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2. Corneal Irregular Astigmatism And Visual Function On Anterior Segment Optical Coherence Tomography In TGFBI Corneal Dystrophy
  
  Explore assets.researchsquare.com Jan 27 2022 Ophthalmology
  
  The purpose of this study was to evaluate corneal irregular astigmatism of patients with granular and lattice corneal dystrophy (GCD and LCD). 70 GCD, 35 LCD, and 23 control eyes were included. Anterior and posterior corneal topographic data obtained from anterior segment optical coherence tomography were expanded into four components via Fourier harmonic analysis. These components were compared with healthy eyes and the association between each component and best-corrected visual ...
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  Mentions: University of Tokyo
3. Association of prediabetes with retinal microvasculature on swept-source optical coherence tomography angiography in the elderly
  
  Explore LWW Online Jan 26 2022 Ophthalmology
  
  Aims: To investigate the retinal microvasculature in the elderly persons with prediabetes mellitus (preDM) and type 2 DM. Methods: This cross-sectional study included a total of 452 eyes without retinal pathologies of 301 elderly volunteers aged 65 years, and they were categorized into nonDM (225 eyes), preDM (177 eyes), and DM (50 eyes) groups based on their HbA1c. Fundus photography, swept-source optical coherence tomography and angiography, and comprehensive systemic examinations ...
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  Mentions: University of Tokyo
4. Predicting 10-2 Visual Field From Optical Coherence Tomography in Glaucoma Using Deep Learning Corrected With 24-2/30-2 Visual Field
  
  Explore TVST Journal Nov 24 2021 Ophthalmology
  
  Purpose: To investigate whether a correction based on a Humphrey field analyzer (HFA) 24-2/30-2 visual field (VF) can improve the prediction performance of a deep learning model to predict the HFA 10-2 VF test from macular optical coherence tomography (OCT) measurements. Methods: This is a multicenter, cross-sectional study. The training dataset comprised 493 eyes of 285 subjects (407, open-angle glaucoma [OAG]; 86, normative) who underwent HFA 10-2 testing and ...
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  Mentions: University of Tokyo Osaka University Kyoto Prefectural University of Medicine
5. Predicting Retinal Sensitivity Using Optical Coherence Tomography Parameters in Central Serous Chorioretinopathy
  
  Explore assets.researchsquare.com Oct 21 2021 Ophthalmology
  
  Purpose To predict the change of retinal sensitivity using optical coherence tomography (OCT) parameters in eyes with central serous chorioretinopathy (CSC). Methods Twenty-three eyes of 23 patients with CSC were enrolled. Retinal sensitivity was measured twice with a microperimetry in all examined eyes. OCT measurement was simultaneously conducted. The relationship between retinal sensitivities and the thicknesses of i) retinal nerve fiver layer + ganglion cell layer (RNFL+GCL), ii) inner nuclear ...
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  Mentions: University of Tokyo
6. Changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study
  
  Explore Journals | PLOS Sep 13 2021 Ophthalmology
  
  ...s of the Declaration of Helsinki, and the study design was approved by the Institutional Review Boards of the University of Tokyo (approval number #11822). The consent form was obtained in writing. We also recruited heal...
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  Mentions: National Institutes of Health Axsun Technologies University of Tokyo
7. Three-Dimensional Distribution Of Fundus Depolarization and Associating Factors Measured Using Polarization-Sensitive Optical Coherence Tomography
  
  Explore TVST Journal Feb 23 2021 Ophthalmology
  
  Purpose : To investigate the three-dimensional distribution and associating demographic factors of depolarization, using polarization-sensitive optical coherence tomography (PS-OCT), to evaluate melanin pigmentation in the retinal pigment epithelium (RPE) and choroid in healthy eyes. Methods : In total, 39 unaffected healthy eyes of 39 subjects were examined using a PS-OCT clinical prototype. The degree of depolarization, expressed as the polarimetric entropy, was assessed in the RPE, the superficial and the total choroid ...
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8. Melanin concentration and depolarization metrics measurement by polarization-sensitive optical coherence tomography
  
  Explore Nature Publishing Group Nov 13 2020 Dermatology , Ophthalmology
  
  Imaging of melanin in the eye is important as the melanin is structurally associated with some ocular diseases, such as age-related macular degeneration. Although optical coherence tomography (OCT) cannot distinguish tissues containing the melanin from other tissues intrinsically, polarization-sensitive OCT (PS-OCT) can detect the melanin through spatial depolarization of the backscattered light from the melanin granules. Entropy is one of the depolarization metrics that can be used to detect malanin ...
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  Mentions: University of Tokyo Tomey Corporation
9. Imaging of a retinal pigment epithelium aperture using polarization-sensitive optical coherence tomography
  
  Explore Home - Springer Nov 12 2020 Ophthalmology
  
  Purpose: To evaluate cases with a retinal pigment epithelium (RPE) aperture using polarization-sensitive optical coherence tomography (PS-OCT). Study design: Retrospective consecutive case series. Methods: A retrospective study that included three eyes (three patients) with RPE aperture and age-related macular degeneration (AMD) evaluated at the Macular Clinic in Tokyo University Hospital. A three-dimensional dataset of depolarization information was obtained with a clinical prototype of PS-OCT. Results: All patients were categorized as ...
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  Mentions: University of Tokyo
10. Improving visual field trend analysis with optical coherence tomography and deeply-regularized latent-space linear regression
  
  Explore ScienceDirect Aug 14 2020 Ophthalmology
  
  Purpose To investigate whether optical coherence tomography (OCT) measurements can improve visual field (VF) trend analyses in glaucoma patients, using the deeply-regularized latent-space linear regression (DLLR) model. Design Retrospective cohort study Subjects Training and testing datasets included 7,984 VFs from 998 eyes of 592 patients and 1,184 VFs from 148 eyes of 84 patients with open angle glaucoma, respectively. Each eye had a series of eight VFs with ...
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  Mentions: University of Tokyo
11. Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease
  
  Explore Nature Publishing Group Jul 28 2020 Otolaryngology
  
  The symptoms of Menieres disease (MD) are generally considered to be related to endolymphatic hydrops (EH). There are many recent reports supporting the possibility that vasopressin (VP) is closely linked to the formation of EH in Menieres disease. Based on this, we developed a clinically relevant animal model of Menieres disease in which a VP type 2 receptor agonist was administered after electrocauterization of the endolymphatic sac. We report live ...
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  Mentions: University of Tokyo
12. Deep learning model to predict visual field in central 10° from optical coherence tomography measurement in glaucoma
  
  Explore BJO Online Jul 1 2020 Ophthalmology
  
  Background/Aim To train and validate the prediction performance of the deep learning (DL) model to predict visual field (VF) in central 10 from spectral domain optical coherence tomography (SD-OCT). Methods This multicentre, cross-sectional study included paired Humphrey field analyser (HFA) 10-2 VF and SD-OCT measurements from 591 eyes of 347 patients with open-angle glaucoma (OAG) or normal subjects for the training data set. We trained a convolutional neural network ...
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  Mentions: University of Tokyo
13. Frequency of hypotonic maculopathy observed by spectral domain optical coherence tomography in post glaucoma filtration surgery eyes
  
  Explore ScienceDirect Jun 24 2020 Ophthalmology
  
  Purpose To report the frequency of post glaucoma filtration surgery hypotonic maculopathy determined by spectral domain optical coherence tomography (SD-OCT). Methods A cross-sectional retrospective observational study. Post glaucoma filtration surgery patients whose intraocular pressures (IOP) achieved 30% reduction from baseline or was controlled to IOP 14 mm Hg and had SD-OCT images and fundus photographs were enrolled. Hypotonic maculopathy was diagnosed independently on SD-OCT images and on fundus photographs. Results ...
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  Mentions: University of Tokyo
14. Comparison of post‐stent optical coherence tomography findings: Layered versus non‐layered culprit lesions
  
  Explore Wiley Online Library Apr 25 2020 Cardiology
  
  Objectives This study aimed to investigate the vascular response of lesions with a layered phenotype. Background Recent studies have shown that layered plaques at culprit lesions detected by optical coherence tomography (OCT) have greater plaque burden and more inflammatory features than non‐layered plaques. Methods This is a retrospective observational study. A total of 193 target lesions from 193 patients [100 patients with acute coronary syndromes (ACS) and 93 with ...
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  Mentions: Massachusetts General Hospital Harvard University University of Tokyo
15. OCT-Based Management of Nilotinib-Associated CAD in a Patient With Chronic Myeloid Leukemia
  
  Explore ScienceDirect Dec 21 2019 Cardiology
  
  Chronic myeloid leukemia (CML) is a myeloproliferative disorder of pluripotent hematopoietic stem cells caused by Bcr-Abl tyrosine kinase, the product of the Philadelphia chromosome. Bcr-Abl tyrosine kinase inhibitors (TKIs) have dramatically improved the prognosis of patients with CML (1). Although w 20% of patients with CML develop intolerance or resistance to the first Bcr-Abl TKI, imatinib mesylate, several second-generation TKIs, including nilotinib, dasatinib, and bosutinib, have overcome this issue (2 ...
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  Mentions: University of Tokyo
16. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY OF CHOROIDAL NEOVASCULARIZATION ASSOCIATED WITH EARLY-ONSET DRUSEN
  
  Explore LWW Online Jan 28 2019 Ophthalmology
  
  Purpose: To report three middle-aged cases with choroidal neovascularization (CNV) associated with early-onset drusen documented with optical coherence tomography angiography (OCTA). Methods: Three patients with bilateral early-onset drusen were referred to our hospital. Fundus examination, fluorescein angiography, indocyanine green angiography , OCTA, and other multimodal imaging were performed. Results: Case 1 involved a 47-year-old woman who presented with sudden unilateral anorthopia. She had no previous systemic pathologies. Funduscopic examination and fluorescein ...
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  Mentions: University of Tokyo
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