1. University of Southern California

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    1. Mentioned In 333 Articles

    2. Comparison of Clinically Relevant Findings from High-Speed Fourier-Domain and Conventional Time-Domain Optical Coherence Tomography

      Purpose To compare the sensitivities of high-speed Fourier-domain optical coherence tomography (FD-OCT) and conventional time-domain (TD) OCT for the detection of clinical findings important in the management of common vitreoretinal disorders. Design Prospective, observational study. Methods FD-OCT scans (128 B scans 512 A scans) were obtained using a prototype instrument (3 D-OCT; Topcon, Tokyo, Japan) in 50 eyes of 28 consecutive patients undergoing conventional high-resolution (6 B scans 512 A ...
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    3. Signal Strength is an Important Determinant of Accuracy of Nerve Fiber Layer Thickness Measurement by Optical Coherence Tomography.

      Purpose: To investigate the effect of signal strength on the measurement of the retinal nerve fiber layer (RNFL) using optical coherence tomography (OCT). Methods: Eyes with known or suspected glaucoma or nonglaucomatous optic atrophy were scanned twice within the same visit using Stratus OCT's Fast Nerve Fiber Layer Thickness protocol. Only those eyes with 2 high-quality scans (signal strengths of at least 5 and different from each other, no ...
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    4. Association Of The Extent Of Diabetic Macular Edema As Assessed By Optical Coherence Tomography With Visual Acuity And Retinal Outcome Variables.

      Purpose: To determine whether the extensiveness of diabetic macular edema using a 10-step scale based on optical coherence tomography explains pretreatment variation in visual acuity and predicts change in macular thickness or visual acuity after laser photocoagulation. Methods: Three hundred twenty-three eyes from a randomized clinical trial of two methods of laser photocoagulation for diabetic macular edema were studied. Baseline number of thickened optical coherence tomography subfields was used to ...
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    5. Evaluation of Optical Coherence Tomography Central Retinal Thickness Parameters for use as Anatomic Outcomes in Clinical Trials for Neovascular Age-Related Macular Degeneration

      Purpose: To investigate the relationship between automated and manually-derived measurements of central retinal thickness from optical coherence tomography (OCT), and to determine the relationship between foveal center point (FCP) and foveal central subfield (FCS), in neovascular age-related macular degeneration (AMD). Methods: Data from 216 patients newly diagnosed with neovascular AMD, who underwent StratusOCT imaging at diagnosis, were collected. Raw StratusOCT images for each patient were analyzed using publicly available custom ...
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    6. Spectral domain OCT results could change treatment

      Spectral domain optical coherence tomography improves upon the sensitivity of interpolated OCT enough to affect 10% of treatment protocols, another speaker said. “We found that, overall, there clearly was an improved sensitivity for detection of various pathologies in spectral domain vs. time domain OCT,” SriniVas R. Sadda, MD, said at the conference. Dr. Sadda conducted a prospective, masked study comparing time domain and spectral domain OCT use on 50 patients ...
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    7. Gaussian fitting on mean curvature maps of parameterization of corneal ectatic diseases

      The present invention discloses a method for characterizing ectatic diseases of the cornea by computing a mean curvature map of the anterior or posterior surfaces of the cornea and fitting the map to a Gaussian function to characterize the surface features of the map. Exemplary ectatic disease that may be characterized include keratoconus and pellucid marginal degeneration. Also disclosed are a system for diagnosing ectatic disease of the cornea and ...
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    8. Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography

      Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography
      We have successfully imaged the retinal tumor in a mouse model using an ultra-high resolution spectral-domain optical coherence tomography (SD-OCT) designed for small animal retinal imaging. For segmentation of the tumor boundaries and calculation of the tumor volume, we developed a novel segmentation algorithm. The algorithm is based on parametric deformable models (active contours) and is driven by machine learning-based region classification, namely a Conditional Random Field. With this algorithm ...
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    9. Retinal blood flow detection in diabetic patients by Doppler Fourier domain optical coherence tomography

      Retinal blood flow detection in diabetic patients by Doppler Fourier domain optical coherence tomography
      We present human retinal blood flow investigation for diabetic patients using Doppler Fourier domain optical coherence tomography (FDOCT). The scanning pattern consisted of two concentric circles around the optic nerve head. The blood flow in one patient with diabetes and no retinpathy and another ... [Opt. Express 17, 4061-4073 (2009)]
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    10. Investigation of retinal blood flow in normal and glaucoma subjects by doppler fourier-domain optical coherence tomography

      We present in vivo human retinal blood flow investigation using Fourier domain optical coherence tomography. A pilot study was performed to evaluate the total retinal blood flow in glaucoma patients and normal subjects. For normal people, the measured total retinal flow was between 40.8 and 52.9 [mu ... [Proc. SPIE 7168, 71680B (2009)] published Thu Feb 19, 2009.
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    11. Quantitative Subanalysis of Intraretinal Cystoid Spaces and Outer Nuclear Layer using Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration

      ...tute, Los Angeles, California, United States ^3 Department of Preventive Medicine, Keck School of Medicine at University of Southern California, Los Angeles, California, United States ^4 Department of Ophthalmology, Dohe...
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    12. Agreement Between Stratus and Visante Optical Coherence Tomography Systems in Tear Meniscus Measurements.

      Aim: To compare the tear meniscus height (TMH) measurements provided by the Stratus and Visante optical coherence tomography systems. Methods: A cross-section image of the lower tear meniscus was captured with both instruments in 26 volunteers. An external application was used to manually measure the TMH as imaged by the Stratus; measurements by the Visante were analyzed by the internal software. Only 1 eye for each subject was considered for ...
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  2. About University of Southern California

    University of Southern California

    University of Southern California is located in Los Angeles, a global center for arts, technology and international trade and is one of the world’s leading private research universities. USC enrolls more international students than any other U.S. university and offers extensive opportunities for internships and study abroad. With a strong tradition of integrating liberal and professional education, USC fosters a vibrant culture of public service and encourages students to cross academic as well as geographic boundaries in their pursuit of knowledge. The Keck School of Medicine is the medical school at the University of Southern California. Founded in 1885 as the USC College of Medicine, it was closed in 1921 and reopened in 1928 as the USC School of Medicine.