1. University of Toronto

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    1. Mentioned In 213 Articles

    2. Automated Deep Learning-based Multi-class Fluid Segmentation in Swept-Source Optical Coherence Tomography Images

      Automated Deep Learning-based Multi-class Fluid Segmentation in Swept-Source Optical Coherence Tomography Images
      Purpose: To evaluate the performance of a deep learning-based, fully automated, multi-class, macular fluid segmentation algorithm relative to expert annotations in a heterogeneous population of confirmed wet age-related macular degeneration (wAMD) subjects. Methods: Twenty-two swept-source optical coherence tomography (SS-OCT) volumes of the macula from 22 from different individuals with wAMD were manually annotated by two expert graders. These results were compared using cross-validation (CV) to automated segmentations using a deep ...
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    3. Advances in IVUS/OCT and Future Clinical Perspective of Novel Hybrid Catheter System in Coronary Imaging

      Advances in IVUS/OCT and Future Clinical Perspective of Novel Hybrid Catheter System in Coronary Imaging
      Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have been developed and improved as both diagnostic and guidance tools for interventional procedures over the past three decades. IVUS has a resolution of 100 m with a high tissue penetration and capability of assessing the entire structure of a coronary artery including the external elastic membrane, whereas OCT has a higher resolution of 1020 m to assess endoluminal structures with a ...
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    4. Endovascular optical coherence tomography imaging in cerebrovascular disease

      Endovascular optical coherence tomography imaging in cerebrovascular disease
      Endovascular optical coherence tomography (OCT) is the highest resolution imaging modality currently available with spatial resolution of 10 m. Although originally developed for interventional cardiology, the ability to visualize the luminal environment and anatomy, along with the stent-vessel interaction could be of great utility for various cerebrovascular diseases, and the adoption of endovascular OCT imaging in the evolving field of interventional neuroradiology seems instinctive. The purpose of this study is ...
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    5. Effects of axial length on retinal nerve fiber layer and macular ganglion cell-inner plexiform layer measured by spectral-domain OCT

      Effects of axial length on retinal nerve fiber layer and macular ganglion cell-inner plexiform layer measured by spectral-domain OCT
      Purpose: To evaluate the influence of ocular axial length on circumpapillary retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in healthy eyes after correcting for ocular magnification effect. Methods: In this cross-sectional study, we evaluated 120 eyes from 60 volunteer participants (myopes, emmetropes, and hyperopes). The thickness of the circumpapillary retinal nerve fiber layer and ganglion cell-inner plexiform layer were measured using the spectral optical coherence tomography (OCT ...
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    6. Dual-Agent Photodynamic Therapy with Optical Clearing Eradicates Pigmented Melanoma in Preclinical Tumor Models

      Dual-Agent Photodynamic Therapy with Optical Clearing Eradicates Pigmented Melanoma in Preclinical Tumor Models
      Treatment using light-activated photosensitizers (photodynamic therapy, PDT) has shown limited efficacy in pigmented melanoma, mainly due to the poor penetration of light in this tissue. Here, an optical clearing agent (OCA) was applied topically to a cutaneous melanoma model in mice shortly before PDT to increase the effective treatment depth by reducing the light scattering. This was used together with cellular and vascular-PDT, or a combination of both. The effect ...
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    7. Optical coherence tomography measures correlate with brain and spinal cord atrophy and multiple sclerosis disease‐related disability

      Optical coherence tomography measures correlate with brain and spinal cord atrophy and multiple sclerosis disease‐related disability
      ackground Both, optical coherence tomography (OCT) and MRI volumetric measures have been postulated as potential biomarkers of MS related disability. Objective To investigate the association between OCT and brain volume (BV) and spinal cord area (SCA) parameters in relapsing MS patients, and to assess their independent associations with disability. Methods Cross‐sectional analysis of 90 MS patients that underwent OCT and MRI exams. Values of peripapillary retinal nerve fibre layer ...
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    8. Classification of Neural Tissue Types for an Endoscopic Full-field Optical Coherence Tomography Imaging System (Thesis)

      Classification of Neural Tissue Types for an Endoscopic Full-field Optical Coherence Tomography Imaging System (Thesis)
      Optical coherence tomography is a volumetric imaging technique that can differentiate brain regions with micron-scale resolution. Our group has previously developed an endoscopic full-field swept-source OCT system with the aim to provide real-time surgical guidance for the implantation of electrodes for deep brain stimulation. This thesis builds on our prior work. Due to the limitations in the resolution and contrast due to scattering from the tissue, to identify different types ...
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    9. 30/80 MHz Bidirectional Dual-Frequency IVUS Feasibility Evaluated In Vivo and for Stent Imaging

      30/80 MHz Bidirectional Dual-Frequency IVUS Feasibility Evaluated In Vivo and for Stent Imaging
      Although intravascular ultrasound (IVUS) is an important tool in guiding complex coronary interventions, the resolution of existing commercial IVUS devices is considerably poorer than that of optical coherence tomography. Dual-frequency IVUS (DF IVUS), incorporating a second, higher frequency transducer, has been proposed as a possible method of overcoming this limitation. Although preliminary studies have shown that DF IVUS can produce complementary images, including large-scale morphology and high detail of superficial ...
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    10. Real-time en-face Gabor optical coherence tomographic angiography on human skin using CUDA GPU

      Real-time en-face Gabor optical coherence tomographic angiography on human skin using CUDA GPU
      We recently proposed an optical coherence tomographic angiography (OCTA) algorithm, Gabor optical coherence tomographic angiography (GOCTA), which can extract microvascular signals from a spectral domain directly with lower computational complexity compared to other algorithms. In this manuscript, we combine a programmable swept source, an OCT complex signal detecting unit, and graphics process units (GPU) to achieve a real-time en-face GOCTA system for human skin microvascular imaging. The programmable swept source ...
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    11. Biophotonics and Imaging Graduate Summer School to be held on August 2020 at National University of Ireland, Galway

      Biophotonics and  Imaging  Graduate  Summer  School to be held on August 2020 at National University of Ireland, Galway
      Dates: August 25th - 29th 2020 This is our eight Biophotonics and Imaging Graduate Summer School. It is an important opportunity for graduate students in 2020 to access the kind of close contact with leading professors that only this kind of environment facilitates. Tutors for BIGSS 2020 will include: Martin Booth (Oxford): Advanced Microscopy Steve Jacques (Washington): Tissue Optics Caroline Boudoux (Montreal): Endoscopy David Sampson (Surrey): OCT Sarah Bohndiek (Cambridge): Photoacoustics ...
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    12. Reliability of Handheld Optical Coherence Tomography in Children Younger Than Three Years of Age Undergoing Vigabatrin Treatment for Childhood Epilepsy

      Reliability of Handheld Optical Coherence Tomography in Children Younger Than Three Years of Age Undergoing Vigabatrin Treatment for Childhood Epilepsy
      Purpose : Vigabatrin-associated retinal toxicity manifests as reduction in the clinical electroretinogram and retinal nerve fiber layer (RNFL) thinning. This observational investigation of RNFL thickness in young vigabatrin-treated children was to identify intravisit and intervisit reliabilities of peripapillary RNFL thickness measurements performed with Envisu (optical coherence tomography) OCT. Secondarily, a longitudinal assessment investigated the presence and extent of RNFL thinning. Methods : We measured the handheld OCT in sedated children to evaluate ...
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    13. Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study

      Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study
      Microvascular networks of human basal cell carcinomas (BCC) and surrounding skin were assessed with optical coherence angiography (OCA) in conjunction with photodynamic therapy (PDT). OCA images were collected and analyzed in 31 lesions pre-treatment, and immediately/24hours/312 months post-treatment. Pre-treatment OCA enabled differentiation between prevalent subtypes of BCC (nodular and superficial) and nodular-with-necrotic-core BCC subtypes with a diagnostic accuracy of 78%; this can facilitate more accurate biopsy reducing sampling ...
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    14. 1-15 of 213 1 2 3 4 ... 13 14 15 »
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  2. About University of Toronto

    University of Toronto

    The University of Toronto (U of T) is a public research university in Toronto, Ontario, Canada. The university's main campus, St. George, is located in Downtown Toronto surrounding Queen's Park and the Ontario Legislature. Its two other campuses, the University of Toronto Scarborough (UTSC) and the University of Toronto at Mississauga (UTM, also informally referred to as "Erindale Campus"), are located in the eastern and western ends, respectively, of the Greater Toronto Area.   The institution was founded as King's College by John Strachan, and was granted its Royal Charter in 1827. Its name was changed to the University of Toronto in 1849, after it ended ties with the Church of England to become a secular institution. University College was created as a constituent college in 1853, and over time, the formerly independent Trinity College, Victoria University and St. Michael's College became federated with the university.  A 2006 university ranking by Newsweek International ranks the University of Toronto 1st in Canada, 18th worldwide, and 5th outside of the United States. Similar academic rankings consistently place the university among the world's best. Research at the University of Toronto has been responsible for the world's first electronic heart pacemaker, artificial larynx, single-lung transplant, nerve transplant, artificial pancreas, chemical laser, G-suit, the first practical electron microscope, the first cloning of T-cells, and the extraction of insulin."