with the university.  A 2006 university ranking by Newsweek International ranks the University of Toronto 1st in Canada, 18th worldwide, and 5th outside of the United States. Similar academic rankings consistently place the university among the world's best. Research at the University of Toronto has been responsible for the world's first electronic heart pacemaker, artificial larynx, single-lung transplant, nerve transplant, artificial pancreas, chemical laser, G-suit, the first practical electron microscope, the first cloning of T-cells, and the extraction of insulin."