1. University of Tokyo

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    1. Mentioned In 53 Articles

    2. Changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study

      Changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study
      ...s of the Declaration of Helsinki, and the study design was approved by the Institutional Review Boards of the University of Tokyo (approval number #11822). The consent form was obtained in writing. We also recruited heal...
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    3. Three-Dimensional Distribution Of Fundus Depolarization and Associating Factors Measured Using Polarization-Sensitive Optical Coherence Tomography

      Three-Dimensional Distribution Of Fundus Depolarization and Associating Factors Measured Using Polarization-Sensitive Optical Coherence Tomography
      Purpose : To investigate the three-dimensional distribution and associating demographic factors of depolarization, using polarization-sensitive optical coherence tomography (PS-OCT), to evaluate melanin pigmentation in the retinal pigment epithelium (RPE) and choroid in healthy eyes. Methods : In total, 39 unaffected healthy eyes of 39 subjects were examined using a PS-OCT clinical prototype. The degree of depolarization, expressed as the polarimetric entropy, was assessed in the RPE, the superficial and the total choroid ...
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    4. Melanin concentration and depolarization metrics measurement by polarization-sensitive optical coherence tomography

      Melanin concentration and depolarization metrics measurement by polarization-sensitive optical coherence tomography
      Imaging of melanin in the eye is important as the melanin is structurally associated with some ocular diseases, such as age-related macular degeneration. Although optical coherence tomography (OCT) cannot distinguish tissues containing the melanin from other tissues intrinsically, polarization-sensitive OCT (PS-OCT) can detect the melanin through spatial depolarization of the backscattered light from the melanin granules. Entropy is one of the depolarization metrics that can be used to detect malanin ...
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    5. Imaging of a retinal pigment epithelium aperture using polarization-sensitive optical coherence tomography

      Imaging of a retinal pigment epithelium aperture using polarization-sensitive optical coherence tomography
      Purpose: To evaluate cases with a retinal pigment epithelium (RPE) aperture using polarization-sensitive optical coherence tomography (PS-OCT). Study design: Retrospective consecutive case series. Methods: A retrospective study that included three eyes (three patients) with RPE aperture and age-related macular degeneration (AMD) evaluated at the Macular Clinic in Tokyo University Hospital. A three-dimensional dataset of depolarization information was obtained with a clinical prototype of PS-OCT. Results: All patients were categorized as ...
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    6. Improving visual field trend analysis with optical coherence tomography and deeply-regularized latent-space linear regression

      Improving visual field trend analysis with optical coherence tomography and deeply-regularized latent-space linear regression
      Purpose To investigate whether optical coherence tomography (OCT) measurements can improve visual field (VF) trend analyses in glaucoma patients, using the deeply-regularized latent-space linear regression (DLLR) model. Design Retrospective cohort study Subjects Training and testing datasets included 7,984 VFs from 998 eyes of 592 patients and 1,184 VFs from 148 eyes of 84 patients with open angle glaucoma, respectively. Each eye had a series of eight VFs with ...
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    7. Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease

      Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease
      The symptoms of Menieres disease (MD) are generally considered to be related to endolymphatic hydrops (EH). There are many recent reports supporting the possibility that vasopressin (VP) is closely linked to the formation of EH in Menieres disease. Based on this, we developed a clinically relevant animal model of Menieres disease in which a VP type 2 receptor agonist was administered after electrocauterization of the endolymphatic sac. We report live ...
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    8. Deep learning model to predict visual field in central 10° from optical coherence tomography measurement in glaucoma

      Deep learning model to predict visual field in central 10° from optical coherence tomography measurement in glaucoma
      Background/Aim To train and validate the prediction performance of the deep learning (DL) model to predict visual field (VF) in central 10 from spectral domain optical coherence tomography (SD-OCT). Methods This multicentre, cross-sectional study included paired Humphrey field analyser (HFA) 10-2 VF and SD-OCT measurements from 591 eyes of 347 patients with open-angle glaucoma (OAG) or normal subjects for the training data set. We trained a convolutional neural network ...
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    9. Frequency of hypotonic maculopathy observed by spectral domain optical coherence tomography in post glaucoma filtration surgery eyes

      Frequency of hypotonic maculopathy observed by spectral domain optical coherence tomography in post glaucoma filtration surgery eyes
      Purpose To report the frequency of post glaucoma filtration surgery hypotonic maculopathy determined by spectral domain optical coherence tomography (SD-OCT). Methods A cross-sectional retrospective observational study. Post glaucoma filtration surgery patients whose intraocular pressures (IOP) achieved 30% reduction from baseline or was controlled to IOP 14 mm Hg and had SD-OCT images and fundus photographs were enrolled. Hypotonic maculopathy was diagnosed independently on SD-OCT images and on fundus photographs. Results ...
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    10. Comparison of post‐stent optical coherence tomography findings: Layered versus non‐layered culprit lesions

      Comparison of post‐stent optical coherence tomography findings: Layered versus non‐layered culprit lesions
      Objectives This study aimed to investigate the vascular response of lesions with a layered phenotype. Background Recent studies have shown that layered plaques at culprit lesions detected by optical coherence tomography (OCT) have greater plaque burden and more inflammatory features than non‐layered plaques. Methods This is a retrospective observational study. A total of 193 target lesions from 193 patients [100 patients with acute coronary syndromes (ACS) and 93 with ...
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    11. OCT-Based Management of Nilotinib-Associated CAD in a Patient With Chronic Myeloid Leukemia

      OCT-Based Management of Nilotinib-Associated CAD in a Patient With Chronic Myeloid Leukemia
      Chronic myeloid leukemia (CML) is a myeloproliferative disorder of pluripotent hematopoietic stem cells caused by Bcr-Abl tyrosine kinase, the product of the Philadelphia chromosome. Bcr-Abl tyrosine kinase inhibitors (TKIs) have dramatically improved the prognosis of patients with CML (1). Although w 20% of patients with CML develop intolerance or resistance to the first Bcr-Abl TKI, imatinib mesylate, several second-generation TKIs, including nilotinib, dasatinib, and bosutinib, have overcome this issue (2 ...
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    12. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY OF CHOROIDAL NEOVASCULARIZATION ASSOCIATED WITH EARLY-ONSET DRUSEN

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY OF CHOROIDAL NEOVASCULARIZATION ASSOCIATED WITH EARLY-ONSET DRUSEN
      Purpose: To report three middle-aged cases with choroidal neovascularization (CNV) associated with early-onset drusen documented with optical coherence tomography angiography (OCTA). Methods: Three patients with bilateral early-onset drusen were referred to our hospital. Fundus examination, fluorescein angiography, indocyanine green angiography , OCTA, and other multimodal imaging were performed. Results: Case 1 involved a 47-year-old woman who presented with sudden unilateral anorthopia. She had no previous systemic pathologies. Funduscopic examination and fluorescein ...
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    13. Using Deep Learning and transform learning to accurately diagnose early-onset glaucoma from macular optical coherence tomography images

      Using Deep Learning and transform learning to accurately diagnose early-onset glaucoma from macular optical coherence tomography images
      Purpose To construct and evaluate a Deep Learning (DL) model to diagnose early glaucoma from spectral domain optical coherence tomography (SD-OCT) images. Design AI diagnostic tool development, evaluation, and comparison Methods Setting: multiple institutional practices. Study population Pre-training data consisted of 4316 OCT images (RS3000, Nidek) from 1565 eyes with open angle glaucoma (OAG) irrespective of the stage of glaucoma and 193 normal eyes. Training data included OCT-1000/2000 (Topcon ...
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    14. Extraction of membrane structure in eyeball from MR volumes

      Extraction of membrane structure in eyeball from MR volumes
      This paper presents an accurate extraction method of spherical shaped membrane structures in the eyeball from MR volumes. In ophthalmic surgery, operation field is limited to a small region. Patient specific surgical simulation is useful to reduce complications. Understanding of tissue structure in the eyeball of a patient is required to achieve patient specific surgical simulations. Previous extraction methods of tissue structure in the eyeball use optical coherence tomography (OCT ...
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    15. Visualizing dynamics of angiogenic sprouting from a three-dimensional microvasculature model using stage-top optical coherence tomography

      Visualizing dynamics of angiogenic sprouting from a three-dimensional microvasculature model using stage-top optical coherence tomography
      Three-dimensional (3D)in vitromicrovasculature in a polydimethylsiloxane-based microdevice was developed as a physiologically relevant model of angiogenesis. The angiogenic process is monitored using stage-top optical coherence tomography (OCT). OCT allows non-invasive monitoring of the 3D structures of the prepared host microvasculature and sprouted neovasculature without fluorescence staining. OCT monitoring takes only a few minutes to scan through the several-millimetre scale range, which provides the advantage of rapid observation of living ...
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  2. About University of Tokyo

    University of Tokyo

    University of Tokyo is a major research university located in Tokyo, Japan. The University has 10 faculties with a total of around 30,000 students, some 2,100 of them foreign. Its five campuses are in Hongō, Komaba, Kashiwa, Shirokane and Nakano.  University of Tokyo Graduate School of Medicine.