1. University of Tübingen

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    1. Mentioned In 26 Articles

    2. Detecting early osteoarthritis through changes in biomechanical properties – A review of recent advances in indentation technologies in a clinical arthroscopic setup

      Detecting early osteoarthritis through changes in biomechanical properties – A review of recent advances in indentation technologies in a clinical arthroscopic setup
      Osteoarthritis (OA) is a degenerative joint disease currently affecting half of all women and one-third of all men aged over 65 and it is predicted to even increase in the next decades. In the variety of causes leading to OA, the first common denominator are changes in the extracellular matrix of the cartilage. In later stages, OA affects the whole joint spreading to higher levels of tissue architecture causing irreversible ...
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    3. Determination of Ischemia Onset Based on Automatically Generated Spectralis SD-OCT Values in Acute Central Retinal Artery Occlusion

      Determination of Ischemia Onset Based on Automatically Generated Spectralis SD-OCT Values in Acute Central Retinal Artery Occlusion
      Acute central retinal artery occlusion (CRAO) induces a time-dependent increase in retinal thickness. By manually measuring the relative retinal thickness increase (RRTI) in comparison to the contralateral eye based on optical coherence tomography (OCT), ischemia onset within the past 4.5 hours could be determined with 100% sensitivity and 94.3% specificity. To enable examiner-independent and quicker diagnostics, we analyzed the RRTI using the automatic retinal thickness measurement. In this ...
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    4. Comparison of Methods for Estimating Retinal Shape: Peripheral Refraction vs. Optical Coherence Tomography

      Comparison of Methods for Estimating Retinal Shape: Peripheral Refraction vs. Optical Coherence Tomography
      Retinal shape presents a clinical parameter of interest for myopia, and has commonly been inferred indirectly from peripheral refraction (PRX) profiles. Distortion-corrected optical coherence tomography (OCT) scans offer a new and direct possibility for retinal shape estimation. The current study compared retinal curvatures derived from OCT scans vs. PRX measurements in three refractive profiles (0 ∘ and 90 ∘ meridians, plus spherical equivalent) for 25 participants via BlandAltman analysis. The radial differences ...
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    5. Optical coherence tomography‐based determination of ischaemia onset – the temporal dynamics of retinal thickness increase in acute central retinal artery occlusion

      Optical coherence tomography‐based determination of ischaemia onset – the temporal dynamics of retinal thickness increase in acute central retinal artery occlusion
      urpose Acute central retinal artery occlusion (CRAO) induces ischaemic retinal oedema. The purpose of this study was to define sensitivity and specificity of optical coherence tomography (OCT) based retinal thickness analysis in determining ischaemia onset in CRAO. Methods The relative retinal thickness increase (RRTI) in comparison with the fellow eye was analysed retrospectively in OCT scans of 66 patients diagnosed with CRAO between January 2010 and December 2019 within 48 ...
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    6. ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD)

      ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD)
      Background/aims The prospective, non-interventional ORCA module of the OCEAN study (Observation of Treatment Patterns with Lucentis in Approved Indications) evaluated the qualiy of spectral domain-optical coherence tomography (SD-OCT) image interpretation and treatment decisions by clinicians in Germany and the impact on visual outcomes over 24 months in patients with neovascular age-related macular degeneration (nAMD). Methods 2286 SD-OCT scans of 205 eyes were independently evaluated by clinicians and reading centres ...
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    7. Fundus autofluorescence, spectral‐domain optical coherence tomography, and histology correlations in a Stargardt disease mouse model

      Fundus autofluorescence, spectral‐domain optical coherence tomography, and histology correlations in a Stargardt disease mouse model
      Stargardt disease (STGD1), known as inherited retinal dystrophy, is caused by ABCA4 mutations. The pigmented Abca4 / mouse strain only reflects the early stage of STGD1 since it is devoid of retinal degeneration. This blue light‐illuminated pigmented Abca4 / mouse model presented retinal pigment epithelium (RPE) and photoreceptor degeneration which was similar to the advanced STGD1 phenotype. In contrast, wild‐type mice showed no RPE degeneration after blue light illumination. In ...
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    8. Cellular-scale evaluation of induced photoreceptor degeneration in the living primate eye

      Cellular-scale evaluation of induced photoreceptor degeneration in the living primate eye
      Progress is needed in developing animal models of photoreceptor degeneration and evaluating such models with longitudinal, noninvasive techniques. We employ confocal scanning laser ophthalmoscopy, optical coherence tomography (OCT) and high-resolution retinal imaging to noninvasively observe the retina of non-human primates with induced photoreceptor degeneration. Photoreceptors were imaged at the single-cell scale in three modalities of adaptive optics scanning light ophthalmoscopy: traditional confocal reflectance, indicative of waveguiding; a non-confocal offset aperture ...
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    9. Phenotyping of Mouse Models with OCT

      Phenotyping of Mouse Models with OCT
      Optical coherence tomography (OCT) is an invaluable technique to perform noninvasive retinal imaging in small animal models such as mice. It provides virtual cross sections that correlate well with histomorphometric data with the advantage that multiple iterative measurements can be acquired in timeline analyses to detect dynamic changes and reduce the number of animals needed per study.
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    10. Ciliary muscle thickness profiles derived from optical coherence tomography images

      Ciliary muscle thickness profiles derived from optical coherence tomography images
      The purpose of this study was to provide an in-depth analysis of the ciliary muscles (CM) morphological changes during accommodation by evaluating CM thickness (CMT) profiles. The CM of 15 near-emmetropic subjects (age 20-39) was imaged via optical coherence tomography (OCT) during far (0 D) and near vision (3 D). A custom-made Java-based program was used for semi-automatic CM segmentation and thickness measurements. CMT profiles were generated to determine regions ...
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    11. Investigating Recurrent Neural Networks for OCT A-scan Based Tissue Analysis

      Investigating Recurrent Neural Networks for OCT A-scan Based Tissue Analysis
      Objectives: Optical Coherence Tomography (OCT) has been proposed as a high resolution image modality to guide transbronchial biopsies. In this study we address the question, whether individual A-scans obtained in needle direction can contribute to the identification of pulmonary nodules. Methods: OCT A-scans from freshly resected human lung tissue specimen were recorded through a customized needle with an embedded optical fiber. Bidirectional Long Short Term Memory networks (BLSTMs) were trained ...
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    12. Spectral-Domain Optical Coherence Tomography Staging and Autofluorescence Imaging in Achromatopsia

      Spectral-Domain Optical Coherence Tomography Staging and Autofluorescence Imaging in Achromatopsia
      Importance Evidence is mounting that achromatopsia is a progressive retinal degeneration, and treatments for this condition are on the horizon. Objectives To categorize achromatopsia into clinically identifiable stages using spectral-domain optical coherence tomography and to describe fundus autofluorescence imaging in this condition. Design, Setting, and Participants A prospective observational study was performed between 2010 and 2012 at the Edward S. Harkness Eye Institute, New York-Presbyterian Hospital. Participants included 17 patients ...
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  2. About University of Tübingen

    University of Tübingen

    University of Tübingen (Eberhard-Karls-Universität Tübingen, sometimes called the "Eberhardina") is a public university located in the city of Tübingen, Baden-Württemberg, Germany. It is one of Germany's oldest universities, internationally noted in medicine, natural sciences and the humanities. Tübingen is one of five classical "university towns" in Germany; the other four being Marburg, Göttingen, Freiburg and Heidelberg. The university has many Nobel laureate alumni, especially in the fields of medicine and chemistry. Currently, about 24,000 students are enrolled. The 17 hospitals in Tübingen affiliated with the university's faculty of medicine have 1,500 patient beds, and cater to 66,000 in-patients and 200,000 out-patients on an annual basis.