1. University of Tokyo

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    1. Mentioned In 43 Articles

    2. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY OF CHOROIDAL NEOVASCULARIZATION ASSOCIATED WITH EARLY-ONSET DRUSEN

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY OF CHOROIDAL NEOVASCULARIZATION ASSOCIATED WITH EARLY-ONSET DRUSEN
      Purpose: To report three middle-aged cases with choroidal neovascularization (CNV) associated with early-onset drusen documented with optical coherence tomography angiography (OCTA). Methods: Three patients with bilateral early-onset drusen were referred to our hospital. Fundus examination, fluorescein angiography, indocyanine green angiography , OCTA, and other multimodal imaging were performed. Results: Case 1 involved a 47-year-old woman who presented with sudden unilateral anorthopia. She had no previous systemic pathologies. Funduscopic examination and fluorescein ...
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    3. Using Deep Learning and transform learning to accurately diagnose early-onset glaucoma from macular optical coherence tomography images

      Using Deep Learning and transform learning to accurately diagnose early-onset glaucoma from macular optical coherence tomography images
      Purpose To construct and evaluate a Deep Learning (DL) model to diagnose early glaucoma from spectral domain optical coherence tomography (SD-OCT) images. Design AI diagnostic tool development, evaluation, and comparison Methods Setting: multiple institutional practices. Study population Pre-training data consisted of 4316 OCT images (RS3000, Nidek) from 1565 eyes with open angle glaucoma (OAG) irrespective of the stage of glaucoma and 193 normal eyes. Training data included OCT-1000/2000 (Topcon ...
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    4. Extraction of membrane structure in eyeball from MR volumes

      Extraction of membrane structure in eyeball from MR volumes
      This paper presents an accurate extraction method of spherical shaped membrane structures in the eyeball from MR volumes. In ophthalmic surgery, operation field is limited to a small region. Patient specific surgical simulation is useful to reduce complications. Understanding of tissue structure in the eyeball of a patient is required to achieve patient specific surgical simulations. Previous extraction methods of tissue structure in the eyeball use optical coherence tomography (OCT ...
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    5. Visualizing dynamics of angiogenic sprouting from a three-dimensional microvasculature model using stage-top optical coherence tomography

      Visualizing dynamics of angiogenic sprouting from a three-dimensional microvasculature model using stage-top optical coherence tomography
      Three-dimensional (3D)in vitromicrovasculature in a polydimethylsiloxane-based microdevice was developed as a physiologically relevant model of angiogenesis. The angiogenic process is monitored using stage-top optical coherence tomography (OCT). OCT allows non-invasive monitoring of the 3D structures of the prepared host microvasculature and sprouted neovasculature without fluorescence staining. OCT monitoring takes only a few minutes to scan through the several-millimetre scale range, which provides the advantage of rapid observation of living ...
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    6. Validating the usefulness of the 'Random Forests’ classifier to diagnose early glaucoma with optical coherence tomography

      Validating the usefulness of the 'Random Forests’ classifier to diagnose early glaucoma with optical coherence tomography
      Purpose To validate the usefulness of the 'Random Forests classifier to diagnose early glaucoma with spectral domain optical coherence tomography (SD-OCT). Method Design: Comparison of diagnostic algorithms Setting: multiple institutional practice Study participants Training dataset included 94 eyes of 94 open angle glaucoma (OAG) patients and 84 eyes of 84 normal subjects and testing dataset included 114 eyes of 114 OAG patients and 82 eyes of 82 normal subjects. In ...
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    7. Optimization of a dispersion-tuned wavelength-swept fiber laser for optical coherence tomography

      Optimization of a dispersion-tuned wavelength-swept fiber laser for optical coherence tomography
      We optimized parameters of a dispersion-tuned wavelength-swept fiber laser by numerically analyzing dynamic characteristics. The optimized laser is experimentally demonstrated and applied to the swept-source optical coherence tomography (SS-OCT) system. The dispersion-tuned wavelength-swept laser (DT-WSL) is a unique tunable fiber laser, whose lasing wavelength can be tuned rapidly without any mechanical tunable filters. Although the wavelength of a DT-WSL can be swept rapidly and widely, the broadening of the instantaneous ...
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    8. Eye motion corrected OCT imaging with Lissajous scan pattern

      Eye motion corrected OCT imaging with Lissajous scan pattern
      Ophthalmic optical coherence tomography (OCT) is a powerful tool which provides high resolution three dimensional (3D) volumetric image of human retina. However, the measurement data of OCT suffer motion artifact due to the involuntary eye motion during data acquisition. To eliminate this motion artifact and provide the true shape of retinal image, an eye motion corrected OCT imaging method based on Lissajous scan pattern is proposed in this paper. In ...
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    9. Optical coherence tomography and intravascular ultrasound evaluation of cardiac allograft vasculopathy with and without intimal neovascularization

      Optical coherence tomography and intravascular ultrasound evaluation of cardiac allograft vasculopathy with and without intimal neovascularization
      Aims Neovascularization is closely associated with plaque progression in non-heart transplantation subjects; on the other hand, cardiac allograft vasculopathy causes unfavourable outcomes. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) can provide microscopic assessment in vivo . The aim of this study was to investigate the impact of neovascularization on intimal proliferation. Methods and results Both IVUS and OCT were attempted in 45 consecutive patients during annual catheterization after heart transplantation ...
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    10. Wide and fast wavelength-swept fiber lasers based on dispersion tuning for real-time OCT

      Wide and fast wavelength-swept fiber lasers based on dispersion tuning for real-time OCT
      Swept-Source Optical coherence tomography (SS-OCT) is a powerful tool for fast medical imaging. For the real-time 3D imaging, the wide tuning range over 100 nm and fast sweep rate over 100 kHz are typically required. We recently proposed a new wavelength-swept laser for SS-OCT. It is based on a principle called dispersion tuning. Since the cavity contains no mechanical components, such as tunable filters, we could achieve the very high ...
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    11. Supercontinuum generation in nonlinear fibers using high-energy figure-of-eight mode-locked fiber laser for SD-OCT application

      Supercontinuum generation in nonlinear fibers using high-energy figure-of-eight mode-locked fiber laser for SD-OCT application
      Generation of flat and broadband supercontinum is demonstrated in an all fiber system using the high-energy noise-like pulses from a stable figure-of-eight fiber laser and nonlinear fibers. This SC source is successfully applied to the spectral domain optical coherence tomography (SD-OCT). The axial resolution is significantly improved compared with the case of the superluminescent diode source. SD-OCT imaging is also demonstrated.
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    12. Cross-sectional study: Does combining optical coherence tomography measurements using the ‘Random Forest’ decision tree classifier improve the prediction of the presence of perimetric deterioration in glaucoma suspects

      Cross-sectional study: Does combining optical coherence tomography measurements using the ‘Random Forest’ decision tree classifier improve the prediction of the presence of perimetric deterioration in glaucoma suspects
      ..., 5. Chihiro Mayama1, 6. Ryo Asaoka1 1. ^1Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 2. ^2Shirato Eye Clinic, Tokyo, Japan 1. Correspondence to Dr Ryo Asao...
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  2. About University of Tokyo

    University of Tokyo

    University of Tokyo is a major research university located in Tokyo, Japan. The University has 10 faculties with a total of around 30,000 students, some 2,100 of them foreign. Its five campuses are in Hongō, Komaba, Kashiwa, Shirokane and Nakano.  University of Tokyo Graduate School of Medicine.